The question intrigues almost all, especially the ones born on this date. This appears rather silly to add a day into the calendar and spoil the sequence and flow of the dates. Actually this is essential because we have to keep the record of Earth’s rotation and revolution around the sun on track.
The Earth takes a total of 365 days and nearly 6 hours to complete a whole year. This means that every year has extra 6 hours spoiling the calendar. To account for this discrepancy, if you like, the calendars are adjusted about every four years by getting a whole new date added to them. February has to take this addition as it already is the shortest month of the year with 28 days normally. Hence we have a special 29th February this very year too.
“Brain Tumor-Related Epilepsy”
In patients with brain tumor (BT), seizures are the onset symptom in 20-40% of patients, while a further 20-45% of patients will present them during the course of the disease. These patients present a complex therapeutic profile and require a unique and multidisciplinary approach. The choice of antiepileptic drugs is challenging for this particular patient population because brain tumor-related epilepsy (BTRE) is often drug-resistant, has a strong impact on the quality of life and weighs heavily on public health expenditures.
In BT patients, the presence of epilepsy is considered the most important risk factor for long-term disability. For this reason, the problem of the proper administration of medications and their potential side effects is of great importance, because good seizure control can significantly improve the patient’s psychological and relational sphere.
In these patients, new generation drugs such as gabapentin, lacosamide, levetiracetam, oxcarbazepine, pregabalin, topiramate, zonisamide are preferred because they have fewer drug interactions and cause fewer side effects. Among the recently marketed drugs, lacosamide has demonstrated promising results and should be considered a possible treatment option.
Read more here: http://benthamscience.com/journals/current-neuropharmacology/volume/10/issue/2/page/124/
Budapest University of Technology and Economics
Current Green Chemistry is an international peer-reviewed journal, which publishes original research, expert reviews and thematic issues in all core areas of green chemistry. The scope covers green chemistry related to synthetic chemistry, process and analytical chemistry, separation science, sustainable resources, and alternative environmentally safer chemical procedures.
For more information: http://benthamscience.com/journals/current-green-chemistry/#top
“Platinum Compounds: A Hope for Future Cancer Chemotherapy”
The discovery of cis-platin and its second and third generation analogues created a hope in cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been used for the treatment of some cancers from a long time. The third generation analogues have superior anti-cancer profiles for curing a few cancers. Unfortunately, certain side effects such as renal impairment, neurotoxicity and ototoxicity etc. are associated with these drugs. But, combination therapy makes these analogues more effective with fewer side effects. In addition, the results of some ongoing clinical trials will make the safety profile clear in near future. The present article describes the current status of cis-platin and its analogues in cancer chemotherapy. In addition, special emphasis has been made on cis-platin discovery, development of second (carboplatin, oxaliplatin, nedaplatin) and third (lobaplatin, heptalatin) generation analogues, comparison of their chemotherapies, mechanism of action, therapeutic status, recent developments and chronology. Moreover, attempts have been made to describe the future perspectives of these drugs in the cancer treatment.
Read more here: http://benthamscience.com/journals/anti-cancer-agents-in-medicinal-chemistry/volume/13/issue/2/page/296/
Method: A comprehensive literature review was employed to establish the recommendations in this report. This article provides a review of adolescent sleep physiology and offers various tools to aid in the clinical assessment and treatment of common sleep disorders. It highlights typical sleep changes throughout adolescence and the impact that these changes have on the development of sleep pathology.
Results: Chronic sleep loss is commonly reported among teenagers. Understanding the relationship between pubertal development and sleep regulation is essential for establishing clinical guidelines regarding adequate sleep. Benzodiazepine-receptor agonists (BzRAs) and cognitive behavioral therapy (CBT) are the most widely studied treatments for insomnia. In addition, bright light therapy and melatonin administration are often effective in treating circadian rhythm disorders. Sleep hygiene techniques are recommended for individuals with various sleep difficulties, yet there is insufficient data to support them as an evidence-based, standalone treatment.
– See more at: http://www.eurekaselect.com/node/131566/article#sthash.SzlvtoS9.dpuf
The prevalence of the metabolic syndrome (MetS), a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder is not only associated with a higher risk of appearance of type 2 diabetes and cardiovascular events, but impacts on the liver in different ways. Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of MetS, and is characterized by triglyceride accumulation and a variable degree of hepatic injury, inflammation, and repair. In the presence of significant hepatocellular injury and inflammation, the picture is defined ‘nonalcoholic steatohepatitis’ (NASH), that has the potential to progress to advanced fibrosis and cirrhosis. Diagnosis of NASH is based on a liver biopsy, and active search for noninvasive tests is ongoing.
– See more at: http://www.eurekaselect.com/node/118614/article#sthash.V6SPy9yJ.dpuf
Dr. Kyrillus S. Shohdy
Cairo University Hospitals,
Al-Saray St., El-Maniel, 11451,
Contributed article: “GPR 120: The Potential Target for Obesity Treatment”
“Nonviral Approach for Targeted Nucleic Acid Delivery”
Despite their relatively lower efficiency, nonviral approaches are emerging as safer alternatives in gene therapy to viral vectors. Delivery of nucleic acids to the target site is an important factor for effective gene expression (plasmid DNA) or knockdown (siRNA) with minimal side effects. Direct deposition at the target site by physical methods, including ultrasound, electroporation and gene gun, is one approach for local delivery. For less accessible sites, the development of carriers that can home into the target tissue is required. Cationic peptides, lipoplexes, polyplexes and nanoplexes have been used as carriers for delivery of nucleic acids. Targeting ligands, such as cell targeting peptides, have also been applied to decorate delivery vehicles in order to enhance their efficacy. This review focuses on delivery strategies and recent progress in non-viral carriers and their modifications to improve their performance in targeting and transfection.
Read more here: http://benthamscience.com/journals/current-medicinal-chemistry/volume/19/issue/2/page/197/
Current Pediatric Reviews publishes frontier reviews, drug clinical trial studies and guest edited thematic issues on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
Articles from the journal in Current Pediatric Reviews, Volume 12, Issue 1:
- Editorial (Thematic Issue: Adolescent Idiopathic Scoliosis – What Pediatricians Should Know About)
- Evidence for Conservative Treatment of Adolescent Idiopathic Scoliosis – Update 2015 (Mini-Review)
- Postural Re-Education of Scoliosis – State of the Art (Mini-review)
- The Influence of Short-Term Scoliosis-Specific Exercise Rehabilitation on Pulmonary Function in Patients with AIS
- Observation and Early Intervention in Mild Idiopathic Scoliosis via Corrective Exercises in Growing Children
- Rehabilitation of Adolescents with Scoliosis During Growth – Preliminary Results Using a Novel Standardized Approach in Russia. (Methodology)
- Bracing Scoliosis – State of the Art (Mini-Review)
- Congenital Scoliosis (Mini-review)
- Clinical Pharmacology of Phenobarbital in Neonates: Effects, Metabolism and Pharmacokinetics
- Vitiligo in Children: A Birds Eye View
- Safe Infant Sleep Interventions: What is the Evidence for Successful Behavior Change?
For details on the articles, please visit this link :: http://bit.ly/1WRp5t7