THOUGHT OF THE DAY!

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New Issue :: Current Drug Targets Volume 19, Issue 2

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

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Articles from the journal Current Drug Targets Volume 19, Issue 2:

                          For details on the articles, please visit this link :: http://bit.ly/2noTuWi

 

 

MOST ACCESSED ARTICLE – Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST) – Drug Metabolism Letters

Journal: Drug Metabolism Letters

Author(s): Ryan H. Takahashi, Cyrus Khojasteh, Matthew Wright, Cornelis E.C.A. Hop, Shuguang Ma

Graphical Abstract:

 

Abstract:

Background: The regulatory guidances on metabolites in safety testing (MIST) by US Food and Drug Administration (FDA) and International Conference on Harmonisation (ICH) describe the necessity to assess exposures of major circulating metabolites in humans at steady state relative to exposures achieved in nonclinical safety studies prior to the initiation of large scale clinical trials. This comparison can be accomplished by measuring metabolite concentrations in animals and humans with validated bioanalytical methods. However, bioanalysis of metabolites in multiple species and multiple studies is resource intensive and may impact the timelines of clinical studies.

Method: A simple, reliable and accurate method has been developed for quantitative assessment of metabolite coverage in preclinical safety species by mixing equal volume of human plasma with blank plasma of animal species and vice versa followed by an analysis using LC-SRM or LC-HRMS. Here, we explored the reliability and accuracy of this method in several development projects at Genentech and compared the results to those obtained from validated bioanalytical methods.

Results: The mixed-matrix method provided comparable accuracy (within ±20%) to those obtained from validated bioanalysis but does not require authentic standards or radiolabeled compounds, which could translate to time and resource savings in drug development.

Conclusion: Quantitative assessment of metabolite coverage in safety species can be made using mixed matrix method with similar accuracy and scientific rigor to those obtained from validated bioanalytical methods. Moving forward, we are encouraging the industry and regulators to consider accepting the mixed matrix method for assessing metabolite exposure comparisons between humans and animal species used in toxicology studies.

To access the article, please visit: http://www.eurekaselect.com/154106

 

World Leprosy Day 2018!

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Leprosy, also known as Hansen’s disease (HD), is a long-term infection by the bacteria Mycobacterium leprae. Symptoms of leprosy include granulomas of the nerves, respiratory tract, skin, and eyes, which result in lack of ability to feel pain and eventual death in case of failure to receive treatment.

Bentham Science publishes research papers that present new studies to help eradicate leprosy. Find the latest studies in the following journals:

  1. Current Immunology Reviews
  2. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
  3. Infectious Disorders – Drug Targets

To Avail 20% Discount on related eBooks, kindly visit: https://ebooks.benthamscience.com/

New Issue :: Mini-Reviews in Organic Chemistry Volume 15, Issue 1

Mini-Reviews in Organic Chemistry publishes original reviews on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly. Mini-reviews will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts.

The journal is essential reading to all organic chemists in both academia and industry.

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Articles from the journal Mini-Reviews in Organic Chemistry Volume 15, Issue 1:

                           For details on the articles, please visit this link :: http://bit.ly/2EmimVN

 

BENTHAM SCIENCE FREE TRIAL IN THE Research Centre for Medical Genetics, Russia

Research Institute of Medical Genetics is one of the leading Russian scientific institutions performing research in the field of medical and human genetics and the only academic institution of this kind beyond the Urals.

The specialized Clinic of Hereditary Diseases of the Institute is the only clinic of this kind in  Russia. The Institute has advanced techniques for fundamental and applied research in genetics and molecular biology.

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BENTHAM SCIENCE FREE TRIAL IN THE Turku University Library, Finland

Turku University Library is the largest academic library in Southwest Finland and it is open to all. Turku University Library consists of six discipline specific libraries situated on the campus and three units (Pori, Raisio and Rauma) outside of Turku.

Based on the Legal Deposit Act, Turku University Library has received free copies of all publications printed in Finland since 1919.

Turku University Library´s e-resources are extensive and cover all disciplines, consisting of over 200 databases, around 27000 e-journals and over 300 000 e-books.

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OPEN ACCESS ARTICLE – Proteomic Changes Between Populus Allotriploids and Diploids Revealed Using an iTRAQ-based Quantitative Approach – Current Proteomics

Journal: Current Proteomics

Author(s): Yi Wang, Yun Li, Yujing Suo, Yu Min, Xiangyang Kang

Graphical Abstract:

 

Abstract:

Background: Polyploid breeding is a powerful approach for Populus genetic improvement because polyploid trees have valuable characteristics, including better timber quality and a higher degree of stress resistance compared with their full-sib diploids. However, the genetic mechanism underlying this phenomenon remains unknown.

Objective: To better understand the proteomic changes between Populus allotriploids and diploids, we examined the proteomic profiles of allotriploid and diploid Populus by iTRAQ labeling coupled with two-dimensional liquid chromatography and MALDI-TOF/TOF mass spectrometry (MS).

Method: iTRAQ labeling coupled with two-dimensional liquid chromatography and MALDITOF/ TOF mass spectrometry (MS).
Results: Between the Populus allotriploid and the full-sib diploid, 932 differentially expressed proteins (DEPs) were identified. These DEPs were primarily involved in stress, defense, transportation, transcriptional and/or translational modification, and energy production. The pathway analysis indicated that most of the DEPs were implicated in carbohydrate transport and metabolism, nitrogen metabolism and glycolysis, and the ribosome assembly pathway. These data suggest high protein divergence between Populus allotriploids and diploids, and rapid changes during hybridization.
Conclusion: The results provide new data for further understanding of the mechanisms of polyploid trees that generally display increased height growth compared with their full-sib diploids.

 

BENTHAM SCIENCE FREE TRIAL IN THE Yuan Ze University, Taiwan

Yuan Ze University is a private university located in Taoyuan City, Taiwan. Established in 1989, YZU campus is in Zhongli District, Taoyuan; Taipei; and Bade District, Taoyuan.

Currently Yuan Ze has five colleges including the Colleges of Engineering, Informatics, Management, Humanities and Social Sciences, and Electrical and Communication Engineering. With over 9,000 students with a 2:1 ratio between undergraduate and graduate students on campus, YZU offers several international programs such as the English Program of Bachelor of Business Administration, Master’s Program in Industrial Engineering and Management. Additionally, the Master’s Programs in the Communication Engineering are all taught in English. With the highest ratio of English-instructed courses in Taiwan, YZU has over 250 international students pursuing degrees and joining exchange programs.

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BENTHAM SCIENCE FREE TRIAL IN THE LIBRARY OF PASTEUR INSTITUTE OF IRAN, IRAN

Pasteur Institute of Iran (IPI) was founded in the heart of  Iran’s capital, Tehran in the 1920s to pave the way for  advanced research and to provide innovative programs in basic and applied medical sciences, and production of biopharmaceuticals and diagnostic kits with special emphasis on infectious diseases.

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