New Issue :: Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry 16, Issue 2

Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new immunology, endocrine & metabolic agents. The scope also covers research on functional foods and nutraceuticals of importance to immunology, endocrine & metabolic agents.

Each issue of the journal contains a series of timely in-depth reviews and original research articles written by leaders in the field covering a range of current topics in immunology, endocrine & metabolic agents.

ac573a3cd78460a79029e5ccf56ef5a4aefbea7f060ca9d19dpimgpsh_fullsize_distr

Articles from the journal Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry 16, Issue 2:

           For details on the articles, please visit this link :: http://bit.ly/2iBI5wL

Press Release for EurekAlert! Zebrafish as an animal model to study the effects of endocrine disruptors

zebra-fish

Water is vital for our survival. However, water quality is always a concern for public health authorities as it may contain diverse environmental pollutants, including endocrine disrupting chemicals (EDCs). Endocrine disrupting chemicals are one group of potentially hazardous substances that comprise natural and synthetic chemicals, with the ability to mimic endogenous hormones or interfere with their biosynthesis, metabolism, and normal functions. Common examples are bisphenol A, triclosan, phthalates, lead, mercury, nickel and polychlorinated biphenyls, among others.

Fish are known to be quite sensitive to the effects of EDCs and therefore, are employed as research models to study the possible impacts of these chemicals in humans. In a review led by Purdue University (USA) and the University of Cartagena (Colombia), a team of researchers has proposed the zebrafish as a model to predict the effects of EDCs on humans using toxicogenomic tools, such as microarrays or whole-genome sequencing. This is possible due to the fact that zebrafish genes that have significantly altered expression after exposure to EDCs are very similar to those found in humans. In addition, many of the glandular system found in zebrafish have similarities with those in humans, making this fish model suitable to study alterations on the endocrine system.

According to the authors, vitellogenin and aromatase cytochrome P450 are key genes that can be monitored in zebrafish to detect the presence of EDCs in water samples, especially at environmentally relevant concentrations.

Toxicogenomic tools also offer the possibility to find new mechanisms by which EDCs alter the reproductive status of zebrafish, allowing its use to test the safety of new products entering the market. The possibilities are immense and the goal is to continue finding new markers of toxicity, and therefore alternative bridges to link EDC exposure to common diseases in humans.

Co-authors of the paper include Karina Caballero-Gallardo, Jesus Olivero-Verbel (University of Cartagena, Cartagena, Colombia) and Jennifer L. Freeman (Purdue University, USA).

Reference: Caballero-Gallardo, K.; et al (2016). Toxicogenomics to Evaluate Endocrine Disrupting Effects of Environmental Chemicals Using the Zebrafish Model., DOI: 10.2174/1389202917666160513105959

For more information about the article, please visithttp://benthamscience.com/journals/current-genomics/volume/17/issue/6/page/515/

Article by Disease – “Cranberry for Urinary Tract Infection: From Bench to Bedside”

Article by Disease on “Urology”

Abstract

Urinary tract infections are common infectious diseases which can occur in any part of the urinary tract such as bladder, kidney, ureters, and urethra. They are commonly caused by bacteria that enter through the urethra. Urinary tract infections commonly develop in the bladder and spread to renal tissues. Up to now, there are different antimicrobial agents which have beneficial role on urinary tract infections. However, most of them cause different adverse effects and therefore, much attention has been paid to the search for effective therapeutic agents with negligible adverse effects. Cranberry is known as one of the most important edible plants, which possesses potent antimicrobial effects against the bacteria responsible for urinary tract infections. Growing evidence has shown that cranberry suppresses urinary tract infections and eradicates the bacteria. Therefore, the aim of this study is to critically review the available literature regarding the antimicrobial activities of cranberry against urinary tract infection microorganisms. In addition, we discuss etiology, epidemiology, risk factors, and current drugs of urinary tract infections to provide a more complete picture of this disease.

Read more: http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/volume/17/issue/3/page/331/

Thought of the Day!

alberteinstein1

New Issue :: Letters in Drug Design & Discovery 14, Issue 2

Letters in Drug Design & Discovery publishes letters, mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

591ade1047cacdce50f1deabce67fe712f76c88273755333d7pimgpsh_fullsize_distr

Articles from the journal Letters in Drug Design & Discovery 14, Issue 2:

               For details on the articles, please visit this link :: http://bit.ly/2iBLoYj

Highlighted Article Flyer for the journal “Current Traditional Medicine”

ctm-articles_2-3-rajangam-udayakumar

http://benthamscience.com/journals/current-traditional-medicine/

Wishing A Very Happy Birthday To Dr. Serena Guiducci!

Print

Dr. Serena Guiducci

Editor-in-Chief: Current Rheumatology Reviews

Via ML King 65,

Pistoia,

Italy

New Issue :: Medicinal Chemistry 13, Issue 1

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

c056627e77d9c26a5cac646bde20ecb5beecc6f32e0b20582apimgpsh_fullsize_distr

Articles from the journal Medicinal Chemistry 13, Issue 1:


For details on the articles, please visit this link :: 
http://bit.ly/2k2Qri6

Press Release for EurekAlert! An innovative active platform for wireless damage monitoring of concrete structures

Structural Health Monitoring (SHM) is playing an important role in evaluationprocess of structural integrity of concrete structures mainly because much of the expected construction demands will have to be accommodated on existing concrete structures with widespread signs of deterioration.

Electromechanical Impedance (EMI) sensing approach has been proven that could be an effective alternative experimental approach for the damage detection of concrete structures even at very early-age stages. The wireless monitoring system proposed in the present work, denoted as Wireless impedance or Admittance Monitoring System (WiAMS), retains the benefits of low-budgeted EMI-based monitoring system but is not limited by the data acquisition device sampling rate in conventional EMI monitoring systems. This is achieved by utilizing a credit card-sized Raspberry Pi single-board computer which is capable of transferring data without a base station, can perform processing-hungry operations like video streaming by just simply adding the WiAMS device to the home network and perform SHM.

Moreover, the use of the Raspberry Pi expands the available hardware interfaces making the sensing device to be ready not only as an SHM control unit, but also as a base station for many other useful sensing platforms like motion with video, audio or environmental sensors.

WiAMS, as a whole, additionally offers extensive features such as remote control, high processing power, wireless data upload to an SQL database, email notifications, scheduled and iterative impedance (or admittance) measurements and frequency spans from 5kHz to 300 kHz with resolution down to 1 Hz.

The proposed WiAMS is successfully applied on various concrete specimens detecting damage even in very early-age stages by establishing a damage identification index based on extreme value statistics.

Reference: Providakis, C.; et al (2016). An Innovative Active Sensing Platform for Wireless Damage Monitoring of Concrete Structures. Current Smart Materials., DOI: 10.2174/2405465801666160830155120

For More information about the article, please visit: http://benthamscience.com/journals/current-smart-materials/article/145156/

 

Wishing A Very Happy Birthday To Dr. Jean-Marc Sabatier!

Dr.Jean-Marc Sabatier- 20 jan

Dr. Jean-Marc Sabatier 

Editor-in-Chief: Infectious Disorders – Drug Targets

30, Chemin de Campbernard,

13790 – ROUSSET,

FRANCE