MOST ACCESSED ARTICLE – Opioids in the Frame of New Psychoactive Substances Network: A Complex Pharmacological and Toxicological Issue

Journal Name: Current Molecular Pharmacology

Author(s): Ludovic Ventura, Felix Carvalho, Ricardo Jorge Dinis-Oliveira*.

 

 

Graphical Abstract:

 

Abstract:

Background: New psychoactive substances (NPS), often referred to as “legal highs” or “designer drugs”, are derivatives and analogues of existing psychoactive drugs that are introduced in the recreational market to circumvent existing legislation on drugs of abuse.

Objective: This systematic review aims to gather the state of the art regarding chemical, molecular pharmacology and toxicological information of opioid class of NPS.

Methods: Chemical, pharmacological, toxicological and clinical effects of opioid class of NPS were searched in books and in PubMed (U.S. National Library of Medicine) without a limiting period.

Results: Within this class, fentanyl analogues are among the most frequently abused and pose several clinical concerns and therefore will be thoroughly discussed. Other opioid sub-categories of NPS frequently misused include AH-7921, MT-45, U-47700, U-50488, desomorphine, mitragynine, tramadol, tapentadol, salvinorin A and its analogue herkinorin.

Conclusion: Due to inefficient monitoring techniques, as well as limited knowledge regarding the acute and long-term effects of opioids NPS, further clinical and forensic toxicological studies are required.

 

 

READ MORE HERE: http://www.eurekaselect.com/153703

Author: Bentham Science

Bentham Science is a leading publishing company in the field of science, technology, and medicine. Established in 1992, the company has grown to become one of the most reputable and respected publishers in the scientific community. Bentham Science publishes more than 100 online and print journals, along with over 300 eBooks and over 2000 reference works. These publications cover a wide range of topics, including pharmaceutical sciences, biotechnology, chemistry, engineering, and more. In addition to its publications, Bentham Science also provides various services to the scientific community, including manuscript editing, article formatting, and language polishing. The company is committed to promoting scientific research and discovery by providing a platform for researchers to share their work with a wider audience. Bentham Science's reputation for excellence is built on a commitment to quality, integrity, and innovation. Its editorial team consists of experts in their respective fields who ensure that all publications are rigorously peer-reviewed and meet the highest standards of scientific accuracy. Overall, Bentham Science is an invaluable resource for scientists, researchers, and academics who are looking to stay up-to-date on the latest developments in their fields. With its wide range of publications and commitment to quality, the company is poised to remain a leader in the scientific publishing industry for years to come.

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