About the EIC of the journal, “Recent Patents on Drug Delivery & Formulation”: Dr. Mark A. Babizhayev

Dr. Mark A. Babizhayev is the Editor in Chief of the Journal Recent Patents on Drug Delivery & Formulation. He is currently the Executive Director of Innovative Vision Products, Inc., Delware (USA), Senior Research Investigator at Moscow Helmholtz Research Institute of Eye Diseases (RF) and Scientific Consultant to Exsymol SAM, Monte Carlo (MC).

Dr. Mark A. Babizhayev graduated from Second Moscow Medical Institute in 1982 and received his PhD inn Biophysics and Pathophysiology. He has dedicated many years to scientific research, principally at the Helmholtz Research Institute of Eye Disease, in Moscow. During that time, he has accumulated over 86 published articles and also has 15 patents to his name. He is also a principle involved in the development of a breakthrough for the treatment and prevention of senile cataract.

Listed below are some recent and notable publications by Dr. Mark A. Babizhayev:


  1. Article Title: “Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with midazolecontaining peptidomimetic antioxidants.

Author(s): Mark A. Babizhayev, Lankin VZ, Savel’Yeva EL, Deyev Al, Yegorov YE.

Journal Name: Recent patents on drug delivery & formulation.

For details, visit: http://www.ncbi.nlm.nih.gov/pubmed/24236935



  1. Article Title: “The detox strategy in smoking comprising nutraceutical formulas of non-hydrolyzed carnosine or carcinine used to protect human health.”

Author(s): Mark A. Babizhayev.

Journal Name: Human & experimental toxicology.

For more details, visit: http://www.ncbi.nlm.nih.gov/pubmed/24220875

3.      Article Title: “Biomarkers of Oxidative Stress and Cataract. Novel Drug Delivery Therapeutic Strategies Targeting Telomere Reduction and the Expression of Telomerase Activity in the Lens Epithelial Cells with N-Acetylcarnosine Lubricant Eye Drops: Anti-Cataract which Helps to Prevent and Treat Cataracts in the Eyes of Dogs and other Animals”

Author(s): Mark A. Babizhayev and Yegor E. Yegorov

Journal Name: Current Drug Delivery

For more details, visit: http://benthamscience.com/journal/abstracts.php?journalID=cdd&articleID=116026

4.      Article Title: “L-Carnosine Modulates Respiratory Burst and Reactive Oxygen Species Production in Neutrophil Biochemistry and Function: May Oral Dosage Form of Non-Hydrolized Dipeptide L-Carnosine Complement Anti-Infective Anti-Influenza Flu Treatment, Prevention and Self-Care as an Alternative to the Conventional Vaccination?”

Author(s):Mark A. Babizhayev, Anatoliy I. Deyev and Yegor E. Yegorov

Journal Name: Current Clinical Pharmacology

For more details, visit: http://benthamscience.com/journal/abstracts.php?journalID=ccp&articleID=120869


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5.      Article Title: “Coated with nanomaterials intraocular lenses, ophthalmic and human body implantable devices with high catalytic antioxidant activities: a new nanotechnology strategy of peroxidase cellular enzyme mimics increasing the biocompatibility and therapeutic deployment of the medical prosthetic device.”

Dr. Mark A. Babizhayev is the Author of the book published in May 30, 2011; “Tragic Accident with Princess Diana: The Effects of Glare and Visual Disability on Driving.

For more details, visit: http://www.ncbi.nlm.nih.gov/pubmed/22934629


6.      Article Title: “Carcinine has 4-hydroxynonenal scavenging property and neuroprotective effect in mouse retina.”

Author(s): Babizhayev MA, Marchette LD, Wang H, Li F, Kasus-Jacobi A.

Journal Name: Investigative ophthalmology & visual science.

For more information, visit: http://www.ncbi.nlm.nih.gov/pubmed/22577078


7.      Article Title: “Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.”

Author(s): Babizhayev MA

Journal Name: Recent patents on drug delivery & formulation.

For more information, please visit: http://www.ncbi.nlm.nih.gov/pubmed/22436026

Dr. Mark A. Babizhayev is the Author of the book published in May 30, 2011; “Tragic Accident with Princess Diana: The Effects of Glare and Visual Disability on Driving.

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Book Description:

This book presents an investigation into some of the most common causes those experts believe are responsible for traffic accidents and vehicle crashes. Using the death of Princess

Diana and Dodi Fayed in a car accident as the main point of reference, the book explores various factors which could have impacted upon their death, and that of many other people.

Many incidents of mortality on the roads are due to the inadequate provision that is made in the country regarding examination of the visual performance of drivers. Especially when driving at night, even drivers with a full visual function reach their psychological limit, with the glare of headlights and street lamps also serving as a considerable impediment. This book emphasizes that regular visual testing of a driver with glare source-based stimuli and application of lenses equipped with the anti-reflection coatings, traffic accidents and deaths could be considerably reduced.

Abstracts from New BSP Journal: Technology Transfer and Entrepreneurship

Image1. The Capital Café: Embracing Alternative Forms and Sources of Capital

Author(s): Karl Dakin

Affiliation: Dakin Capital Services LLC, 7148 S. Andes Circle, Centennial, CO 80016, USA.


There is a growing trend amongst entrepreneurs that they will not start a business unless they first raise cash from a banker, an angel investor or a venture capitalist. The ability to raise capital has become a litmus test as to the viability of a business opportunity. However, the vast majority of business opportunities will not meet the lending or investment criteria of these capital sources. Even if the criteria can be met, the costs of obtaining capital from these sources may be too high. This paper sets forth an alternative approach that may generate multiple sources of capital at lower costs of capital. The approach obtains capital in the form of assets from strategic partners or stakeholders who will benefit from the success of the new business. To successfully implement this approach, a founder of a new business must understand which capital assets are critical to a successful business launch and must understand the motivation of investor candidates to make those assets available to the new business.


2. Outcomes Rather than Outputs: Collaborative Closed-Loop Design and Commercialization

Author(s): Tilak Dutta and Geoffrey Roy Fernie

Affiliation: Toronto Rehabilitation Institute, 550 University Avenue, Toronto, Ontario, M5G 2A2, Canada.


This paper outlines the Toronto Rehabilitation Institute Technology Team’s vision for translational research. The objective of the Technology Team is to help people age successfully by providing tools to manage the disabilities that come with aging. To facilitate this translational research and realizing real world benefits, the Technology Team has developed a collaborative closed-loop design process. We describe the five strategies that make up our approach. The strategies are: 1) Having a collaborative team of clinicians, technical experts, researchers and students; 2) Maintaining prototyping facilities on-site; 3) Using simulators to quickly, safely, and repeatably test ideas with the target population; 4) Building relationships with stakeholders; 5) Careful documentation in preparation of regulatory approvals. Together these strategies have helped our team focus on translating research findings into practical outcomes as the ultimate goal of our research. These outcomes include changes to policy and clinical practice as well as the creation of new products, in addition to the traditional focus of academic research groups on outputs such as publications and grants.

For details on the journal, please visit: Technology Transfer and Entrepreneurship

New BSP Journal: Technology Transfer and Entrepreneurship

Aims & Scope

“Technology Transfer and Entrepreneurship” (TTE) publishes definitive review articles including case histories covering a broad range of topics that underlie the business of biomedical and research, specifically translating basic scientific discoveries into commercial opportunities. This includes understanding of the technology transfer process and entrepreneurship in academia, the biotechnology and pharmaceutical industries; directed towards economic development, better healthcare, and long-term job creation.

The journal scope includes economic insights on how technology is transferred within the bioscience and healthcare industries, and the underlying entrepreneurship that embodies scientific and biomedical research.

The journal will be published in April 2014. Open access will be encouraged as much as possible, with issues in the first year being available online free of charge. TTE will be published by Bentham Science Publishers (www.benthamscience.com), a world leader in scientific publishing.

Interested authors should send a 1-page proposal and outline for their proposed review/original research article to either of the journal Editors atcbeyer@padrugdiscovery.org or areitz@padrugdiscovery.org.


For learning more about the journal, please visit: http://benthamscience.com/journal/index.php?journalID=tte#top

BSP Attended Events: Experimental Biology 2014

Bentham Science Publishers attends international #events, all year round.
Another upcoming event in the #global #calendar of #BSP is Experimental Biology 2014.
This meeting  will be held at San Diego, USA on the April, 26th – 30th 2014.
For details on the Annual Meeting, please visit: http://experimentalbiology.org/2014/Home.aspx
For information on Bentham Science Publishers, please visit: www.benthamscience.com


About the Editorial Advisory Board Member of the journal, “Current Psychiatry Reviews”: Michael Angus Crawford

ImageMichael Angus Crawford is the Editorial Advisory Board Member of Current Psychiatry Reviews. He is currently a visiting professor, Imperial College, Department of Cancer and Surgery, Division of Reproductive Physiology, Obstetrics and Gynecology Chelsea and Westminster Hospital Campus, London, UK.

Dr. Michael Angus Crawford graduated from Edinburgh University in 1952 with a BSc in Chemistry received his PhD in Chemical Pathology from Royal Postgraduate Medical School, University of London in 1960.

Dr. Crawford had received The International Award for Modern Nutrition for work on unsaturated fatty acids in early human development and health and another Award from University of Louisiana – for Neuroscience and Medicine.

He also completed his PhD thesis in ‘Influence of pH on the excretion of some weak acids and bases’ from The University of London in 1960.

Listed below are some recent publications by Dr. Michael Angus Crawford:

  1. Article Title: “Observations on the pharmacology of mecamylamine”

Author(s): MD Milne, G G Rowe, M A Crawford, K Somers, R C Muehrcke.

Journal Name: Clinical Science

For details, visit: http://www.ncbi.nlm.nih.gov/pubmed/13489900


  1. Article Title: “Fatty acid correlates of temperament in adolescent boys with attention deficit hyperactivity disorder”

Author(s):Sumich AL, Matsudaira T, Heasman B, Gow RV, Ibrahimovic A, Ghebremeskel K, Crawford MA, Taylor E.

Journal Name: Prostaglandins Leukotrienes and Essential Fatty Acids Journal.

For details, visit: http://www.plefa.com/article/S0952-3278(13)00053-7/abstract


  1. Article Title: “Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder”

Author(s):  Gow RV, Vallee-Tourangeau F, Crawford MA, Taylor E, Ghebremeskel K, Bueno AA, Hibbeln JR, Sumich A, Rubia K.

Journal Name: Prostaglandins Leukotrienes and Essential Fatty Acids Journal.

For more details, visit: http://www.sciencedirect.com/science/article/pii/S0952327813000707


  1. Article Title: “A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signaling throughout evolution”

Author(s):Crawford MA, Leigh Broadhurst C, Guest M, Nagar A, Wang Y,  Ghebremeskel K, Schmidt WF.

Journal Name: Prostaglandins Leukotrienes and Essential Fatty Acids Journal.

For more details, visit:http://www.sciencedirect.com/science/article/pii/S0952327812001470


  1. Article Title: “Effect of omega-3 (n-3) fatty acid supplementation in patients with sickle cell anemia: randomized, double-blind, placebo-controlled trial”

Author(s):AA Daak, Ghebremeskel K, Hassan Z, Attallah B, Azan HH, Elbashir MI, Crawford M

Journal Name: American Journal of Clinical Nutrition.

For more details, visit: http://ajcn.nutrition.org/content/97/1/37.short


  1. Article Title: “Dietary fat intake, body composition and blood lipids of university men and women.”

Author(s): Neville MM, Geppert J, Min Y, Grimble G, Crawford MA, Ghebremeskel K.

Journal Name: Nutrition and Health.

For more details, visit: http://nah.sagepub.com/content/21/3/173.short


  1. Article Title: “NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells.”

Author(s): Msika O, Brand A, Crawford MA, Yavin E.

Journal Name:Biochimica et Biophysica Acta (BBA)

For more information, visit: http://www.sciencedirect.com/science/article/pii/S1388198112000881


  1. Article Title: “The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: The challenge for human sustainability.”

Author(s): Crawford MA, Broadhurst CL.

Journal Name: Nutrition and Health.

For more information, visit: http://nah.sagepub.com/content/21/1/17.short


  1. Article Title: “Hydroxyurea TherapyMobilises Arachidonic Acid from Inner Cell Membrane Aminophospholipids in Patients with Homozygous Sickle Cell Disease.”

Author(s): Daak AA, Ghebremeskel K, Elbashir MI,  Bakhita A, Hassan Z, Crawford MA .

Journal Name: Journal of Lipids.

For more details, visit: http://www.hindawi.com/journals/jl/2011/718014/


 10. Article Title: “Childrens’ learning and behaviour and the association with cheek cell polyunsaturated fatty acid levels.”

Author(s): Kirby A, Woodward A, Jackson S, Wang Y, Crawford MA.

Journal Name: Research in Developmental Disabilities.

For more details, click: http://www.sciencedirect.com/science/article/pii/S0891422210000168

Contribution of Japanese Authors, in a BSP Journal ‘Current Organic Chemistry’

1. Preparation of Novel Isotropic Pitch with High Softening Point and Solvent Solubility for Pitch-based Electrospun Carbon Nanofiber

Author(s): Byung-Jun Kim, Hyunsig Kil, Naoki Watanabe, Min-Hyun Seo, Bo-Hye Kim, Kap Seung Yang, Osamu Kato, Jin Miyawaki, Isao Mochida and Seong-Ho Yoon

Affiliation: Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.


The novel isotropic pitch that exhibits both high solvent solubility (100% soluble in THF) and a high softening point (over 200°C) was successfully synthesized by the bromination of 2-methylnaphthalene followed by dehydrobromination/polymerization and extraction in n-hexane to eliminate lighter constituents. The molecular structure of the pitch was relatively linear with flexible methylene cross-linkages between naphthalene molecules. During bromination, a reaction temperature of 180°C was necessary to induce bromine substitution of methyl hydrogen. Methylene cross-linkages were formed after the dehydrobromination reaction. The obtained pitch is a suitable precursor for electrospinning and meltspinning to prepare carbon nanofibers and carbon fibers, respectively.


2. Production and Purification of Functional Lipids Through Enzymatic and Microorganism-Mediated Processes

Author(s): Toshihiro Nagao, Yomi Watanabe, Hirofumi Nakano and Yuji Shimada

Affiliation: Biomaterials and Commodity Chemicals Research Division, Osaka Municipal Technical Research Institute, 1-6-50 Morinomiya, Joto-ku, Osaka 536-8553, Japan.


The most remarkable difference between a chemical reaction and a lipase reaction is the fact that lipase possesses several substrate specificities, in particular, fatty acid specificity on hydrolysis, esterification, or transesterification reaction of the ester bond. Several lipases act weakly on polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and arachidonic acid. Through fatty acid specificity of lipases, a DHA-rich oil (acylglycerols) has been industrially produced from tuna oil. Lipase specificity also facilitates purification of PUFAs, conjugated linoleic acid isomers, tocopherols, and sterol esters and production of triacylglycerol that is DHA– rich at the sn– 1(3) position. Microorganism-mediated processes using Aeromonas hydrophila N– 6 are effective for production of rare unsaturated fatty acids and rare unsaturated fatty alcohols from several vegetable oils. These lipids are rarely observed in natural oils. We also demonstrate that Acinetobacter sp. N– 476– 2 effectively converts functional arachidonic acid to functional arachidonyl alcohol, which can be used as a substrate for medicine.


3. Selective Photocatalytic Oxidation Of Benzyl Amine By O2 Into N-Benzylidenebenzylamine on Tio2 Using Visible Light

Author(s): Shinya Higashimoto, Yoshiaki Hatada, Ryo Ishikawa, Masashi Azuma, Yoshihisa Sakata and Hisayoshi Kobayashi

Affiliation: College of Engineering, Osaka Institute of Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan


This paper deals with the photocatalytic oxidation of benzyl amine by O2 on TiO2 under visible light irradiation, and it was found that the benzyl amine is selectively converted into N-benzylidenebenzylamine with high conversion (>80 %). The origin of visible light response is not due to the band-gap transition of TiO2, but to the excitation of the charge transfer surface complex constructed by the interaction of benzyl amine with the TiO2 surface, as characterized by spectroscopic analysis such as UV-Vis, FT-IR and DFT calculations. Moreover, investigations of the role of the surface OH groups on TiO2, the electron-transfer from the surface complex as well as kinetic studies provided insight into the reaction mechanisms.


4. Photocatalytic Reduction of Carbon Dioxide over Shape-Controlled Titanium(IV) Oxide Nanoparticles with Co-catalyst Loading

Author(s): Naoya Murakami, Daisuke Saruwatari, Toshiki Tsubota and Teruhisa Ohno

Affiliation: Department of Materials Science, Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensuicho, Tobata, Kitakyushu 804-8550, Japan, and JST, PRESTO, 4-1-8 Honcho Kawaguchi, Saitama 332- 0012, Japan, and JST, ACT-C, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan


Photocatalytic reduction of carbon dioxide (CO2) was carried out using titanium(IV) oxide (TiO2). Methanol (CH3OH) was detected as the main product, and trace amounts of formic acid, carbon monoxide, methane, and hydrogen were also detected. The prepared decahedral-shaped anatase TiO2 with larger {011} and smaller {001} exposed crystal faces showed larger CH3OH generation than that of commercial anatase TiO2 powder, ST-01 (Ishihara Sangyo Co.). Photodeposition of silver and gold nanoparticles on the decahedral-shaped anatase TiO2 induced an increase in CH3OH production because the deposited metal particles work as reductive sites for multi-electron reduction of CO2.

For details, on the journal, please visit: Current Organic Chemistry