New Issue :: Current Women`s Health Reviews 12, Issue 2

Current Women’s Health Reviews publishes original research papers, frontier reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on obstetrics and gynecology. The journal’s aim is to publish the highest quality articles dedicated to research in the field. The journal is essential reading for all clinicians and researchers in the fields of obstetrics and gynecology.

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Articles from the journal Current Women`s Health Reviews 12, Issue 2:

 

                   For details on the articles, please visit this link :: http://bit.ly/2laL5FX

Press Release for EurekAlert! Neural circuits underlying fly larval locomotion

In recent decades, larval fruit flies have generally been considered as a promising model to examine neural locomotor circuits. Drosophila larval locomotion offers a valuable opportunity to link genes to behavior, and also link sensory inputs to motor outputs in cellular and molecular resolution. This review article will provide a brief introduction to Drosophila larval locomotion for researchers who are new to the field and curious about what tiny maggots tell us.

Locomotion is a complex motor behavior that may be expressed in different ways using a variety of strategies depending upon species and pathological or environmental conditions. Quadrupedal or bipedal walking, running, swimming, flying and gliding constitute some of the locomotor modes enabling the body, in all cases, to move from one place to another. Despite these apparent differences in modes of locomotion, both vertebrate and invertebrate species share, at least in part, comparable neural control mechanisms for locomotor rhythm and pattern generation and modulation. Significant advances have been made in recent years in studies of the genetic aspects of these control systems. Findings made specifically using Drosophila (fruit fly) models and preparations have contributed to further understanding of the key role of genes in locomotion. This review focuses on some of the main findings made in larval fruit flies while briefly summarizing the basic advantages of using this powerful animal model for studying the neural locomotor system.

Reference: Kohsaka, H.; (2016). Neural circuits underlying fly larval locomotion. Curr. Pharm. Des., DOI: 10.2174/1381612822666161208120835

For more information about the article, please visit: http://benthamscience.com/journals/current-pharmaceutical-design/article/148210/

 

Article by Disease – “Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design”

ARTICLE BY DISEASE ON “DIABETES”

Abstract:

The bacterial enzyme UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC), catalyzing the first committed step of lipid A biosynthesis, represents a promising target in the development of novel antibiotics against Gram-negative bacteria. Structure, catalytic reaction mechanism and regulation of the Zn2+-dependent metalloamidase have been intensively investigated. The enzyme is required for growth and viability of Gram-negative bacteria, displays no sequence homology with any mammalian protein, but is highly conserved in Gram-negative bacteria, thus permitting the development of Gram-negative selective antibacterial agents with limited off-target effects. Several smallmolecule LpxC inhibitors have been developed, like the substrate analog TU-514 (12a), the aryloxazoline L-161,240 (13w), the sulfonamide BB-78485 (23a), the N-aroyl-L-threonine derivative CHIR-090 (24a), the sulfone-containing pyridone LpxC-3 (43e), and the uridine-based inhibitor 1-68A (47a), displaying diverse inhibitory and antibacterial activities. Most of these compounds share a Zn2+-binding hydroxamate moiety attached to a structural element addressing the hydrophobic tunnel or the UDP binding site. The butadiynyl derivative ACHN-975 (28) is the first LpxC inhibitor entering clinical trials.

Read more: http://www.eurekaselect.com/node/141238/article

SMI EVENT – 12th Annual ADMET!

The SMi Group is proud to announce the return of the 12th annual ADMET conference taking place in London on the 12th – 13th June 2017.

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Join our expert speaker panel at the 12th annual ADMET conference for yet another successful run! Presenting new developments, case studies and challenges in the areas of DMPK. PBPK, PKPD, in vivo/ in vitro/ in silico, transporters, hazards and safety assessment, ADMET modelling and many more!

This event will explore ADMET technologies which determine properties of a drug candidate in the preclinical stage of drug discovery, structure based prediction of ADME properties, PK/PD modelling to validate drug targets and toxicity and many more.

Visit the website for further details at http://www.admet-event.com/asd or contact at kwilliams@smi-online.co.uk

Journal: Current Drug Metabolism

EBook: Frontiers in Drug Design and Discovery, Volume 5

 

Upcoming Thematic Issue – Pediatric and Adolescent Gynecology

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http://benthamscience.com/journals/current-womens-health-reviews/

Testimonial by Dr. Gjumrakch Aliev!

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Contributed Article: “Nanotechnology For Alzheimer Disease”

New Issue :: Current Protein & Peptide Science 18, Issue 3

Current Protein & Peptide Science publishes review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover the field by discussing research from the leading laboratories in the field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.

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Articles from the journal Current Protein & Peptide Science 18, Issue 3:

 

               

   For details on the articles, please visit this link :: http://bit.ly/2lefwui

 

Highlighted Article Flyer for the journal “Current Drug Metabolism”

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http://benthamscience.com/journals/current-drug-metabolism/

Upcoming Thematic Issue – Smart and Controllabe Systems for Gene Delivery

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http://benthamscience.com/journals/current-gene-therapy/

Podcast: Dendritic Cells Modulate Iron Homeostasis and Inflammatory Abilities

Author(s): Vanessa Galleggiante, Stefania De Santis, Elisabetta Cavalcanti, Aurelia Scarano, Maria De Benedictis, Grazia Serino, Maria Lucia Caruso, Mauro Mastronardi, Aldo Pinto, Pietro Campiglia, Dale Kunde, Angelo Santino and Marcello Chieppa

For article details, visit: https://benthamscience.com/journals/current-pharmaceutical-design/article/149200/ 

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