Letters in Drug Design & Discovery publishes letters, mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
Following are the articles from the journal Letters in Drug Design & Discovery, 12 Issue 5:
Article: Discovery of Novel HDAC Inhibitors by Structure-based Optimization of Cinnamic Hydroxamic Scaffold
Author(s): Chengqing Ning, Wenyuan Huang, Wen Wu, Cheng Lu, Yujun He, Lei Yao, Lifei Liu, Xiaohe Zhen, Xiaoyu Liu and Niefang Yu
Article: Development of Structure Activity Correlation Model on Azetidin-2-ones as Tubulin Polymerization Inhibitors
Author(s): Vijay Kumar Patel, Kavibhushan Singh Chouhan, Avineesh Singh, Deepak Kumar Jain, Ravichandran Veerasamy, Pradeep Kumar. Singour, Rajesh Singh Pawar and Harish
Article: Synthesis and Anticancer Activity of 7,8-dihydroxy-4-arylcoumarins
Author(s): Jianrui Wu, Ting Peng, Fang Chen, Yixin Leng, Linjiang Tong, Mengyuan Li, Rong Qu, Hua Xie, Jian Ding and Wenhu Duan
Article: Hybrid Pharmacophore Design and Synthesis of Naphthalimide– Benzimidazole Conjugates as Potential Anticancer Agents
Author(s): Ahmed Kamal, Pogula Praveen Kumar, Mohammed Naseer Ahmed Khan, Bobburi Naga Sheshadri and Olepu Srinivas
Article: Promising Anticancer Drug Candidates Based on the 7-methoxychromone Scaffold: Synthesis and Evaluation of Antiproliferative Activity
Author(s): Hoang Le Tuan Anh, Nguyen Thi Cuc, Pham Hai Yen, Nguyen Xuan Nhiem, Bui Huu Tai, Do Thi Thao, Nguyen Hoai Nam, Chau Van Minh, Phan Van Kiem and Young Ho Kim
Article: Design, Synthesis and Biological Evaluation of Novel Fluorinated Heterocyclic Hybrid Molecules Based on Triazole & Quinoxaline Scaffolds Lead to Highly Potent Antimalarials and Antibacterials
Author(s): Adimulam Chandra Shekhar, Boddupally Pedda Venkat Lingaiah, Pamulaparthy Shanthan Rao, Banda Narsaiah, Aparna Devi Allanki and Puran Singh Sijwali
Article: Synthesis of Derivatives of Artesunate α-Aminophosphonate and Their Antimicrobial Activities
Author(s): Sheng He, Xilin Ouyang, Xiaochao Huang, Weisong Hu, Weilong Dai, Xiaoyan Tian, Yingming Pan, Shiwen Huang and Hengshan Wang
Article: Synthesis and Preliminary Biological Evaluation of New Heterocyclic Carboxamide Models
Author(s): Kamal Sweidan, Jorn Engelmann, Walid Abu Rayyan, Dima Sabbah, Musa Abu Zarga, Tariq Al-Qirim, Yusuf Al-Hiari, Ghassan Abu Sheikha and Ghassan Shattat
Article: Synthesis and Analysis of Anticonvulsant Activities of New 4-[2-(4- alkoxybenzylamino)ethyl]-2H-1,2,4-triazol-3(4H)-one Derivatives
Author(s): Qing-Kun Shen, Shi-Ben Wang, Guo-Hua Gong, Xiu-Mei Yin and Zhe-Shan Quan
Article: Nematicidal Activity of Sprio and Bridged Heterocyclic Neonicotinoid Analogues against Meloidogyne incognita
Author(s): Minming Zou, Xue Tian, Nanyang Chen and Xusheng Shao
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