Free to download article from the journal ‘Current Pharmaceutical Design’

The article entitled ‘Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure in the journal Current Pharmaceutical Designis now open for all to view and access.

Abstract: Improved treatments for heart failure patients will require the development of novel therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ homeostasis is recognized as a major contributor to the heart failure phenotype, as it plays a key role in systolic and diastolic dysfunction, arrhythmogenesis, and hypertrophy and apoptosis signaling. In this review, we outline existing knowledge of the involvement of Ca2+homeostasis in these deficits, and identify four promising targets for therapeutic intervention: the sarcoplasmic reticulum Ca2+ ATPase, the Na+-Ca2+exchanger, the ryanodine receptor, and t-tubule structure. We discuss experimental data indicating the applicability of these targets that has led to recent and ongoing clinical trials, and suggest future therapeutic approaches.

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National Nutrition Week 1 -7 Sep 2015


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For research articles on nutrition, please visit Bentham Science journal Current Nutrition & Food Science.

It publishes frontier research on advances in food and nutrition pertaining to their nutrition value, their impact on health and disease and their molecular and biochemical actions. The journal aims to publish high quality original research and review articles, and thematic issues. It is an essential reading for all nutrition and food scientists.

Research articles by Indian contributors in the journal ‘Medicinal Chemistry’

Screening of SdiA Inhibitors from Melia dubia Seeds Extracts Towards the Hold Back of Uropathogenic E.coli Quorum Sensing-Regulated Factors

Author(s): Vinothkannan Ravichandiran, Karthi Shanmugam and Adline Princy Solomon.

Abstract: Plants have always been a supreme source of drugs and India is endowed with a wide variety of them with high medicinal values. The Quorum Sensing (QS) quenching efficiency of various solvent extracts of Melia dubia seeds was investigated against uropathogenic Escherichia coli (UPEC) to screen the competitive inhibitor of SdiA, a transcriptional activator of quorum sensing in E. coli. In this study, potentiality of five different extracts of Melia dubia seeds for quorum sensing inhibitory activity was investigated against uropathogenic ..

Curcumin Bioconjugates: Studies on Structure-Activity Relationship and Antibacterial Properties against Clinically Isolated Strains

Author(s): Diwakar Rai, Garima Kumari, Anuradha Singh and Ramendra K Singh.

Abstract: Curcumin bioconjugates, with folic acid, fatty acids and dipeptide, have shown much lower MIC than curcumin against clinically isolated Gram-positive, S.viridians, and Gram-negative bacterial strains, E. coli, P. mirabilis and K. pneumoniae. Polynomial regression analysis was performed to establish a correlation between lipophilicity (logP) and antibacterial activity (pMIC), which showed the efficacy of these molecules against the bacterial strains..

A QSAR Study on Some Series of Anticancer Tyrosine Kinase Inhibitors

 Author(s): Zaihra Anwer and Satya P Gupta.

Abstract: A quantitative structure-activity relationship (QSAR) study has been made on two different series of anticancer tyrosine kinase inhibitors, namely a series of 4-alkynyl and 4-alkenyl-quinazolines and a series of N-4,6-pyrimidine-Nalkyl- N’-phenyl ureas. For the first series, QSAR results indicate that the activity is controlled by the hydrophobicity of the molecules and molecular connectivity index of the substituent, whereas for the second series of compounds the activity is found to be controlled by the molecular connectivity index of the substituent and some indicator variables.

Substituted Naphthalen-1-yl-Acetic Acid Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Analysis

Author(s): Rakesh Narang, Balasubramanian Narasimhan, Sunil Sharma, Erik De Clercq, Christophe Pannecouque and Jan Balzarini.

Abstract:A series of naphthalen-1-yl-acetic acid benzylidene/(1-phenyl-ethylidene)-hydrazides (1-36) was synthesized and tested, in vitro, for antiviral, antibacterial and antifungal activities. The antibacterial and antifungal screening results indicated that compounds having o-bromo, methoxy and hydroxy substitutents were the most active ones. The results of antiviral evaluation showed that none of the synthesized derivatives inhibited the viral infection at subtoxic concentrations. QSAR investigations revealed that the multi-target QSAR model was more effective in describing the antimicrobial activity than the one-target QSAR models.

Synthesis, Molecular Docking and Antiamnesic Activity of Selected 2- Naphthyloxy Derivatives

Author(s): Poonam Piplani, Paramveer Singh and Anuradha Sharma.

Abstract: The present paper describes the design and synthesis of a series of some 2-naphthyloxy derivatives with their antiamnesic activity using mice as the animal model and piracetam as the reference drug. All the synthesized compounds were characterized by spectroscopic techniques and were screened for their efficacy as cognition enhancers by elevated plus maze test and acetylcholinestrase inhibitory assay.

For details of the journal, please visit:

New Issue ::: Current Medicinal Chemistry

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Articles from the journal Current Medicinal Chemistry, 22 issue 20

Article: Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions

Author(s): Daniel W. Ferreira, Philippe Naquet and Jose E. Manautou


Article: Glycation and Hypoxia: Two Key Factors for Adipose Tissue Dysfunction

Author(s):  Paulo Matafome, Tiago Rodrigues and Raquel Seica


Article: Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-Targeting Molecules

Author(s): Cláudia M. Deus, Gabriela L. Santos, Rute Loureiro, Ignacio Vega-Naredo, Henrique Faneca and Paulo J. Oliveira


Article: Trends in Mitochondrial Therapeutics for Neurological Disease

Author(s): Ana Leitão-Rocha, Pedro Guedes-Dias, Brígida R. Pinho and Jorge M. A. Oliveira


Article: Regulation of Mitochondrial Function and its Impact in Metabolic Stress

Author(s):  Filipe V. Duarte, Joao A. Amorim, Carlos M. Palmeira and Anabela P. Rolo


Article: Modulation of Mitochondrial Permeability Transition in Ischemia-Reperfusion Injury of the Heart. Advantages and Limitations 

Author(s): Fabio Di Lisa and Paolo Bernardi


Article: Multiple Targets for Drug-Induced Mitochondrial Toxicity

Author(s): Kendall B. Wallace


Article: Mitochondrial Mechanisms of Metabolic Reprogramming in Proliferating Cells

Author(s):  Maria Ines Sousa, Ana Sofia Rodrigues, Sandro Pereira, Tania Perestrelo, Marcelo Correia and Joao Ramalho-Santos


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New issues published in different journals of Bentham Science

Current Organic Chemistry, 19 Issue 19

Current Medicinal Chemistry, 22 Issue 24

Current Stem Cell Research & Therapy, 10 Issue 5

Current Clinical Pharmacology, 10 Issue 3new Issue 1

Current Bioactive Compounds, 11 Issue 2

Current Organic Chemistry, 19 Issue 18

Innovations in Corrosion and Materials Science, 5 Issue 1

Recent Patents on Nanotechnology, 9 Issue 2

Current Radiopharmaceuticals, 8 Issue 2

Neuroscience and Biomedical Engineering, 3 Issue 1

Current Molecular Medicine, 15 Issue 6