Press Release | Dose-dependent effects of esmolol-epinephrine combination therapy in myocardial ischemia

 

The article by Dr. Tobias Eckle et al. is published in Current Pharmaceutical Design, Volume 25, 2019. The complete paper is published in Current Pharmaceutical Design. Please visit the following link to access the paper: http://www.eurekaselect.com/node/172732/article/dose-dependent-effects-of-esmolol-epinephrine-combination-therapy-in-myocardial-ischemia-and-reperfusion-injury

 

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Epinephrine has been included in resuscitation guidelines worldwide since the 1960s. It is believed that epinephrine increases the chance of restoring a person’s heartbeat and improves long-term neurological outcome through increasing coronary and cerebral perfusion pressure. However, recent studies have raised doubts about the benefit of epinephrine regarding neurological outcomes in cardiac arrest. Moreover, epinephrine use in the stabilization of a cardiogenic shock in post-myocardial infarction patients has been found to increase the incidence of refractory shock. In fact, beta-adrenergic receptor stimulation has been suggested to have deleterious effects as stimulation of this pathway increases oxygen consumption and reduces sub-endocardial perfusion. In contrast, esmolol, a cardio-selective β1-blocker, has been shown to provide cardioprotection after myocardial ischemia in animal and human studies. Therefore, esmolol co-administration with epinephrine may help to reduce epinephrine-reperfusion injury but maintain esmolol-cardioprotection and epinephrine mediated increases in chronotropy and inotropy. Indeed, recent studies in animals have uncovered beneficial effects of epinephrine and esmolol co-administration in a cardiac arrest model. Based on these findings, Dr. Tobias Eckle and his team at the University of Colorado School of Medicine, University of Colorado have investigated esmolol-epinephrine combination therapy in a mouse model of myocardial ischemia and reperfusion injury.

Comparing different esmolol doses in combination with epinephrine in a mouse model of myocardial infarction, Eckle’s team demonstrated that at a specific esmolol-epinephrine ratio (15:1), esmolol-cardioprotection and epinephrine β1 mediated hemodynamic activity can both simultaneously exist during myocardial ischemia and reperfusion injury. “These findings might have implications for current clinical practice in the treatment of patients with cardiogenic shock or cardiac arrest”, says Eckle. “In fact, a cardiogenic shock after myocardial ischemia disallows the use of esmolol due to hemodynamic instability.” Interestingly, a definite recommendation for a specific catecholamine regimen in cardiogenic shock is lacking.

Combination therapy of epinephrine with esmolol seems less intuitive in cardiogenic shock after myocardial ischemia according to the research; higher esmolol doses could compromise epinephrine mediated increases of cardiac output via β1 adrenergic receptor inotropic and chronotropic effects, or higher epinephrine doses could compromise esmolol mediated cardioprotection via β1 adrenergic receptor blockade. Surprisingly, by increasing the esmolol dose, the study team was able to restore esmolol-cardioprotection while heart rate and some blood pressures in the early reperfusion phase were significantly increased compared to an esmolol treatment alone. “This finding is novel and highlights that esmolol cardioprotection is not fully understood,” says Eckle. Having increased heart rates, which is β1 mediated, and at the same time seeing cardioprotection via esmolol β1 blockade, indicates that only a part or short-term blockade of β1 receptors is necessary for the salutary effects of esmolol in myocardial ischemia and reperfusion injury.

While some clinicians occasionally use esmolol in patients on epinephrine infusion due to cardiogenic shock going off cardiac bypass to treat epinephrine-induced arrhythmias, no study to date has evaluated potential cardioprotective effects of esmolol-epinephrine co-administration during cardiac bypass surgery or a cardiogenic shock. As this is the first animal study on epinephrine-esmolol co-administration during myocardial ischemia and reperfusion injury, further studies in larger animals using multiple dosing protocols are suggested. Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2019-07/bsp-deo070219.php

Editors Choice Article | Thermal Performance of Electrochromic Smart Window with Nanocomposite Structure under Different Climates in Iran

 

Journal Name: Micro and Nanosystems

Author(s): Siamak Hoseinzadeh*.

 

Graphical Abstract:

 

Abstract:

Objective: This study investigated the optimization of thermal energy consumption using electrochromic components with a new nanocomposite layer (WO3+Ag) in a larger size (window) for a room with an educational application for five cities with different climatic conditions in Iran (Yazd, Tehran, Bandar Abbas, Tabriz, and Sari).

Materials and Methods: For this simulation platform, the software was implemented in Energy Plus. This feasibility study was modeled by DesignBuilder software which reported reduced thermal energy consumption across all climates in Iran (hot and dry, warm and semi-humid, warm and wet, moderate and dry, and mild and humid.). Four strategies were considered for better comparison. The first strategy used for common double-glazed windows, while the second to fourth strategies involved the use of the electrochromic window in three different modes; bleached mode (Off), colored mode (On), and switchable mode (controlled below comfort conditions).

Results: The third and fourth strategies indicated a reduction in thermal energy consumption in different climates from 25 to 45% relative to typical windows. The best result of cooling energy consumption was observed in Tehran.

Conclusion: For this climate, the average energy consumption dropped to 34% for the warm months of the year and even 42% for the warmest month of the year (August). To read out more, please visit: http://www.eurekaselect.com/170061/article

New Issue | Current Catalysis; Volume 8 Issue 1

 

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Current Catalysis is an international peer-reviewed journal, which publishes original research, full-length reviews/ mini reviews and thematic issues in all core areas of catalysis including theoretical, experimental and applied research. The scope includes heterogeneous catalysis, homogeneous catalysis, bio-catalysis, synthesis and properties of new catalysts including synthesis and catalytic function of novel inorganic solids and complexes, studies that relate catalytic function to fundamental chemical processes in metal complexes and at surfaces, novel concepts in surface chemistry, preparation, activation, aging, deactivation, rejuvenation, regeneration of commercially interesting model catalysts, techniques, adsorption

 

Articles from the journal: Current Catalysis; Volume 8 Issue 1:

 

For details on the articles, please visit this link: http://www.eurekaselect.com/node/700/current-catalysis/issue/8/2551/1/9089

Become Bentham Ambassador | Current Nutraceuticals

 

Become-an-Ambassador

 

The Journal Current Nutraceuticals is interested in appointing active Bentham Ambassador on the Journal’s Board. If you are working in the related field as of the journal and are interested in becoming an Ambassador, please send us your CV. If, however, the scope of the journal is not directly related to your field, you may, if you wish, also recommend some young researchers as “Associate Bentham Ambassadors” to magnify this effort, and, if possible, send their CV.

Mention in the subject line, the field of interest and send your CV at: hermain@benthamscience.net and CC: faizan@benthamscience.net

 

Benefits available to Bentham Ambassadors

Bentham has developed a comprehensive system of rewards and benefits for Bentham Ambassadors some of which are mentioned below:

1.  As a Bentham Ambassador, you would have the possibility of having your article(s) published as Open Access in any Bentham Science journal of your choice (once you have earned enough points to avail this facility). For a listing of journals please refer to http://benthamscience.com/

2.  You would have the possibility to get complementary online access to any three selected Bentham eBooks (http://ebooks.benthamscience.com/) for one calendar year.

3.  The most active Ambassadors can avail discounts on conferences supported by Bentham in respect of registration fee.

4.  You will also receive a souvenir (such as tie, collar logo, or pure leather wallet bearing the Bentham logo).

5.  Your name and affiliation will be mentioned on a dedicated Bentham Ambassadors web page which will help you in your promotional activities as your position will be visible for all to see.

6.  As a Bentham Ambassador you will also be entitled to avail a 25% discount on all Bentham Science content as well as various other Bentham services like Quick Track, Open Access plus, e-prints/reprints, color figures, figures enhancement services, etc.

http://www.benthamambassadors.com/

Become a Reviewer | NEW JOURNALS 2020

 

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BECOME A REVIEWER FOR THE FOLLOWING JOURNALS, NEW IN 2020!

NEW JOURNALS

Current Chinese Medical Science
Current Chinese Chemistry
Current Chinese Computer Science
Current Chinese Engineering Science
Journal of Photocatalysis
Venoms and Toxins
Current Nutraceuticals 
Current Dentistry

Bentham Science is interested in appointing active Reviewers on the Board for the journal’s listed below. If you are working in the related field as of the journals and are interested in becoming Reviewers, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at: hermain@benthamscience.net and CC: faizan@benthamscience.net

Become an Editorial Board Member (EBM) | NEW JOURNALS IN 2020

 

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BECOME A EDITORIAL BOARD MEMBERS (EBM) FOR THE FOLLOWING JOURNALS, NEW IN 2020!

NEW JOURNALS

Current Chinese Medical Science
Current Chinese Chemistry
Current Chinese Computer Science
Current Chinese Engineering Science
Journal of Photocatalysis
Venoms and Toxins
Current Nutraceuticals 
Current Dentistry

Bentham Science is interested in appointing active Editorial Board Members (EBM) on the Board for the journal’s listed below. If you are working in the related field as of the journals and are interested in becoming an Editorial Board Members, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at: hermain@benthamscience.net and CC: faizan@benthamscience.net

 

 

Bentham Science Free Trial in Showa Pharmaceutical University | Free Trial ends on 13th November, 2019

 

FREE-TRIAL

 

It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Showa Pharmaceutical University. The trial subscription covers access to Bentham Science journal content.

Bentham Science uses the platform; Eurekaselect (our proprietary platform) for offering journal trials. The trial has been activated on Eureka

Members of your library can view all Bentham Science journal issues (2000-2019) in full text, via the following URL: www.eurekaselect.com

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Eureka Select: http://www.eurekaselect.com/bypublication

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

 

 

Science Alert | This Photo Is Black And White. Here’s The Science That Makes Your Brain See Colour

 

A bizarre and brilliantly effective optical illusion going viral on the internet tricks your brain into seeing a colour image… but if you look closer, you’ll notice the photo you’re staring at is only black and white.

“An over-saturated coloured grid overlaid on a grayscale image causes the grayscale cells to be perceived as having colour,” Kolås explains on his Patreon page.

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So what’s going on here to make our brains actually interpret this black-and-white picture as if it’s full colour image?

According to vision scientist Bart Anderson from the University of Sydney, the effect we’re seeing in this illusion isn’t particularly surprising.

“The colour system is what vision scientists refer to as ‘low pass’, i.e., many of the receptive fields that code colour are quite large,” Anderson told ScienceAlert.

“So the grids get ‘averaged’ with the achromatic background, which then gets attributed to that part of the image.”

In other words, our brain kind of compresses visual information when we look at things, giving us an overall impression of what’s there if we don’t take the time to examine objects closely.

If you’ve seen this illusion doing the rounds, you might notice this isn’t the main image being shared.

Some of the people in that photo hadn’t given permission for it to be shared online, and Kolås has asked for it not to be used, which is why we’ve put up one of his other examples instead.

The illusion isn’t just created by using coloured grids, either. While Kolås finds grids offer the best effect, he’s also played around with other ways of achieving the visual trick, using alternatives like dots and lines:

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“The raster of dots gives a nice analogy to half-toning as used in print, where colour assimilation aids the optical mixture of colours that already happens before our visual system gets involved,” Kolås explains on his Patreon page.

And here’s an example using lines to create the same effect:

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And another:

Another one, with horizontal lines instead of a grid.

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Most impressively of all, the way this illusion works doesn’t seem to require static images.

In the video below, Kolås shows how even full-motion video with the grid overlay is able to trick the brain into thinking its seeing a colour image, all by virtue of the ‘low pass’ way our visual system attributes colour:

 

To read out more, please visit: https://bit.ly/33feqSB

New Issue | Central Nervous System Agents in Medicinal Chemistry; Volume 19 Issue 2

 

Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents.

Containing a series of in-depth/mini reviews, original research articles, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.

 

CNSAMC

Articles from the journal: Central Nervous System Agents in Medicinal Chemistry; Volume 19 Issue 2:

 

 

For details on the articles, please visit this link: http://www.eurekaselect.com/node/613/central-nervous-system-agents-in-medicinal-chemistry-/issue/19/2536/2/9203

eBook | Improved Indirect Power Control (IDPC) of Wind Energy Conversion Systems (WECS)

 

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BY

FAYSSAL AMRANE, AZEDDINE CHAIBA

 

During the past decade, the installed wind power capacity in the world has been increasing more than 30%. Wind energy conversion system (WECSs) based on the doubly-fed induction generator (DFIG) dominated the wind power generations due to the outstanding advantages, including small converters rating around 30% of the generator rating, lower converter cost.

Due to the non-linearity of wind system, the DFIG power control presents a big challenge especially under wind-speed variation and parameter’s sensibility.

To overcome these major problems; an improved IDPC (Indirect Power Control); based on PID “Proportional-Integral-Derivative” controller, was proposed instead the conventional one (based on PI), in order to enhance the wind-system performances in terms; power error, tracking power and overshoot. Unfortunately using robustness tests (based on severe DFIG’s parameters changement); the wind-system offers non-satisfactory simulation results which were illustrated by the very bad power tracking and very big overshoot (> 50%).

In this context; adaptive, robust & intelligent controllers were proposed to control direct & quadrature currents (Ird & Irq) under MPPT (Maximum Power Point Tracking) strategy to main the unity power factor (PF≈1) by keeping the reactive power at zero level. In this case, the new IDPC based on intelligent controllers offered an excellent wind-system performance especially using robustness tests, which offered a big improvement especially using Type-1 Fuzzy Logic Controller (T1-FLC), Type-2 Fuzzy Logic Control (T2-FLC; is the New class of fuzzy logic) & Neuro-Fuzzy Logic (NFC).

In this sense, I think that this edited book is an important contribution to help students already in mastery of the basis of power electronic circuits and control systems theory to achieve these pedagogical goals. The proposed book describes with easy manner the modeling & control of Wind-turbine DFIG in order to control the stator powers using different topologies of robust, adaptive and intelligent controllers.

The book present numerous intelligent control techniques that help in the control design of the DFIG wind-system (WT).

The textbook “Improved Indirect Power Control (IDPC) of Wind Energy Conversion Systems (WECS)” proposes a collection of concepts, organized in a synergic manner such that to ease comprehension of the WT control design.

The book’s contribution goes towards completing the already existing literature by offering a useful integration of control techniques, worthy to be read, understood and employed in the various WT applications. Please enjoy reading this book. Read out the full version here.

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