Bentham Science Media Partnership | BIO Asia International Conference – 2019

Accelerate your pathway to partnerships in Asia


The BIO Asia International Conference is an exclusive partnering forum convening U.S. & European drug development companies with Asian biotech and pharma companies interested in research collaborations and licensing agreements. 




Learn more about #BIOASIA19:

Article by Disease | Synthesis, Cytotoxicity and Antioxidant Activity of New Analogs of RC-121 Synthetic Derivatives of Somatostatin

Bentham Oncology Collection| Oncology | Cervical Cancer





Background: Based on the structure of RC-121 (D-Phe-c (Cys-Tyr-D-Trp-Lys-Val-Cys)-Thr-NH2, – synthetic derivatives of somatostatin), some analogs were synthesized and tested for in vitro cytotoxic and antioxidant activity.

Objectives: The new analogs were modifyed at position 5 with Dap (diaminopropanoic acid), Dab (diaminobutanoic acid) and Orn and at position 6 with the unnatural amino acids Tle (t-leucine).

Methods: The in vitro cytotoxic effects of the substances were investigated against a panel of human tumor cell lines HT-29 (Human Colorectal Cancer Cell Line), MDA-MB-23 (Human Breast Cancer Cell Line), Hep G-2 (Human Hepatocellular Carcinoma Cell Line) and HeLa (cervical cancer cell line). The antioxidant capacities were tested by ORAC (Oxygen Radical Antioxidant Capacity) and HORAC (Hydroxyl Radical Averting Capacity) methods.

Results: All substances expressed significantly higher antioxidant capacity by comparison with galic acid and Trolox. All substances showed considerable antioxidant capacity as well. Compound 2T (D-Phe-c(Cys-Tyr-DTrp- Dap-Tle-Cys)-Thr-NH2)had the highest antioxidant effect. The compound 4T (D-Phe-c(Cys-Tyr-D-Trp- Orn-Tle-Cys)-Thr-NH2) displayed antiproliferative effect on HeLa cells with IC50 30 μM. The peptide analog 3T (D-Phe-c(Cys-Tyr-D-Trp-Lys-Tle-Cys)-Thr-NH2) exerted the most pronounced inhibition on the cell vitality up to 53%, 56% and 65% resp. against MDA-MB-23, Hep G-2, HeLa in the higher tested concentration.

Conclusion: the somatostatin analogs showed moderate influence on the vitality of different tumor cells and could be used in changing their pathology.


Read out more at:

Editor’s Choice Article | GUT-Brain Axis and Psychiatric Disorders

Journal Name: Current Psychiatry Reviews

Author(s): Alper Evrensel*, Uskudar University, Department of Psychiatry, Istanbul, Turkey Barış Önen Ünsalver, Uskudar University, Department of Psychiatry, Istanbul, Turkey Mehmet Emin Ceylan. Uskudar University, Department of Psychiatry, Istanbul, Turkey


Graphical Abstract:


Background: Studies on the effects of microorganisms living in the guts of human health and the etiopathogenesis of diseases, especially psychiatric disorders, have rapidly increased in recent years. According to the results of these studies, evidence has been found that there is direct and indirect (immune system) interaction between the microbiota bacteria and their metabolites and neurons.

Objective: The purpose of this review is to discuss the current research findings focusing on the relationship between the gut microbiota and psychiatric disorders. In this context, the effectiveness of microbiota-based treatments (probiotics and fecal microbiota transplantation) on the treatment of psychiatric disorders is also discussed.

Method: A review of the literature was conducted that includes the following words: gut-brain axis, microbiota, dysbiosis, psychiatry and mental disorders.

Results: There are few clinical studies examining the gut-brain relationship. In the light of the evidence from these clinical trials and animal experiments, it can be suggested that gut microbiota has a distinct and determinative role in brain function.

Conclusion: Gut microbiota creates a determining and life-long effect on the emergence of the immune system and the brain in the fetus starting with birth. Delivery mode, breastfeeding, diet, drugs (antibiotics, psychotropics) and aging may change the composition of gut microbiota. Disruption of microbiota composition (dysbiosis) may lead to the emergence of psychiatric disorders. Microbiotabased treatments have a therapeutic potential by repairing dysbiosis. There is a need for more randomized controlled studies in order for the effects of gut microbiota on psychiatric disorders to be completely understood.


Read out more at:

Bentham Science Free Trial in Hebei Medical University | Free Trial ends on January 31, 2019


Hebei Medical University is a university in Shijiazhuang, Hebei, People’s Republic of China, under the provincial government. Located in Shijiazhuang, the capital city of Hebei Province which is 4 hours away from Beijing by car and 1 and a half hours by train. Hebei Medical University Established in 1894, it is one of the oldest and AAA graded medical schools in China.

Hebei Medical University has long history of enrolling international students from countries including the United States, Japan, Korea, Philippines, Taiwan, the UK, India, Pakistan, Nepal and Bangladesh. Currently there are over 400 international students. In collaboration with International Education College of Jiangxi University of Traditional Chinese Medicine total of more than 300 international students have already completed their Bachelor of Medicine, Bachelor of Surgery (MBBS) from the University in 2010 – 2011.

The university has six affiliated hospitals, in which there are 4,566 in-patient beds. Four hospitals have been granted the status of “first-class hospitals in the third category”. In addition, it also has 77 teaching hospitals and practice bases providing students with sites of clinical teaching, specialist teaching and practice.



Bentham Science Free Trial in HeBei University| Free Trial ends on January 31, 2019


Hebei University is a public Comprehensive University in Hebei which is directly supported by Hebei provincial government and the national government. It’s located in Baoding, Hebei Province, China. The university currently has an enrollment of 33,000, including 6,100 full-time graduates and 26,900 full-time undergraduates.

The University campus covers an area of over 700 acres (2.8 km2). It is well equipped with first-class facilities, notably in the areas of science and technology. The University library has a collection of 3,900,000 books and 5,000 periodicals published at home and abroad. It has one of the largest collections of rare books among the universities in China. The University museum houses more than 8,000 historical relics over 70 of which enjoy the highest degree of national protection. Furthermore, the museum also possesses some rare specimens of animals and plants.



Bentham Science Free Trial in Jagiellonian University Medical Library | Free Trial ends on March 05, 2019


The JU MC Medical Library’s collections are rich, with almost 300,000 volumes, over 300 journal titles, all doctoral and habilitation theses submitted at the Jagiellonian University Medical College, and over 30,000 other non-electronic items including old prints, microfilms, standards, patents, and audiovisual material. Part of them form a Reference Collection (dedicated to student use) and collections of the institute libraries.

The digital holdings are represented by varying number of electronic databases (about 20), journals (about 7,000 titles) and books from the following platforms: Ibuk, Access Medicine, Access Surgery, MyiLibrary, Medicine Complete, Ebrary Academic Complete. Doctoral dissertations submitted from 2004 are accessible in full-text versions in Digital Medical Library.


Bentham Science Free Trial in Eastern Mediterranean University | Free Trial ends on March 05, 2019


The Eastern Mediterranean University , located in Northern Cyprus, was established in 1979 under the leadership of Onay Fadıl Demirciler (then Undersecretary of the Ministry of Education) as a higher-education institution of technology for Turkish Cypriots. In 1986, it was converted to a state university. The campus is located within the city of Famagusta.

The university has 141 programs (11 Faculties and 5 Schools) offering undergraduate and postgraduate degrees, as well as a research infrastructure. The medium of instructions are in Turkish and English. However, English Preparatory School is available for students who need to improve their English. The university offers variety of sports and social activities. Academic Programs of EMU are broad and include Physical and Social Sciences with considerable research studies via Research Advisory Board.



Bentham Science Free Trial in Nicolaus Copernicus University Library | Free Trial ends on March 05, 2019


The Nicolaus Copernicus University Library was established on August 24, 1945, alongside the Nicolaus Copernicus UniversityToruńPoland.

Based on the results of the evaluation of scientific achievements, the State Committee for Scientific Research granted the NCU Library category 3, which places it in the company of other university libraries in KrakówPoznań and Warsaw.

In 2002, the NCU Library was honoured with the medal of “Bibliotheca Magna Perennisque” for its “contribution to Polish librarianship.”


In December 2002, the NCU Library webpage won third place in a competition for the best Polish library websites, in a research libraries category, organised under the auspices of the Polish Librarians Association.



Bentham Science Free Trial in Medical University of Łódź | Free Trial ends on March 05, 2019


The Medical University of Łódź was founded on October 1, 2002 as a merger of the Medical Academy of Łódź(founded January 1, 1950) and the Military Medical Academy of Łódź (founded July 1, 1958). It is the largest teaching hospital unit in Poland and a European research center.

It comprises

  • 6 research institutes,
  • 49 chairs,
  • 7 fully equipped university teaching hospitals with a total capacity of 2900 beds, as well as
  • 438,000 specialist consultations every year in specialist outpatient clinics, in addition to the
  • collaboration with 22 international universities.


At the Medical University of Lodz, students are instructed from a 250 plus Basic Science and Clinical Medicine Faculty, composed of physicians, teachers and researchers. Most faculty members of the university holds a dual MD/PhD. Degree, and all are board certified in their respective specialties.

The Medical University is the biggest state medical university in Poland implementing the following basic tasks:

  • educating students in medicine, dentistry, pharmacy and medicine-allied disciplines;
  • educating research staff and conducting research work;
  • conducting postgraduate training of highly qualified health care system staff;
  • participating in health care programs set by the social health care system.

The university made an important evolution of a unique system, based on the availability -during posted office hours- of all professors for individual consultations with students in their offices. This helps promote better interaction between students and faculty as opposed to the previous Soviet style system.




eBooks Press Release — NEWS | Fourth Volume of Frontiers in Natural Product Chemistry

Editor: Atta-ur-Rahman; published on Oct 8, 2018.


Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series.

The fourth volume of the series brings seven reviews covering these topics:

  • natural antiamoebic medicines, analgesics and antimalarials
  • essential oils and cognitive performance
  • cannabis and drug development
  • lectins in biosensors
  • brassinosteroids

About The Editor:

Atta-ur-Rahman, Ph.D. in organic chemistry from Cambridge University (1968), has 1080 international publications in several fields of organic chemistry including 751 research publications, 37 international patents, 69 chapters in books and 221 books published largely by major U.S. and European presses. He is the Editor-in-Chief of eight European Chemistry journals. He is Editor of the world’s leading encyclopedic series of volumes on natural products, Studies in Natural Product Chemistry, 54 volumes of which have been published under his Editorship by Elsevier during the last two decades.


Keywords: Natural Product Chemistry, Essential Oils, Biosensors, brassinosteroids, cannabis drug development, natural analgesics, antimalarials, lectins.

To view full eBook, please visit:

%d bloggers like this: