Most Accessed Article – “Ru-Hydroxyapatite: An Efficient and Reusable Catalyst for the Multicomponent Synthesis of Pyranopyrazoles under Facile Green Conditions”

Journal: Current Organic Synthesis

Author(s): Surya Narayana Maddila, Suresh Maddila, Werner E. van Zyl, Sreekantha B. Jonnalgadda



An efficient, green and facile protocol for the synthesis of pyranopyrazole derivatives through the reaction of aromatic aldehydes, malononitrile, hydrazine hydrate and ethyl acetoacetate was developed using Ru loaded hydroxyapatite (Ru-CaHAp) as catalyst. The eco-friendly one-pot reactions in an ethanol-water mixture are fast (15 min) and occur at room temperature. The catalyst was fully characterized by various techniques. The chemical structures of the synthesized compounds were identified and confirmed by 1H, 15N and 13C NMR, FT-IR and HR-MS spectral data. The noteworthy advantages offered by this method are an environmentally-friendly simple procedure, mild conditions, short reaction times, recycling of catalyst and good to excellent (89 to 98%) yield of products.

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Bentham Science Publishers

A major STM journal publisher of more than 100 online and print journals and related print/online book series, Bentham Science answers the information needs of scientists in the fields of pharmaceutical, biomedical, medical, engineering, technology, computer and social sciences.

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