Articles by Diseases – TYPE 1 OBESITY

 

Food Addiction Spectrum: A Theoretical Model from Normality to Eating and Overeating Disorders 

Author(s): Armando Piccinni, Donatella Marazziti, Federica Vanelli, Caterina Franceschini, Stefano Baroni, Davide Costanzo, Ivan Mirko Cremone, Antonello Veltri and Liliana Dell’Osso 

Abstract: The authors comment on the recently proposed food addiction spectrum that represents a theoretical model to understand the continuum between several conditions ranging from normality to pathological states, including eating disorders and obesity, as well as why some individuals show a peculiar attachment to food that can become an addiction. Further, they review the possible neurobiological underpinnings of these conditions that include dopaminergic neurotransmission and circuits that have long been implicated in drug addiction. The aim of this article is also that at stimulating a debate regarding the possible model of a food (or eating) addiction spectrum that may be helpful towards the search of novel therapeutic approaches to different pathological states related to disturbed feeding or overeating.

– See more at: http://www.eurekaselect.com/node/128902/article

 

See more articles categorized by diseases in the tab ‘Articles by Disease’ on our website www.benthamscience.com

 

Mini-Reviews in Medicinal Chemistry – Most Cited Article

Article: “An Overview of the Modulatory Effects of Oleic Acid in Health and Disease”

Evidences in the last years have showed the effects of oleic acid (OA) in human health and disease. Olive oil, rich in oleic acid, is supposed to present modulatory effects in wide physiological functions, while some studies also suggest a beneficial effect on cancer, autoimmune and inflammatory diseases, besides its ability to facilitate wound healing. Read more about this article here: http://bit.ly/1KYBh2R

 

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The results reported in the manuscript must be original and authentic work of the authors. They should be devoid of any plagiarism and the material should not have been published earlier. Studies which report some reproduced results, for example a new clinical trial, may also be considered for publication.

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Most Downloaded Article ::: Naturally Occurring Methyl Salicylate Glycosides

Abstract: As an important part of non steroids anti-inflammation drug (NSAIDs), salicylate has developed from natural substance salicylic acid to natrium salicylicum, to aspirin. Now, methyl salicylate glycoside, a new derivative of salicylic acid, is modified with a -COOH group integrated one methyl radical into formic ether, and a -OH linked with a monosaccharide, a disaccharide or a trisaccharide unit by glycosidic linkage. It has the similar pharmacological activities, anti-inflammatory, analgesic, antipyretic and antithrombotic as the previous salicylates’ without resulting in serious side effects, particularly the gastrointestinal toxicity. Owing to the superiority of those significant bioactivities, methyl salicylate glycosides have became a hot research area in NSAIDs for several years. This paper compiles all 9 naturally occurring methyl salicylate glycosides, their distribution of the resource and pharmacological mechanism, which could contribute to the new drug discovery.

Mini-Reviews in Medicinal Chemistry, 14(1): 56-63.

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MOST DOWNLAODED ARTICLE

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Articles by Diseases – Pediatrics and Neonatology

 

Ethical Considerations in Conducting Pediatric and Neonatal Research in Clinical Pharmacology 

Author(s): Michelle Roth-Cline and Robert M. Nelson

Abstract: The critical need for pediatric research on drugs and biological products underscores the responsibility to ensure that children are enrolled in clinical research that is both scientifically necessary and ethically sound. In this chapter, we review key ethical considerations concerning the participation of children. We review a basic ethical framework to guide pediatric research, and suggest how this framework might be operationalized in linking science and ethics. Topics examined include: the status of children as a vulnerable population; the appropriate balance of risk and potential benefit in research; and parental permission and child assent to participate in research.

– See more at: http://www.eurekaselect.com/node/134570/article#sthash.fjOBAIGJ.dpuf

Neonatology

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New Issue ::: Current HIV Research 14 issue 1

Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.

Articles from the journal in Current HIV Research, 14 issue 1:

  • Perspectives of Genome-Editing Technologies for HIV Therapy
  • Role of HIV-1 Envelope Glycoproteins Conformation and Accessory Proteins on ADCC Responses
  • Synergistic Inhibition of R5 HIV-1 by the Fusion Protein (FLSC) IgG1 Fc and Maraviroc in Primary Cells: Implications for Prevention and Treatment
  • Microarray Analysis Reveals Altered Lipid and Glucose Metabolism Genes in Differentiated, Ritonavir-Treated 3T3-L1 Adipocytes
  • Expression of Signaling Molecules in Progressive Multifocal Leukoencephalopathy
  • Raltegravir Plus Nevirapine as Maintenance Antiretroviral Therapy in HIV-Positive Patients: Safety, Efficacy and Pharmacokinetics
  • Changes in Serum Markers of Inflammation and Endothelial Activation in HIV-Infected Antiretroviral Naive Patients Starting A Treatment with Abacavir-Lamivudine or Tenofovir-Emtricitabine Plus Efavirenz
  • Longitudinal Analysis of Adherence to First-Line Antiretroviral Therapy: Evidence of Treatment Sustainability from an Indian HIV Cohort

For details on the articles, please visit this link :: http://bit.ly/1MzENpQ

Podcast by Dr. Dioguardi ::: Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients

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Patented Small Molecules Used for Reprogramming