CALL FOR PAPERS | Thematic Issue for Current Alzheimer Research

Journal: Current Alzheimer Research

Guest Editor(s): Keshen Li
Tentative Publication Date: July, 2019


Systems Genetics of Alzheimer’s disease: From GWAS to
Disease Pathways


Alzheimer’s disease (AD) is the most common dementia and neurodegenerative disease in the elderly. AD is highly heritable and complex. In recent years, genetic studies especially genomewide association studies (GWAS) and next-generation sequencing have identified several AD risk variants and pathways associated with the potential pathogenesis and genetic mechanisms of AD. Until now, more than 20 risk loci that affect AD have been identified. These loci are estimated to explain about 28% of the heritability of liability, 30% of familial risk, and over 50% of sibling recurrence risk of developing AD. Despite these successes, the majority of genetic risk remains to be further identified. The identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. In the post-genome era, the major challenge is to mine novel disease risks from multi-level omics data using system biology methods, which may expand our knowledge of the causes of AD. Therefore, we propose a Special Issue of the topic ‘Systems genetics of Alzheimer’s disease: From GWAS to disease
pathways’. This special issue will focus on the mechanism of genesis and development of AD, as well as valuable clues for the development of novel therapeutic approaches of AD. We believe the systems genetics will help us move from disease risk loci to disease aetiology. This Special Issue welcomes reviews and original papers covering recent genetic research on AD using system biology methods. For more details please visit:


Email here to submit your paper:



Author: Bentham Science

Bentham Science is a leading publishing company in the field of science, technology, and medicine. Established in 1992, the company has grown to become one of the most reputable and respected publishers in the scientific community. Bentham Science publishes more than 100 online and print journals, along with over 300 eBooks and over 2000 reference works. These publications cover a wide range of topics, including pharmaceutical sciences, biotechnology, chemistry, engineering, and more. In addition to its publications, Bentham Science also provides various services to the scientific community, including manuscript editing, article formatting, and language polishing. The company is committed to promoting scientific research and discovery by providing a platform for researchers to share their work with a wider audience. Bentham Science's reputation for excellence is built on a commitment to quality, integrity, and innovation. Its editorial team consists of experts in their respective fields who ensure that all publications are rigorously peer-reviewed and meet the highest standards of scientific accuracy. Overall, Bentham Science is an invaluable resource for scientists, researchers, and academics who are looking to stay up-to-date on the latest developments in their fields. With its wide range of publications and commitment to quality, the company is poised to remain a leader in the scientific publishing industry for years to come.

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