Become a Reviewer | Current Alzheimer Research

 

Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer’s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ‘bird’s-eye view’ of the current state of Alzheimer’s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

The Journal Current Alzheimer Research is interested in appointing active Reviewer  on the Journal’s Board. If you are working in the related field as of the journal and are interested in becoming an Reviewer, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at:

• hermain@benthamscience.net and;
• CC faizan@benthamscience.net

 

Become an Editorial Board Member (EBM) | Current Alzheimer Research

 

Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer’s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ‘bird’s-eye view’ of the current state of Alzheimer’s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

The Journal Current Alzheimer Research is interested in appointing active Editorial Board Member  on the Journal’s Board. If you are working in the related field as of the journal and are interested in becoming an Editorial Board Member, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at:

• hermain@benthamscience.net and;
• CC faizan@benthamscience.net

 

Editors Choice Article | Bioactive Medications for the Delivery of Platelet Derivatives to Skin Wounds

Journal Name: Current Drug Delivery

Author(s): Maria Cristina Bonferoni*, Silvia Rossi, Giuseppina Sandri, Carla Caramella, Claudia Del Fante, Cesare Perotti, Dalila Miele, Barbara Vigani, Franca Ferrari.

 

 

Chronic wounds are the result of alterations in the complex series of events of physiological wound healing. In particular, the prolonged inflammation results in increased protease activity, in the degradation of extracellular matrix (ECM) and of growth factors (GFs). The relevance of platelet GFs in maintaining and restoring the complex equilibrium of different moments in wound healing is well recognized. Moreover, the observed decrease of their levels in chronic wounds suggested a possible therapeutic role of the external application to the wounds. It has been also pointed out that tissue regeneration can be more efficiently obtained by the synergic use of different GFs. Platelet derivatives such as platelet- rich plasma (PRP) and platelet lysate (PL) are able to release GFs in a balanced pool. Their therapeutic use in regenerative medicine and wound healing has been therefore more and more frequently proposed in clinical trials and in the literature. The development of a suitable formulation able to control the GFs release rate, to protect the GFs, and to assure their prolonged contact with the wound site, is of paramount importance for the therapeutic success. The present review considers some formulation approaches for PRP and PL application to wounds. Read out full article at: http://www.eurekaselect.com/170878/article

 

 

Press Release | Autophagy and Mitochondria: Targets in Neurodegenerative Disorders (image)

 

Autophagy is a cellular degradation process that can cause the death of a cell in certain conditions. Autophagy is necessary to maintain cellular homeostasis by clearing out damaged cellular organelles and proteins through certain pathways. Mitochondria are cell organelles responsible for the constant supply of energy to maintain cellular physiology and energy metabolism.

Ashutosh Kumar et al. at the National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India present a review on autophagy in neuronal cells. The researchers believe that autophagy on the neuronal cells can lead to neurodegenerative diseases and countering the effects of this process through targeted drugs can be beneficial in the fight against such diseases. Neuronal cells are more vulnerable to such bioenergetic depletion as most of their function crucially depends on availability of energy derived mainly from mitochondrial function. Any incidence of mitochondrial dysfunction inevitably results in neurodegeneration. Therefore, mitochondrial autophagy (mitophagy) plays an integral role in the onset of neurodegenerative diseases as the instance and failure of these pathways can have destructive effects on cellular homeostasis.

Previous studies show significant association between neurodegenerative disorders and mitochondrial dysfunction and abnormal mitophagy. Abnormal mitophagy leads to the accumulation of protein aggregates and consequential neurodegeneration. Future treatments for neurodegenerative disorders could involve drugs targeting mitochondria and autophagy-related proteins and enzymes. This review discusses the involvement of mitochondrial and autophagy dysfunction in neurodegenerative disorders specifically focusing on Alzheimer’s, Parkinson’s, and Huntington’s disease. Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2018-12/bsp-aam122618.php

 

 

This article by Dr. Ashutosh Kumar et al. is published in CNS & Neurological Disorders – Drug Targets, Volume 17, Issue 9, 2018. The article is Open Access till 31st January, 2019. To obtain the article, please visit: http://www.eurekaselect.com/164678

CALL FOR PAPERS | Thematic Issue for Current Alzheimer Research

Special Thematic Issues | Forthcoming Issues

Journal: Current Alzheimer Research

Guest Editor(s): Keshen Li
Tentative Publication Date: July, 2019

 

Systems Genetics of Alzheimer’s disease: From GWAS to
Disease Pathways

 

Alzheimer’s disease (AD) is the most common dementia and neurodegenerative disease in the elderly. AD is highly heritable and complex. In recent years, genetic studies especially genomewide association studies (GWAS) and next-generation sequencing have identified several AD risk variants and pathways associated with the potential pathogenesis and genetic mechanisms of AD. Until now, more than 20 risk loci that affect AD have been identified. These loci are estimated to explain about 28% of the heritability of liability, 30% of familial risk, and over 50% of sibling recurrence risk of developing AD. Despite these successes, the majority of genetic risk remains to be further identified. The identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. In the post-genome era, the major challenge is to mine novel disease risks from multi-level omics data using system biology methods, which may expand our knowledge of the causes of AD. Therefore, we propose a Special Issue of the topic ‘Systems genetics of Alzheimer’s disease: From GWAS to disease
pathways’. This special issue will focus on the mechanism of genesis and development of AD, as well as valuable clues for the development of novel therapeutic approaches of AD. We believe the systems genetics will help us move from disease risk loci to disease aetiology. This Special Issue welcomes reviews and original papers covering recent genetic research on AD using system biology methods. For more details please visit: https://bit.ly/2M2i6mo

 

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

Bentham Science Media Partnership | 2nd Global Bioprocessing, Bioanalytics and ATMP Manufacturing Congress

EXPLORING THE NEXT-GENERATION TECHNOLOGIES AND NOVEL MANUFACTURING STRATEGIES ACCELERATING THE EFFICIENT PRODUCTION OF BIOLOGICS AND CELL AND GENE THERAPIES

30+ presentations will be given at the 2019 meeting. Over two days, leaders in biopharmaceutical production will elaborate on their research into innovative manufacturing strategies for complex biotherapeutics and advanced therapies by exploiting new technologies. There will be a focus on overcoming bottlenecks within the manufacturing process, efficiency and maintaining high-quality standards. As well as assessing the manufacturing processes and regulatory challenges for biologics, the congress also features a track dedicated to the complex manufacturing of cell and gene therapies. To know more about the conference, please visit: http://www.global-engage.com/event/bioprocessing-bioanalytics/

Bentham Science is offering 20% discounts on purchasing eBooks and subscriptions on Journals to delegates attending the conference. TO AVAIL, QUOTE “BSPCNF2019” at www.eurekaselect.com or email at faizan@benthamscience.net

 

Infographics | All about Cloning

Shared by HayleyMoore

Category: Science

Science Alert | For The First Time, DNA Has Been Edited With CRISPR in Space

 

The goal wasn’t to create super space yeast. The astronauts were studying how DNA repair mechanisms work in space, so they snipped through strands of the fungus’s genetic code in a number of places to mimic radiation damage.

“The damage actually happens on the space station and the analysis also happens in space,” said Emily Gleason of miniPCR Bio, the company that designed the DNA lab aboard the ISS. “We want to understand if DNA repair methods are different in space than on Earth.”

Space is actually a pretty hazardous place, and radiation is one of the biggest concerns.

Although at its average altitude of 408 kilometres (253 miles) the ISS is still protected by Earth’s magnetic field, in six months onboard, on average the astronauts are subjected to around 30 times the radiation a human receives in a year on Earth.

It’s well documented that space radiation puts ISS astronauts at risk for radiation sickness, as well as raising long-term risk for cancer, degenerative diseases and central nervous system problems.

For a mission to Mars, which would be a lot longer than six months spent outside Earth’s protective bubble, the radiation hazard increases. So figuring out how DNA repairs itself from radiation damage could be incredibly useful.

Humans may not be able to burp properly in space, but we can now edit a genome. For the first time, astronauts aboard the International Space Station (ISS) have used CRISPR-Cas9 to edit the DNA of brewer’s yeast. To read out more, please visit: https://bit.ly/2HYWjqc

 

Bentham Science Free Trial in King Faisal University | Extended Free Trial ends on August 22, 2019

 

King Faisal University (KFU) is a public university with the main campus in the city of Hofuf in Al Ahsa, Saudi Arabia founded in 1975. KFU was initially established with four colleges: two in Dammam and the other two in Al-Ahsa. Later, the colleges in Dammam have been segregated to become the University of Dammam.

The university was founded in 1975 by the Royal Decree No. H / 67 1395 e in the eastern region of the country. In its first year, it leased buildings, and in subsequent years it used some prefabricated buildings for the colleges.

The first four scientific colleges were: The College of Agricultural and Food Sciences and the College of Veterinary Medicine and Animal Husbandry at the main campus in Al Ahsa; and the College of Architecture and Planning and the College of Medicine and Medical Sciences in Dammam. In later years, with the intent to meet the future needs of the Kingdom, with the issuance of Royal decree No. 7 / b / 11155, and with the consent of the Custodian of the Two Holy Mosques and the Chairman of the Board of Higher Education, the College of Education was founded in 1981, and the Faculty of Administrative Sciences and Planning in 1984. The teaching hospital, the King Fahd University Hospital, is in Khobar, although a newer hospital is currently under construction near the main campus of the university.

One of the main goals of the university was in the area of scientific research to be one of the basic requirements so as to address the problems of society. Since its inception, and through years of development, the university has sought to revitalize and strengthen scientific research in various fields and disciplines through intensive activity carried out by colleges and research centers, as well as through coordination with other centers from outside the university, the university has completed more than forty national research projects.^[3] It has also published more than 2,000 scientific articles in domestic and international scientific journals.

The university also developed and modernised its curriculam, study plans and educational programmes in all colleges to be consistent with the requirements of the Saudi society, as well as to cope with the latest scientific and technical developments.

 

 

eBooks Press Release — NEWS | Bentham Science Publishes New Edition Of Higgin’s Organ Donation Guide

 

Advances in the science of immunology have improved the success rate of organ transplantations since the mid twentieth century. Organ transplantation is now a lifesaving medical procedure for thousands of patients around the world with end-organ diseases.

The lifesaving potential of transplantation has been limited by the number and quality of appropriate organ donors. The evolution of brain death criteria by the Harvard Ad-Hoc Committee Report has opened the door to understanding the importance of medical, legal and ethical challenges of organ donation in support of the growth of the transplant science. The possibility of organ donation from living donors has enhanced organ availability for patients with kidney failure. Modern inotropes and immunosuppression regimens have been critical to the success of other organ transplant procedures. However, the cornerstone of successful transplantation continues to be the appropriate selection, evaluation, preservation of organ tissues and the successful surgical procurement process to mitigate the impact of tissue ischemia and reperfusion.

In the multi-organ donor: a guide to selection, preservation and procurement, the art and science of organ donation and tissue preservation is examined. Through this authoritative text by leaders in the field, the editors provide a state of the art review of modern preservation techniques, patient selection and screening criteria, as well as best practices for multi-organ procurement. Information presented in the book will familiarize readers with the initial steps of determining organ availability which ultimately enables health care professionals to realize the extraordinary potential of successful multi-organ transplant procedures. This guide is intended to be a fundamental resource for students, residents, faculty and staff for all disciplines allied to health care delivery and organ donation. To read out more, please visit: https://ebooks.benthamscience.com/press-releases/19012101/