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BENTHAM INSIGHT

An insight to Bentham Science Publishers

Highlighted article from the journal Current Physical Chemistry

CPC-Articles_5--4

For more detail, visit: http://benthamscience.com/journals/current-physical-chemistry/

EurekAlert! –Rational autologous cell sources for therapy of heart failure

Vehicles and targets for gene and RNA therapies.

The combination of cell and gene therapy is rapidly raising clinical interest, although their combination has been under investigation for several decades. This is mainly due to the availability and feasibility of clinically relevant gene delivery options. This review focuses on cell therapies for heart failure and their use combined with cardiac surgery as well as with gene therapy. The review also provides insight into how financial and authority-based decisions and restrictions influence research in this field. Particular focus is given to autologous cardiac cell therapy that can be applied concomitantly to a cardiac operation.


Lampinen M, Vento A, Laurikka J, Nystedt J, Mervaala E, Harjula A, Kankuri E 

Faculty of Medicine, Department of Pharmacology,

University of Helsinki, Finland

World Asthma Day 2016!

banner-World Asthma Day

World Asthma Day is a worldwide event held every year. Bentham Science Publishers  knows the importance of asthma care and awareness, and hence the journal related to this day is Current Respiratory Medicine Reviews

Celebrating the birthday of Thomas Henry Huxley!

thomas-huxley

Thomas Henry Huxley, was born on the 4th of May 1825. He was a British Biologist.

EurekAlert! – Hot melt extruded and injection moulded dosage forms

Hot melt extrusion and injection moulding are becoming more prevalent in the drug delivery field due to their advantages over current pharmaceutical manufacturing techniques.

Hot Melt Extrusion (HME) and Injection Moulding (IM) are becoming more prevalent in the drug delivery field due to their advantages over current pharmaceutical manufacturing techniques. HME is a continuous process that can be used in the pharmaceutical industry to increase the solubility of poorly water soluble drugs, through the generation of solid dispersions, and to manufacture dosage final dosage forms. IM, which is usually combined with HME (HME-IM) is a rapid, versatile and continuous manufacturing technique, that is easily scaled up and can be used to manufacture a range of pharmaceutical dosage forms from oral tablets to implantable devices.


Ian major and Christopher McConville

School of Pharmacy, Faculty of Science and Engineering,

University of Wolverhampton, Wulfrana Street,

Wolverhampton WV1 1LY, UK.

See more at: http://www.eurekalert.org/pub_releases/2016-04/bsp-hme042716.php

Most Cited Article: “Synthesis and Application of Graphene Nanoribbons”

Current Physical Chemistry

Author(s): Xiaochen Dong, Xin Zhao, Lianhui Wang and Wei Huang.

CPCAbstract: Graphene, a single-atom-thick planar sheet of graphite with zero-band gap, has great potential applications in nanoelectrics, biosensing, energy storage owing to its unique electrical, mechanical, and physical properties. Graphene nanoribbons (GNRs) are narrow and straight-edged stripes of graphene sheets. They are predicted to exhibit band gaps useful for field-effect transistors with high on/off ratio and carrier mobility. Over the past few years, they have attracted increasing attentions and became the attractive candidates for carbon-based nanoelectronics. This review provides a brief overview on the synthesis, properties and applications of GNRs. The effects of synthetic process on their morphology and electronic properties are discussed in detail. In addition, the applications of graphene nanoribbons in different fields have also briefly presented.

See more here: http://benthamscience.com/journals/current-physical-chemistry/volume/3/issue/3/page/291/

“Evaluation of Vitamin C as a Personalized Adjuvant Medicine: Pharmacogenomic Studies”

Current Pharmacogenomics and Personalized Medicine , Volume 13 – Number 1

Author(s): Seyeon Park

CPPMAbstract

Background: Although clinicians failed to reproduce Pauling and Cameron’s earlier reports on the therapeutic effects of vitamin C on cancer, new information on the pharmacokinetics and pharmacodynamics of vitamin C as well as new clinical data has provided more in depth understanding of the critical aspects of vitamin C’s therapeutic effects. Previous clinical studies suggested that vitamin C, introduced to cancer patients by intravenous and oral pathways, might improve their symptoms. Methods: This review summarizes and focuses on different pharmacological effects of vitamin C that are currently under investigation in pharmacogenomic studies related to transporter gene polymorphism. Conclusion: From the information available, it seems clear that vitamin C is involved in a variety of disease mechanisms. This review might provide an evaluation of vitamin C as a personalized adjuvant medicine.

For details, visit: http://benthamscience.com/journals/current-pharmacogenomics-and-personalized-medicine/volume/13/issue/1/page/3/

 

“Click Chemistry, A Potent Tool in Medicinal Sciences”

Current Medicinal Chemistry, Volume 22 – Number 17

CMCAbstract: This review focuses on the application of click chemistry in medicinal sciences, and particularly on its role in drug discovery. Because of its high modularity, click chemistry helps to accelerate the current drug discovery process, which relies on massive screening of chemical libraries. This article describes examples of click chemistry applications that are aimed at finding new lead candidates against pathologies such as cancer, AIDS and Alzheimer’s disease, and explores the impact that the technique could have in therapy and prevention in the near future, through application in drug delivery systems, bioconjugation and diagnostic. An introduction, addressed to researchers who intend to use this methodology, examines the opportunities to perform click reactions according to the most common and best studied techniques, such as synthesis in water, on solid phase, and under microwave or ultrasound irradiation. Every topic is furnished with examples which have appeared in the literature in the last five years and is clarified by schemes and figures.

For details, visit: http://benthamscience.com/journal/abstracts.php?journalID=cmc&articleID=130516

EurekAlert! –Improving utilization of ammonia and carbon dioxide in microalgal cultivation

This article focuses on approaches to improve ammonia and carbon dioxide utilization in algal cultivation practices to reduce loss of valuable nutrients through the process of volatilization.

Algaculture or algae farming, like any form of agriculture, is highly sensitive to fertilizer costs. A major roadblock to commercial algae farming is efficient utilization of volatile nutrients, specifically ammonia and carbon dioxide (CO2), to feed the algae being farmed. Currently, society produces large quantities of waste streams in the air and water that are not being efficiently treated or not treated at all. This includes multiple agricultural and industrial waste streams that can provide nutrients for large-scale algal cultivation rather than contaminating surface and ground waters or the air. However, new methods need to be developed for using these waste streams to remove uncertainty in the yield and cost of production of algae for biofuels and feed/food.


Everett Eustance, Joshua T. Wray, Shahrzad Badvipour and Milton R Sommerfeld

Arizona Center for Algae Technology and Innovation,

Arizona State University,

Mesa, USA

Read more here: http://www.eurekalert.org/pub_releases/2016-05/bsp-iuo050216.php

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