Spanish Society of Pharmacology (SEF) partners with Bentham Science Publishers

Bentham Science has entered into a collaboration with Spanish Society of Pharmacology (SEF) for our High Impact journals including Current Neuropharmacology (JCR IF: 7.36), Current Medicinal Chemistry (JCR IF: 4.53), Current Topics in Medicinal Chemistry (JCR IF: 3.295), and Current Pharmaceutical Design (JCR IF: 3.116). This collaboration facilitates members of the society to publish their research in Bentham journals with significant concessions.

The SEF was founded in 1972 to bring together all Spanish pharmacologists, in order to facilitate organizing scientific meetings (an annual meeting at the national level) with the aim of promoting scientific and social exchange among Spanish pharmacologists as well as joint meetings with other Pharmacology Societies within the framework of the International Pharmacology Association and the European Pharmacology Association (IUPHAR and EPHAR). The Society represents researchers in national and international organizations, helps networking at scientific and technical meetings, awards scholarships and prizes to stimulate pharmacological research in Spain. In addition, it manages the operation of different working committees reviewing specific issues in pharmacology and allied research.

Bentham Science Publishers is a major international science, technology, and medical publisher, providing academic researchers and industrial professionals with the latest information in diverse fields of science and technology. Our peer-reviewed scholarly journals and books have an ever-increasing readership of millions of researchers worldwide.

Bentham Science currently publishes more than 130 journals in both electronic and printed formats. Our journals cover various disciplines in pharmaceutical research and development, medical subspecialties, engineering, technology, and social sciences. The journals are indexed in recognized indexing agencies and Information on our journals’ indexation, by various indexing agencies, can be viewed at

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Remedial and Environmental Chemistry

Experimental Developments and Models Part II

Editor(s): Tahmeena Khan , Abdul Rahman Khan , Saman Raza , Iqbal Azad and Alfred J. Lawrence

Environmental pollution leads to non-communicable diseases which are a result of chronic exposure to toxic pollutants and environmental chemicals. Climate change, global warming, exposure to allergens, radiation, pathogens etc. merely add to the burden. Increased urbanization and industrialization as well as lifestyle changes cause exposure to hazardous pollutants. Today, diseases like chronic obstructive pulmonary disease, asthma, cancers of the lungs and skin, allergies etc. that have become a severe health risk for humans worldwide, can all be attributed to environmental pollution. Therefore, it has become utmost necessary to restore the environmental balance and also provide remedial measures for associated diseases with the help of latest drug discovery and therapeutic techniques. The first book of the two had introduced and explored the close association and interdependence of medicinal chemistry and environmental chemistry. The present book Medicinal and Environmental Chemistry: Experimental Advances and Simulations further explores the association between these two focal areas, with an aim to provide solutions and curative strategies for the well-being of humans and the environment as a whole. The first chapter of the book is dedicated to air pollution, its causes and health hazards along with general preventive measures. The biochemical aspect of Cytochrome P450 and its association with mitigation strategy upon the exposure of smog on the human body has been explored in the second chapter. The third chapter of the book elaborates the utility of computational modelling for drug discovery and disease progression with respect to COPD. The next two chapters of the book explore water pollution, heavy metal toxicity and remedial measures through chelation therapy and polymeric ceramic composite membrane technology. Experimental techniques like the use of quantification methods for pharmaceuticals and persistent organic pollutants, chemosensors have been dealt with in the following chapters. Nanotechnology is an important field to explore for environment friendly drug discovery and the concept has been explored for the synthesis and use of gold and silver nanoparticles from plant-based sources. Likewise use of bio-isosteric groups in chemical synthesis for effective and improved environmental health has been elaborated in one of the chapters. Antibiotic pollution, its causes and remediation like adjuvant therapy has been explored in the other. An interesting chapter also explains ligand identification for effective drug development through virtual screening, taking the example of COVID-19.

The eleven chapters included in the second part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. This part is more specialized in nature, focusing primarily on the effects of air pollution and water contamination on human health. Chapters covering pharmaceutical interventions and pollution control measures, respectively follow these initial topics.

Part II also features specialized topics that aim to address some unique challenges of the above mentioned problems including antibiotic pollution, pharmaceutical analysis of pollutants, chemosensors, biosteric modifications and new drug development strategies against SARS-CoV2.

This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

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Medicinal and Environmental Chemistry

Experimental Advances and Simulations Part I

Editor:Tahmeena Khan, Abdul Rahman Khan, Saman Raza, Iqbal Azad and Alfred J. Lawrence

This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

With the rise in environmental pollution and degradation, the ecological balance has been disturbed leading to new diseases and an increase in mortality. The novel coronavirus SARS-CoV-2, being the most recent instance, has caused a great loss of human lives all over the world. To date, no concrete medicinal solution has been formulated to tackle the menace caused by the deadly virus which calls for the exploration of novel remediation strategies which are cost and time effective. There are several factors including climate change, which may facilitate the spread of the virus. Global warming is creating an opportunity for pathogens to get into new hosts. Climate change has deadly consequences including the increased risk of pandemic. Pieces of evidence are also showing that the people who are exposed to poor air quality are more likely to suffer. Therefore it is utmost necessary to understand the environmental chemistry and its role in disease spread to come up with accurate and customized medicinal solutions. This book is intended to introduce the concept of environmental and medicinal chemistry to the readers and the interdependence between the two streams through specialized and dedicated chapters. By exploring the association between these two focal areas, the book aims to provide solutions and curative strategies for the well-being of humans and the environment as a whole. The ten chapters included in this book are focused on diverse topics trying to blend the fields of environmental chemistry and medicinal chemistry and have been authored by renowned scientists and academicians from premier research and academic institutions. The book opens with the first two chapters which introduces medicinal and environmental chemistry and the various opportunities and challenges the two fields offer. The following two chapters are dedicated to persistent organic pollutants and xenoestrogens and the toxicity caused by them along with remedial solutions. Two of the chapters are focused on heavy metal toxicity in diet and plastics and the potent risks associated with it. The last few chapters are dedicated to effective drug designing principles and natural compounds with therapeutic potential. The medicinal perspective is explored for remediation of environmental hazards, ranging from the therapeutic strategies available to the design of new and safer drugs, through experimental and simulation approaches. To further elaborate the importance of safe chemical practice, the concept of green chemistry has also been introduced along with some environment-friendly solvents and drugs to address ecotoxicity. Few chapters have also been dedicated to computational drug designing and in-silico predictions to make futuristic and accurate predictions to assist efficient drug discovery. The book will prove beneficial for academicians, students of environmental chemistry, pharmacy, researchers, scientists, computational chemists, pharmacologists, environmentalists, policymakers and postgraduate students. It would also provide researchers and medicinal chemists, information about the latest research done and the modern techniques used to develop more effective and safer drugs that would not be harmful to the environment. In this way, the proposed book would be highly beneficial to the audience it hopes to cater to.

The ten chapters included the contributions from more than 30 experts, in the first part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. 

Specialized chapters have been included in the book about persistent organic pollutants, heavy metal and plastic pollutants, the effect of environmental xenoesterogens on human health and the potential of natural curing agents to combat ecotoxicity.

This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.


Scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels; readers interested in occupational medicine, environmental health and environmental toxicology.

About the Editor:

Dr. Tahmeena Khan is currently working as an Assistant Professor, in the Department of Chemistry, Integral University. A gold medalist in her master’s course, she holds a specialization in Inorganic Chemistry. She specialized in Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging for her M.Phil. and worked on automated 3D structure determination of proteins for dissertation. For her doctoral degree, she worked on mixed ligand-metal and mixed metal-ligand complexes of thiosemicarbazones and their therapeutic properties. She holds thirteen years of teaching experience and has supervised several dissertations of M.Sc. students. She has a number of research papers and chapters to her credit, and has edited conference proceedings. She is also a life member of several academic bodies. Her other areas of interest include computer aided drug designing and environmental contaminants’ assessment and remediation.


Environmental Xenoestrogens, Persistent Organic Pollutants,  Ecotoxic Carcinogens, Environmental Toxicology, Green Chemistry, Environmental Risk Assessment

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Limitations in Anti-Infective Agents.

Editors: Parvesh SinghVipan KumarRajshekhar Karpoormath

Book Name: Frontiers in Anti-infective Agents

Frontiers in Anti-Infective Agents Volume 5 is a collection of notable research efforts, successful anti-infective drug development programmes and a comprehensive overview of the successes and failures of recent clinical trials in this domain. The volume covers interesting topics: 1) the treatment of acute wounds with the vikut® formula, 2) anti-infective treatment of ocular diseases and 3) sars-cov vaccine development and antimicrobial therapy for SARS symptoms. A chapter summarizing recent anti-infective approaches rounds up the contents of this volume.

This volume is a timely reference for postgraduate scholars and researchers seeking updates in specific areas of anti-infective drug development. Allied healthcare professionals (clinical and public healthcare professionals) can also benefit from the information presented within.

Audience:Postgraduate scholars, researchers studying anti-infective drug developments; Allied healthcare professionals involved in the administration of anti-infective agents.

About the Editors:

Parvesh Singh

Dr. Parvesh Singh is an NRF-rated researcher in the School of Chemistry and Physics (SCP) at the University of KwaZulu-Natal (UKZN), Durban (South Africa). After completing his Ph.D. degree (Organic Chemistry), in 2006, from the Guru Nanak Dev University (India), Dr. Singh joined a pharmaceutical company (Jubilant Organosys) as a Research Scientist and then moved to South Africa to pursue his Post-doctoral studies at the Durban University of Technology. In 2014, Dr. Singh was appointed as a Senior Lecturer at UKZN and then promoted to Associate Professor in the same institution. Dr. Singh’s research primarily focuses on the synthesis of heterocyclic scaffolds and their biological testing and molecular modelling studies. Dr. Singh is a recipient of a prestigious DST-NRF Free-standing fellowship and has been featured as one of the emerging researchers in South Africa by the National Research Foundation (NRF). He has also been a recipient of top University and College research awards on several occasions. He has co-authored more than 100 research papers in top tier international journals and serving as an editorial board member and ambassador for several reputed publishers.

Vipan Kumar

Dr. Vipan Kumar Ph.D. has been working as an Assistant Professor in the Department of Chemistry, Guru Nanak Dev University, Amritsar, since 2009. He obtained his Ph.D. with Prof. Mohinder P Mahajan in the Department of Applied Chemistry, GNDU. In 2007, he moved to the University of Cape Town (UCT), South Africa, to pursue his post-doctoral studies with Prof. Kelly Chibale. In 2015, he was awarded a research fellowship from Carl Tryggers research foundation, Sweden to carry out research at University of Umea, Sweden. His research interests include the development of diverse synthetic protocols for the synthesis of novel molecular frameworks targeting tropical infections. He has also been engaged in the utilization of b-lactam synthon protocols for the synthesis of functionally decorated and biologically relevant heterocycles with medicinal potential.

Rajshekhar Karpoormath

Prof. Rajshekhar Karpoormath graduated with his Ph.D. (2013) from the School of Chemistry and Physics, University of KwaZulu-Natal (UKZN), Durban, South Africa. He is currently an Associate Professor and Academic Leader of Research in the College of Health Sciences, UKZN.  He is also a nationally recognized rated researcher by National Research Foundation-South Africa (NRF-SA). Prof Karpoormath started his independent research carrier in 2014 and established a research group, Synthetic and Medicinal Chemistry Research Group (SMCRG), at UKZN. Over the years, he has successfully secured several national and institutional grants and has established a well-equipped Drug Discovery Laboratory at UKZN. His research work is focused on target-based drug design and synthesis, Methodology development, and development of nanomaterial-based electrochemical biosensors. Since 2014, his research group has published more than 100 peer-reviewed articles in international journals, four book chapters, and two patents. He has successfully graduated 23 postgraduate students (12 Ph.Ds. and 11 Masters) since 2014. He is one of the top researchers at UKZN and was the recipient of several awards in recognition of his achievements.   


Antibiotic administration in pregnancy, SARS-COV-2, Vikut® formula, antivirals, antimicrobials, evere acute respiratory syndrome, vaccine technology, Natural Products, Tuberculosis drugs, Phage Therapy, Quorum sensing, Leptospirosis, ocular infections

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Trefftz and Essential Solution-Based Finite Element Methods

Editor Name: Qing-Hua Qin

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This reference explains hybrid-Trefftz finite element method (FEM). Readers are introduced to the basic concepts and general element formulations of the method. The book consists of two major parts: Part I Trefftz FEM and Part II fundamental solution based FEM. In the first part, Chapter 1 gives an introduction and overview of the hybrid-Trefftz FEM. Followed by topics on non-homogeneous parabolic problems, thermal analysis of composites, and heat conduction in nonlinear functionally graded materials. A brief summary of the fundamental solution based-FEM is also presented followed by a discussion on axisymmetric potential problems and the rotordynamic response of tapered composites. The book is rounded by chapters which cover the n-sided polygonal hybrid finite elements and analysis of piezoelectric resources. It includes solutions to problems in the numerical analysis of different material types and solutions to some problems encountered in civil engineering (seepage, heat transfer, etc).

This reference is suitable for Scholars at graduate and postgraduate levels in mathematics, civil engineering and materials science. Professionals involved in developing analytical tools for materials and construction testing can also benefit from the methods presented in the book.

About the Editor:

Qing-Hua Qin

Dr. Qing-Hua Qin is a Professor at Shenzhen MSU-BIT University. He received his Bachelor of Engineering degree in mechanical engineering from Chang An University and earning his Master of Science degree and PhD degree from Huazhong University of Science and Technology (HUST) in China. Both MS and PhD are in applied mechanics. He has worked in several leading Australian and Chinese institutions and was awarded a Queen Elizabeth II fellowship and professional fellowship at the University of Sydney. He was also awarded a Cheung Kong Professorship at Tianjin University from the Ministry of Education of China. His research is interdisciplinary which spans the fundamentals of solid mechanics, computational engineering, materials engineering, manufacturing and machine learning – to application areas such as functional materials, additive manufacturing, topology optimisation and integrating hybrid finite element methods with machine learning. He has published more than 300 journal papers and 8 English monographs in the field of applied mechanics.


Finite element method, Dual Reciprocity Method, Trefftz function, variational principle, Fundamental solution, piezoelectricity, Numerical analysis, Two-dimensional elasticity, functionally graded material, Heat transfer, Special purposed element, n-sided polygonal element, tapered composite shaft, Non-homogeneous parabolic problem.

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Simulations, Systems and Applications of Artificial Intelligence.

Book Name: Artificial Intelligence: Models, Algorithms and Applications

Artificial Intelligence: Models, Algorithms and Applications presents focused information about applications of artificial intelligence (AI) in different areas to solve complex problems. The book presents 8 chapters that demonstrate AI based systems for vessel tracking, mental health assessment, radiology, instrumentation, business intelligence, education and criminology. The book concludes with a chapter on mathematical models of neural networks.

The book is primarily intended for students as it serves as an introductory book about AI applications at undergraduate and graduate levels and as a reference for industry professionals working with AI based systems, Researchers and engineers that are interested in AI and how it may be used to solve concrete problems. The structure of the book is organized as several different topics. We hope that technology developers and companies also find it interesting to be used in industry.

The book focuses on new achievements in AI and how AI may be introduced in different application areas, and how these areas may be changed when AI models and algorithms are used. The aim of this book is to give an introduction to the field of AI, its models and algorithms and how this may be used to solve problems in different application areas.

About the Editor:

Terje Solsvik Kristensen

The editor Terje Solsvik Kristensen is a professor Emeritus of informatics at Western Norway University of Applied Sciences in Bergen, Norway. His main interest is using AI to solve complex problems using machine learning and multi agent systems. His main focus has been in designing algorithms using AI metods and mathematics, for instance the development of algorithms for supervision of autonomous cars in a traffic intersection.


Radiological oncology, Nuclear medicine, surgical oncology, Medical Imaging, Artificial Intelligence, Industry, Radiology, Instrumentation industry, Neural Networks, Image Recognition.

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The Future of Human-Computer Interactions in Smart and Interconnected Environments

Editors: Nirmalya ThakurB.D. Parameshachari

In this era of rapidly advancing technology, the future of living and functional environments would involve humans interacting, coordinating, and collaborating with computers, machines, robots, and various technology-laden systems in a multitude of ways. Examples of such smart and interconnected environments include Smart Homes, Smart Industries, Smart Workplaces, Smart Buildings, and Smart Cities, just to name a few. These two books present discoveries, innovative ideas, concepts, theoretical findings, practical solutions, improvements, and novel applications in Human-Computer Interaction (HCI) aimed at developing trust, user acceptance, enhancing user performance, improving quality of life, and fostering human-technology partnerships in the future of technology-laden living and functional environments.

This book, Part 1 of this 2-part book set, consists of chapters that present approaches for facilitating rich user experiences in multiple healthcare-based applications, results from digital product usability tests conducted with children having atypical development, results from usability testing of Twitter, applications of HCI in healthcare for diagnosis of Rheumatoid Arthritis, approaches to highlight the role of end-user programmers in custom graphical user interface designs for the future of HCI-enhancing devices and a specific application of optimization techniques in artificial neural networks with a human-in-the-loop focus. This book also presents two review chapters related to assistive technologies for the visually impaired and gamified online learning user experience. Each chapter has an abstract and keywords followed by the introduction, methodologies, and other sections. Readers can determine their interest level in any chapter quickly based on the keywords and the abstract. The chapters in this book were contributed by experts in the field of HCI and its interrelated disciplines from 8 different countries – Chile, China, Croatia, India, Iran, Malaysia, Peru, and South Korea.

Human-Computer Interaction and Beyond: Advances Towards Smart and Interconnected Environments is an informative reference for scientists, researchers, and developers in both academia and industry who wish to learn, design, implement, and apply these emerging technologies in HCI in different sectors, with the goal of realizing futuristic technology-driven living and functional smart cities and environments.

About the Editors:

Nirmalya Thakur is currently affiliated with the Department of Electrical Engineering and Computer Science at the University of Cincinnati in Ohio, United States. His research interests include Human-Computer Interaction, Artificial Intelligence, Machine Learning, and Natural Language Processing. He has authored 33 publications in these fields and has received about $60,000 in funding support for his research. By serving as a reviewer for different conferences and journals, he has reviewed more than 360 papers. Nirmalya has received several national and international awards and has also been featured on Yahoo News, Business Insider, IEEE TV, and in different newspapers for his contributions to advancing research in these fields. For more details about his work, please visit:

Parameshachari B.D. is currently working as a Professor and Head in the Department of TCE at GSSS Institute of Engineering & Technology for Women, Mysuru. He is recognized as Research Guide at VTU, Belagavi, and currently, Five Research Scholars are pursuing Ph.D. Degree under his supervision. He was instrumental in establishing collaboration between GSSSIETW and Multimedia University, Malaysia, and University of Sannio, Italy. To add, he was instrumental in establishing the IEEE ITS Bangalore Chapter and the IEEE MYSS under IEEE Bangalore Section. He was the recipient of the IEEE Bangalore Section Outstanding Volunteer Award in 2020. More details can be found on his webpage:


Human-Computer Interaction, Smart Homes, Human Centered Design, Smart Cities, User Centered Design, User Interface, Human Factors, User Interaction, Human Centered AI, Data Science, User Experience, Big Data, Usability, Internet of Things, Artificial Intelligence, Smart Environments, Assistive Technologies, Healthcare, Natural Language Processing, Computer Science.

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Psychological Assessment and Interventions for Individuals Linked to Radicalization and Lone Wolf Terrorism

Author Name: Carlo Lazzari

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In recent times, the phenomenon of lone wolf terrorism has been observed with the social assumption that a radicalized individual is only guided by personal, social, and ethnic reasons to commit an extremist act. Nevertheless, there is still much to understand about this phenomenon and improve the methods of investigation or psychiatric interventions. This handbook attempts to cover gaps in understanding the psychiatric aspects of radicalization and the phenomenon of lone-wolf terrorism. Edited by expert clinical psychologists, the contributors have taken both a qualitative and theoretical route to analyze the phenomenon, prompted by their clinical experience with mental health professionals, being in contact with radicalized people living in local towns and prisons.

Psychological Assessment and Interventions for Individuals Linked to Radicalization and Lone Wolf Terrorism serves as a practical handbook for psychologists, psychiatrists, criminologists, social workers, allied professionals (such as law enforcement officers) and students (in criminology, social science or psychology programs for example) who want to learn about the causes and prevention of terrorism, with a focus on radicalization processes and lone wolf agents.

In this book one can discover that the psychiatry and psychology could provide additional insight into individual radicalization, called the lone wolf phenomenon. As in any other country, our personnel and researchers are from different ethnic backgrounds, giving higher depth to radicalization analysis. We witnessed the multifold aspects that generate political, religious, social, and organizational radicalization in our lands. As experts in mental health, all the researchers who contributed to the current book had regional and international experience in radicalization and lone wolf terrorism. This strong background has allowed us to examine the psychology of radicalization and lone wolf in its multifold aspects, meeting individuals who were radicalized or potential victims of it. We extrapolated our findings to interpret them from the psychiatric perspective, when possible, and expand our observations and make inferences at a broader, interpersonal, social, regional, or global level.

The Introduction is a free exploration of the phenomenon of radicalization and lone wolf terrorism as linked to humankind’s history. As stated in the chapter, any act of perpetrating maltreatment to others with the simple aim of having victims recognized as adversaries of the own ideology or group should be scrutinized as signifying an act of radicalization.

Book Comprises of 6 Chapters. Each Chapter enlightens a new attribute.

Chapter 1 gives a broad social and cultural perspective of the phenomenon of radicalization and terrorism. The traditional interpretations to observe individuals and society under different aspects. We used Delphi groups to interpret social events linked to radicalization. We could identify radicalization and lone wolf phenomena in any social endeavor liberating the definition from boundaries related to the war, conflicts, or inter-ethnic genocides. With a socio-psychiatric diagnosis, we could identify that radicalization is a way of behaving and believing that it is diffuse. Simultaneously, a radicalized act could have different presentations that are more distributed than those classically described in the literature.

Chapter 2 continues in the psychiatric analysis of radicalization and lone wolf terrorism, including children and women. We adopted an ethnographic approach of Internet sources to explore the topic and study how individuals become radicalized, the cognitive routes to accept terrorist ideas, and the impact of radicalization on children and women. How important is a leader in radicalizing the masses? How crucial are interventions of de-radicalization during child development? How do women become radicalized? We tried to answer these questions.

Chapter 3 explores the phenomenology and social psychology of lone wolf radicalization. We tried to identify emotions, behaviors, prejudicial thoughts, and beliefs that could indicate a process of radicalization in the individual.

Chapter 4 explores the instruments of the prevention of radicalization. Using an actuarial, social, psychiatric, and mathematical model, we aimed to deliver the information that some events linked to lone wolf radicalization could be explored by mathematical models and could be somehow prevented.

Chapter 5 represents a further exploration of the psychiatric analysis of lone wolf individuals. Mental-health professionals can help identify and prevent radicalization by robust assessment of people at risk of radicalization. Also, community mental-health practitioners are privileged to detect social signs that indicate a radicalized entourage that might favor potential victims of it, including children.

Chapter 6 explores the methodological basis for the use of psychology in research on radicalization and terrorism. It has a philosophical cut, although it has been created to provide the ground of the assumptions or truth delivered into the book. Besides, the chapter gives some indication of what grounds psychiatric research on radicalization was conducted.

The Appendices report the instrument frequently used by the authors during the assessment of lone-wolves or to guide Delphi-group discussions.

About the Editor:

Carlo Lazzari, MD, is a medical doctor and psychiatrist working in the United Kingdom. He has a particular interest in the study of forensic psychiatry and social factors leading to the emergence of lone-wolf terrorism. Lazzari has published articles in peer-reviewed journals on radicalization and lone-wolf terrorism. He collaborates with several organizations to prevent extremism. He has also operated in conflict areas to reduce factors leading to the radicalization of children and adolescents. In research on radicalization, the author has extended the concept to include less-known aspects of radicalization, including corporate forms of the phenomenon.


Forensic Psychiatry, Psychology of Terrorism, De-radicalization, Terrorism Prevention, Research on Terrorism, re-education, Handbook of the Criminology of Terrorism, Criminology, Ethnography, Focus Groups, Delphi Groups, Psychiatry,  Psychology

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Podcast: A podcast by Dr. Rajnish Srivastava

Research Article: Formulation and Evaluation of α-Pinene Loaded Self-emulsifying Nanoformulation for In-vivo Anti-Parkinson’s Activity

Author(s): Rajnish Srivastava*P.K. ChoudhurySuresh Kumar DevVaibhav Rathore

Journal Name: Recent Patents on Nanotechnology

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Postcast link on YouTube:


Aim: The present study was aimed to developed and optimize the self-nano emulsifying drug delivery system of α-pinene (ALP-SNEDDS) and evaluate its in-vivo anti-Parkinson’s activity.

Background: Different lipid-based drug delivery technologies have been researched to upgrade drug bioavailability and expand their clinical adequacy upon oral administration. Self-emulsifying drug delivery systems (SEDDS) have pulled in developing the interest specifically for self nano emulsifying drug delivery systems (SNEDDS).

Objective: The present work was attempted to improve the bioavailability of the ALP by defining the role of self-nano emulsifying formulations for its neuroprotective effect.

Methods: Miscibility of the ALP was estimated in various excipient components to select the optimized combination. Self-nano emulsification, thermodynamic stability, the effect of dilution on robustness, optical clarity, viscosity, and conductivity tests were performed. The in-vivo anti-Parkinson’s activity of the ALP-SNEDDS formulations were done using Pilocarpine antagonism induced Parkinsonism in rodents. Behavioral tests like tremulous jaw movements, body temperature, salivation, and lacrimation are performed.

Result: Two optimized formulations, composed of Anise oil, Tween 80, and Transcutol-HP of Oil: Smix ratio (4:6 and 3:7) were selected. The Smix ratio for both the formulation was 2:1. The particle size was found to consistent with the increase in dilution. The mean negative zeta potential of the formulations was found to be increased with an increase in dilution. The TEM images of the formulations revealed spherical shape of the droplet. The in-vitro drug release profile was found to be significant as compared to plain ALP suspension.

Conclusion: The results of in-vivo studies indicate that nanosizing and enhanced solubilization of oral ALP-SNEDDS formulations significantly improved the behavioral activities compared to plain ALP suspension.

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Recent Patents on Nanotechnology – Aims and Scope


Recent Patents on Nanotechnology publishes full-length/mini reviews and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of nanotechnology. A selection of important and recent patents on nanotechnology is also included in the journal. The journal is essential reading for all researchers involved in nanotechnology. To know more about the journal, please visit:

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