EDITOR’S CHOICE ARTICLE – Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature

Journal Name: Current Drug Safety

Author(s): Devis Benfaremo, Lucia Manfredi , Michele Maria Luchetti*, Armando Gabrielli.




Graphical Abstract:



Background: Immune checkpoint inhibitors are a new promising class of antitumor drugs that have been associated with a number of immune-related Adverse Events (AEs), including musculoskeletal and rheumatic disease.

Methods: We searched Medline reviewing reports of musculoskeletal and rheumatic AEs induced by immune checkpoint inhibitors.

Results: Several musculoskeletal and rheumatic AEs associated with immune checkpoint inhibitors treatment are reported in the literature. In particular, arthralgia and myalgia were the most common reported AEs, whereas the prevalence of arthritis, myositis and vasculitis is less characterized and mainly reported in case series and case reports. Other occasionally described AEs are sicca syndrome, polymyalgia rheumatica, systemic lupus erythematosus and sarcoidosis.

Conclusion: Newly induced musculoskeletal and rheumatic diseases are a frequent adverse event associated with immune checkpoint inhibitors treatment.



For more details, please visit: http://www.eurekaselect.com/161936/article


CALL FOR PAPERS – Special Thematic Issues

Forthcoming Special Issues of the journal Current Chemical Biology”




CCB -THEMATIC FLYER-Emanuele Calabrò

Guest Editor(s): Emanuele Calabrò

Tentative Publication Date: April, 2019

For more details please visit: https://bit.ly/2xjlr6y

Email here to submit your paper:  faizan@benthamscience.net

BENTHAM SCIENCE FREE TRIAL IN THE University of Groningen Library

Free Trial Ends on 17th December


The University of Groningen (abbreviated as UG; Dutch: Rijksuniversiteit Groningen, abbreviated as RUG) is a public research university in the city of Groningen in the Netherlands. The university was founded in 1614. Since its founding, more than 200,000 students have graduated. It is a member of the distinguished Coimbra Group of European universities.




CALL FOR PAPERS – Special Thematic Issues

Forthcoming Special Issues of the journal Current Drug Targets”

“The Computational Methods in Drug Targets Discovery “


Guest Editor: Hao Lin

Tentative Publication Date: March, 2019

Read the abstract here: https://bit.ly/2xjlr6y 

Email here to submit your paper:  hlin@uestc.edu.cn

CC at faizan@benthamscience.net

BENTHAM SCIENCE FREE TRIAL IN Gannan Medical University (Until 14th December)


Gannan Medical University (GMU) is located in Ganzhou, a famous historical and cultural city alongside Beijing-Kowloon Railway in the south of Jiangxi province. Professor Han Jisheng, an academician of China Science Academy, works as the honorary president of GMU. Founded as Ganxian Advanced Midwifery Vocational School of Jiangxi Province in 1941, GMU developed to be Gannan Medical Technical School in 1958 and Gannan Medical College in 1988, and started to recruit undergraduates. GMU enjoyed the bachelor degree authorization in 1993 and the master’s in 2013, and started to recruit graduates in 2014. GMU is the sole undergraduate medical university in Jiangxi province.





AIMS & SCOPE – Current Stem Cell Research & Therapy

Aims & Scope

Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research




For more details, please visit: https://benthamscience.com/journals/current-stem-cell-research-and-therapy/aims-scope/#top

MOST ACCESSED ARTICLE – Mesenchymal Stem Cells-Derived Exosomes: A Possible Therapeutic Strategy for Osteoporosis

Journal Name: Current Stem Cell Research & Therapy

Author(s): Yue Li, Daxiang Jin*, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren, Zenglin Xiao.





Osteoporosis is a common age-related disorder characterized by low bone mass and deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture risk. The pathophysiology of osteoporosis is multifactorial. It is related to the imbalance between osteoblasts and osteoclasts; reduced bone mass and increased adipogenesis in the bone marrow. Moreover, angiogenesis, inflammatory process and miRNAs have shown effects in the formation of osteoporosis. In the recent years, mesenchymal stem cells (MSCs) have been regarded as an excellent choice for cell-based tissue engineering therapy of osteoporosis. Growing evidence showed that paracrine effect has been considered as the predominant mechanism for the role of MSCs in tissue repair. Recently, many studies have proposed that MSCs-derived exosomes are effective for a variety of diseases like cancer, cardiovascular diseases, etc. However, whether the MSCs-derived exosomes could serve as a novel therapeutic tool for osteoporosis has not clearly described. In this review, we summarize the MSCs-derived exosomes and the relationship with osteogenesis, osteoclast differentiation, angiogenesis, immune processes and miRNAs. Finally, we suggest that MSCs-derived exosomes might be a promising therapeutic method for osteoporosis in the future.


For more details, please visit: http://www.eurekaselect.com/160963

OPEN ACCESS ARTICLE – Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine

Journal Name: Current Stem Cell Research & Therapy

Author(s): Sheng Yi, Fei Ding, Leiiei Gong, Xiaosong Gu.





The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a promising approach for tissue engineering. Emerging studies demonstrate that extracellular matrix scaffolds are able to create a favorable regenerative microenvironment, promote tissue-specific remodeling, and act as an inductive template for the repair and functional reconstruction of skin, bone, nerve, heart, lung, liver, kidney, small intestine, and other organs. In the current review, we will provide a critical overview of the structure and function of various types of extracellular matrix, the construction of three-dimensional extracellular matrix scaffolds, and their tissue engineering applications, with a focus on translation of these novel tissue engineered products to the clinic. We will also present an outlook on future perspectives of the extracellular matrix in tissue engineering and regenerative medicine.



For more details, please visit: http://www.eurekaselect.com/145332

E-BOOK – Arduino meets MATLAB: Interfacing, Programs and Simulink





This book titled Arduino meets MATLAB. .. Interfacing, Programs and Simulink will provide a platform for the beginners to get started with Arduino and its interfacing with the MATLAB. The book provides the basic knowledge of the programming and interfacing of the devices with Arduino and MATLAB. This book also explains in a lucid manner the basic steps to understand the interfacing and programming with Arduino and MATLAB. This book goes from basic to advanced level of Arduino and interfacing with various input/output devices through various communication modules in well defined sequence which will be easily understandable to the undergraduate and post graduate students. This book will be specially beneficial to those researchers looking for hardware based implementation platforms.

The USP of this book lies in the fact that a new concept has been introduced for the researchers and students for prototype development of the real time projects using Arduino, MATLAB and I/O devices in the single platform. Another important point to mention will be that this book is entirely based on the practical experience of the authors while undergoing projects with the students and industries.


For more details, please visit: https://ebooks.benthamscience.com/book/9781681087276/


dr Vladimir-gifts

Vladimir P. Torchilin

Editor-in-Chief: Current Drug Discovery Technologies

Department of Pharmaceutical Science Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University
Boston, MA 02115