CRISPR-Cas9 – Revolutionizing Gene Editing

Scientific discoveries seem to have no end. Novel findings, inventions and innovations keep coming up every day and the world gets the vital opportunity to further decipher all the concealed secret tools nature can offer.

Another such breakthrough that has vastly influenced 2015 is CRISPR-Cas9, the gene editing tool that is meant to allow scientists to alter the genetic networks in the cells of human beings. This immense step forward has the potential to eradicate or at least bar the spreading of many a diseases.

CRISPR-Cas9 and other gene editing tools are a very promising prospect to fight off malignant cancer cells, as the research, Current Genome Editing Tools in Gene Therapy: New Approaches to Treat Cancer published in the journal, Current Gene Therapy defines. The researchers at the Laboratory of Gene Expression Regulation, Institute of Cytology RAS, Russia who published the research state, ‘Cancer is a complex disease, which strongly depends on a particular genetic make-up and hence can be treated with gene therapy.’ They further tell that, ‘Cancer is a complex disease, which strongly depends on a particular genetic make-up and hence can be treated with gene therapy.’

This development in genetics is a milestone that may change the course of treatment of cancer forever.

Christmas’ Interesting Facts – Did You Know!!

Read and enjoy the fascinating facts on Christmas…

1. The first ever Christmas trees were made by Germans who used dyed goose feathers to make them.
2. Santa’s reindeers mostly are given masculine names like Cupid. Although male reindeers are known to shed their antlers off by Christmas. So the reindeers pulling Santa’s carriage are actually female.
3. Green, red and gold are the three colors of Christmas. Green symbolizes life and reincarnation. Red depicts the blood of Christ and gold signifies light and royalty.
4. Santa Claus is based on a real person, St. Nikolas of Myra (also known as Nikolaos the Wonderworker, Bishop Saint Nicholas of Smyrna, and Nikolaos of Bari), who lived during the fourth century. Born in Patara (in modern-day Turkey), he is the world’s most popular non-Biblical saint, and artists have portrayed him more often than any other saint except Mary. He is the patron saint of banking, pirating, butchery, sailing, thievery, orphans, royalty, and New York City.
5. Pope Julius I, bishop of Rome, declared 25^th December as the official date of Jesus Christ’s birth.

   Wish you all a blessed year ahead!!!!

 

Source: http://facts.randomhistory.com/christmas-facts.html

Celebrating Birthdays of Famous Personalities in History! – Joseph Rudyard Kipling

 

How to Judge You Are Stressed Out Due To Work

Holiday season is on and we are all enjoying lovely winter break. This is the best time to realize how far away from stressors we are. But, off the work, if we are feeling relaxed then it is a tell-tale sign that work has been adding to our stress big-time! We can fight the stress off but for some people it becomes a chronic problem. Their jobs need to bear the blame.

Here are some common signs that your work is stressful and you need to do something about it:

1. Getting frequent headaches on and off our work
2. Feeling pain in the jaw is also a marker. Often we unintentionally are grinding or teeth in tension or stiffening our jaw bones. This habit can become a usual habit and hurts most of the time
3. Watch out for troubling tummy as stress can make it ache. Work-related stress can give you bugs in the stomach
4. Oily skin, freckles and pimples are also an unwelcome sign as stress increases cortisol in body and spoils your skin
5. Thinning of hair can be attributed to stress too. Beware!!

Keep track of your health and never ignore yourself … Happy holidays!!!!

Podcast by Dr. Dibakar C. Deka on ‘An Improved Method for the Synthesis of β-Aminocarbonyl… Microwave Irradiation’

 An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation

by

Author(s): Monmi Saikia, Dibakar C. Deka and Sanjeeb Karmakar.

More on the article ::: http://bit.ly/1MvRRHW

Subscribe to our YouTube channel ::: http://bit.ly/1lr0czy

Open Access Plus Article :: “Potential Health Benefits of Berries”

 

Current Nutrition & Food Science 

http://bit.ly/1R380Ln

Articles by Disease ::: OBSTETRICS AND GYNECOLOGY

An Update on Developments in Female Hormonal Contraception

Author(s): Deborah A. Garside, Ayman Gebril, Natalie Nimmo, Manal Alsaadi, Alexander B. Mullen and Valerie A. Ferro

Abstract:

The human population continues to grow in some parts of the world, which has severe impact on resources, health and the environment. Individually, contraception enables women to choose their optimal family size and birth spacing, while in resource-poor countries it can help lift families out of poverty..

– See more at: http://www.eurekaselect.com/node/106402/article#sthash.qsr6rIXf.dpuf

Podcast on the eBook ::: ‘Evidence-Based Occlusal Management for Temporomandibular Disorders’ by Dr. Kengo Torii

Current main stream treatments for temporomandibular disorders (TMDs) are mainly conservative therapies. However, these conservative treatments are symptomatic treatments, not causal treatments. Therefore, the patients with severe symptoms have not been completely relieved.

For eBook details: http://bit.ly/1JDLqmr

Subscribe to our YouTube channel ::: http://bit.ly/1lr0czy

Upcoming Thematic Issue:: Current trends in the mycotoxin detection, biosynthesis regulation and control

Email to submit: tomicroj@hbenthamopen.com
More information: http://benthamopen.com/TOMICROJ/home/
Deadline: May 31, 2016

New Issue ::: Drug Metabolism Letters 9 Issue 2

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition. In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Articles from the journal in Drug Metabolism Letters, 9 Issue 2:

• Editorial (Thematic Issue: Recent Advances in Developmental Drug Disposition)
• Biochemical Screening for in utero Drug Exposure
• Alterations in Hepatic Lipid Metabolism, and their Relation to Dietary Macronutrients in Pediatric Nonalcoholic Fatty Liver Disease
• Predicting Pediatric Drug Disposition-Present and Future Directions of Pediatric Physiologically-Based Pharmacokinetics
• The Effects of Obesity on Drug Metabolism in Children
• Ontogeny of Human Conjugating Enzymes
• Adverse Drug Events in Children: How Big is the Problem?
• Downregulation of Hepatic Carbonyl Reductase Type 1 in End-Stage Renal Disease
• Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats
• The Detection of Anti-adalimumab Antibodies in a Series of Inflammatory Polyarthritis: three ELISA Methods Compared

For details on the articles, please visit this link: http://bit.ly/1NqxYDw