WISHING A VERY HAPPY BIRTHDAY TO Dr. Serena Guiducci!

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Dr. Serena Guiducci

EDITOR-IN-CHIEF: Current Rheumatology Reviews

Department of Biomedicine, Division of Rheumatology
University of Florence
Florence
Italy

WISHING A VERY HAPPY BIRTHDAY TO Dr. Jean-Marc Sabatier!

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Dr. Jean-Marc Sabatier

EDITOR-IN-CHIEF: Infectious Disorders – Drug Targets

Laboratoire ERT 62 ‘Ingénierie des peptides à visée thérapeutique’
Université de la Méditerranée
Faculté de Médecine Nord
Boulevard Pierre Dramard
13916 – MARSEILLE, Cedex 20
France

HEALTHY WEIGHT WEEK 2018!

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Healthy Weight Week signifies the importance of balance diet and healthy lifestyle. Being healthy does not mean losing weight and going on a diet. It means pursuing livable and sustainable healthy lifestyle through eating well, living actively and feeling good.
Bentham Science publishes important research publications that promote this idea.

Click here to find related articles: http://benthamscience.com/journals/current-nutrition-and-food-science/

To Avail 20% Discount on related eBooks, kindly visit: https://ebooks.benthamscience.com/

ARTICLE TO READ ON HEALTHY WEIGHT WEEK

Bioactive Compounds of Virgin Olive Oil Extracted from Bladi and Arbequina Cultivars

Journal: Current Nutrition & Food Science

Author(s): M.S. Mirrezaie Roodaki, M.A. Sahari*, B. Ghiassi Tarzi, M. Barzegar, M. Gharachorloo

Graphical Abstract:

 

Abstract:

Background: Virgin Olive Oil (VOO) is known as a nutraceutical resource. Virgin olive oil is stable oil and its shelf life is longer than the other edible oils. Bladi and Arbequina are the most extensive and important olive cultivars in Iran-Qom region. The aim of this research was to evaluate stability and the bioactive compounds of two olive cultivars (Bladi and Arbequina) that have beneficial effects on body’s health.

Methods: Olive fruits from Bladi and Arbequina cultivars were collected, indexes of weight, dimension, oil and moisture content of whole fruit, pulp and kernel were studied; their oil was extracted (cold press) and free fatty acid, peroxide, polar compounds, conjugated dienes and trienes, induction period, refractive index, chlorophyll and carotenoid contents, fatty acid, phenolic and tocopherol profiles were investigated.

Results: The results showed that the dimensions and weights of the whole fruit, pulp and kernel of cultivars were significantly different. With the same amount of moisture, oil contents of fruit, pulp and kernel in Bladi (18.44, 34.94, 3.82%, respectively) were less than those in Arbequina (30.72, 45.1 and 8.75%). The composition of fatty acids in Bladi and Arbequina’s oil mainly consisted of oleic (50.16, 57.43%), palmitic (22.33, 19.79%) and linoleic acid (18.38, 14.72%),. Induction period of Arbequina was higher than Bladi, although polyphenols and tocopherols contents were higher in Bladi.

Conclusion: The fatty acids composition and the presence of antioxidants mainly phenols and tocopherols are established key factors for the resistance of the oil to autoxidation.

Read more here: http://www.eurekaselect.com/155341

 

UPCOMING THEMATIC ISSUE – Recent Advances in Bio-medicinal and Pharmaceutical Applications of Bio-based Materials – CURRENT MEDICINAL CHEMISTRY

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https://benthamscience.com/journals/current-medicinal-chemistry/special-issues/

BENTHAM SCIENCE FREE TRIAL IN THE BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, INDIA

Birla Institute of Technology & Science, Pilani is an Indian institute of higher education and a deemed university under Section 3 of the UGC Act 1956. The university has 15 academic departments, and focuses primarily on undergraduate education in engineering and the sciences and on its management programme.

The institute was established in its present form in 1964. During this period, the institute’s transformation from a regional engineering college to a national university was backed by G.D. Birla. BITS has established centres at Pilani, Goa, Hyderabad and Dubai.

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THOUGHT OF THE DAY!

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TESTIMONIAL BY PEDRAZA CARMEN!

Pedraza Carmen

Contributed Article: “Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway

MOST ACCESSED ARTICLE – The Use of Biomarkers in Sepsis – Current Pharmaceutical Biotechnology

Journal: Current Pharmaceutical Biotechnology

Author(s): Konstantinos Giannakopoulos*, Ursula Hoffmann, Uzair Ansari, Thomas Bertsch, Martin Borggrefe,Ibrahim Akin, Michael Behnes

Graphical Abstract:

 

Abstract:

Background: Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways being expressed by alterations of various molecules in human tissues. The detection and measurement of the concentration of such molecules, known as biomarkers, may be a diagnostic tool of great significance for clinicians dealing with suspected sepsis. Additionally, biomarkers may predict patients ´ outcome and may play a role in monitoring response to therapy.

Methods: Most relevant clinical and experimental biomarker studies on sepsis were retrieved and reviewed in this article.

Results: Although many biomarkers were evaluated for the diagnosis and prognosis in sepsis, until now not one has been proven to be absolutely reliable in the clinical field. Currently C-reactive proteine (CPR) and procalcitonin (PCT) are used worldwide routinely, nevertheless their values may elevate in clinical settings without sepsis, while they often fail to provide reliable prediction of the patient outcome.
Conclusion: This review outlines most relevant circulating biomarkers in sepsis.
To access the article, please visit: http://www.eurekaselect.com/152828

 

OPEN ACCESS ARTICLE – Antiplasmodial Compounds from Leaves of Dodonaea angustifolia – Current Bioactive Compounds

Journal: Current Bioactive Compounds

Author(s): Yadessa Melaku, Tefera Worku, Yemane Tadesse, Yalemtsehay Mekonnen, Juergen Schmidt,Norbert Arnold, Ermias Dagne

Graphical Abstract:

 

Abstract:

Background: Dodonaea angustifolia is used in Ethiopian traditional medicine to treat malaria. The objective of this work was to conduct bioassay guided fractionation of the leaves of D. angustifolia using Plasmodium berghei infected mice.

Method: The antiplasmodial activity of the extracts and pure compounds was evaluated using the standard Peter’s four-day suppressive method. The structures of isolated compounds were elucidated using chemical and spectroscopic methods.

Results: In this study, the ethyl acetate soluble portion of the 80% aqueous MeOH extract of the leaves significantly suppressed parasitaemia in Plasmodium berghei infected mice (80.28% at 150 mg/kg). Three active compounds which exhibited significant percent suppression of parasitaemia by 81% at 40 mg/kg, 80% at 50 mg/kg and 70% at 40 mg/kg, respectively were identified. These are the flavanone pinocembrin (1), the flavanol santin (2) and the clerodane diterpene 2-hydroxy-15,16-epoxyceloda- 3,13(16),14-trien-18-oic acid (3). Under similar conditions, chloroquine suppressed parasitaemia by 100% at 25 mg/kg. Chemical study of the ethanol extract of the leaves yielded 5,7,4′-trihydroxy-3,6- dimethoxyflavone (4), ent-16-hydroxy-labdan-3,8-dihydroxy,13(14)-en-15,16-olide (5) and 5,6,7- trihydroxy-3,4′-dimethoxyflavone (6). Compound 6 has not been reported before as a natural product.
Conclusion: From the leaves of D. angustifolia, three compounds with significant antiplasmodial activities were isolated and characterized, with pinocembrin as the most active compound.