Research articles by Indian contributors in the journal ‘Medicinal Chemistry’

Screening of SdiA Inhibitors from Melia dubia Seeds Extracts Towards the Hold Back of Uropathogenic E.coli Quorum Sensing-Regulated Factors

Author(s): Vinothkannan Ravichandiran, Karthi Shanmugam and Adline Princy Solomon.

Abstract: Plants have always been a supreme source of drugs and India is endowed with a wide variety of them with high medicinal values. The Quorum Sensing (QS) quenching efficiency of various solvent extracts of Melia dubia seeds was investigated against uropathogenic Escherichia coli (UPEC) to screen the competitive inhibitor of SdiA, a transcriptional activator of quorum sensing in E. coli. In this study, potentiality of five different extracts of Melia dubia seeds for quorum sensing inhibitory activity was investigated against uropathogenic ..

http://bit.ly/1KnjZ5M

Curcumin Bioconjugates: Studies on Structure-Activity Relationship and Antibacterial Properties against Clinically Isolated Strains

Author(s): Diwakar Rai, Garima Kumari, Anuradha Singh and Ramendra K Singh.

Abstract: Curcumin bioconjugates, with folic acid, fatty acids and dipeptide, have shown much lower MIC than curcumin against clinically isolated Gram-positive, S.viridians, and Gram-negative bacterial strains, E. coli, P. mirabilis and K. pneumoniae. Polynomial regression analysis was performed to establish a correlation between lipophilicity (logP) and antibacterial activity (pMIC), which showed the efficacy of these molecules against the bacterial strains.. 

http://bit.ly/1KWLj5h

A QSAR Study on Some Series of Anticancer Tyrosine Kinase Inhibitors

 Author(s): Zaihra Anwer and Satya P Gupta.

Abstract: A quantitative structure-activity relationship (QSAR) study has been made on two different series of anticancer tyrosine kinase inhibitors, namely a series of 4-alkynyl and 4-alkenyl-quinazolines and a series of N-4,6-pyrimidine-Nalkyl- N’-phenyl ureas. For the first series, QSAR results indicate that the activity is controlled by the hydrophobicity of the molecules and molecular connectivity index of the substituent, whereas for the second series of compounds the activity is found to be controlled by the molecular connectivity index of the substituent and some indicator variables.

 http://bit.ly/1FbECu0

Substituted Naphthalen-1-yl-Acetic Acid Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Analysis

Author(s): Rakesh Narang, Balasubramanian Narasimhan, Sunil Sharma, Erik De Clercq, Christophe Pannecouque and Jan Balzarini.

Abstract:A series of naphthalen-1-yl-acetic acid benzylidene/(1-phenyl-ethylidene)-hydrazides (1-36) was synthesized and tested, in vitro, for antiviral, antibacterial and antifungal activities. The antibacterial and antifungal screening results indicated that compounds having o-bromo, methoxy and hydroxy substitutents were the most active ones. The results of antiviral evaluation showed that none of the synthesized derivatives inhibited the viral infection at subtoxic concentrations. QSAR investigations revealed that the multi-target QSAR model was more effective in describing the antimicrobial activity than the one-target QSAR models. 

http://bit.ly/1EsHibH

Synthesis, Molecular Docking and Antiamnesic Activity of Selected 2- Naphthyloxy Derivatives

Author(s): Poonam Piplani, Paramveer Singh and Anuradha Sharma.

Abstract: The present paper describes the design and synthesis of a series of some 2-naphthyloxy derivatives with their antiamnesic activity using mice as the animal model and piracetam as the reference drug. All the synthesized compounds were characterized by spectroscopic techniques and were screened for their efficacy as cognition enhancers by elevated plus maze test and acetylcholinestrase inhibitory assay.

http://bit.ly/1EvkdW5

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New Issue ::: Current Medicinal Chemistry

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Articles from the journal Current Medicinal Chemistry, 22 issue 20

Article: Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions

Author(s): Daniel W. Ferreira, Philippe Naquet and Jose E. Manautou

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Article: Glycation and Hypoxia: Two Key Factors for Adipose Tissue Dysfunction

Author(s):  Paulo Matafome, Tiago Rodrigues and Raquel Seica

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Article: Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-Targeting Molecules

Author(s): Cláudia M. Deus, Gabriela L. Santos, Rute Loureiro, Ignacio Vega-Naredo, Henrique Faneca and Paulo J. Oliveira

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Article: Trends in Mitochondrial Therapeutics for Neurological Disease

Author(s): Ana Leitão-Rocha, Pedro Guedes-Dias, Brígida R. Pinho and Jorge M. A. Oliveira

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Article: Regulation of Mitochondrial Function and its Impact in Metabolic Stress

Author(s):  Filipe V. Duarte, Joao A. Amorim, Carlos M. Palmeira and Anabela P. Rolo

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Article: Modulation of Mitochondrial Permeability Transition in Ischemia-Reperfusion Injury of the Heart. Advantages and Limitations 

Author(s): Fabio Di Lisa and Paolo Bernardi

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Article: Multiple Targets for Drug-Induced Mitochondrial Toxicity

Author(s): Kendall B. Wallace

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Article: Mitochondrial Mechanisms of Metabolic Reprogramming in Proliferating Cells

Author(s):  Maria Ines Sousa, Ana Sofia Rodrigues, Sandro Pereira, Tania Perestrelo, Marcelo Correia and Joao Ramalho-Santos

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Current Stem Cell Research & Therapy, 10 Issue 5

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Current Clinical Pharmacology, 10 Issue 3new Issue 1

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Current Bioactive Compounds, 11 Issue 2

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Current Organic Chemistry, 19 Issue 18

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Innovations in Corrosion and Materials Science, 5 Issue 1

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Recent Patents on Nanotechnology, 9 Issue 2

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Current Radiopharmaceuticals, 8 Issue 2

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Articles from Bentham Science Impact Factor Journals Current Organic Chemistry

Current Organic Chemistry aims to provide in-depth reviews on the current progress in the fields of asymmetric synthesis, organo-metallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry and analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic chemistry.
Articles from the journal Current Organic Chemistry
Article: Editorial (Thematic Issue: Graphene: From Synthesis and Functionalization to Applications)
Author(s): Georgios Sakellariou

Article: Surface Initiated Polymerization from Graphene Oxide
Author(s): Nikolaos Politakos, George Liontos, Apostolos Karanastasis, George Zapsas, Dimitrios Moschovas and Apostolos Avgeropoulos

Article: Metallic Particle Assemblies on Graphene
Author(s): Manos Gkikas

Article: Non-covalent Interactions of Graphene with Polycyclic Aromatic Hydrocarbons
Author(s): Panagiota Zygouri, Georgia Potsi, Eleftherios Mouzourakis, Konstantinos Spyrou, Dimitrios Gournis and Petra Rudolf

Article: Non-covalent Graphene/Polymer Functional Materials
Author(s): Theodosis Skaltsas, Nikos Tagmatarchis and Stergios Pispas

Article: Polyelectrolyte-graphene Nanocomposites for Biosensing Applications
Author(s): Dimitrios Priftis

Article: Polymer Functionalized Graphene Oxide: A Versatile Nanoplatform for Drug/Gene Delivery
Author(s): George V. Theodosopoulos, Panayiotis Bilalis and Georgios Sakellariou

Article: Recent Advances in Graphene-Based Materials for Lithium Batteries
Author(s): George S. Pappas, Stefania Ferrari and Chaoying Wan

Article: Graphene Nanoribbons: Towards Graphitic Materials with Predefined Dimensions and Electronic Properties
Author(s): Eleftherios K. Pefkianakis, Georgios Sakellariou and Georgios C. Vougioukalakis

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Articles from Bentham Science Impact Factor Journals Current Organic Chemistry

Current Organic Chemistry aims to provide in-depth reviews on the current progress in the fields of asymmetric synthesis, organo-metallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry and analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic chemistry.

Articles from the journal Current Organic Chemistry

Article: Peptide Self-Assembly for Therapeutic Applications

Author(s): Joana Durao and Luis Gales


Article: An Overview: Recent Development of Titanium Dioxide Loaded Graphene Nanocomposite Film for Solar Application.

Author(s): Chin W. Lai, Foo W. Low, Soon W. Chong, Christelle P.P. Wong, Siti Z. Binti Mohamed Siddick, Joon C. Juan and Sharifah B. Abdul Hamid


Article: Cyclization: A Useful Approach for the Synthesis of Nitrogen Heterocyclic N-Oxides

Author(s): Ning Liu, Yuan-Jie Shu, Bo-Zhou Wang, Xiang-Zhi Li and Fu-Qiang Bi


Article: Fungal Laccases and their Biotechnological Significances in the Current Perspective: A Review

Author(s): Pankaj K. Chaurasia, Shashi L. Bharati, Manisha Sharma, Sunil K. Singh, Rama S. S. Yadav and Sudha Yadava


Article: Several Classes of Natural Products with Metal ion Chelating Ability

Author(s): Yutong Shi, Wei Jiang, Bibi N. Auckloo and Bin Wu


Article: Synthesis and Characterization of Ferrocenyl Carboxilic Surface-Functionalized Resorcinaren-PAMAM Dendrimers

Author(s): Sandra Cortez-Maya, Elena Klimova, R. I. Puente Lee, Andres Borja-Miranda and Marcos Martinez-Garcia.


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