EDITOR’S CHOICE – Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery – INFECTIOUS DISORDERS – Current Drug Metabolism

Journal: Current Drug Metabolism

Author(s): Ogheneochukome Lolodi, Yue-Ming Wang, William C. Wright, Taosheng Chen*

Graphical Abstract:

 

Abstract:

Background: Cancer cells use several mechanisms to resist the cytotoxic effects of drugs, resulting in tumor progression and invasion. One such mechanism capitalizes on the body’s natural defense against xenobiotics by increasing the rate of xenobiotic efflux and metabolic inactivation. Xenobiotic metabolism typically involves conversion of parent molecules to more soluble and easily excreted derivatives in reactions catalyzed by Phase I and Phase II drug metabolizing enzymes.

Methods: We performed a structured search of peer-reviewed literature on P450 (CYP) 3A, with a focus on CYP3A4 and CYP3A5.

Results: Recent reports indicate that components of the xenobiotic response system are upregulated in some diseases, including many cancers. Such components include the pregnane X receptor (PXR), CYP3A4 and CYP3A5 enzymes. The CYP3A enzymes are a subset of the numerous enzymes that are transcriptionally activated following the interaction of PXR and many ligands.

Conclusion: Intense research is ongoing to understand the functional ramifications of aberrant expression of these components in diseased states with the goal of designing novel drugs that can selectively target them.

Read more here: http://www.eurekaselect.com/152811

 

WISHING A VERY HAPPY BIRTHDAY TO DR. RUEY-SHIN JUANG!

Dr. Ruey-Shin Juang

DR. RUEY-SHIN JUANG

EDITOR-IN-CHIEF: Current Biochemical Engineering

Department of Chemical and Materials Engineering
Chang Gung University
Kwei-Shan, Taoyuan
Taiwan

 

UPCOMING THEMATIC ISSUE – INFECTIOUS CAUSES OF CHILDHOOD DISABILITY – Infectious Disorders – Drug Targets

IDDT-THEMATIC FLYER-Gulam Khandaker

https://benthamscience.com/journals/infectious-disorders-drug-targets/

Thought of the Day!

nikoskazantzakis1-2x

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Medicinal Chemistry Volume 14, Issue 2
http://bit.ly/2ESFuxH

Clinical Immunology, Endocrine & Metabolic Drugs Volume 4, Issue 1
http://bit.ly/2FhuhVc

Anti-Cancer Agents in Medicinal Chemistry Volume 17, Issue 14
http://bit.ly/2Ca5K5H

Letters in Organic Chemistry Volume 15, Issue 3
http://bit.ly/2BG12fa

Current Molecular Medicine Volume 17, Issue 6
http://bit.ly/2ofkAiZ

Protein & Peptide Letters Volume 24, Issue 12
http://bit.ly/2CxVmk9

recent-issues

WISHING A VERY HAPPY BIRTHDAY TO DR. BIN WU!

Confetti Golden Birthday Card

DR. BIN WU

EDITOR-IN-CHIEF: The Natural Products Journal
Zhejiang University
Hangzhou
China

WISHING A VERY HAPPY BIRTHDAY TO DR. SEAN L. KITSON!

Dark Blue with Neon Birthday Elements Birthday Poster

DR. SEAN L. KITSON

EDITOR-IN-CHIEF: Current Radiopharmaceuticals

Department of Biocatalysis and Isotope Chemistry Almac Sciences
Almac House
Craigavon
Northern Ireland

 

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Reviews on Recent Clinical Trials Volume 13, Issue 1
http://bit.ly/2BEm6T8

Central Nervous System Agents in Medicinal Chemistry Volume 18, Issue 1
http://bit.ly/2ohkDtE

Drug Delivery Letters Volume 8, Issue 1
http://bit.ly/2sK71wE

Current Nanoscience Volume 14, Issue 2
http://bit.ly/2EFSs2A

Current Nanomedicine Volume 8, Issue 1
http://bit.ly/2FgGuth

Current Gene Therapy Volume 17, Issue 5
http://bit.ly/2EFzFnY

Nanoscience & Nanotechnology-Asia Volume 8, Issue 1
http://bit.ly/2oiZsrl

Adolescent Psychiatry Volume 7, Issue 2
http://bit.ly/2HuVBAj

recent-issues

Bentham Science Exhibits at ICTO 2018!

Bentham Science is attending The 2nd International Congress on Clinical Trials in Oncology and Hemato-Oncology (ICTO2018) held on 19-20 February 2018 in Berlin, Germany. Meet us at Booth no. 7 and view our range of publications.

ICTO -18

ICTO2018 follows the success of the 1st inaugural Congress which took place March 2017 in London and will again bring together world renowned speakers in the field of Clinical Trials in Oncology and Hemato-Oncology.  The Congress will welcome oncology professionals, treatment experts, CRO’s, industry leaders and other experts to the majestic city of Berlin.

ICTO2018 will provide an outstanding scientific, educational and networking experience.

 

MOST ACCESSED ARTICLE – Diagnostic Imaging of Hepatocellular Carcinoma – Current Medical Imaging Reviews

Journal: Current Medical Imaging Reviews

Author(s): Tomasz K. Nowicki*, Karolina Markiet, Edyta Szurowska

Graphical Abstract:

 

Abstract:

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, which develops mostly in the setting of chronic liver disease. European Association for the Study of the Liver (EASL) and European Organization for Research and Treatment of Cancer (EORTC) prepared guidelines for screening, follow-up and diagnosis of HCC to facilitate decision making and optimize both diagnostic and therapeutic protocols.

 

The review briefly describes etiology, epidemiology and histopathology of HCC and presents EASL-EORTC guidelines for surveillance and diagnosis of HCC. Target population and screening algorithm is presented in the surveillance section. Ultrasound imaging of HCC and the role of contrast enhanced ultrasound are described as well as the value of laboratory tests in screening. Further, radiological features of HCC in multiphase CT and dynamic contrast enhanced MRI and diagnostic criteria are presented. Additionally, the advantages of advanced techniques in MRI such as diffusion weighed imaging and the use of hepatocyte-specific contrast agents are discussed.

Lastly, the EASL-EORTC guidelines are compared with the guidelines of the American Association for the Study of Liver Diseases and the Japan Society of Hepatology. Also LI-RADS and the Barcelona Clinic Liver Cancer classification are mentioned.
In the near future, due to the ongoing advances in imaging a revision of the guidelines may be expected.