WISHING A VERY HAPPY BIRTHDAY TO Dr. C. Christian Neri!

Dr C.CHRISTIAN nERI

Dr. C. Christian Neri

EDITOR-IN-CHIEF: CURRENT GENOMICS

Institute of Biology Paris-Seine
CNRS UMR 8256 and UPMC
Paris, 75005
France

EDITOR’S CHOICE – Neoflavonoids as Prospective Compounds Against Parasitic Neglected Tropical Infections and Human Immunodeficiency Virus – Current Bioactive Compounds

Journal: Current Bioactive Compounds 

Author(s): Gláucio B. Saldanha, George L.S. Oliveira, José C.C.L. da Silva, Maria C.P. Oliveira, Ana P.S.C.L. da Silva*, Juceni P. de Lima David

Graphical Abstract:

 

Abstract:

Background: Neoflavonoids comprise a group of compounds that have a C6-C3-C6 carbon skeleton and that naturally occur in higher plants from families Clusiaceae, Leguminosae, Rubiaceae, Passifloraceae, Asteraceae and Rutaceae.

Objective: Neoflavonoids have drawn great interest lately due to their pharmacological and biochemical properties found in vitro and in vivo studies, which is attributed to the pattern of substitutions found in their basic chemical structure.

Methods: This review was prepared by analyzing articles selected from Science Direct, Scopus, Pub Med, Web of Science and SciFinder.
Results: Among other pharmacological activities, in vitro and in vivo studies have highlighted these compounds as promising bioactive molecules in the treatment of some parasitic neglected tropical infections (NTIs) such as malaria, leishmaniasis and American trypanosomiasis (Chagas Disease). Neoflavonoids have also showed activity against HIV-1 (human immunodeficiency virus type 1), and have been used to develop new molecules for the treatment of HIV/AIDS.
Conclusion: Therefore, a more intensive research of neoflavonoids can provide inputs to discover and develop alternative therapies from new bioactive molecules. Thus, this review summarizes the results of studies involving neoflavonoids and their derivatives with therapeutic implications in the treatment of NTIs and HIV.

TESTIMONIAL BY FEDERICA POLLASTRO!

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Contributed Article: “Cannabis Phenolics And Their Bioactivities

HIGHLIGHTED ARTICLE – Designing of Ivabradine Hydrochloride Transdermal Patch by D-optimal Mixture Design – Current Drug Therapy

cdt-Articles_12- 2-Vaishali Tejas Thakkar

To access the article, please visit: http://www.eurekaselect.com/152950/article

Thought of the Day!

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PODCAST: Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity

Author(s): Chukwumaobim D.U. Nwokwu, Sameera R. Samarakoon, Desiree N. Karunaratne*, Nuwanthi P. Katuvawila, Meran K. Ediriweera, Kamani H. Tennekoon.

For article details, visit: http://www.eurekaselect.com/154755

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TESTIMONIAL BY FARZANEH BOZORGGHALATI!

Farzaneh Bozorgghalati.jpg

Contributed Article: “Molecular Biomarkers of Anaplastic Thyroid Carcinoma

HIGHLIGHTED ARTICLE – Homology Modelling Inspired Synthesis of 5-HT2A Receptor Inhibitors – Central Nervous System Agents in Medicinal Chemistry

CNSAMC- Articles_17-3-Graham B. Jones

To access this article, please visit: http://www.eurekaselect.com/151905/article

OPEN ACCESS ARTICLE – Comparative Neurophysiologic Study of Pain in Patients with Parkinson’s Disease and Patients with Persistent Pain After Spinal Surgery – Neuroscience and Biomedical Engineering

Journal: Neuroscience and Biomedical Engineering

Author(s): Masanaka Takeda, Hisao Tachibana, Fumiaki Okada, Shuhei Kasama, Hiroo Yoshikawa

Graphical Abstract:

Abstract:

Background: Pain is a common and troublesome non-motor symptom in Parkinson’s disease (PD). Similarly, severe postoperative pain is common after major spinal surgery and may become chronic. The pathophysiologic mechanism underlying those conditions remains unclear. In this study, we recorded pain-related evoked potentials induced by intra-epidermal electrical stimulation in patients with PD and patients with persistent pain after spinal surgery and compared the results between the two groups.

Objective: The purpose of this study was to investigate the pathophysiology of pain in patients with persistent pain after spinal surgery and in patients with PD.

Methods: We recorded pain-related evoked potentials in 23 patients with PD (64.0 years), 6 patients with persistent pain after spinal surgery (69.5 years) and 12 healthy controls (59.6 years).

Results: Major negative (N1) and positive (P1) deflections were observed after each stimulation. The amplitudes between N1 and P1 (N1-P1), which are thought to originate from the anterior cingulate cortex and insula, were significantly lower in both patients with PD and persistent pain after spinal surgery than in the controls (both P<0.01). However, there was no significant difference in N1-P1 amplitude between the patients with PD and the patients with persistent pain after spinal surgery. No significant differences in N1 and P1 latencies were observed among the three groups.

Conclusion: These results suggest that abnormal central processing of pain is present in patients with PD and those with chronic persistent pain after spinal surgery and that these two conditions share similar pathophysiologic mechanisms, at least partially.

Read more here: http://www.eurekaselect.com/152597

HIGHLIGHTED ARTICLE – DIGITAL INFRARED THERMAL IMAGING ANALYSIS OF THYROID NODULES – CURRENT MEDICAL IMAGING REVIEWS


CMIR- Articles_13-4-Nuray Bayar Muluk

To access this article, please visit: http://www.eurekaselect.com/154167/article