Month: March 2019

Bentham Science Free Trial in Hefei University of Technology | Free Trial ends on June 29, 2019


Hefei University of Technology is a major and key university in China, with particular strength in Engineering and Management Science. Located in Hefei, the capital of the Anhui Province, it is also a Chinese Ministry of Education Double First Class Discipline University, with Double First Class status in certain disciplines.

Hefei University of Technology is a national key university administrated directly by the Ministry of Education of P.R. China. It has been listed in major national initiatives seeking to enhance the international competitiveness of the top-tier universities in China such as Project 211 and Project 985 Innovation Platform.

HFUT has four campuses, namely, Tunxilu, Lu’anlu, Feicuihu and Xuancheng, covering an area of about 3,417,390 m². The first three campuses are all located in Hefei, the provincial capital of Anhui, and the fourth in Xuancheng, a city about 194 kilometers away from Hefei.

Campuses in Hefei have 19 schools covering a wide range of fields with a strong focus on engineering science. The schools offer 82 undergraduate programs, 32 first-level disciples with authorization to confer master’s degrees, 12 first-level disciples for doctoral programs as well as 12 post-doctoral programs. 4 disciplines are selected as national key disciplines, 28 provincial key disciplines. The university has 1 state key lab, 1 national engineering lab, 4 national university-industry joint engineering research centers and 46 research centers at the ministerial or provincial level as well as 1 national A-level architectural design and research institute. The campus in Xuancheng has 5 departments.

At present, HFUT enrolls 29,480 undergraduate students and 11,800 graduate students. It has made remarkable achievements in student education. Throughout the years, key disciplines, courses, textbooks, teaching and experiment centers, teaching staff of HFUT have won numerous awards at all levels, highly reputed in China. It is among the first batch of 61 pilot colleges and universities to conduct the Education and Development Plan for Outstanding Engineers initiated by the Ministry of Education. About 200 projects carried out by HFUT students have been funded by the National University Student Innovation Program.




Press Release | Impact of a psycho-educational team in early breast cancer patients’ coping strategies


Cancer is a psychologically traumatic experience for affected individuals. Chemotherpautic medications can also be painful to the same patients. Researchers at Fondazione Poliambulanza, Brescia, Italy conducted a psycho-educational study on early stage breast cancer patients. The main objective of the study was to help women to cope with the physical emotional, and lifestyle changes after the diagnosis of breast cancer by evaluating the effect of group action on the participating women. A total of 97 women, participated in the study and were grouped into in 13 psycho-educational groups. All the groups consisted of female patients suffering from breast cancer with no recurrence or metastasis.

All the patients were evaluated using the Hospital Anxiety and Depression Scale (HADS) and the Body Image Scale (BIS). No significant effect on anxiety and body image was found by the researchers. They, however, noted a statistical difference between the results of the HADS depression test at T0 (first evaluation) and T1 (second evaluation) intervals. Read full press release to find out more at:




This article by Dr. Fausto Meriggi et al. is published in Reviews on Recent Clinical Trials, Volume 13, Issue 4, 2018. To obtain the article, please visit:


AIMS & SCOPE | Letters in Drug Design & Discovery


Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery. To learn more about the journal, please visit:



Most Accessed Articles | Design, Synthesis and Characterization of Novel Urolithin Derivatives as Cholinesterase Inhibitor Agents

Author(s): Maryam Norouzbahari, Emine V. Burgaz, Tugba Ercetin, Amirhossein Fallah, Alireza Foroumadi, Loghman Firoozpour, Mustafa F. Sahin, Mustafa Gazi, Hayrettin O. Gulcan*.

Journal Name: Letters in Drug Design & Discovery

Considering the limitations of current cholinesterase inhibitor drugs for the treatment of Alzheimer’s disease, there is ongoing research activities to find out alternative drug candidates. The aryl-spacer-N-benzyl pharmacophore model has been effectively utilized to design various types of cholinesterase inhibitor molecules, including donepezil. Within this research study, we have questioned the significance of the benzyl group within this pharmacophore employing the urolithin derivatives. Urolithins are benzo[c]chromene analogue metabolites of ellagitannins, abundantly found in pomegranate and berry fruits. Read out full article here:



Open Access Articles | Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

Author(s): Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao, Liyun Zheng*.

With the approval of gefitinib, erlotinib, afatinib, and osimertinib for clinical use, targeting Epidermal Growth Factor Receptor (EGFR) has been intensively pursued. Similar to most therapies, challenges related to the treatment resistance against these drugs have emerged over time, so new EGFR Tyrosine Kinase Inhibitors (TKIs) need to be developed. This study aimed to investigate the potential use of a series of thiophene-bearing quinazoline derivatives as EGFR inhibitors. We designed and synthesized nine quinazolin derivatives, among which five compounds (5e, 5f, 5g, 5h, and 5i) were reported for the first time. Read out full article here:


Open acces

Press Release | Coenzyme Q10 supplementation on metabolic profiles of patients with chronic kidney disease


Chronic Kidney disease (CKD) is highly associated with all-cause mortality, Diabetic Nephropathy (DN), cardiovascular events and hospitalization whether the patient has an existing risk or current cardiovascular disease or not. CKD can increase the chances of cardiovascular disease by two to fifty times and 50% mortality of patients with end stage renal disease (ESRD) on dialysis attributed to CVD and its complications. In this review, Co-enzyme Q10 (CoQ10) was tested as a potential treatment for CKD. The systemic review and meta-analysis of randomized control trials (RCTs) was conducted to evaluate the effects of CoQ10 supplementation on metabolic profiles of patients diagnosed with CKD.

CoQ10 is a potent lipophilic antioxidant that couple’s electron transport to oxidative phosphorylation in mitochondria. It is generally used as an alternative and complementary therapy for diseases with metabolic disorders. The supplementary protein has shown beneficial effects during the treatment of heart failure. It was found that the circulating concentration in patients with CKD had been decreased. This suggested that the CoQ10 antioxidant treatment would be an ideal solution for the disease. The results accumulated during meta-analysis proved that the CoQ10 supplementation significantly reduced total-cholesterol, malondialdehyde, and creatinine levels in patients diagnosed with CKD. It did not affect Triglycerides, HDL-cholesterol, fasting glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and C-reactive protein (CRP) concentrations. Read full press release to find out more at:



The article by Dr. Zatollah Asemi et al. is published in Current Pharmaceutical Design, Volume 24, Issue 31, 2018. To obtain the article, please visit:

Bentham Science Free Trial in Shandong University of Traditional Chinese Medicine | Free Trial ends on June 26, 2019


Shandong University of Traditional Chinese Medicine (SDUTCM) is a university based in Jinan City, Shandong Province, China. It was established on October 16, 1958 as the Shandong Traditional Chinese Medicine College. In 1978, the college became a national college for Traditional Chinese Medicine College. In 1981, the college was classified as a higher education institution in the province. In 1996, the university restructured into a public university and became officially as the Shandong University of Traditional Chinese Medicine.


It is currently the only independently established medical university in Shandong Province, and rated excellent in the national undergraduate education evaluation conducted by the Ministry of Education. It is one of the first “five preeminent featured universities” approved by Shandong provincial government. The university covers a total area of 122 hectares, with a building area of 545,000 square meters and a collection of 1,100,000 paper books in the library. The university includes 13 colleges, 3 directly-affiliated hospitals, 11 indirectly-affiliated hospitals, 22 teaching hospitals and over 50 clinical teaching bases. It has 21 undergraduate programs, and offers doctoral degrees of 15 specialties in 3 top disciplines and master’s degrees of 44 specialties in 8 top disciplines. It has an enrollment of over 20,000 students, including over 18,100 undergraduates, over 2,600 postgraduates and over 200 students from foreign countries, Hong Kong and Macaw. It has excellent teaching and practice conditions, complete living facilities. It has leaped into the front ranks of TCM universities in mainland China in the fields of undergraduate and postgraduate education, development of key disciplines, scientific research project and its achievement level.

Wishing you a very Happy Birthday | Prof. Ben M. Dunn


Prof  ben M Dunn.jpg


Prof. Ben M. Dunn

Editor in Chief: Current Protein & Peptide Science


Department of Biochemistry and Molecular Biology University of Florida
College of Medicine, P.O. Box 100245, Gainesville
Florida, FL 32610-0245

Bentham Science Free Trial in Universidad Autónoma de San Luis Potosí | Free Trial ends on June 21, 2019


The Autonomous University of San Luis Potosí  is a public university in Mexico. It is the largest, oldest, and most comprehensive university in the state of San Luis Potosí, as well as one of the most important ones in Mexico. Among other historic milestones, in 1923, UASLP was the first university in Mexico to have autonomy constitutionally granted

UASLP is organized in faculties (schools that offer postgraduate education) , schools, coordinations, academic units and departments; it is divided into 15 faculties, 1 schools, 4 coordinations, 1 departments, 7 institutes, 12 research institutes, and 2 academic units for different and specific areas. Both undergraduate and graduate studies are available on each faculty. To date, UASLP has a student population of more than 32,000 people, and offers 99 undergraduate programs and 88 postgraduate programs.



Bentham Science Free Trial in Fourth Military Medical University | Free Trial ends on June 15, 2019


Fourth Military Medical University is a military institution of higher learning, affiliated to the People’s Liberation Army of the People’s Republic of China. It was formed by the merger of former Fourth Military Medical University (First Military Medical College) and Fifth Military Medical University (Third Military Medical College ). The predecessor of Fifth Military Medical University is the “Medicine School of National Central University”, which was the best medicine school in China, founded in Nanjing in 1935. It was renamed the “Medicine School of Nanjing University” in 1949, and renamed “Eastern Military Medical College” and then “Third Military Medical College” and “Fifth Military Medical University” in 1952. The “People’s Medical College of Northwestern Military Region”, the predecessor of former Fourth Military Medical University was founded in 1941, relocated in Xi’an in 1948, and renamed “Northwestern Military Medical College” and then “First Military Medical College” and “Fourth Military Medical University” in 1952. The two medical universities were merged to form the new Fourth Military Medical University affiliated to PLA in 1954 in Xi’an, the capital of Shaanxi Province, China. It is a Chinese Ministry of Education Double First Class Discipline University, with Double First Class status in certain disciplines.



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