The Institute of Advanced Study in Science & Technology (IASST) was set up in 1979 by the Assam Science Society with the prime objective of setting up a premier research establishment in the NE region to deal with problems of the north east in particular and the country in general. The Institute was inaugurated by the Nobel Laureate Prof. Dorothy Hodgkin on 3rd November 1979. The Assam Science Society provided the necessary facilities at the beginning and The Government of Assam provided a lump sum annual grant-in-aid to the Institute since 1991-92 to carry out research in frontier areas of science & technology.
The IASST was registered as a separate entity in 1991 under the Societies Registration Act XXI of 1860 under Regd. No. 4219 of 1990-91. The Institute was later shifted to its present location near “Deepar beel”, a natural lake in western side of Guwahati, in June 2004.
The Institute has been recently taken over as an autonomous research Institute by the Government of India under the Department of Science and Technology.
Author(s): Jie Li, John A. Johnson, Huabo Su*.
Post-translational modification represents an important mechanism to regulate protein function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of protein modifiers that share a certain extent of sequence and structure similarity. Conjugation of Ub or UBLs to target proteins is dynamically regulated by a set of UBL-specific enzymes and modulates the physical and physiological properties of protein substrates. Ub and UBLs control a strikingly wide spectrum of cellular processes and not surprisingly are involved in the development of multiple human diseases including cardiac diseases. Further identification of novel UBL targets will expand our understanding of the functional diversity of UBL pathways in physiology and pathology. Here we review recent findings on the mechanisms, proteome and functions of a subset of UBLs and highlight their potential impacts on the development and progression of various forms of cardiac diseases.
Read more here: http://www.eurekaselect.com/137683/article
International Journal of Sensors, Wireless Communications and Control publishes timely research articles, reviews and communications on these three strongly related areas, with emphasis on networked control systems whose sensors are interconnected via wireless communication networks.
The emergence of high speed wireless network technologies allows a cluster of devices to be linked together economically to form a distributed system. Wireless communication is playing an increasingly important role in such distributed systems. Transmitting sensor measurements and control commands over wireless links allows rapid deployment, flexible installation, fully mobile operation and prevents the cable wear and tear problem in industrial automation, healthcare and environmental assessment. Wireless networked systems has raised and continues to raise fundamental challenges in the fields of science, engineering and industrial applications, hence, more new modelling techniques, problem formulations and solutions are required.
Articles from the International Journal of Sensors, Wireless Communications and Control Volume 7, Issue 3:
For details on the articles, please visit this link :: https://bit.ly/2KtXBwW
The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
Articles from the journal Mini-Reviews in Medicinal Chemistry Volume 18, Issue 12:
For details on the articles, please visit this link :: https://bit.ly/2y8EhAj
Journal: Current Pharmaceutical Design
Author(s): Albert Roger, Maria Basagana, Aina Teniente-Serra, Nathalie Depreux, Yanina Jurgens , Clara Padro, Sira Miquel, Carolina Elduque, Eva M. Martinez-Caceres*.
The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed or are currently under clinical trials. Besides new routes of administration, new types of allergens are being developed. The use of adjuvants may amplify the immune response towards tolerance to the antigens. In this review, we analyze different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.
Read more here: http://www.eurekaselect.com/159081/article
Journal: Current Neuropharmacology
Author(s): Hikaru Takeuchi*, Ryuta Kawashima.
Background: The mean diffusivity (MD) parameter obtained by diffusion tensor imaging provides a measure of how freely water molecules move in brain tissue. Greater tissue density conferred by closely arrayed cellular structures is assumed to lower MD by inhibiting the free diffusion of water molecules.
Methods: In this paper, we review studies showing MD variation among regions of the brain dopaminergic system (MDDS), especially subcortical structures such as the putamen, caudate nucleus, and globus pallidus, in different conditions with known associations to dopaminergic system function or dysfunction. The methodologies and background related to MD and MDDS are also discussed.
Results: Past studies indicate that MDDS is sensitive to pathological derangement of dopaminergic activity, neural changes caused by cognitive and pharmacological interventions that are known to affect the dopaminergic system, and individual character traits related to dopaminergic function.
Conclusion: These results suggest that MDDS can be one useful tool to tap the neural differences related to the dopaminergic system.
Read more here: http://www.eurekaselect.com/156969
Current Protein & Peptide Science publishes review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
Articles from the journal Current Protein & Peptide Science Volume 19, Issue 8:
For details on the articles, please visit this link :: https://bit.ly/2l8nm7t