Testimonial by Estibaliz Sansinenea!

Estibaliz Sansinenea.jpg

Contributed Article: “Cyclic Dipeptides: Secondary Metabolites Isolated from Different Microorganisms with Diverse Biological Activities

Highlighted Article – Phytochemical Investigation and Quantitative Analysis of the Fatty Acids and Sterol Compounds of Seven Pharmaceutical valuable Seeds – Current Pharmaceutical Analysis


View the article: http://www.eurekaselect.com/153939/article

Thought of the Day!

Thought of t

New Issue :: Current Topics in Medicinal Chemistry 17, Issue 23

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.


Articles from the journal Current Topics in Medicinal Chemistry 17, Issue 23:


For details on the articles, please visit this link :: http://bit.ly/2wtTPwD



New Issue :: Current Pharmaceutical Analysis 13, Issue 5

Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.


Articles from the journal Current Pharmaceutical Analysis 13, Issue 5:

For details on the articles, please visit this link :: http://bit.ly/2xveFbz



Wishing A Very Happy Birthday to Michael Edward Thase!


Michael Edward Thase.jpg

Michael Edward Thase

EDITOR-IN-CHIEF: Current Psychiatry Reviews

University of Pennsylvania School of Medicine
3535 Market St, Suite 670
Philadelphia, PA 19104


Highlighted Article – Cold induced Anaphylaxis – Endocrine, Metabolic & Immune Disorders – Drug Targets

EMIDDT-Paolo Romita


Press Release for EurekAlert! Virus-derived expression vectors as gene therapy vehicles

This research article by Dr. Srividhya Venkataraman et al has been published in Recent Patents on Biotechnology, Volume 11, Issue 2, 2017

Graphical Abstract:


Even as new viruses are being identified, the emerging field of virus discovery, identification of their nucleotide sequences, gene expression patterns and complexities of virus-host interactions at the molecular level are being used in recent years towards applications in the human medicine as well as veterinary, agricultural and other biotechnological purposes. Several patents pertaining to this field have been filed successfully and the current review addresses recent patents pertaining to the use of virus sequences as RNA silencing agents and virus-derived expression vectors as gene therapy vehicles. Specifically, these patents demonstrate the use of viral sequences to silence positive-sense RNA viruses such as Flaviviruses, Picornaviruses, Togaviruses, Herpesviruses and minus-stranded RNA viruses such as Filoviruses, virus-induced gene silencing in plants, expression vectors of Poxviruses, Flaviviruses, Influenza viruses, Adeno-associated viruses, expression vectors based on plant viruses and viral expression vectors applicable to the fish industry. Virus-derived short double-stranded RNAs and DNA-based antisense antiviral compounds are used at low dosage to specifically and effectively mediate RNA interference or RNA silencing and downregulate viral replication. Also, Virus-Induced Gene Silencing (VIGS) is used to identify gene functions in plants. Expression vectors based on poxviruses engineered to code for HIV and other viral immunogens are popular vaccine candidates. Pseudoinfectious viruses that can undergo a single round of infection in vivo, mimicking whole viral infections while inducing strong T- and B-cell immunity are also discussed. Another patent discusses a multi-vector scheme for generating recombinant and reassortant Influenza Viruses. A recombinant Papaya Mosaic Virus coat protein forming virus-like particles (VLPs) with Influenza Virus epitopes exposed on their surface is also mentioned. However, the current inventions addressed in these patents require scrupulous testing in clinical trials (for medical and veterinary uses) and field trials (for agricultural uses) that are yet to be achieved. It is also important to consider the influence of prior host-environment interactions and the previous history of exposure to pathogenic organisms. Testing of these virus-derived genetically engineered vehicles has to go further beyond mere success in laboratory-derived cell culture systems and experimental animals / plants.

For more information, please visit http://www.eurekaselect.com/150556

Upcoming Thematic Issue – To find new Targets for the inhibition of Epileptogenesis – Current Medicinal Chemistry



Most Accessed Article – Psychological Stress in Pathogenesis of Essential Hypertension – Current Hypertension Reviews

Journal: Current Hypertension Reviews

Author(s): Alexey V. Ushakov, Vera S. Ivanchenko, Alina A. Gagarina.

Graphical Abstract:



The article represents literature review and provides evidence for psychological stress to play essential role in the development of arterial hypertension. The pathogenesis of hypertension is complex with a significant diversity and variability of the mechanisms involved in individual patient. In this regard, the determination of specific pathogenic pathways underlying sustained blood pressure elevation in each patient would substantially individualize therapeutic approaches, and hence increase the effectiveness of treatment. Psychological stress is proposed as a significant factor contributing to the development of hypertension. Global urbanization, sedentary lifestyle, daily stress at workplace, lack of physical activity and social support lead to increased anxiety, uncertainty, and finally to chronic mental and emotional stress. This review provides information about alterations in neuroendocrine and immune systems as the main pathogenic pathways linking psychological stress and hypertension. Endothelial dysfunction is considered not only as a consequence but also a primary factor causing prohypertensive state. Moreover, physical inactivity is discussed as one of the plausible mechanisms playing a key role in the development of hypertension in modern lifestyle conditions. Particularly the loss of connection between psychosocial strain and physical activity may underlie the deleterious effect of stress on cardiovascular and metabolic health.

To access the article, please visit: http://www.eurekaselect.com/148822/article

%d bloggers like this: