Testimonial by Gui-Hua Lu!

Gui-Hua Lu

Contributed Article: “Impact of Glyphosate on the Rhizosphere Microbial Communities of An EPSPS-Transgenic Soybean Line ZUTS31 by Metagenome Sequencing

Recently Published Issues – Bentham Science Journals

Clinical Immunology, Endocrine & Metabolic Drugs 3, Issue 2
http://bit.ly/2w51xtF

Current Proteomics 14, Issue 3
http://bit.ly/2jFlR2R

Current Protein & Peptide Science 18, Issue 10
http://bit.ly/2xiGOFG

MicroRNA 6, Issue 2
http://bit.ly/2jIps0j

Recent Patents on Inflammation & Allergy Drug Discovery 11, Issue 1
http://bit.ly/2wsQ9vy

Mini-Reviews in Medicinal Chemistry 17, Issue 14
http://bit.ly/2xuAnj4

recent-issues

Thought of the Day!

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Open Access Article – iTRAQ-based Proteomic Analysis of APPSw,Ind Mice Provides Insights into the Early Changes in Alzheimer’s Disease – Current Alzheimer Research

Journal: Current Alzheimer Research

Author(s): Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-hong Luo, Junyu Xu.

Abstract:

Background: Several proteins have been identified as potential diagnostic biomarkers in imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse models. However, biomarkers for presymptom diagnosis of AD are still under investigation, as are the presymptom molecular changes in AD pathogenesis.

Objective: In this study, we aim to analyzed the early proteomic changes in APPSw,Ind mice and to conduct further functional studies on interesting proteins.

Methods: We used the isobaric tags for relative and absolute quantitation (iTRAQ) approach combined with mass spectrometry to examine the early proteomic changes in hippocampi of APPSw,Ind mice. Quantitative reverse transcription polymerase chain reaction (RT-PCR) and immuno-blotting were performed for further validation. Finally, the functions of interesting proteins β-spectrin and Rab3a in APP trafficking and processing were tested by shRNA knockdown, in N2A cells stably expressing β-amyloid precursor protein (APP).
Results: The iTRAQ and RT-PCR results revealed the detailed molecular changes in oxidative stress, myelination, astrocyte activation, mTOR signaling and Rab3-dependent APP trafficking in the early stage of AD progression. Knock down of β -spectrin and Rab3a finally led to increased APP fragment production, indicating key roles of β-spectrin and Rab3a in regulating APP processing.
Conclusion: Our study provides the first insights into the proteomic changes that occur in the hippocampus in the early stages of the AD mouse model. In addition to improving the understanding of molecular alterations and functional cascades involved in early AD pathogenesis, our findings raise the possibility of developing potential biomarkers and therapeutic targets for early AD.

Highlighted Article – Ag (I) Catalyzed Oxidation of SO2 in Aqueous Solution Differing Effect of Benzoate Ions in Acidic Medium – Current Physical Chemistry

CPC-Articles_7-4-Rashmi Sharma

To access this article, please visit: http://www.eurekaselect.com/152978

Testimonial by Diego de Carvalho Carneiro!

Diego de Carvalho Carneiro

Contributed Article: “Conjugative Post-Translational Modifications for Pharmacological Improvement of Therapeutic Proteins

Upcoming Thematic Issue – Application of Computational Techniques in Pharmacy and Medicine – Current Topics in Medicinal Chemistry

ctmc-THEMATIC FLYER - Qi Zhao

http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/special-issues/

Editor’s Choice – Model Validity in Nanoimmunosafety: Advantages and Disadvantages of In vivo vs In vitro Models, and Human vs Animal Models – Current Bionanotechnology

Journal: Current Bionanotechnology

Author(s): Diana Boraschi, Paola Italiani.

Graphical Abstract:

 

Abstract:

The thorough understanding of the interaction between nanomaterials and the immune system is the starting point both for nanomaterial exploitation in nanomedicine and for the implementation of an effective regulatory framework concerning nanosafety for human health and the environment. In this context, the use of valid models, in vitro and in vivo, is central for assessing both the positive and the detrimental effects of nanomaterials, thereby predicting their possible risks for human and environmental health. Thus, predicting models are sought that allow us on one side defining hazard posed by nanomaterials, and therefore implementing safety regulation and safe-by-design nanotechnologies, and on the other side exploiting nanomaterials for more effective therapeutic and preventive medical strategies. Here, we consider the advantages and limitation of the current in vitro and in vivo human and animal models, and the appropriateness of their use for assessing the effects of nanomaterials on immunity.

Read more here: http://www.eurekaselect.com/142770

Recently Published Issues – Bentham Science Journals

Current Drug Discovery Technologies 14, Issue 3
http://bit.ly/2w2jZTC

Combinatorial Chemistry & High Throughput Screening 20, Issue 4
http://bit.ly/2woIa2O

Current Drug Targets 18, Issue 11
http://bit.ly/2jDw9QS

Drug Delivery Letters 7, Issue 2
http://bit.ly/2xbZVj6

Current Pharmaceutical Biotechnology 18, Issue 6
http://bit.ly/2f3CRe1

The Natural Products Journal 7, Issue 3
http://bit.ly/2xJdR7d

recent-issues

Highlighted Article – Differential Protein Analysis of Hexavalent Chromium Stress Response in Marine Staphylococcus xylosus – Current Proteomics

CP-Articles_14-4-Nagappa Ramaiah.jpg

To access this article, please visit: http://www.eurekaselect.com/154503