New Issue Published!!

Current Drug Safety – 9 Issue 2

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Aims & Scope

Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.

 www.eurekaselect.com

Abstracted & Indexed in:

Chemical Abstracts, PubMed/MEDLINE, Scopus, EMBASE, Genamics JournalSeek, PubsHub, J-Gate, EMCare.

 http://www.eurekaselect.com/123007/issue/2

SMI Event!!

Advances in Cell Based Assays

11TH NOV – 12TH NOV 2014

Marriott Regents Park Hotel, London UK

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Description:

The pioneering conference series on Advances in Cell based Assays, returns to London this autumn on 11th and 12th November. The 7th instalment comes at the perfect time to discuss key topics such as phenotypic screening, application of 3d cultures, stem cells, label free technology, plus much more.  Expand your scientific horizons and hear from an array of industry leaders including GSK, Astra Zeneca and MedImmune. For further details visit http://www.smi-online.co.uk/goto/2014cellbasedassay10.asp

Endorsement of BSP Journal, Current Medicinal Chemistry, by Nobel Laureates

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“Current Medicinal Chemistry represents an important review journal of great value to medicinal chemists in universities and pharmaceutical industries.”

Sir D.H.R. Barton
Nobel Laureate

“Current Medicinal Chemistry is an important review journal in the field of medicinal chemistry which should provide research scientists in the field with recent developments in various frontier areas. The journal is strongly recommended to the scientific community.”

Herbert C. Brown
Nobel Laureate

“Current Medicinal Chemistry is a frontier review journal which contains comprehensive reviews written by leading scientists in their respective fields. The journal presents the latest developments in various areas of medicinal chemistry. I strongly recommend it to scientists working in the field.”

Robert Huber
Nobel Laureate

“In view of the growing volume of literature, the role of a high quality review journal has become increasingly important. “Current Medicinal Chemistry” presents expert overviews in the field of medicinal chemistry of general interest to the scientific community”

Jean-Marie Lehn
Nobel Laureate

“Current Medicinal Chemistry” is a leading journal in the field of medicinal chemistry where cutting edge reviews in hot topic areas are regularly published. It provides scientists in the field with comprehensive review articles written by experts and eminent researchers in the field and allows them to keep abreast with the latest developments in the field. The journal is highly recommended to all scientists in the field of medicinal chemistry”

Ferid Murad
Nobel Laureate

 

Special Thematic Issue of Current Drug Metabolism

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Tentative Outline
Special Issue for Current Drug Metabolism

Guest Editor: Jose A.G. Agúndez

CLINICAL USE OF BIOMARKERS IN DRUG METABOLISM
AND ADVERSE DRUG REACTIONS

Aims & Scope:
In spite of the large effort and the huge amount of pharmacogenomics information available in
the literature, until now only a small number of pharmacogenomics biomarkers are being used routinely
in clinical practice. Several barriers to implementing the use of pharmacogenomics testing exist. This
special issue will focus on developments, barriers and regulatory issues regarding clinical use of
biomarkers. These will include (but not limited to) new procedures for the identification of biomarkers
(NG sequencing, microRNAs, exploitation of the 1000 genomes project); Barriers to implementing the
use of pharmacogenomics testing; Non-genetic biomarkers of drug response; Identification and validation
of Gene/drug pairs; Refinement in the predictive capacity of conventional pharmacogenomic tests;
Development of clinical practice recommendations or guidelines for the clinical use of biomarkers related
to drug response.

Keywords:
Biomarkers, pharmacogenetics, drug response, gene/drug pairs, barriers, refinement, bioinformatics,
guidelines.

Subtopics:
Barriers in the clinical use of biomarkers.
Pharmacogenomic tests: gene-drug pairs.
Refinement if the predictive capacity of biomarkers.
New challenges in the use of pharmacogenomic biomarkers.
New computational approaches for the exploitation of genetic data.

Schedule:

Manuscript submission deadline: July 2013

Peer Review Due: August 2013

Revision Due: September 2013

Notification of acceptance by the Guest Editor: October 2013

Final manuscripts due: October 2013

 

For details, please visit: http://benthamscience.com/journal/special-issues.php?journalID=cdm

New eBooks Published!

Model-Driven-Business-Proce-Optimized

1) Model Driven Business Process Engineering (23/06/2014):

INTRODUCTION:

Model Driven development (MDD) is a software and systems development model that involves the application of visual modeling principles and best practices throughout the System Development Life Cycle (SDLC). These models enhance the efficiency and security of software by extracting technical details of specific platforms, database administration, distribution scenarios, etc.. MDD empowers developers to concentrate on business logic and design software in alignment with favorable business objectives. These models are then brought into a translation stage by coding a series of model transformations in a high level programming language which provides an entire accomplishment of the specified business logic on a certain platform with the help of a set of supporting technologies.

Model transformations are a core element of model-driven development, allowing the improvement of systems from specification to implementation, and the quality enhancement of specifications. Model transformations are generally expressed by using specification languages specially designed for the progress of transformations. MDD and model-transformation languages are now adequately fully developed to begin to be utilized in industrial practice. This leads to the advancement complex transformations and initiates a need for sustaining and emerging transformation specifications – including platforms, languages and other factors.

Model-Driven Business Process Engineering surveys the latest model transformation specification and composition techniques, and also provides guidelines for the practical application of model transformations to large transformation issues to the readers. The ebook comprises of chapters written by paramount experts in the field of model transformation. It comprehensibly explains the main techniques that define model transformation composition and evolution. Starting from the structuring and modularisation of model transformations, the eBook covers the composition techniques for model transformations (external and internal composition). The book also features chapters covering the evolution of metamodels and model transformation approaches such as ATL, ETL, QVT, Viatra and Kermeta, which are currently in industrial use on a broad scale.

Model-Driven Business Process Engineering is a useful reference intended for novice developers and working professionals seeking information on current practices in MDD and model transfoModel Driven development (MDD) is a software and systems development model that involves the application of visual modeling principles and best practices throughout the System Development Life Cycle (SDLC). These models enhance the efficiency and security of software by extracting technical details of specific platforms, database administration, distribution scenarios, etc.. MDD empowers developers to concentrate on business logic and design software in alignment with favorable business objectives. These models are then brought into a translation stage by coding a series of model transformations in a high level programming language which provides an entire accomplishment of the specified business logic on a certain platform with the help of a set of supporting technologies.

Model transformations are a core element of model-driven development, allowing the improvement of systems from specification to implementation, and the quality enhancement of specifications. Model transformations are generally expressed by using specification languages specially designed for the progress of transformations. MDD and model-transformation languages are now adequately fully developed to begin to be utilized in industrial practice. This leads to the advancement complex transformations and initiates a need for sustaining and emerging transformation specifications – including platforms, languages and other factors.

Model-Driven Business Process Engineering surveys the latest model transformation specification and composition techniques, and also provides guidelines for the practical application of model transformations to large transformation issues to the readers. The ebook comprises of chapters written by paramount experts in the field of model transformation. It comprehensibly explains the main techniques that define model transformation composition and evolution. Starting from the structuring and modularisation of model transformations, the eBook covers the composition techniques for model transformations (external and internal composition). The book also features chapters covering the evolution of metamodels and model transformation approaches such as ATL, ETL, QVT, Viatra and Kermeta, which are currently in industrial use on a broad scale.

Model-Driven Business Process Engineering is a useful reference intended for novice developers and working professionals seeking information on current practices in MDD and model transformations in today’s global and commercial environment

For details, please visit: http://benthamscience.com/ebooks/9781608058921/index.htm

 

Frontiers-in-Clinical-3-Op

 

2) Frontiers in Clinical Drug Research: Hematology (23/06/2014):

Introduction:

Frontiers in Clinical Drug Research – Hematology is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of hematological disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of anemias, coagulopathies, vascular diseases and hematological malignancies. Reviews in this series also include research on specific antibody targets, therapeutic methods, genetic hemoglobinopathies and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Hematology is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of hematology, oncology and vascular pharmacology.
The first volume of this series features 6 chapters that cover a variety of topics including:
-Computational methods, molecular docking, and molecular dynamics simulation
-Recent advances in the treatment of Beta-Thalassemia Major
-Research on multiple myeloma and leukemia
-Molecular imaging in hematology

For details: http://benthamscience.com/ebooks/9781608058587/index.htm

New Issue Announced of BSP Journal: Current Organic Synthesis

The contribution in the journal of Current Organic Synthesis by various authors is as below:

Synthesis and Transformation of Halochromones

Author(s): Sara M. Tome, Artur M.S. Silva and Clementina M.M. Santos

Affiliation: Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.

Abstract

Herein, an overview of the most important developments on the synthesis and reactivity of halogen-containing chromones, namely simple chromones, flavones, styrylchromones, thiochromones and furochromones are reviewed (since 2003).

 
 

Sugar Furanoses as Useful Handles for Molecular Diversity

Author(s): Ana M. Gomez, Clara Uriel, Fernando Lobo and Jose Cristobal Lopez

Affiliation: Instituto de Quimica Organica General (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

Abstract

Carbohydrates have been recognized as privileged structures for the regio- and stereo-controlled appendage of pharmacophores to generate new derivatives with potential application in drug discovery processes. Even though most of the carbohydrate templates have been generated from pyranoses, other sugar derivatives have also been employed in the assembly of such structures. In this review, attention has been directed to the use of sugar-furanose platforms, and an account of the recent developments in the generation of furanose-based templates aiming at the generation of molecular diversity, including those from our research group, is presented.

 
 

Catalytic Asymmetric Darzens Reactions

Author(s): Peter Bako, Zsolt Rapi and Gyorgy Keglevich

Affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, PO Box 91, 1521 Budapest, Hungary.

Abstract

Optically active α,β-epoxy derivatives can be converted into many types of useful chiral compounds, such as chiral building blocks and synthetic intermediates for biologically active compounds. The most up-to-date and most economical method for the preparation of enantiomeric pure epoxides is the catalytic asymmetric Darzens condensation. The homogeneous phase and heterogeneus phase (phase-transfer [PT]) catalytic methods for the synthesis of chiral α,β-epoxycarbonyl, epoxysulfonyl and epoxy-amide compounds are reviewed. The effect of chiral catalysts on the yields and enantioselectivities of the epoxides was studied in homogeneous phase and under PT conditions. The use of the most important chiral PT catalysts (ephedrinium salts, cinchona-derived salts and chiral crown ethers) in Darzens condensation is also summarized. In some cases, the relationship between the structure of catalyst and its activity is also studied.

 
 

Fluorescent Probes for Selective Probing Thiol-containing Amino Acids

Author(s): Jin-Gang Yu, Xiu-Hui Zhao, Lin-Yan Yu, Hua Yang, Xiao-Qing Chen and Jian-Hui Jiang

Affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China and Key Laboratory of Resources Chemistry of Nonferrous Metals, Ministry of Education (Central South University), Changsha, Hunan 410083, China.

Abstract

Thiol-containing biomolecules, such as cysteine (Cys), homocysteine (Hcy), glutathione (GSH), play crucial roles in maintaining biological systems. For example, elevated levels of Hcy have been implicated as an independent risk factor for tumor invasion and metastasis. Being associated with a wide variety of cancer progressions, there is a significant interest in looking for the fluorescent detection of such thiol species (Cys, Hcy, and GSH) in cancer cells. Various thiol-specific probes have been developed on the basis of different strategies. This review focuses on recent contributions for the fluorescent or colorimetric sensors for thiol-containing amino acids, with special emphasis on the design and application of novel fluorophores for detecting thiol-containing amino acids with higher sensitivity.

 
 

Recent Advances in the Synthesis of Heterocycles from Oximes

Author(s): Edgars Abele and Ramona Abele

Affiliation: Latvian Institute of Organic Synthesis, Riga, LV1006, Latvia.

Abstract

This review demonstrates that oximes and their derivatives are valuable starting materials for the preparation of many classes of heterocyclic compounds. The main group of reactions includes the cyclization of unsaturated oxime derivatives. Using these starting materials pyrroles, isoxazoles, pyridines and isoquinolines were prepared. Some heterocyclic systems (for example, seven-membered rings) were obtained using the classical Beckmann rearrangement and novel reagents and conditions.

 
 

P-C Bond Formation by Coupling Reactions Utilizing >P(O)H Species as the Reagents

Author(s): Erzsebet Jablonkai and Gyorgy Keglevich

Affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.

Abstract

In this review, the methods forming P-C bonds by coupling reactions, utilizing different >P(O)H species, are surveyed systematically. The components of the reactions are organic halides, >P(O)H species comprising dialkyl phosphites, H-phosphinates or secondary phosphine oxides and the catalyst, that is in most cases the complex of palladium or its salts. The Hirao reaction discovered in 1980 is in the focus that is the coupling of aryl halides or other aryl derivatives with mainly dialkyl phosphites in the presence of a variety of catalyst complexes. Beside P-C= and P-C bonds, P-CΞ bonds can also be established. The topic has also green chemical aspect, as it is a serious challenge for organic chemists to elaborate simple and cheap catalyst systems.

 
 

Electrogenerated Base Induced Dehydrodimerization and Dehydrotrimerization of Pyrazolones

Author(s): Wei-Cui Li, Zheng-Zheng Zhang, Cheng-Chu Zeng, Li-Ming Hu and Hong-Yu Tian

Affiliation: College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China.

Abstract

Electrogenerated base induced dehydrocoupling of pyrazol-5-ones was investigated. The results showed that dehydrodimers and dehydrotrimers were generated simultaneously under electrolytic conditions, and their ratio was mainly dependent on the reaction temperature and the nature of the supporting electrolyte. It was observed that the formation of dimer 2 is preferred at lower temperatures and that trimer 3 is preferentially formed at higher temperatures. In addition, higher yields of 3 could be obtained when NaI was used as the supporting electrolyte. The dehydrocoupling reaction of pyrazol-5-ones to form dimer 2 and trimers 3 and 4 was proposed to be through an EGB-induced cascade mechanism.

 
 

Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring

Author(s): Olga Bortolini, Iqbal Mulani, Antonio De Nino, Loredana Maiuolo, Alessandro Melicchio, Beatrice Russo and Donatella Granchi

Affiliation: Dipartimento di Chimica e Tecnologie Chimiche, Via P. Bucci, cubo 12C, Universita della Calabria, Rende (Italy).

Abstract

A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.

 
 

Hydration of 5-Oxo-1-Alkynes by a One-Pot Oxy-Iodination/Reduction Sequence: Synthesis of Methyl Ketones with Anchimeric Assistance

Author(s): Julia Trossarello, Adegboyega Egunjobi, Whitney J. Morgan, Rayaj Ahamed and Karelle S. Aiken

Affiliation: Chemistry Department, PO Box 8064, Georgia Southern University, Statesboro, GA 30460, USA.

Abstract

Methyl ketone derivatives can be accessed from 5-oxo-1-alkynes in an iodine-initiated hydration of the terminal alkynes. Use of molecular iodine in this manner is novel, inexpensive and a greener alternative to the traditional use of transition metal catalysts. Herein, we report the results of a methodology study which sheds light on the underlying mechanism of this new, metal-free reaction. Our findings indicate that the hydration of the alkyne proceeds via an important anchimeric assistance in which the neighboring keto group participates with a 5-exo-dig cyclization.

 

Major Article Contributions by Some of our Indian Authors in Bentham Science Publishers Journal: Medicinal Chemistry

mc-journal-cover

New Quinolinyl–1,3,4–Oxadiazoles: Synthesis, In Vitro Antibacterial, Antifungal and Antituberculosis Studies

Author(s): Rahul V. Patel, Premlata Kumari and Kishor H. Chikhalia

Affiliation: Department of Applied Chemistry, S. V. National Institute of Technology, Surat–395007, Gujarat, India.

Abstract

In order to generate hybrid antimicrobial remedies with novel mode of action, two series of quinoline based 1,3,4-oxadiazole derivatives condensed with N-aryl/benzothiazolyl acetamides were synthesized and the MIC values of the compounds towards eight reference bacterial strains (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, S. flexneri), four fungi (A. niger, A. fumigatus, A. clavatus, C. albicans) and Mycobacterium tuberculosis H37Rv were assayed in vitro. Quinoline–6–carboxlic acid was treated with thionyl chloride in refluxing methanol to obtain the corresponding ester derivative to be hydrazinolyzed by 99% hydrazine hydrate in ethanol to produce carbohydrazide intermediate. The carbohydrazide precursor underwent cyclization by carbon disulfide and ethanolic KOH to construct 5–quinolinyl–6–yl–1,3,4–oxadiazol–2–thiol. Substituted 2–chloro–N–phenyl(benzothiazolyl)aceta-mide derivatives were then condensed to 1,3,4-oxadiazole nucleus via sulphur linkage to yield the desired products. Target products bearing N–benzothiazolyl–2–chloroacetamides displayed good inhibitory potential. The biological screening identified that many final analogues exhibited a significant inhibition of the growth of microorganisms at 3.12-25 μg/mL of MIC, which were comparable to control drugs. The influence of the presence of various functional groups to the phenyl/benzothiazolyl ring on activity profiles was investigated. The proposed structures of the newly prepared products were confirmed with the aid of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. These results may provide new insights in the design of a novel pool of bioactive templates.

A Combination of 3D-QSAR Modeling and Molecular Docking Approach for the Discovery of Potential HIF Prolyl Hydroxylase Inhibitors

Author(s): Mahesh Kumar Teli and Rajanikant Golgodu Krishnamurthy

Affiliation: School of Biotechnology Coordinator, Bioinformatics Centre National Institute of Technology Calicut Calicut – 673601, Kerala, India.

Abstract

Suppression of HIF prolyl hydroxylase (PHD) activity by small molecule inhibitors leads to the stabilization of HIF and offers a potential therapeutic option for treating ischemic disorders. In this study, pharmacophore based QSAR modeling, virtual screening and molecular docking approaches were concurrently used to identify target-specific PHD inhibitors with better ADME properties and to readily minimize false positives and false negatives. A 3D-QSAR based method was used to generate a pharmacophore hypothesis (AAAN). The obtained 3D-QSAR model has an excellent correlation coefficient value (r2 = 0.99), Fisher ratio (F = 386) and exhibited good predictive power (q2 = 0.64). The hypothesis was validated and utilized for chemical database screening and the retrieved compounds were subjected to molecular docking for further refinement. Quantitative AAAN hypothesis comprised three H-bond accepter and one negative ionizable group feature and it give good predictive ability because all the QSAR information it was providing matched with the active site information. The hypothesis was validated and used as a 3D query for database screening. After manual selection, molecular docking and further refinement, based on the molecular interactions of inhibitors with the essential amino acids residues, 12 candidates with good ADME and blood brain barrier permeability values were selected as potential PHD inhibitors.

Modeling of LIM-Kinase 2 Inhibitory Activity of Pyrrolopyrimidine Analogues: Useful in Treatment of Ocular Hypertension and Glaucoma

Author(s): Gagandip Singh, Manish K. Gupta, Viney Kumar and Yenamandra S. Prabhakar

Affiliation: Molecular Modeling and Pharmacoinformatics Lab, Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, India.

Abstract

The LIM-Kinase 2 (LIMK2) inhibitory activity of a series of pyrrolopyrimidine analogs has been analyzed through combinatorial protocol in multiple linear regressions (CP-MLR) and partial least square (PLS) using different descriptors obtained from DRAGON software. The empirical, topological and charge descriptors have led to statistically significant QSAR models and showed good external predictivity as reflected in test set R2 values (0.782 to 0.888). The obtained structure-activity correlations underlined the significance of bulkiness and molecular polarizability in improving the activity. The topological descriptors suggested that open chain or branched substituents are favorable while cyclic /ring substituents are unfavorable for the activity. The descriptors identified in the study showed that pyrrolopyrimidine scaffold holds scope for modulating LIMK2 inhibitory activity. The study gives a direction for further exploration of chemical space of pyrrolopyrimidine analogs as LIMK2 inhibitors.

Variable Selection Based QSAR Modeling on Bisphenylbenzimidazole as Inhibitor of HIV-1 Reverse Transcriptase

Author(s): Surendra Kumar and Meena Tiwari

Affiliation: Computer Aided Drug Design Lab, Department of Pharmacy, Shri G. S. Institute of Technology and Science, 23, Park Road, Indore-452003, (M.P.), India.

Abstract

The emergence of mutant virus in drug therapy for HIV-1 infection has steadily risen in the last decade. Inhibition of reverse transcriptase enzyme has emerged as a novel target for the treatment of HIV infection. The aim to decipher the structural features that interact with receptor, we report a quantitative structure activity relationship (QSAR) study on a dataset of thirty seven compounds belonging to bisphenylbenzimidazoles (BPBIs) as reverse transcriptase inhibitors using enhanced replacement method (ERM), stepwise multiple linear regression (Stepwise-MLR) and genetic function approximation (GFA) method for selecting a subset of relevant descriptors, developing the best multiple linear regression model and defining the QSAR model applicability domain boundaries. The enhanced replacement method was found to give better results r2=0.8542, Q2(loo) = 0.7917, r2pred = 0.7812) at five variables as compared to stepwise MLR and GFA method, evidenced by internal and external validation parameters. The modified r2 (r2m) of the training set, test set and whole data set were calculated and are in agreement with the enhanced replacement method. The results of QSAR study rationalize the structural requirement for optimum binding of ligands. The developed QSAR model shows that hydrophobicity, flexibility, three dimensional surface area, volume and shape of molecule are important parameters to be considered for designing new compounds and to decipher reverse transcriptase enzyme inhibition activity of these compounds at molecular level. The applicability domain was defined to find the similar analogs with better prediction power.

3 rd Minicircle & DNA Vector Conference- 07 – 09 May 2014, Bielefeld (Germany)

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Conference showed remarkable progress in Minicircle and DNA Vector technology

Europe’s leading scientists met in Bielefeld, Germany, to exchange information about new approaches in Minicircle and DNA Vector technology

After the first two Minicircle Conferences in 2007 and 2008, the Minicircle and DNA Vector technology has evolved considerably. This was clearly demonstrated at the conference now taking place. More than 60 participants enjoyed the very fruitful and stimulating meeting.

The 3rd Minicircle & DNA Vector Conference served as a meeting ground for scientists working in different fields of research. Various leading scientists from all over Europe reported on their current research projects and results. “We wanted to specifically invite young scientists to present their research and give them the possibility to learn more about the latest developments in the Minicircle technology and its applications in DNA vaccination and gene therapy.” said Dr. Martin Schleef – CEO of PlasmidFactory (www.plasmidfactory.com) and scientific organizer of the conference.

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In the unique atmosphere of the Kunsthalle Bielefeld the conference found a perfect frame between Expressionist artwork, e.g. of Hermann Stenner, a remarkable young painter from Bielefeld, who fell already in 1914 at the age of only 23 years in 1st World War.

BSP Journals Impacting Science: ‘Current Pharmaceutical Analysis’ and ‘Current Proteomics’

Current Pharmaceutical Analysis

Editor-in-Chief:

Atta-ur-Rahman, FRS

Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

Aims & Scope

Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.

 

Current Proteomics

Editor-in-Chief:

Bernd Rehm

Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand

Aims & Scope

Research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.

Current Proteomics publishes review articles in all aspects of the fast-expanding field of proteomics. All areas of proteomics are covered together with the methodology, softwares, databases, technological advances and applications of proteomics, including functional proteomics. Diverse technologies covered include but are not limited to:

  • Protein separation and characterization techniques
  • 2-D gel electrophoresis and image analysis
  • Techniques for protein expression profiling including mass spectrometry-based methods and algorithms for correlative database searching
  • Determination of co-translational and post- translational modification of proteins
  • Protein/peptide microarrays
  • Biomolecular interaction analysis
  • Analysis of protein complexes
  • Yeast two-hybrid projects
  • Protein-protein interaction (protein interactome) pathways and cell signaling networks
  • Systems biology
  • Proteome informatics (bioinformatics)
  • Knowledge integration and management tools
  • High-throughput protein structural studies (using mass spectrometry, nuclear magnetic resonance and X-ray crystallography)
  • High-throughput computational methods for protein 3-D structure as well as function determination
  • Robotics, nanotechnology, and microfluidics

 

In addition to in-depth reviews, articles highlighting recent proteomics papers of special interest as well as book reviews are published. Mini-reviews and perspective articles are also published. In view of the importance of specific technology and software developed for advancement of proteomics research, a separate section is devoted to product and technology reports. Proceedings of proteomics meetings with selected review articles on topics presented are also published.

BSP Patent Journals: ‘Recent Patents on Biotechnology’ and ‘Recent Patents on Catalysis’

Editor-in-Chief:

ImageRongling Wu

Departments of Public Health Sciences and Statistics
Pennsylvania State College of Medicine
Hershey, PA
USA

Aims & Scope

Recent Patents on Biotechnology publishes review and research articles, and guest edited thematic issues on recent patents in the field of biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.

Editor-in-Chief:

ImageShaobin Wang

Department of Chemical Engineering
Curtin University of Technology
Perth, WA 6845
Japan

Aims & Scope

Recent Patents on Catalysis publishes review, research articles and guest edited thematic issues on recent patents in the field of catalysis. The journal aims to provide recent patent information in all areas of catalysis science, including heterogeneous, homogeneous catalysis, synthesis and properties of new catalysts including synthesis and catalytic function of novel inorganic solids and complexes, studies that relate catalytic function to fundamental chemical processes in metal complexes and at surfaces, novel concepts in surface chemistry. A selection of important and recent patents on catalysis is also included in the journal. The journal is essential reading for all academic and industrial researchers, including IP authorities who wish to be kept informed about important patent breakthroughs in catalysis science and technology.