Healthy Weight Week!


Healthy Weight Week signifies the importance of balance diet and healthy lifestyle. Being healthy does not mean losing weight and going on a diet. It means pursuing livable and sustainable healthy lifestyle through eating well, living actively and feeling good.
Bentham Science publishes important research publications that promote this idea.

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Most Accessed Article – “HER3 and its Ligand, Heregulin, as Targets for Cancer Therapy”

Journal: Recent Patents on Anti-Cancer Drug Discovery

Author(s): Hisato Kawakami and Kimio Yonesaka



Emerging evidence suggests that human epidermal growth factor receptor 3 plays a critical role in cell-survival and drug-resistance in cancer cells. Several kinds of agents targeting this receptor are currently progressing through preclinical or clinical investigations. These agents are usually monoclonal antibodies with unique characteristics, and some have shown efficacy and been welltolerated in clinical trials. For example, patritumab and seribantumab are thought to compete with ligand binding and have proven efficacy for some malignancies in Phase II clinical trials. LJM716 locks the human epidermal growth factor receptor 3 in the inactive conformation in both ligand-dependent and – independent cancers. Lumretuzumab is a glycoengineered antibody, which enhances antibody-dependent cell-mediated cytotoxicity. Duligotumab is an antibody that targets both the human epidermal growth factor receptors 1 and 3. Heregulin is a human epidermal growth factor receptor 3 ligand that represents an encouraging candidate biomarker for the prediction of the efficacy of agents targeting this receptor.

Conclusion: A number of antibodies that interact with human epidermal growth factor receptors have been evaluated for clinical use. Ongoing clinical trials will address the remaining issues related to optimization of drug combination therapy and improving the targeting of each agent to the most appropriate individuals.

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Highlighted Article Flyer for the journal “Current Diabetes Reviews”


New Issue :: Current Pediatric Reviews 12, Issue 4

Current Pediatric Reviews publishes frontier reviews, drug clinical trial studies and guest edited thematic issues on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.


Articles from the journal Current Pediatric Reviews 12, Issue 4:

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Podcast: Phenolic compounds as nutraceuticals or functional food ingredients

Author(s): Cristina Caleja, Andreia Ribeiro, Maria Filomena Barreiro and Isabel CFR Ferreira

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Recently Published Issues – Bentham Science Journals

Current Neuropharmacology 15, Issue 1

Current Protein & Peptide Science 18, Issue 2

Current Nanomedicine 6, Issue 3

Current Diabetes Reviews 13, Issue 1

Current Genomics 18, Issue 1

Current Gene Therapy 16, Issue 4

Current Medicinal Chemistry 23, Issue 40

Current Stem Cell Research & Therapy 12, Issue 2 

Current Organic Synthesis 14, Issue 1

Current Organocatalysis 4, Issue 1

Recent Issues

Highlighted Article Flyer for the journal “Recent Patents on Biotechnology”


New Issue :: Recent Patents on Food, Nutrition & Agriculture 8, Issue 2

Recent Patents on Food, Nutrition & Agriculture publishes review and research articles, and guest edited thematic issues on recent patents in all fields of food science & technology, nutrition and agricultural science & technology. A selection of important and recent patents in the areas covered is also included in the journal. The journal is essential reading for all researchers involved in food, nutrition and agricultural sciences and technology. The journal also covers recent research (where patents have been registered) in fast emerging technologies related to food additives, micro & macro-molecular food supplements, edible alternatives, food technology, nutraceuticals, healthy diet, nutritional value, calorie intake, malnutrition & related diseases, plant derivatives, agricultural technology and products, crop improvement and safety issues related to food, nutrition & agriculture.


Articles from the journal Recent Patents on Food, Nutrition & Agriculture 8, Issue 2:

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Upcoming Thematic Issue – Cold Atmospheric Plasma Activated Solution: A new Approach for Cancer Treatment


Press Release for EurekAlert! The effect of exercise on vascular function and stiffness in type 2 diabetes

A new study from the University of Sydney has found that regular aerobic exercise can improve artery health in people with type 2 diabetes (T2D). The findings from this study have been published in Current Diabetes Reviews, and shed new light on exercise as a therapy in this population.

Compromised arterial health is an underlying mechanism that promotes the progression of cardiovascular disease (CVD), which is the leading cause of death in individuals with T2D. Effectively managing CVD risk in this population is a major challenge for health professionals.

Exercise is one of the first lines of treatment recommended by health professionals to manage the array of complications associated with T2D, such as controlling blood sugar. While it has been consistently shown that exercise is exceptionally beneficial for managing CVD, blood pressure medication is the main treatment used to manage arterial health problems.

This new study combined the results of nine randomised controlled clinical trials investigating the effects of exercise in T2D. Kimberley Way, who leads the research, says: “We focussed on measures looking at arterial stiffness, vascular reactivity and smooth muscle function, because there is evidence that suggests they are closely associated with disease progression and CVD mortality.”

Ms Way statesadds: “What we found from our analysis, is that aerobic exercise, such as brisk walking or cycling appears to have a significantly beneficial effect on the stiffness and the function of the smooth muscles in the arteries. This makes our findings very valuable to health professionals, because aerobic exercise can be used as a primary treatment strategy for arterial health, while also assisting with other health complications associated with T2D. “

Citation: Way, K.L., Keating, S. E., Baker, M.K., Chuter, V.H., & Johnson, N.A. (2016). The Effect of Exercise on Vascular Function and Stiffness In Type 2 Diabetes: A Systematic Review and Meta-Analysis. Current Diabetes Reviews, 12(4), 369-383.

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