New Issue:: Current Inorganic Chemistry 7, Issue 1

Current Inorganic Chemistry, a peer-reviewed journal, publishing original research, review articles and guest edited thematic issues in all areas of inorganic chemistry. The journal’s scope includes the synthesis, crystal structure, physical methods, thermodynamics, reactivity, spectroscopy, electronic and bonding properties of significant new and known (bio) inorganic and organometallic compounds.

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Articles from the journal Current Inorganic Chemistry 7, Issue 1:

For details on the articles, please visit this link:: https://bit.ly/2HvylCz

EDITOR’S CHOICE – Y-shaped Folic Acid-Conjugated PEG-PCL Copolymeric Micelles for Delivery of Curcumin – Anti-Cancer Agents in Medicinal Chemistry

Journal: Anti-Cancer Agents in Medicinal Chemistry

Author(s): Runliang Feng, Wenxia Zhu, Wei Chu, Fangfang Teng, Ning Meng, Peizong Deng, Zhimei Song

Abstract:

Background: Curcumin is a natural hydrophobic product showing anticancer activity. Many studies show its potential use in the field of cancer treatment due to its safety and efficiency. However, its application is limited due to its low water-solubility and poor selective delivery to cancer.

Objective: A Y-shaped folic acid-modified poly (ethylene glycol)-b-poly (ε-caprolactone)2 copolymer was prepared to improve curcumin solubility and realize its selective delivery to cancer.

Method and Results: The copolymer was synthesized through selective acylation reaction of folic acid with α- monoamino poly(ethylene glycol)-b-poly(ε-caprolactone)2. Curcumin was encapsulated into the copolymeric micelles with 93.71% of encapsulation efficiency and 11.94 % of loading capacity. The results from confocal microscopy and cellular uptake tests showed that folic acid-modified copolymeric micelles could improve cellular uptake of curcumin in Hela and HepG2 cells compared with folic acid-unmodified micelles. In vitro cytotoxicity assay showed that folic acid-modified micelles improved anticancer activity against Hela and HepG2 cells in comparison to folic acidunmodified micelles. Meanwhile, both drug-loaded micelles demonstrated higher activity against Hela cell lines than HepG2.
Conclusion: The research results suggested that the folic acid-modified Y-shaped copolymeric micelles should be used to enhance hydrophobic anticancer drugs’ solubility and their specific delivery to folic acid receptors-overexpressed cancer.

 

WISHING A VERY HAPPY BIRTHDAY TO DR. GEORGE PERRY!

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DR. GEORGE PERRY

EDITOR-IN-CHIEF: MINI-REVIEWS IN MEDICINAL CHEMISTRY & Letters in Drug Design & Discovery

COLLEGE OF SCIENCES,
THE UNIVERSITY OF TEXAS AT SAN ANTONIO,
TEXAS,
USA

New Issue:: CNS & Neurological Disorders – Drug Targets 16, Issue 10

CNS & Neurological Disorders – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders – Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

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Articles from the journal CNS & Neurological Disorders – Drug Targets 16, Issue 10:

For details on the articles, please visit this link:: https://bit.ly/2vcL7n4

EDITOR’S CHOICE – Advances in Anti-Doping Analytical Approaches – Current Pharmaceutical Analysis

Journal: Current Pharmaceutical Analysis

Author(s): Xianchi Li, Peiying Zhang*

Graphical Abstract:

 

Abstract:

Background: Performance enhancement substances and methods other than exercise training and physical conditioning have become a major problem in athletic competitions. Over the last few years, there has been an increase in the number of these doping approaches used by some athletes, including pharmaceuticals, slightly modified endogenous compounds and also blood transfusions. In order to control and prevent these doping practices by athletes, World Anti-Doping Agency has stipulated several guidelines and approved various methods on the basis of reproducibility, sensitivity and adaptability. The number, design and type of doping substances are increasing on daily basis necessitating the rapid development of analytical methods to detect these substances and to prevent doping.

Objective: In this review, we address the various methodological developments in the last few years to track down the novel doping substances as well as doping methods.

Results: There have been significant advances in the area of mass spectroscopy and the associated detection devices to measure small quantities of test substance or their metabolites in body tissues and fluids. Some of the doping substances have short biological half-life but leave imprints of their action in the form of altered gene expression, protein expression or metabolism, which can be detected by OMICs technologies.

Conclusion: The rapid advance in biological instrumentation and our understanding of the molecular basis of the actions of doping substances have paved the way to enforce ‘true play’ in athletic competitions. But this is an incessant and a continuous process as long as the doping practices continue.

Read more here: http://www.eurekaselect.com/151469/article

 

 

World Parkinson’s Day 2018

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Parkinson’s Disease is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking.

Bentham Science publishes articles related to Parkinson’s Disease in its high impact journals including:

CNS & Neurological Disorders – Drug Targets

Current Neurovascular Research

Thought of the Day!

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New Issue:: Current Organocatalysis 4, Issue 3

Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. It is the premier source of organocatalysis related information for chemists, biologists and engineers pursuing research in industry and academia.

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Articles from the journal Current Organocatalysis 4, Issue 3:

For details on the articles, please visit this link :: https://bit.ly/2GTC5MP

 

EDITOR’S CHOICE – Cytotoxicity of Silver Nanoparticles Against Bacteria and Tumor Cells – Current Protein & Peptide Science

Journal: Current Protein & Peptide Science

Author(s): Tianyuan Shi, Xuesong Sun*, Qing-Yu He

Abstract:

With the rapid increase of multiple drug-resistant bacteria, silver nanoparticles (AgNPs) with broad-spectrum antibacterial activities have been widely applied in the treatment of bacterial infection. Meanwhile, AgNPs also have anticancer activities against different cell lines. The toxic effects of AgNPs depend on concentration, size, shape, coated materials and surrounding environments. In order to better understand the antibacterial and antitumor effects of AgNPs, various investigations have been carried out to uncover the molecular mechanism of action. This review summarizes the recent studies on the action mechanisms of AgNPs related to their antibacterial activities including collapsing cell walls, inducing reactive oxygen species, inhibiting aerobic respiration and damaging DNA and their antitumor effects including impairing mitochondria, blocking cell cycle, and activating apoptosis. In these investigations, the systematic approaches have not been extensively applied. Increasingly matured omics techniques including genomics, transcriptomic, translatomics and proteomics should be more widely explored to provide the comprehensive views of the cytotoxic effects of AgNPs to bacteria and tumor cells and thus globally illustrate the molecular mechanisms of the cytotoxicity, promoting the better medical application of AgNPs in the future.

Read more here: http://www.eurekaselect.com/147155/article

 

Current Genomics Thematic Issue Now Available on Amazon

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Buy Now: https://www.amazon.com/dp/1681086816