EDITOR’S CHOICE – Cell Wall Associated Factors of Mycobacterium tuberculosis as Major Virulence Determinants – Current Drug Targets

Journal: Current Drug Targets

Author(s): Gurdyal Singh, Arbind Kumar, Pratibha Maan, Jagdeep Kaur

Graphical Abstract:

Abstract:

Background: Mycobacteria genus is responsible for deadly diseases like tuberculosis and leprosy. Cell wall of bacteria belonging to this genus is unique in many ways. It plays a major role in the pathogenesis and intracellular survival inside the host. In intracellular pathogens, their cell wall acts as molecular shield and interacts with host cell milieu to modulate host defense responses.

Objectives: In this review, we summarize the factors that participate in the biosynthesis of unique mycobacterial cell wall, understand their potential as drug targets and the recent developments where they have been evaluated as possible drug targets.

Results: Several cell wall associated factors that play crucial roles in the synthesis of cell wall components like Antigen 85 complex, Glycosyltransferases (GTs), LM (lipomannan) and LAM (lipoarabinomannan), mAGP Complex, lipolytic enzyme have been categorically documented. Most of the presently used anti TB regimens interrupted cell wall synthesis, but the emergence of drug resistant strains made it mandatory to identify new drug targets. Novel drug candidates which could inhibit the synthesis of cell wall components have been thoroughly studied worldwide.

Conclusion: Studies demonstrated that the cell wall components are unique in terms of their contribution in mycobacterium pathogenesis. Targeting these can hamper the growth of M. tuberculosis. In this study, we scrutinize the drugs under trials and the potential candidates screened through in silico findings.

 

To access the article, please visit: http://www.eurekaselect.com/154134

BENTHAM SCIENCE FREE TRIAL IN THE EGE UNIVERSITY LIBRARY, TURKEY!

As the educational and cultural focal point of İzmir, Ege University takes its place in the middle with its half a century long history. The University is built in one of the largest districts of the city, Bornova. The campus located in Bornova offers a 3450 decare space full of buildings that provide the people and the students with educational, cultural and sport related service.

In the university campus, an edge of technology modern library, indoor and outdoor pool, indoor sports salon, spaces of football, basketball, mini-football and tennis courts, an exhibition salon, with its 730 visitors capacity Prof. Dr. Yusuf Vardar – MÖTBE culture center, a Students’ Village dormitory that is highly accessible to the public, cafeterias, students shopping center, hypermarket, guest houses and locales for students and the personnel can be found.

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WISHING A VERY HAPPY BIRTHDAY TO DR. KHURSHID ZAMAN!

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DR. KHURSHID ZAMAN

EDITOR-IN-CHIEF: Recent Patents on Anti-Cancer Drug DiscoveryRecent Patents on Inflammation & Allergy Drug Discovery & Recent Patents on Mechanical Engineering

Bentham Science Publishers
USA

WISHING A VERY HAPPY BIRTHDAY TO DR. JONG MOON PARK!

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DR. JONG MOON PARK

EDITOR-IN-CHIEF: Current Environmental Engineering

Department of Chemical Engineering
Pohang University of Science and Technology
Pohang, Kyungbuk
Korea

 

Thought of the Day!

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NEW ISSUE :: Current Diabetes Reviews 14, ISSUE 1

Current Diabetes Reviews publishes frontier reviews, original research articles, drug clinical trial studies and guest edited issues on all the latest advances on diabetes and its related areas dedicated to clinical research e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care and therapy.

The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.

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Articles from the journal Current Diabetes Reviews, Volume 14, Issue 1:

For details on the articles, please visit this link : http://bit.ly/2oVfbjK

OPEN ACCESS ARTICLE – Optimization and Validation of Two High-Throughput Methods Indicating Antiradical Activity – Current Analytical Chemistry

Journal: Current Analytical Chemistry

Author(s): Graciela Granados-Guzman, Ricardo Salazar-Aranda, Marsela Garza-Tapia, Rocio Castro-Rios,Noemi Waksman de Torres

Graphical Abstract:

 

Abstract:

Background: The search for new natural or synthetic products with antioxidant activity is commonly based on methods that involve reduction of either 2,2-diphenyl-1-picrylhydrazyl (DPPH) or 2-2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). However, the reported values of the effective concentrations are highly variable, even in controls. Herein, we optimize and validate both methods of determining antiradical activity.

Methods: Optimization was carried out using both a fractionated factorial design and a basic sequential simplex method, by monitoring the reduction percentage. Quercetin or Trolox were used as positive control. Furthermore, for each method, linearity, precision, accuracy, robustness, plate uniformity, signal variability, and Z factor, were established.

Results: The optimized conditions for the DPPH method were: DPPH 280 µM in ethanol and 15 min of reaction time in the dark. The linear range was between 7 and 140 µM with an R2 value of 0.9987. The optimized conditions for the ABTS method were: ABTS adjusted to 0.7 absorbance units, 70% concentration in ethanol, and a reaction time of 6 min in the dark. The linear range was found to be between 1 and 70% with an R2 = 0.9991. For both methods, the accuracy and precision were within limits and the Z factor value was higher than 0.89. The applicability of each method was assessed by analyzing eight plant extracts.

Conclusion: The DPPH and ABTS reduction methods were optimized and validated on a microscale and could be expected to be implemented in any laboratory.

Read more here: http://www.eurekaselect.com/149376/article

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Micro and Nanosystems 9-1

http://bit.ly/2zjvQR5

Protein & Peptide Letters 24-9

http://bit.ly/2jcmBcM

Current Medicinal Chemistry 24-34

http://bit.ly/2Cy6zBE

Drug Metabolism Letters 11-1

http://bit.ly/2BuviHQ

Current Medicinal Chemistry 24-35

http://bit.ly/2BDqzWE

Recent Patents on Anti-Cancer Drug Discovery 12-4

http://bit.ly/2jbBv2I

Current Topics in Medicinal Chemistry 17-28

http://bit.ly/2BrEgFr

Current Traditional Medicine 3-3

http://bit.ly/2ySDhLT

Current Protein & Peptide Science 19-1

http://bit.ly/2B8evNJ

Current HIV Research 15-5

http://bit.ly/2kcvDHJ

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Bentham Science offers Special New Year Discount!

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Starting from 15 Dec 2017 till 31 Jan 2018, Bentham Science Publishers is offering a substantial discount on its publications and other ancillary services:

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MOST ACCESSED ARTICLE – Targeted Nanosystems for Cancer Therapy – Current Cancer Therapy Reviews

Journal: Current Cancer Therapy Reviews

Author(s): Ruhee Jain, Tahseen Khan, Sourabh Jain, Ashutosh Pal Jain, Aakanchha Jain

Graphical Abstract:

Abstract:

Background: Significant shortcomings have been displayed in conventional chemotherapeutics delivery which possesses some genuine side effects including harm of the immunity and different organs with quickly multiplying cells because of nonparticular focus on the absence of dissolvability and powerlessness to enter the tumor core bringing about debilitated treatment with diminished dosage and with low survival rate. Rapid development has adapted nanocarriers as distinct therapeutics which can directly access the tumor cells specifically with expanded medication limitation and cell take-up for cancer treatment.

Methodology: This review focuses on core objective of drug targeting to the cancerous cells by demonstrating the advantages of the young medical field, “nanocarriers” including liposomes, polymer based nanoparticles, metal based nanoparticles, dendrimers, protein linked systems, co-polymers and fullerenes, which have been proven remarkably promising in enhancing drug distribution and bioavailability, increasing half life and achieving targeted drug delivery, thus reducing toxicity.

Conclusion: Here we provide an update on the recent clinical trials in nanocarrier based therapy of colon rectal cancer, food and drug administration (FDA) approved nanomedicines for cancer and those in nanoplatforms which have reached an advanced stage of clinical development.
To access the article, please visit: http://www.eurekaselect.com/153540/article

 

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