Recently Published Issue of the Journal Combinatorial Chemistry & High Throughput Screening

Combinatorial Chemistry & High Throughput Screening(CCHTS) publishes full length original research articles and reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Following are the articles from the journal Combinatorial Chemistry & High Throughput Screening, 18 Issue 4:

Editorial: (Thematic Issue: Advances in Cheminformatics: Drug Discovery, Computational Toxicology and Nanomaterials (Part II))

Author(s): Antreas Afantitis and Georgia Melagraki

 

Article: Is There a Relationship Between Sweet Taste and Seizures? Anticonvulsant and Proconvulsant Effects of Non-Nutritive Sweeteners

Author(s): Mauricio E. Di Ianni, Andrea V. Enrique, Maria E. Del Valle, Blanca Aldana, María A. Rosella, Luisa Rocha, Eduardo A. Castro, Luis E. Bruno-Blanch and Alan Talevi

 

Article: G-Protein Coupled Receptors (GPCRs): A Comprehensive Computational Perspective

Author(s): M. Ramesh and Mahmoud E. Soliman

 

Article: Quantitative Structure-Activity Relationships for Cellular Uptake of Surface-Modified Nanoparticles

Author(s): Rong Liu, Robert Rallo, Muhammad Bilal and Yoram Cohen

 

Article: The Monte Carlo Method Based on Eclectic Data as an Efficient Tool for Predictions of Endpoints for Nanomaterials – Two Examples of Application

Author(s): Andrey A. Toropov, Alla P. Toropova, Aleksandar M. Veselinovic, Jovana B. Veselinovic, Karel Nesmerak, Ivan Raska Jr, Pablo R. Duchowicz, Eduardo A. Castro, Valentin O. Kudyshkin, Danuta Leszczynska and Jerzy Leszczynski

 

 

Article: Systematic Comparison of the Performance of Different 2D and 3D Ligand-Based Virtual Screening Methodologies to Discover Anticonvulsant Drugs

Author(s): Mauricio E. Di Ianni, Melisa E. Gantner, María E. Ruiz, Eduardo A. Castro, Luis E. Bruno-Blanch and Alan Talevi

 

Article: In Silico Identification of Irreversible Cathepsin B Inhibitors as Anti- Cancer Agents: Virtual Screening, Covalent Docking Analysis and Molecular Dynamics Simulations

Author(s): Mbatha Sbongile and Mahmoud E.S. Soliman

 

Article: Exploring Structural Requirements of Imaging Agents Against Aβ Plaques in Alzheimer’s Disease: A QSAR Approach

Author(s): Pravin Ambure and Kunal Roy

 

Article: Using Online Tool (iPrior) for Modeling ToxCast™ Assays Towards Prioritization of Animal Toxicity Testing

Author(s): Ahmed Abdelaziz, Yurii Sushko, Sergii Novotarskyi, Robert Korner, Stefan Brandmaier and Igor V. Tetko

 

For details, please visit: http://bit.ly/1bZxN6w

 

 

Author: Bentham Science Publishers

A major STM journal publisher of more than 100 online and print journals and related print/online book series, Bentham Science answers the information needs of scientists in the fields of pharmaceutical, biomedical, medical, engineering, technology, computer and social sciences.

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