EDITORS CHOICE ARTICLE – An Evolutionary Approach to the Maximum Edge Weight Clique Problem

Journal Name: Recent Advances in Electrical & Electronic Engineering

Author(s): Dalila B.M.M. Fontes*, Jose Fernando Goncalves, Fernando A.C.C. Fontes.




Graphical Abstract:




Background: This work addresses the maximum edge weight clique problem (MEWC), an important generalization of the well-known maximum clique problem.

Methods: The MEWC problem can be used to model applications in many fields including broadband network design, computer vision, pattern recognition, and robotics. We propose a random key genetic algorithm to find good quality solutions for this problem. Computational experiments are reported for a set of benchmark problem instances derived from the DIMACS maximum clique instances.

Results: The results obtained show that our algorithm is both effective and efficient, as for most of the problem instances tested, we were able to match the best-known solutions with very small computational time requirements.


Read more here: http://www.eurekaselect.com/159819/article


New Issue :: Current Vascular Pharmacology (Volume: 16, Issue: 5)


Current Vascular Pharmacology publishes clinical and research-based reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research.

Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).




Articles from the journal Current Vascular Pharmacology Volume 16 Issue 5:


For details on the articles, please visit this link ::  https://bit.ly/2JJgKqk


New Issue :: Current Catalysis (Volume: 7, Issue: 2)


Current Catalysis is an international peer-reviewed journal, which publishes original research, expert reviews and thematic issues in all core areas of catalysis including theoretical, experimental and applied research. The scope includes heterogeneous catalysis, homogeneous catalysis, bio-catalysis, synthesis and properties of new catalysts including synthesis and catalytic function of novel inorganic solids and complexes, studies that relate catalytic function to fundamental chemical processes in metal complexes and at surfaces, novel concepts in surface chemistry.



Articles from the journal Current Catalysis Volume 7 Issue 2:



For details on the articles, please visit this link ::  https://bit.ly/2O2eZrv


New Issue :: Current Pharmaceutical Design (Volume: 24, Issue: 13)


Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.




Articles from the journal Current Pharmaceutical Design Volume 24, Issue 13:



For details on the articles, please visit this link ::  https://bit.ly/2muurQA








Editor-in-Chief: Current Clinical Pharmacology

Flinders University and Flinders Medical Centre
Adelaide, SA

New Issue :: Current Pharmaceutical Biotechnology (Volume: 19, Issue: 3)


Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology.




Articles from the journal Current Pharmaceutical Biotechnology Volume 19 Issue 3:


For details on the articles, please visit this link ::  https://bit.ly/2LxuTbK

EDITOR’S CHOICE ARTICLE – Physical Activity-does it Really Increase Bone Density in Postmenopausal Women? A Review of Articles Published Between 2001-2016

Journal Name: Current Aging Science

Author(s): Daria Segev, Devora Hellerstein, Ayelet Dunsky*.


Graphical Abstract:



Background: Physical activity is known for its many health benefits; among them being the positive effect on bone health during the life cycle. During childhood, physical stress stimulates bone remodeling and increases density. However, due to hormonal changes during adulthood, and mainly during postmenopause the rate of bone remodeling is slowed down and is less efficient. As a result, argument has arisen in the literature regarding the benefit or harm of physical activity on bone health among postmenopausal women.

Objective: The study aims to examine the efficacy of physical activity for improving Bone Mineral Density (BMD) in postmenopausal women based on a review of the literature.

Methods: The articles included in the review were chosen from three databases (PubMed, SPORT Discus with full text and Science Direct). Only publications with intervention studies which provided BMD measures clearly affected by physical activity in postmenopausal women were included. Twelve articles met the criteria for inclusion.

Results: In general, physical activity had a positive effect on BMD. Exercise prevented bone loss and in some cases, it contributed to the increase in BMD.

Conclusion: Physical activity may improve BMD in postmenopausal women. However, the exact type of activity, its intensity, its duration and its frequency, are still unclear. Further studies are needed to determine the precise training protocol for postmenopausal women.



READ MORE HERE: http://www.eurekaselect.com/155692/article

PODCAST: Preparation and Characterization of Stable Nanosuspension for Dissolution Rate Enhancement of Furosemide: A Quality by Design (QbD) Approach




Author(s): Akbar L. Marzan, Rahnuma Tabassum, Basarat Jahan, Mehedi H. Asif, Hasan M. Reza, Mohsin Kazi*,Sultan M. Alshehri, Marcel de Matas, Mohammad H. Shariare*.

For article details, visit: http://www.eurekaselect.com/159279/article

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Hepatitis Day related Article

Rational Drug Discovery of HCV Helicase Inhibitor: Improved Docking Accuracy with Multiple Seeding in AutoDock Vina and In Si tu Minimization


Journal Name: Current Computer-Aided Drug Design

Author(s): See K. Lim, Rozana Othman, Rohana Yusof, Choon H. Heh*.


Graphical Abstract:



Background: Hepatitis C is a significant cause for end-stage liver diseases and liver transplantation which affects approximately 3% of the global populations. Despite the current several direct antiviral agents in the treatment of Hepatitis C, the standard treatment for HCV infection is accompanied by several drawbacks, such as adverse side effects, high pricing of medications and the rapid emerging rate of resistant HCV variants.

Objectives: To discover potential inhibitors for HCV helicase through an optimized in silico approach.Methods: In this study, a homology model (HCV Genotype 3 helicase) was used as the target and screened through a benzopyran-based virtual library. Multiple-seedings of AutoDock Vina and in situ minimization were to account for the non-deterministic nature of AutoDock Vina search algorithm and binding site flexibility, respectively. ADME/T and interaction analyses were also done on the top hits via FAFDRUG3 web server and Discovery Studio 4.5.Results: This study involved the development of an improved flow for virtual screening via implemention of multiple-seeding screening approach and in situ minimization. With the new docking protocol, the redocked standards have shown better RMSD value in reference to their native conformations. Ten benzopyran-like compounds with satisfactory physicochemical properties were discovered to be potential inhibitors of HCV helicase. ZINC38649350 was identified as the most potential inhibitor.

Conclusion: Ten potential HCV helicase inhibitors were discovered via a new docking optimization protocol with better docking accuracy. These findings could contribute to the discovery of novel HCV antivirals and serve as an alternative approach of in silico rational drug discovery.
For more details, Please visit: http://www.eurekaselect.com/147807 

Hepatitis day related Articles

The Role of MicroRNA in Pathogenesis and as Markers of HCV Chronic Infection


Journal Name: Current Drug Targets

Author(s): Chang Ho Lee*, Ji Hyun Kim, Seong-Wook Lee*.



Graphical Abstract:



Hepatitis C virus (HCV) is a worldwide major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Accumulating evidence indicates that a number of microRNAs (miRNAs), which are able to exert an effect on liver biology and pathology, can regulate or be regulated by HCV infection. Many studies demonstrate that HCV utilizes host miRNAs and modulates expression of miRNAs in infected hepatocytes for its infection and propagation. In turn, host miRNAs can directly regulate HCV replication through interaction with the HCV RNA genome or by indirectly controlling the host pathways associated with the virus replication, which eventually induce HCV-related liver diseases such as liver fibrosis, hepatic cirrhosis, or HCC. Recently, extracellular miRNAs (circulating miRNAs) detected in human serum and plasma are proposed as biomarker candidates for pathological conditions due to their remarkably stable nature and the non-invasiveness of their detection. Since these circulating miRNAs exhibit consistent levels between healthy individuals but significantly changed profiles in disease conditions, considerable effort has been employed to investigate the alteration in the circulating miRNA pattern that is related with HCV infection and associated liver diseases. In this review, we summarize the features of miRNAs critical for HCVassociated liver disease initiation and progress, and discuss growing evidence that distinctive circulating miRNA patterns are related with HCV infection and associated liver diseases. These will shed light on the development of miRNA-based therapeutic modalities and non-invasive biomarkers for the diagnosis and prognosis of HCV infection and associated diseases.



For more details, Please visit: http://www.eurekaselect.com/140895