Animated Abstract | A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration


Journal Name: Current Topics in Medicinal Chemistry

Author(s): Bo Lu, Xue-Hui Liu, Si-Ming Liao, Zhi-Long Lu, Dong Chen, Frederic A. Troy II, Ri-Bo Huang*, Guo-Ping Zhou*.


Graphical Abstract:


Animated Abstract:





Polysialic acid (polySia) is a novel glycan that posttranslationally modifies neural cell adhesion molecules (NCAMs) in mammalian cells. Up-regulation of polySia-NCAM expression or NCAM polysialylation is associated with tumor cell migration and progression in many metastatic cancers and neurocognition. It has been known that two highly homologous mammalian polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST), can catalyze polysialylation of NCAM, and two polybasic domains, polybasic region (PBR) and polysialyltransferase domain (PSTD) in polySTs play key roles in affecting polyST activity or NCAM polysialylation. However, the molecular mechanisms of NCAM polysialylation and cell migration are still not entirely clear. In this minireview, the recent research results about the intermolecular interactions between the PBR and NCAM, the PSTD and cytidine monophosphate-sialic acid (CMP-Sia), the PSTD and polySia, and as well as the intramolecular interaction between the PBR and the PSTD within the polyST, are summarized. Based on these cooperative interactions, we have built a novel model of NCAM polysialylation and cell migration mechanisms, which may be helpful to design and develop new polysialyltransferase inhibitors. To know more about our Animated Abstract, please visit:

Author: Bentham Science

Bentham Science is a leading publishing company in the field of science, technology, and medicine. Established in 1992, the company has grown to become one of the most reputable and respected publishers in the scientific community. Bentham Science publishes more than 100 online and print journals, along with over 300 eBooks and over 2000 reference works. These publications cover a wide range of topics, including pharmaceutical sciences, biotechnology, chemistry, engineering, and more. In addition to its publications, Bentham Science also provides various services to the scientific community, including manuscript editing, article formatting, and language polishing. The company is committed to promoting scientific research and discovery by providing a platform for researchers to share their work with a wider audience. Bentham Science's reputation for excellence is built on a commitment to quality, integrity, and innovation. Its editorial team consists of experts in their respective fields who ensure that all publications are rigorously peer-reviewed and meet the highest standards of scientific accuracy. Overall, Bentham Science is an invaluable resource for scientists, researchers, and academics who are looking to stay up-to-date on the latest developments in their fields. With its wide range of publications and commitment to quality, the company is poised to remain a leader in the scientific publishing industry for years to come.

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