Manganese Superoxide Dismutase Gene Therapy Protects Against Irradiation- Induced Intestinal Injury

Author(s): Chao Yang, Hai-Xu Chen, Yong Zhou, Min-Xia Liu, Yan Wang, Jie-Xi Wang, Su-Ping Ren, Ying Han and Ben-Yan Wu
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Affiliation: Beijing Institute of Transfusion Medicine, Beijing 100850, China.

Abstract: Radiation-induced intestinal injury is a common complication in radiotherapy for solid organ malignancies in abdomen or pelvis. However, currently there are no approved medical countermeasures for radiation-induced intestinal injury. Therefore, it is urgent to develop new treatments for radiation-induced intestinal injury. In the present study, we demonstrated that bone marrow derived mesenchymal stem cells (MSCs) and overexpression of human manganese superoxide dismutase (MnSOD) could ameliorate radiation-induced intestinal syndrome.

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Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of genetic diseases. Cell therapy manuscripts can also include application in non-genetic diseases when cells have been genetically modified. Current Gene Therapy publishes reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of genetic diseases.