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BENTHAM INSIGHT

An insight to Bentham Science Publishers

Testimonial by Dr. Kamal Usef Sadek!

Dr Kamal Usef

Dr. Kamal Usef Sadek

Chemistry Department, Faculty of Science,

Minia University, El-Minia 61519, Egypt 

Contributed Article: Zn(L-Proline)2: An Efficient and Recyclable Catalytic System for the Asymmetric Multicomponent Synthesis of 2-Amino-4H-Chromenes in Water under Controlled Microwave Heating

New Issue ::: CNS & Neurological Disorders – Drug Targets, 15 Issue 6

CNS & Neurological Disorders – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders – Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Articles from the journal CNS & Neurological Disorders – Drug Targets, 15 Issue 6

For details on the articles, please visit this link :: http://bit.ly/2aYehrv

Podcast: “Docetaxel-loaded bovine serum albumin nanoparticles conjugated docosahexaenoic acid for inhibiting lung cancer metastasis to bone “

Author: Shougang Jiang

For Article details, visit: http://benthamscience.com/journals/anti-cancer-agents-in-medicinal-chemistry/article/144890/

Subscribe to our YouTube channelhttp://bit.ly/1lr0czy

A very Happy Birthday to Professor Ignacio Anegon!

8-29-2016 12-05-15 PM

Editor-in-Chief: Current Gene Therapy

Prof. Ignacio Anegon

INSERM UMR 643, CHU de Nantes. 30,

boulevard Jean Monnet. 44093 Nantes France

Highlighted Article Flyer for the journal “Current Physical Chemistry”

CPC-Articles_6-2- V-I-Dybkov

http://benthamscience.com/journals/current-physical-chemistry/

Editors Choice Article – “Drivers’ Visual Scanning Impairment Under the Influences of Alcohol and Distraction: A Literature Review”

Journal: Current Drug Abuse Reviews

Author(s): Brook Shiferaw, Con Stough and Luke Downey

cdarAbstract: Alcohol intoxication and distraction are two of the leading factors associated with impaired driving and fatalities, especially among younger drivers. However, it is currently unclear how these conditions affect mechanisms of visual attention considered essential for driving. The present article first reviews the literature to provide an overview of visual attention as it relates to driving. Secondly, the effects of alcohol and distraction on neurocognitive mechanisms of visual attention are summarised to provide a background which informs discussion of selected driving studies. Visual scanning impairment is identified as a consequence of both alcohol and distraction. Thus, experimental studies combining the use of simulated driving and eye tracking technologies are selected and critically reviewed to assess the relationship between eye movements and driving errors as possible indicators of visual scanning impairment. Seven of the eight studies selected investigated the effects of distraction while only one addressed alcohol. Evaluation of these studies suggests that distraction may affect visual scanning by increasing cognitive load which interferes with visual processing. The evidence for effects of alcohol on drivers’ visual scanning capacity is currently scarce due to the lack of research with a specific focus on impairments of eye movement in intoxicated drivers. Lack of consistency between studies is identified as a current issue which makes it difficult to compare the results of different studies. Finally, we note that our strict selection of driving studies to avoid greater disparity between them is a limitation of the present review.

Read more here: http://benthamscience.com/journals/current-drug-abuse-reviews/volume/7/issue/3/page/174/

Open Access Articles – “A Novel Material for Removal of Organochlorine Pesticides from Aqueous Environment: Kinetics and Thermodynamics Investigations”

Journal: Current Environmental Engineering

Author(s): Abdul Ghaffar, Azhar Mashiatullah and Naveed Iqbal

ceeAbstract: Chitosan Grafted Silica (CGS) material was prepared by using tetraethyl-orthosilicate as grafting and/or cross linking agent. The structure of the material was characterized by SEM (Scanning Electron Microscopy), FTIR (Fourier transform infrared Spectroscopy), and BET (Brunauer, Emmett and Teller) analysis. The higher sorption potential of synthesized material for organo-chlorine pesticides (OCPs) like DDT and DDE was attributable to its large surface area, porous rigid structure and active sites such as –OH, –NH2, and –CONH2. Most removal of DDT (94±2.9%) and DDE (86 ±1.8%) was achieved at 40°C and pH 6 with agitation of 2 and 3 hours, respectively. The thermodynamics data suggested an endothermic, spontaneous and higher stable sorption process with no structural changes at the solid-solution interface. The ΔG value was increased with an increase in temperature up to 40°C, indicating a greater driving force ensuing a higher sorption capacity. The co-efficient of correlation (R2) suggested that the sorption data was best fitted in Freundlich isotherm rather than the Langmuir isotherm, indicating a multilayer sorption. The Freundlich sorption isotherm proposed a favorable sorption of DDT as compare to DDE. The developed method was applied to real industrial waste at laboratory level. The experimental data revealed that developed method might be employed for the removal of DDT and DDE from aqueous industrial effluents before discharging them into water bodies.

Read more here: http://benthamscience.com/journals/current-environmental-engineering/volume/1/issue/2/page/100/

Most Accessed Articles – “Recent Updates on Peroxisome Proliferator-Activated Receptor δ Agonists for the Treatment of Metabolic Syndrome”

Journal: Medicinal Chemistry

mcAbstract: Metabolic syndrome is a disorder described by reduced insulin sensitivity, overweight, hyperlipidaemia, high blood pressure and myocardial disorders, mainly due to high fat diet and lack of physical activity. The peroxisome proliferator activated receptors (PPARs) are type II nuclear hormone receptors that regulate a number of processes in living systems, such as metabolism of carbohydrates and fatty acids, growth and differentiation of cell, and inflammatory reactions. Alpha, gamma and delta are the three distinct isoforms of PPAR. The stimulation of PPARδ alters body’s energy fuel preference from glucose to fat. The PPARδ isoform is expressed ubiquitously in all tissues, especially in those tissues which involved in metabolism of lipids like adipose tissue, liver, kidney, and muscle. Currently, PPARδ is an emerging therapeutic target for the pharmacological therapy of disorders associated with metabolic syndrome. Several PPARδ selective agonists had been reported in last ten years, many of them had been advanced into the late phase of clinical trials such as Endurobol (GW501516). However, no PPARδ agonists are yet approved for human use. The present work had been planned to cover wide variety of PPARδ agonists reported till now along with their potential role to tackle various metabolic disorders. The present review has been planned to focus mainly the most popular PPARδ agonists.

Read more here: http://benthamscience.com/journals/medicinal-chemistry/volume/12/issue/1/page/3/

Most Cited Articles – “MRI of Focal Liver Lesions”

Journal: Current Medical Imaging Reviews

Author(s): Nils Albiin

cmirAbstract: Magnetic resonance imaging, MRI has more advantages than ultrasound, computed tomography, CT, positron emission tomography, PET, or any other imaging modality in diagnosing focal hepatic masses. With a combination of basic T1 and T2 weighted sequences, diffusion weighted imaging, DWI, and hepatobiliary gadolinium contrast agents, that is gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB), most liver lesions can be adequately diagnosed. Benign lesions, as cyst, hemangioma, focal nodular hyperplasia, FNH or adenoma, can be distinguished from malignant lesions. In a non-cirrhotic liver, the most common malignant lesions are metastases which may be hypovascular or hypervascular. In the cirrhotic liver hepatocellular carcinoma, HCC, is of considerable importance. Besides, intrahepatic cholangiocarcinoma and other less common malignancies has to be assessed. In this review, the techniques and typical MRI features are presented as well as the new algorithm issued by American Association for the Study of the Liver Diseases (AASLD).

Read more here: http://benthamscience.com/journals/current-medical-imaging-reviews/volume/8/issue/2/page/107/

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