Upcoming Thematic Issue – Arterial Mechanics and Dynamics in Hypertension – Current Hypertension Reviews



Highlighted Article – A Novel Hybrid Approach for Medical Image Compression – Current Medical Imaging Reviews

CMIR-Sajid Ullah Khan

 To access this article, please visit: http://www.eurekaselect.com/152030/article

Press Release for EurekAlert! Nutlin-3, a p53-Mdm2 antagonist for nasopharyngeal carcinoma treatment

This article by Dr. Voon Yee-Lin et al. is published in Mini-Reviews in Medicinal Chemistry, Volume 17, 2017


Nasopharyngeal carcinoma (NPC) is a common epithelial squamous cell head and neck cancer which is strongly associated with gamma herpes Epstein-Barr virus infection and the intake of salted fish. NPC incidence remain significantly high among men in the populations of Southern China, Hong Kong, Taiwan, Northern Africa and Southeast Asia. It has claimed many thousands of lives worldwide with approximately 80,000 new cases diagnosed annually and a mortality rate that exceeds 50,000. There are several approaches to fight NPC, which include surgery, radiation therapy and chemotherapy. NPC treatment remain one of the most intractable challenge for medicine. Radiation therapy alone has failed to provide a significant improvement in the overall survival rate of NPC, compared to chemotherapy. Radiocurable NPC is still dependent on concurrent treatment of megavoltage radiation with chemo drugs. Chemo-resistance persists as the major challenge in the management of patients diagnosed with metastatic NPC. In view of these challenges, it is understandable that scientists are trying to discover p53-based targeted therapy which could be applied as effective NPC therapies.

Recent discoveries have demonstrated that utilizing Nutlin-3 as a p53 activator is promising strategy for cancer management in the future. This review describes the potential use of newly discovered anticancer molecule Nutlin-3 and the future directions of its clinical research for NPC treatment. Nutlin-3 specifically targets p53-Mdm2 interaction and offers new therapeutic opportunities by enhancing cancer cell growth arrest and apoptosis through the restoration of the p53-mediated tumor suppression pathway while producing minimal cytotoxicity and side effects. In this regard, restoration of p53 tumor suppressor gene with Nutlin-3 could be explored for the discovery of alternative NPC therapies. However, further research is necessary before such new therapeutic strategies can be fully realized. New cancer therapeutic strategies, induce p53-dependent actions and currently ongoing clinical trials for drugs against human cancers have also been mentioned in the review. This study suggests that the development of effective cancer therapeutics is still in progress. Although Nutlin-3 is far from ready for its clinical use for NPC, it is still an attractive alternative drug that should be given attention and explored further, given the poor prognosis and limited treatment choices for NPC.

This article is open access and can be downloaded from: http://www.eurekaselect.com/154246

Upcoming Thematic Issue – Global Regulatory Overview of Nanopharmaceuticals and Nanocosmetics – Applied Clinical Research, Clinical Trials and Regulatory Affairs



Most Accessed Article – Ethyl Lactate As a Green Solvent – Current Green Chemistry

Journal: Current Green Chemistry

Author(s): Sanjay Paul, Koyel Pradhan, Asish R. Das.


Background: Solvents are required for most of the chemical transformations to increase the contact between the reagents and catalysts. Solvent also ensures a suitable isolation process of products from the reaction mixture. Ethyl lactate is a bio-based, environmentally benign and economically viable solvent with effectiveness comparable to petroleum-based solvents. This review focuses on the background of this bio-based solvent and the recent application for green chemistry development in this unconventional media. Application of ethyl lactate in organic synthesis: Recently synthetic organic chemists are paying attention to use ethyl lactate as reaction medium as it has some useful advantages. Ethyl lactate has been used for asymmetric induction, multi-component reactions, ligand free coupling reactions, light induced synthesis, stereoselective synthesis, cycloaddtion reaction etc. The advantages and limitations of this solvent are also demonstrated. In this article, we demonstrated some representative examples of organic reactions in ethyl lactate media.

Conclusion: Being a promising green media this bio-based solvent ethyl lactate has an important contribution in synthesis and medicinal chemistry as well.

To access the article, please visit: http://www.eurekaselect.com/137526

Highlighted Article – Calcium Signaling, PKC Gamma, IP3R1 and CAR8 Link Spinocerebellar Ataxias and Purkinje Cell Dendritic Development – Current Neuropharmacology

CN-Articles_15-8-Etsuko Shimobayashi

View the article: http://www.eurekaselect.com/152745

Wishing A Very Happy Birthday to Dr. Herman S. Cheung!


Dr. Herman S. Cheung

EDITOR-IN-CHIEF: Current Tissue Engineering

Department of Biomedical Engineering
University of Miami
Miami, FL 33101

Wishing A Very Happy Birthday to Dr. Zulfiqar Ali!


Dr. Zulfiqar Ali

EDITOR-IN-CHIEF: Micro and Nanosystems

School of Health and Social Care
Teesside University
United Kingdom

Podcast: Personalized And Precision Medicine In Cancer By Dr. Partha S Choudhury

Author(s): Partha S Choudhury, Manoj Gupta.

For article details, visit: http://www.eurekaselect.com/154535/article

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