Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.
Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
Articles from the journal in Current Pharmaceutical Design, Volume 22 Issue 4:
- Editorial (Thematic Issue: Recent Advances in Management of Myocarditis)
- Viral Myocarditis and Dilated Cardiomyopathy: Etiology and Pathogenesis
- Recent advances in the management of autoimmune myocarditis: insights from animal studies.
- Drugs Targeting the Canonical NF-κB Pathway to Treat Viral and Autoimmune Myocarditis
- Oxidative stress and myocarditis
- The Role of Protease-Activated Receptors for the Development of Myocarditis: Possible Therapeutic Implications
- Autonomic Nervous System in Viral Myocarditis: Pathophysiology and Therapy
- Protective effects of andrographolide derivative AL-1 on high glucose-induced oxidative stress in RIN-m cells
- The In-Situ One-Step Synthesis of a PDC Macromolecular Pro-Drug and the Fabrication of a Novel Core-Shell Micell
For details on the articles, please visit this link :: http://bit.ly/1Tr7icz
Do You Play Video Games At Night?
Addiction for smoking, drug abuse, alcohol and such has been feared for ages to be devastating for human body and mind but we seldom let our radar increase its span to cover more novel addictions that are playing demonic. Among these new arrivals one is most prominent, i.e. video games addiction. Video games started intruding our life in 1970s and 80s probably, and got popular instantly. Especially youngsters caught the craze of games like Mario Bros, Street Fighters, Pac Man and others, that were good enough to keep them engaged for hours.
This craze has only grown since, and spread to every teenager with thousands of unique ideas materializing into virtual worlds with numerous characters, plots, settings, moves and challenges to dare in the form of gaming. But the question that remained hidden for years is that, does gaming adversely affect our lives in anyway. Few researches proved the question worth asking. For instance, the researchers at Department of Psychiatry, Massachusetts General Hospital, USA, found that video games can readily mess with the youngsters’ sleep.
In the research paper Video Games and Sleep: An Overlooked Challenge, published in the journal, Adolescent Psychiatry, the researchers shed light on how this vividly destructive activity pushes the sleep further late. Not only does this push, it also disturbs the slumber making the kids’ minds overly restless.
Video games may be creative but can be equally destructive.
Normally, tissues demonstrate a slightly acidic intracellular pH (pHi) and slightly alkaline extracellular pH (pHe). However, proliferating tissues demonstrate transient pH Gradient Reversal i.e. alkalinization of pHi and acidification of pHe. Persistent and magnified pH Gradient Reversal is a hallmark of cancer. High acidic pHe is toxic to normal cells and beneficial to tumor cells giving them a proliferative advantage. It further augments tumorigenesis by upregulating proteolysis, genomic instability, immunosuppression, thereupeutic resistance and angiogenesis..
Some advice from Dalai Lama. Something for us to ponder..
This eBook provides critical information for mental health providers, including counselors, psychologists, and social workers, who are interested in providing services for children with chronic illnesses. The contents of the eBook focus on enhancing resilience in children with chronic illnesses or medical conditions and their families as they strive to adjust as the child copes with the waxing and waning symptoms of his or her illness. Practical suggestions for working with children and families are also provided along with a thorough review of relevant literature. Readers of this eBook will gain a better understanding of social work and health care issues related to promoting health and wellness among children suffering from long term illnesses. This eBook is also useful for graduate students training to become counselors or therapists.
For eBook details: http://ebooks.benthamscience.com/book/9781608058907/
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Current Vascular Pharmacology
Cumulative evidence in the literature indicate that CM preparations possess anti-inflammatory activities, antioxygenation, antibiosis, antibacterial, antiallergic and beneficial effect on the viability of fibroblasts. Case record suggested that after CM treatment the patient with Wagner Grade IV ulcers healed completely.
Read more here: http://benthamscience.com/journals/current-vascular-pharmacology/volume/13/issue/4/page/520/
Current Medicinal Chemistry, Volume 22 – Number 15
Fluorescent tagged glucose probes offer an attractive alternative to traditional, radioactive based methods for measuring glucose flux in biological systems. Thus, it could be envisaged that these probes would be widely used. However, this is not the case and, since their development in the mid-1980s, fluorescent tagged glucose bioprobes are relatively underutilized in biological research compared to radioactive methods, with only a small number (<10) publications per year using these probes. However, within the past five years there has been a surge in research activity. By the year 2012, numerous novel probes were developed and the number of research publications dramatically increased. This was especially relevant for drug discovery applications related to cancer, neurology and diabetes research.
Read more here: http://benthamscience.com/journals/current-medicinal-chemistry/volume/22/issue/15/page/1793/