Journal Name: Recent Patents on Anti-Infective Drug Discovery
Vol.8, No. 2, 2013
Article: “Photosensitizers as an alternative to antibiotics.
Author: Dr. Marina Nisnevitch
Journal Name: Current Cancer Drug Targets
Article Title: DNA Methyltransferase-1 Inhibitors as Epigenetic Therapy for Cancer
Author(s): Varinder Singh, Prince Sharma and Neena Capalash
DNA methylation is an epigenetic modification involved in gene expression regulation. In cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor suppressor genes to undergo promoter hypermethylation and become transcriptionally silent. Reexpression of methylation silenced tumor suppressor genes by inhibiting the DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) has emerged as an effective strategy against cancer. The expression of DNA methyltransferase 1 (DNMT1) being high in S-phase of cell cycle makes it a specific target for methylation inhibition in rapidly dividing cells as in cancer. This review discusses nucleoside analogues (azacytidine, decitabine, zebularine, SGI-110, CP-4200), non-nucleoside ihibitors both synthetic (hydralazine, RG108, procaine, procainamide, IM25, disulfiram) and natural compounds (curcumin, genistein, EGCG, resveratrol, equol, parthenolide) which act through different mechanisms to inhibit DNMTs. The issues of bioavailability, toxicity, side effects, hypomethylation resistance and combinatorial therapies have also been highlighted.
For more information, visit:http://benthamscience.com/journal/contents.php?journalID=ccdt&issueID=109879
For details on this article, visit:http://benthamscience.com/journal/abstracts.php?journalID=ccdt&articleID=109882
Journal Name: Anti-Cancer Agents in Medicinal Chemistry
Article Title: The Use of Lentinan for Treating Gastric Cancer
Author(s): Kenji Ina, Takae Kataoka and Takafumi Ando
Abstract: Natural compounds containing fungal β-glucans have been used to improve general health for thousands of years in China and Japan. Lentinan, the backbone of β-(1, 3)-glucan with β-(1, 6) branches, is one of the active ingredients purified from Shiitake mushrooms and has been approved as a biological response modifier for the treatment of gastric cancer in Japan. Despite recent advances in chemotherapeutic agents, unresectable or recurrent gastric cancer remains an incurable disease, with survival rates being far from satisfactory. Recent clinical studies have shown that chemo-immunotherapy using lentinan prolongs the survival of patients with advanced gastric cancer, as compared to chemotherapy alone. In addition, trastuzumab, an antibody against HER2/neu growth factor receptor, has been used for the treatment of gastric cancer in combination with cytotoxic chemotherapeutic agents. Lentinan may exert a synergistic action with anti-cancer monoclonal antibodies to activate complement systems through the mechanism of antibody-dependent cellular cytotoxicity and complement dependent cytotoxicity. Because a better understanding of its biological activities should enable us to use lentinan more efficiently in the treatment of gastric cancer, immunological effects provided by β-glucans, a possible mode of action of lentinan, and its clinical application including future potential uses are discussed in the present review.
For more details, click here: http://benthamscience.com/journal/abstracts.php?journalID=acamc&articleID=110379
Journal Name: “ Current Computer-Aided Drug Design”.
Volume.9 , No.4, 2013
Article: “ Drug DNA Interaction”
Dr. Ashesh Nandy
A Special Session on ‘Neurodegenerative Disorders’ will be chaired by Prof. Dr. D.K. Lahiri, the EIC of Current Alzheimer Research of Bentham Science Publishers at Drug Discovery & Therapy World Congress 2014
Ebook: “Physiologic Autoimmunity and Preventive Medicine”
Speaker: Proff. Alexander Poletaev
We invite you to kindly visit he Bentham Science Publishers’ exhibition booth at the American Association for Cancer Research Annual Meeting, from April 5-9, 2014, in San Diego Convention Center, San Diego, California. Please stop by our booth # 536 to explore the latest issues of our Cancer Research journals and related eBooks. Our representatives look forward to welcoming you there.
Ebook: ‘Jožef Stefan: His Scientific Legacy on the 175th Anniversary of His Birth’
by Dr. Crepeau