Highlighted Article – Engineering Crops for the Future: A Phosphoproteomics Approach – Current Protein & Peptide Science

http://www.eurekaselect.com/149960/article

Thought of the Day!

Highlighted Article – Advances And Perspectives In Cancer Nanotherapy – Current Nanomedicine

http://www.eurekaselect.com/151515/article

New Issue :: Current Organic Synthesis 14, Issue 4

Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.

Articles from the journal Current Organic Synthesis 14, Issue 4:

• Chiral Ionic Liquids: Design, Synthesis and Applications in Asymmetric Organo- Catalysis
• Diversity and Chemoselectivity in the Acid-Catalyzed Rearrangements of N,N’- Diarylhydrazines
• Methods for Metal and Non-Metal Catalyzed Synthesis of Six-Membered Oxygen Containing Poly-Heterocycles
• New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines
• Applications of Michael Addition Reaction in Organic Synthesis
• Synthesis of Polytetrazines, Pyrazoles and Polypyrazoles Based on 1,3-Dipolar Cycloaddition
• Synthesis of a Sulfonamide Pyruvate Kinase M2 Activator for Cancer Therapy
• Synthesis of 2-Arylbenzothiazoles via Condensation of Disulfides with Aldehydes Catalyzed by Na2S under Microwave Irradiation
• 2-Azetidinones in One-Pot from Imines and Carboxylic Acids via 1,4-Dichlorophthalazine
• Preparation of 5-Hydroxymethylfurfural from Glucose and Fructose in Ionic Liquids by Reactive Vacuum Distillation Over a Solid Catalyst
• An Efficient One-Pot Synthesis of Benzo[1,4]Thiazines, Benzo[1,3]Thiazoles and Benzo[1,5]Thiazepines
• Stereoselective Synthesis and Antiproliferative Activity of Monoterpene-Fused 2- Imino-1,3-oxazines
• Synthesis, Molecular Docking and Anticancer Evaluation of New Arylazothiazoles

               For details on the articles, please visit this link :: http://bit.ly/2tQKZUE

Highlighted Article – Acousto-Optic Logic Gate Controlled by Third-Order Nonlinear Optical Effects in Bimetallic Au-Pt Nanoparticles – Current Nanoscience

http://www.eurekaselect.com/152538/article

Testimonial by Maria Jose Redondo!

Contributed Article: Heterogeneity of Type 1 Diabetes: The Effect of Ethnicity

Active free trials in the universities around the world!

Izmir Institute of Technology, Turkey

İzmir Institute of Technology is one of the state universities in Turkey and one that was established in 1992 with a view to offering a high level of education and carrying out research in technological fields. The medium of education at our Institute is English. It is one of the two Turkish institutes of technology, which are the most advanced models of technical universities in today’s world.

Highlighted Article – Estimation of Taft ρ* of Dissociation Equilibriums of Methanium Ions RCH4+ the Hydrocarbon Super Acids – Current Physical Chemistry

http://www.eurekaselect.com/152889/article

Article by Disease – Treatment of Patients with Advanced Thyroid Cancer – Current Biomarkers

Article by Disease on “THYROID CANCER”

Abstract:

Background: Thyroid cancers are frequent in the endocrine system especially differentiated thyroid carcinoma and 95% of all thyroid cancer cases are differentiated neoplasmas. They have a favorable prognosis; however although, a small group present recurrence in 10-15% of patients following the standard treatment, surgery and radioiodine. Medullary thyroid carcinoma which is a neoplasm of the parafollicular C cells of the thyroid is responsible for a high number of thyroid cancer related deaths.

Objective: Nowadays, the therapeutic options for advanced differentiated neoplasms, metastatic disease or anaplastic carcinoma are scarce. Recently, multitargeted kinase inhibitors are considered as new treatments for differentiated thyroid neoplasms and have been introduced in their management. The American Thyroid Association recommendations stated in the guideline of 2015 that tyrosine kinase inhibitors should be used in the treatment of patients with refractory differentiated thyroid carcinoma and in those cases that present progression.

Methods: In this review, the purpose is to analyze the thyroid cancer tumorigeniesis and the action of the different targeted agents over these pathways of activation and the results in those cases of thyroid cancer without other possible treatments.

Results: Multikinase inhibitors, the most widely studied, are able in thyroid cancer to interfere in the proliferation, invasion, and neoangiogenesis of neoplastic cells in thyroid cancer. Recently, the US Food and Drug Administration and the European Medicine Agency approved sorafenib and lenvatinib, which in Europe received an orphan designation by European Medicine Agency for follicular thyroid cancer. Some other controlled trials with tyrosine kinase inhibitors, as vandetanib and carbozantinib, have been finished and are now the two approved drugs in advanced medullary thyroid cancers.

Conclusion: Thus, drug targeting represents a challenging approach with promising potential to circumvent some problems associated with many toxic effects of antineoplastic drugs.

Read more: http://www.eurekaselect.com/node/143979/article

New Issue :: Current Topics in Medicinal Chemistry 17, Issue 13

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Articles from the journal Current Topics in Medicinal Chemistry 17, Issue 13:

• EDITORIAL: Recent Contributions of Medicinal Chemistry to Nano Drug Delivery Systems and Bio-Conjugates
• Synergistic Interplay of Medicinal Chemistry and Formulation Strategies in Nanotechnology – From Drug Discovery to Nanocarrier Design and Development
• Advances in Micelle-based Drug Delivery: Cross-linked Systems
• Nanocarriers for Effective Brain Drug Delivery
• Sugar Based Biopolymers in Nanomedicine; New Emerging Era for Cancer Imaging and Therapy
• Amphiphilic Cyclodextrin Derivatives for Targeted Drug Delivery to Tumors
• rDNA Mediated Bioconjugates: Fusion Proteins and their Intended Use in Medicine
• Chemical Structure and Surface Modification of Dendritic Nanomaterials Tailored for Therapeutic and Diagnostic Applications
• Template Synthesis of Tubular Nanostructures for Loading Biologically Active Molecules
• Nanofibers: New Insights for Drug Delivery and Tissue Engineering
• Target Recognition Molecules and Molecular Modeling Studies
• Current HPLC Methods for Assay of Nano Drug Delivery Systems

               For details on the articles, please visit this link :: http://bit.ly/2sUzQVS