Major Article Contributions by some of the Japanese Authors of Bentham Science Publishers Journal; Current Protein & Peptide Science

7-28-2014 9-06-18 AM

Journal Title: Current Protein & Peptide Science

Article Title: Exploring New CGRP Family Peptides and their Receptors in Vertebrates

Author(s): Yoshio Takei, Maho Ogoshi and Shigenori Nobata

Abstract:

Vertebrates have expanded their habitats from aquatic to terrestrial environments, which has accompanied the evolution of cardiovascular and osmoregulatory hormones. Specifically, mammals have developed mechanisms to maintain high blood pressure and blood volume, while extant fishes have developed hypotensive and Na-extruding mechanisms to adapt to the marine environment where they underwent a vast diversification. The CGRP family is one of the hormone systems that decrease blood pressure and blood volume. Within the CGRP family of teleost fishes, we found that adrenomedullins (AMs) have diversified and five paralogs (AM1-5) form an independent subfamily. Based on this discovery in fishes, we found AM2 and AM5 in mammals. In mammalian species that have AM2 and/or AM5, the peptides assume greater importance in the case of pathophysiological disturbances in pressure and fluid balance such as hypertension and cardiac and renal failure. In addition, novel functions of AM peptides have been suggested by the discovery of AM2 and AM5 in mammals. Current research on the CGRP family is focused on the identification of new receptors for AM2/AM5 and the establishment of AM2 knockout mice, which will enable new developments in the basic and clinical research on this intriguing hormone family. Importantly, comparative fish studies can contribute to new developments in our understanding of the function of the AM peptides.
Article Title: Functions of Third Extracellular Loop and Helix 8 of Family B GPCRs Complexed with RAMPs and Characteristics of their Receptor Trafficking
Author(s): Kenji Kuwasako, Debbie L Hay, Sayaka Nagata, Manabu Murakami, Kazuo Kitamura and Johji Kato

Abstract:

At least one of three receptor activity-modifying proteins (RAMP1, RAMP2 and RAMP3) can interact with 10 G protein-coupled receptors (GPCRs; nine Family B GPCRs and a Family C GPCR). All three RAMPs interact with the calcitonin (CT) receptor (CTR), the CTR-like receptor (CLR), the vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating polypeptide (PACAP) 1 (VPAC1) and the VPAC2 receptor, which are all Family B GPCRs. Three RAMPs enable CTR to function as three heterodimeric receptors for amylin, which is a feeding suppression peptide. These RAMPs also transport the CLR to the cell surface, where they function as a CT gene-related peptide (CGRP) receptor (CLR/RAMP1 heterodimer) and two adrenomedullin (AM) receptors (CLR/RAMP2 and CLR/RAMP3 heterodimers). CGRP and AM are potent hypotensive peptides that exert powerful protective effects against multi-organ damage. We recently reported that the third extracellular loop (ECL3) of CLR governs the activation of AM, but not CGRP, signaling in the three CLR/RAMP heterodimers. Furthermore, we showed that in the presence of RAMP2, the eighth helix (helix 8) in the proximal portion of the cytoplasmic C-terminal tail of the CLR, which is thought to be present in all family B GPCRs, participates in receptor signaling. In addition, we demonstrated that overexpression of GPCR kinase (GRK) 2, GRK3 and GRK4 enhances the AM-induced internalization of the CLR/RAMP2 heterodimer. In this review, we describe these studies and consider their implications for other Family B GPCRs that can interact with RAMPs.

For more details, visit: http://benthamscience.com/journal/abstracts.php?journalID=cpps&articleID=113130

 

Article Title: Adrenomedullin as a Potential Therapeutic Agent for Inflammatory Bowel Disease

Author(s): Shinya Ashizuka, Haruhiko Inatsu, Kyoko Inagaki-Ohara, Toshihiro Kita and Kazuo Kitamura

Abstract:

Adrenomedullin (AM) was originally isolated from human pheochromocytoma as a biologically active peptide with potent vasodilating action but is now known to exert a wide range of physiological effects, including cardiovascular protection, neovascularization, and apoptosis suppression. A variety of tissues, including the gastrointestinal tract, have been shown to constitutively produce AM. Pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1, and lipopolysaccharides, induce the production and secretion of AM. Conversely, AM induces the downregulation of inflammatory cytokines in cultured cells. Furthermore, AM downregulates inflammatory processes in a variety of different colitis models, including acetic acid-induced colitis and dextran sulfate sodium-induced colitis. AM exerts antiinflammatory and antibacterial effects and stimulates mucosal regeneration for the maintenance of the colonic epithelial barrier. Here, we describe the first use of AM to treat patients with refractory ulcerative colitis. The results strongly suggest that AM has potential as a new therapeutic agent for the treatment of refractory ulcerative colitis.
Article Title: Ectodomain Structures of the CGRP and AM Receptors
Author(s): Seisuke Kusano and Shigeyuki Yokoyama

Abstract:

Receptor activity-modifying proteins (RAMPs) 1–3, which are classified as type I transmembrane proteins, serve as the partner proteins of several family B GPCRs for physiologically active peptides, including the calcitonin receptor- like receptor (CLR). The properties of the GPCRs are defined by the RAMP and peptide ligand combination. The CLR•RAMP1 heterodimer functions mainly as the calcitonin gene-related peptide (CGRP) receptor, while the CLR•RAMP2 and CLR•RAMP3 heterodimers primarily function as the adrenomedullin 1 and adrenomedullin 2 (AM1 and AM2) receptors, respectively. The crystal structures of the RAMP1 and RAMP2 ectodomains exhibited three-helix bundles, and those of their complexes with the N-terminal extracellular domain of CLR revealed how the two ectodomains associate to form the CGRP and AM1 receptors, respectively. On this structural framework, the various intermolecular interactions of CLR with RAMP1 and RAMP2 result in the distinct shapes of the putative ligand-binding sites, where several residues are uniquely presented. Therefore, the differences in the shapes and the presented residues of the binding sites determine the specificities of the receptors to either CGRP or AM. These structural features of the ectodomains are consistent with mutagenesis results, and are useful to further examine the binding modes of the peptide ligands to the full-length CGRP and AM1 receptors.

Article Title: Insulin Resistance-Induced Hypertension and a Role of Perivascular CGRPergic Nerves

Author(s): Shingo Takatori, Yoshito Zamami, Narumi Hashikawa-Hobara and Hiromu Kawasaki

Abstract:

Insulin resistance is defined as a preliminary step of type 2 diabetes mellitus with decreased insulin action evoked by continuous postprandial hyperglycemia, which is provoked by high fat and calories dieting, a lack of physical activity and obesity. In the early phase of type 2 diabetes mellitus, patients have a hyperinsulinemia to compensate deficient insulin action by increased secretion from the pancreas to maintain euglycemia. Then, pancreatic β cells progressively decrease secretion function, resulting in the development of diabetes mellitus with decreased serum insulin levels. Accumulating evidences show that insulin resistance is associated with hypertension. However, the mechanisms underlying hypertension associated with type 2 diabetes mellitus have still unknown. Therefore, to elucidate the mechanisms of insulin resistance-induced hypertension, we investigated that the effects of hyperinsulinemia or hyperglycemia on vascular responses mediated by perivascular nerves including sympathetic adrenergic nerves and calcitonin gene-related peptide (CGRP)-containing nerves (CGRPergic nerves). In this article, we show evidence that insulin resistance-induced hypertension could be resulted from increased density and function of sympathetic nerve, and decreased density and function of CGRPergic nerves. Furthermore, our findings provide a new insight into the research of therapeutic drugs for insulin resistance- induced hypertension.

Recent Issues of the Following Journals have been published:

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 8 Issue 2

Aims & Scope

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery publishes review and research articles, and guest edited thematic issues on recent patents in the field of endocrine, metabolic and immune drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in endocrine, metabolic and immune drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to endocrine, metabolic and immune drug discovery.

 http://www.eurekaselect.com/123599/issue/2

Abstracted & Indexed in:

PubMed/MEDLINE, Chemical Abstracts, Scopus, EMBASE, Cambridge Scientific Abstracts (CSA), METADEX, PubsHub, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, J-Gate.

For details, visit: http://benthamscience.com/journal/index.php?journalID=rpemi

 

Current HIV Research, 12 Issue 2 

Aims & Scope

Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.

http://www.eurekaselect.com/123580/issue/2

Abstracted & Indexed in:

Science Citation Index Expanded™, Thomson Web of Science, ISI Alerting Services, Journal Citation Reports/Science Edition, BIOSIS, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Chemical Abstracts, MEDLINE/Index Medicus, Scopus, EMBASE, EMBASE/Excerpta Medica, PubsHub, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, J-Gate, PubMed.

For details, visit: http://benthamscience.com/journal/index.php?journalID=chivr

 

Current Medicinal Chemistry, 21 Issue 25 

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

http://www.eurekaselect.com/123573/issue/25

Abstracted & Indexed in:

Biochemistry and Biophysics Citation Index®, BIOSIS, Chemical Abstracts, Current Contents/Life Sciences, EMBASE/Excerpta Medica, MEDLINE/Index Medicus, Reference Update, Research Alert, Science Citation Index®, Prous Science Integrity®, Science Citation Index Expanded, PubsHub, Journal Citation Reports/Science Edition, Index to Scientific Reviews®, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, EMBASE, BIOBASE, Genamics JournalSeek, J-Gate, PubMed, MediaFinder®-Standard Periodical Directory.

For details, visit: http://benthamscience.com/journal/index.php?journalID=cmc

 

Current Bioactive Compounds, 10 Issue 1

Aims & Scope

The journal aims to provide comprehensive review articles as well as research papers on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.

http://www.eurekaselect.com/123561/issue/1

Abstracted & Indexed in:

EMBASE, Scopus, Chemical Abstracts, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, J-Gate.

For details, visit: http://benthamscience.com/journal/index.php?journalID=cbc

 

Recent Patents on Inflammation & Allergy Drug Discovery, 8 Issue 2

Aims & Scope

Recent Patents on Inflammation & Allergy Drug Discovery publishes review and research articles, and guest edited thematic issues on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to inflammation and allergy drug discovery.

http://www.eurekaselect.com/123478/issue/2

Abstracted & Indexed in:

Scopus, PubMed/MEDLINE, EMBASE, Cambridge Scientific Abstracts (CSA), METADEX, Chemical Abstracts, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, J-Gate, PubsHub.

For details, visit: http://benthamscience.com/journal/index.php?journalID=rpiad

 

Current Genomics, 15 Issue 4

Aims & Scope

Current Genomics,a peer-reviewed journal, publishes authoritative and comprehensive reviews and guest edited issues covering all the latest and outstanding developments in genome science and computational / systems biology. Guest edited issues provide expert views on specific questions giving an extensive and comprehensive analysis of a specific field of activities in genomics. All aspects of genetic analysis and gene function will be covered; particularly in the growing areas of human genomics, functional genomics and deep sequencing, molecular evolution, developmental biology, aging and longevity and system modeling. The journal is essential reading for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments in genome science.

http://www.eurekaselect.com/123477/issue/4

Abstracted & Indexed in:

Science Citation Index Expanded, Biochemistry & Biophysics Citation Index, Journal Citation Reports/Science Edition, BIOSIS, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, PubMed Central, PubMed, EMBASE/Excerpta Medica, BIOBASE, EMBASE, Scopus, Chemical Abstracts, EMBiology, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, J-Gate.

For details, visit: http://benthamscience.com/journal/index.php?journalID=cg

 

Current Pediatric Reviews, 10 Issue 3

Aims & Scope

Current Pediatric Reviews publishes frontier reviews, drug clinical trial studies and guest edited thematic issues on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.

http://www.eurekaselect.com/123503/issue/3

Abstracted & Indexed in:

PubMed/Medline, Chemical Abstracts, EMBASE, Scopus, EMNursing, CINAHL® (CUMULATIVE INDEX TO NURSING AND ALLIED HEALTH LITERATURE), Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, METADEX, PubsHub, J-Gate.

For more details, visit: http://benthamscience.com/journal/index.php?journalID=cpr

Bentham Science Publishers Free 3 Months Trial Is Active In:

Institute: Rashid Medical Library

About The University: 

Dubai Health Authority (DHA) subscribes to a number of data bases, services and products. They are for individual, non-commercial educational or research purposes only. Use of this product is restricted to members of the DHA community, Library patrons and Users of the Library’s physical facilities. It is the responsibility of each user to ensure that they do not systematically download or retain substantial portions of information. For further information please speak with a librarian.

For information about the university, visit: [http://web.dohms.gov.ae/medlib/]

 

BSP Patent Journal- Recent Patents on Biomarkers

Recent Patents on Biomarkers

7-24-2014 11-31-47 AM

ISSN: 2210-3104 (Online)
ISSN: 2210-3090 (Print)

Volume 4, 3 Issues, 2014

Aims & Scope

Recent Patents on Biomarkers publishes review and research articles, and guest edited thematic issues on important recent patents on biomarkers. The coverage includes novel biomarkers in basic, medical, environmental, and pharmaceutical research. A selection of important and recent patents on biomarkers is also included in the journal. The journal is essential reading for all researchers involved in biomarker research and discovery. The journal also covers recent research (where patents have been registered) in fast emerging patent biomarker applications; discovery and validation are covered for drug discovery, clinical development and molecular diagnostics.

Abstracted & Indexed in:

Chemical Abstracts, MediaFinder®-Standard Periodical Directory, J-Gate, PubsHub, CABI.

For more details, visit: http://benthamscience.com/journal/index.php?journalID=rpbm

BSP Text Book- Micro and Nanomachining Technology Size, Model and Complex Mechanism by, Xuesong Han

Micro and Nanomachining Technology Size, Model and Complex Mechanism

7-24-2014 11-26-51 AM

“Recent advances in science and technology such as online monitoring techniques, coupling of various processing methods, surface characterization and measurement techniques have greatly promoted the development of ultraprecise machining technology. This precision now falls into the micrometer and nanometer range – hence the name micro & nanomachining technology (MNT).

Machining is a complex phenomenon associated with a variety of different mechanical, physical, and chemical processes. Common principles defining control mechanisms such as O Jamie de geometry, Newton mechanics, Macroscopic Thermodynamics and Electromagnetics are not applicable to phenomena occurring at the nanometer scale whereas quantum effects, wave characteristics and the microscopic fluctuation become the dominant factors. A remarkable enhancement in computational capability through advanced computer hardware and high performance computation techniques (parallel computation) has enabled researchers to employ large scale parallel numerical simulations to investigate micro & nanomachining technologies and gain insights into related processes.

Micro and Nanomachining Technology – Size, Model and Complex Mechanism introduces readers to the basics of micro & nanomachining (MNT) technology and covers some of the above techniques including molecular dynamics and finite element simulations, as well as complexity property and multiscale MNT methods.

This book meets the growing need of Masters students or Ph.D. students studying nanotechnology, mechanical engineering or materials engineering, allowing them to understand the design and process issues associated with precision machine tools and the fabrication of precision components.”

For more details, visit: http://ebooks.benthamscience.com/book/9781608057696/

Recent Issues of the Following Journals have been Published!

Current Topics in Medicinal Chemistry, 14 Issue 12

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

  http://www.eurekaselect.com/122889/issue/12

Abstracted & Indexed in:

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedT, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/Excerpta Medica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, J-Gate.

For details, visit: http://benthamscience.com/journal/index.php?journalID=ctmc

 

Current Medicinal Chemistry, 21 Issue 23

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

 http://www.eurekaselect.com/122876/issue/23

Abstracted & Indexed in:

Biochemistry and Biophysics Citation Index®, BIOSIS, Chemical Abstracts, Current Contents/Life Sciences, EMBASE/Excerpta Medica, MEDLINE/Index Medicus, Reference Update, Research Alert, Science Citation Index®, Prous Science Integrity®, Science Citation Index Expanded, PubsHub, Journal Citation Reports/Science Edition, Index to Scientific Reviews®, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, EMBASE, BIOBASE, Genamics JournalSeek, J-Gate, PubMed, MediaFinder®-Standard Periodical Directory.

For more details, visit: http://benthamscience.com/journal/index.php?journalID=cmc

 

Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 14 Issue 2

Aims & Scope

This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders. Original articles related to Immune Disorders and Drug Targeting are also considered for publication.

http://www.eurekaselect.com/122905/issue/2

Abstracted & Indexed in:

Chemical Abstracts, MEDLINE/Index Medicus, EMBASE/Excerpta Medica, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, J-Gate, Science Citation Index (Thomson Reuters).

For details, click: http://benthamscience.com/journal/index.php?journalID=emiddt

 

Current Pharmaceutical Design, 20 Issue 24

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

http://www.eurekaselect.com/122931/issue/24

Abstracted & Indexed in:

Biochemistry & Biophysics Citation Index®, BIOSIS, Chemical Abstracts, Current Contents®/Life Sciences, EMBASE/Excerpta Medica, MEDLINE/Index Medicus, Medical Documentation Service®, Research Alert®, Science Citation Index®, Science Citation Index Expanded (SciSearch®), Cambridge Scientific Abstracts (CSA), PubsHub, Journal Citation Reports/Science Edition, Index to Scientific Reviews®, Custom Information Services®, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, Genamics JournalSeek, J-Gate.

For more information, visit: http://benthamscience.com/journal/index.php?journalID=cpd

 

Protein & Peptide Letters, 21 Issue 8

Aims & Scope

Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations.

Protein & Peptide Letters focuses on:

  • Structure Studies
  • Advances in Recombinant Expression
  • Drug Design
  • Chemical Synthesis
  • Function
  • Pharmacology
  • Enzymology
  • Conformational Analysis
  • Immunology
  • Biotechnology
  • Protein Engineering
  • Protein Folding
  • Sequencing
  • Molecular Recognition
  • Purification and Analysis

 

http://www.eurekaselect.com/122942/issue/8

Abstracted & Indexed in:

Journal Citation Reports/Science Edition, Science Citation Index, Science Citation Index Expanded (SciSearch)®, MEDLINE/Index Medicus, PubMed, BIOSIS, BIOSIS Previews, Biochemistry & Biophysics Citation Index®, Biochemistry, Chemical Abstracts, Scopus, BIOBASE, Biomed Link, EMBASE/Excerpta Medica, Current Awareness in Biological Sciences (CABS), Biological Abstracts, EMBiology, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, J-Gate.

For more details, visit: http://benthamscience.com/journal/index.php?journalID=ppl

 

Combinatorial Chemistry & High Throughput Screening, 17 Issue 6

Aims & Scope

Combinatorial Chemistry & High Throughput Screening(CCHTS) publishes full length original research articles and reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

http://www.eurekaselect.com/122963/issue/6

Abstracted & Indexed in:

Chemical Abstracts, Current Contents®/Life Sciences, EMBASE/Excerpta Medica, MEDLINE/Index Medicus, Science Citation Index ExpandedTM, BIOBASE, CAB Abstracts, Journal Citation Reports/Science Edition, Chemistry Citation Index®, Reaction Citation Index®, Biological Abstracts, BIOSIS, BIOSIS Previews, Scopus, EMBiology, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, J-Gate.

For more information, visit: http://benthamscience.com/journal/index.php?journalID=cchts