BENTHAM SCIENCE FREE TRIAL IN Beilinson Hospital (Rabin Medical Center)

Beilinson Hospital was founded in 1936 to serve the nearby agricultural settlements. All Jewish workers in central Palestine agreed to donate two days’ worth of wages toward its construction. The hospital opened with 70 beds. It was named for Dr. Moshe Beilinson, one of its founders.

HaSharon Hospital was built in 1942 as an extension of Beilinson. In 1954, a new building in the International Style was designed by Arieh Sharon and Benjamin Idelson, pioneers of Israeli modernist architecture.

In 1938, the country’s first blood bank was established at Beilinson. Beilinson Hospital was the first medical institution in the country to have a dermatology department, a nephrology institute, and a dialysis unit. In 1968, the first heart transplant in Israel was performed there. The first implantation of an artificial heart in Israel was performed at Beilinson in 1995.

 

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Testimonial bY MD YOUSUF ANSARI!

 

Md Yousuf Ansari.jpg

 

Contributed Article: “Synthesis, cytotoxic evaluation, and molecular docking studies of new oxadiazole analogues

New Issue :: Current Rheumatology Reviews (Volume: 14, Issue: 2)

Current Rheumatology Reviews publishes frontier reviews, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field.

 

Articles from the journal Current Rheumatology Reviews Volume 14, Issue 2:

For details on the articles, please visit this link ::  https://bit.ly/2mdV24g

EDITORS CHOICE ARTICLE – Predictable and Preventable: Historical and Current Efforts to Improve Child Injury Prevention

JOURNAL: Current Pediatric Reviews

AUTHOR(S): Karen E. Forward*, Eman Loubani.

 

Graphical Abstract:

 

Abstract:

Background: Childhood injuries are a global epidemic. Accidents resulting in childhood injury and death were first identified as a concern over a century ago. However, “accidents” leading to injury were not recognized as being predictable and preventable until more recently.

Objectives: To describe the worldwide epidemic of childhood injuries, and look at international successes in the field of injury prevention.

Methods: Literature pertaining to injury prevention was reviewed to describe the history of childhood injury prevention, guiding principles of injury prevention, successful strategies for prevention, and future directions.

Result and Conclusion: Through surveillance, evidence-based injury prevention initiatives, and multi-disciplinary collaboration, we anticipate further reduction in childhood injuries.

 

Read more here: http://www.eurekaselect.com/156309/article

MOST ACCESSED ARTICLE – Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update

Author(s): Ylenia Cau, Daniela Valensin, Mattia Mori, Sara Draghi, Maurizio Botta*.

 

Abstract:

14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-protein interactions (PPIs). They are usually found in all eukaryotes with a conserved secondary structure and high sequence homology among species. 14-3-3 proteins are involved in many physiological and pathological cellular processes either by triggering or interfering with the activity of specific protein partners. In the last years, the scientific community has collected many evidences on the role played by seven human 14-3-3 isoforms in cancer or neurodegenerative diseases. Indeed, these proteins regulate the molecular mechanisms associated to these diseases by interacting with (i) oncogenic and (ii) pro-apoptotic proteins and (iii) with proteins involved in Parkinson and Alzheimer diseases. The discovery of small molecule modulators of 14-3-3 PPIs could facilitate complete understanding of the physiological role of these proteins, and might offer valuable therapeutic approaches for these critical pathological states.

 

Read more here: http://www.eurekaselect.com/151895

OPEN ACCESS ARTICLE – Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

Journal Name: Current Medicinal Chemistry

Author(s): Yasushi Ikarashi, Kyoji Sekiguchi, Kazushige Mizoguchi*.

 

Abstract:

Background: Geissoschizine methyl ether (GM) is one of the indole alkaloids in Uncaria hook, and an active ingredient of yokukansan (YKS) that improves behavioral and psychological symptoms of dementia (BPSD) in patients with several types of dementia. The pharmacological action of GM has been related to various serotonin (5-HT) receptor subtypes.

Objective: The aim of this article is to review the binding characteristics of GM to the 5-HT receptor subtypes in the brains using our own data and previous findings.

Method: Competitive receptor-binding and agonist/antagonist activity assays for several 5-HT receptor subtypes were performed. Moreover, the articles describing pharmacokinetics and brain distribution of GM were searched in PubMed.

Results: GM bound the following 5-HT receptor subtypes: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5- HT4, 5-HT5A, 5-HT6, and 5-HT7. Among these receptors, GM had partial agonistic activity for 5-HT1A receptors and antagonistic activity for 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7 receptors. Also, GM was metabolized by various CYP isoforms, mainly CYP3A4. Parent/unchanged GM was detected in both the blood and brain of rats after oral administration of YKS. In the brains, GM was presumed to bind to 5- HT1A, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7 receptors on neuron-like large cells mainly in the frontal cortex.

Conclusion: These results suggest that GM is a pharmacologically important alkaloid that regulates various serotonergic activities or functions by binding to multiple 5-HT receptor subtypes. Thus, this review provides recent 5-HT receptor-related evidence that GM is partly responsible for pharmacological effects of YKS.

 

READ MORE HERE: http://www.eurekaselect.com/151003 

New Issue :: Current Nano-materials (Volume: 2, Issue: 3)

 

Current Nanomaterials, a peer reviewed journal publishes reviews, original research articles and thematic issues on experimental and applied research on nano-materials. The scope covers the synthesis, structure, properties, characterization and application of nano-materials. The journal will cover all areas of nano-material science, engineering and nanotechnology with emphasis on all aspects of research on a wide range of nano-materials including nano-composites, inorganic materials, polymeric and biological materials and hybrid materials.

 

Articles from the journal Current Nano-materials Volume 2, Issue 3:

 

For details on the articles, please visit this link ::  https://bit.ly/2uiced9

E-Book – Research on Corporate Environmental Responsibility in China

 

9781681086477-1

By

Wang Hong

 

This book aims to discuss the importance of corporate environmental responsibility (CER), and strive to answer these questions: How to view the development of CER in China? How to determine the key work of current CER? How to use the Internet to release environmental information and enable the public to play an active role in participation? If you are reading this preface, you are likely to be the manager, responsible for social relations, public affairs, environmental management of a company; Or perhaps you are a government official, concerned with the implementation and improvement of environmental policies; Or perhaps you are a business school teacher or student, thinking about corporate social responsibility (CSR) in the relevant courses. In this book, you will perceive the spark of thoughts and the perspective of philosophy.

The author has been engaged in the research of CSR and environmental management for more than ten years. Successively, she participated in the 2005 Conference on Environmental Economic Research Center of Fudan University, 2006 Management Case Conference in Renmin University of China, 2008 Chinese and the United States Scholars conference on Management Science and Engineering in Shanghai Jiaotong University, 2008 CSR International Conference in University of Durham UK, 11th Biennial 2010 Conference of the International Society of the Ecological Economics in the University of Oldenburg and Breman in Germany, and 2012 CSR International Conference in Lahti Finland. Gradually, she has a unique insight in the research of CER.

 

Read this insightful eBook here: https://ebooks.benthamscience.com/book/9781681086477/ 

OPEN ACCESS ARTICLE – Does Ceruloplasmin Defend Against Neurodegenerative Diseases?

Journal Name: Current Neuropharmacology

Author(s): Bo Wang , Xiao-Ping Wang*.

 

 

Abstract:

Ceruloplasmin (CP) is the major copper transport protein in plasma, mainly produced by the liver. Glycosylphosphatidylinositol-linked CP (GPI-CP) is the predominant form expressed in astrocytes of the brain. A growing body of evidence has demonstrated that CP is an essential protein in the body with multiple functions such as regulating the homeostasis of copper and iron ions, ferroxidase activity, oxidizing organic amines, and preventing the formation of free radicals. In addition, as an acute-phase protein, CP is induced during inflammation and infection. The fact that patients with genetic disorder aceruloplasminemia do not suffer from tissue copper deficiency, but rather from disruptions in iron metabolism shows essential roles of CP in iron metabolism rather than copper. Furthermore, abnormal metabolism of metal ions and oxidative stress are found in other neurodegenerative diseases, such as Wilson’s disease, Alzheimer’s disease and Parkinson’s disease. Brain iron accumulation and decreased activity of CP have been shown to be associated with neurodegeneration. We hypothesize that CP may play a protective role in neurodegenerative diseases. However, whether iron accumulation is a cause or a result of neurodegeneration remains unclear. Further research on molecular mechanisms is required before a consensus can be reached regarding a neuroprotective role for CP in neurodegeneration. This review article summarizes the main physiological functions of CP and the current knowledge of its role in neurodegenerative diseases.

 

Read more here: http://www.eurekaselect.com/161925 

New Issue :: Current Analytical Chemistry (Volume: 14, Issue: 4)

 

Current Analytical Chemistry publishes expert reviews and original research articles on the most recent advances in analytical chemistry. All aspects of the field are represented, including analytical methodology, techniques, and instrumentation in both fundamental and applied research topics of interest to the broad readership of the journal. Current Analytical Chemistry strives to serve as an authoritative source of information in analytical chemistry and in related applications such as biochemical analysis, pharmaceutical research, quantitative biological imaging, novel sensors, and nanotechnology.

 

Articles from the journal Current Analytical Chemistry Volume 14, Issue 4:

For details on the articles, please visit this link ::  https://bit.ly/2KSq2pc