Editor’s Choice – Saccharomyces cerevisiae as Cell Factory for the Production of Plant Natural Products – Current Biotechnology

Journal: Current Biotechnology

Author(s): Hilde C. Coumou, Pia D. Petersen, Uffe H. Mortensen.

Graphical Abstract:



Background: Plant natural products (PNPs) play a key role in human health and life quality through the treatment of diseases and as supplements in the food and healthcare industry. These high-value metabolites are traditionally extracted from the natural resource, but ongoing research is exploring the possibilities to construct efficient microbial cell factories that can replace current production methods.

Objective: This review describes recent progress for producing PNPs in S. cerevisiae.
Conclusion: Various PNPs, including stillbenoids, flavonoids, terpenoids and glucosinolates can now be produced in the baker’s yeast Saccharomyces cerevisiae. As a result of the growing interest in the expression of plant biosynthetic pathways in yeast, many studies have aimed at developing platform strains delivering an improved supply of precursor metabolites. Synthetic biology tools facilitate the identification of superior enzymes, balance gene expression levels in the pathway, and enable the spatial arrangement of plant-derived enzymes in yeast to optimize the performance of the introduced pathways even further.
Perspectives: The entry of CRISPR/Cas9 based technologies may allow other yeast species or filamentous fungi to be engineered for the production of PNPs.

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Testimonial by Abdelrahman Ibrahim Abushouk!

Abdelrahman Ibrahim Abushouk

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Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research


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For details on the articles, please visit this link :: http://bit.ly/2uXZH0C




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Wishing A Very Happy Birthday Dr. Pavel N. Nesterenko!

Dr, Pavel N. Nesterenko

Dr. Pavel N. Nesterenko!

EDITOR-IN-CHIEF: Current Chromatography

Australian Centre for Research on Separation Science (ACROSS)
School of Chemistry, University of Tasmania


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Testimonial by Ourania E. Tsitsilonis!

Ourania E. Tsitsilonis

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New Issue :: Current Neuropharmacology 15, Issue 4

Current Neuropharmacology aims to provide current, timely and comprehensive reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience.

The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.


Articles from the journal Current Neuropharmacology 15, Issue 4:

For details on the articles, please visit this link :: http://bit.ly/2uouuCd


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