Become an Editorial Board Member (EBM) | Current Pharmaceutical Design

Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

The Journal Current Pharmaceutical Design is interested in appointing active Editorial Board Member  on the Journal’s Board. If you are working in the related field as of the journal and are interested in becoming an Editorial Board Member, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at:

• hermain@benthamscience.net and;
• CC faizan@benthamscience.net

 

Become a Reviewer | Current Pharmaceutical Design

 

Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

The Journal Current Pharmaceutical Design is interested in appointing active Reviewer  on the Journal’s Board. If you are working in the related field as of the journal and are interested in becoming an Reviewer, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at:

• hermain@benthamscience.net and;
• CC faizan@benthamscience.net

 

Editors Choice Article | The Scalability of Wet Ball Milling for The Production of Nanosuspensions

 

Journal Name: Pharmaceutical Nanotechnology

Author(s): Maria L.A.D. Lestari, Rainer H. Müller, Jan P. Möschwitzer *

 

 

Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be performed on a large scale. Ideally, the information generated at small scale is predictive for large scale production.

Objective: This study was aimed to investigate the scalability when producing nanosuspensions starting from a 10 g scale of nanosuspension using low energy wet ball milling up to production scales of 120 g nanosuspension and 2 kg nanosuspension by using a standard high energy wet ball milling operated in batch mode or recirculation mode, respectively.

Methods: Two different active pharmaceutical ingredients, i.e. curcumin and hesperetin, have been used in this study. The investigated factors include the milling time, milling speed, and the type of mill.

Results: Comparable particle sizes of about 151 nm to 190 nm were obtained for both active pharmaceutical ingredients at the same milling time and milling speed when the drugs were processed at 10 g using low energy wet ball milling or 120 g using high energy wet ball milling in batch mode, respectively. However, an adjustment of the milling speed was needed for the 2 kg scale produced using high energy wet ball milling in recirculation mode to obtain particle sizes comparable to the small scale process.

Conclusion: These results confirm in general, the scalability of wet ball milling as well as the suitability of small scale processing in order to correctly identify the most suitable formulations for large scale production using high energy milling. Read out full article at: http://www.eurekaselect.com/171179/article

Wishing you a very Happy Birthday | Prof. Christian N. Madu

 

Prof. Christian N. Madu

Editor in Chief: Sustainability and Disaster Risk Management 

Centre for Environmental Management
University of Nigeria Enugu Campus
Enugu
Nigeria

Wishing you a very Happy Birthday | Dr. Anastasios Economou

 

Dr. Anastasios Economou

Editor in Chief: Current Pharmaceutical Analysis

University of Athens
Athens
Greece

Infographics | Animals in Space

Space travel is not the exclusive domain of humans. See how many corners of the animal kingdom have ventured off our planet.

Tags: science, space, animals

Source: http://rigb….s-in-space

Category: Science

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Publisher:

Royal Institution

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Designer:

Anthony Lewis

Bentham Science Ambassador’s Program

 

 

Bentham Science Publishers is a well-known, and reputed Science, Technology and Medicine (STM) publisher, which publishes over 100 journals, both in print and online formats. Bentham Science Publishers also publishes books in 20 broad disciplines. Many of the journals published by Bentham Science Publishers are recognized in the scientific community and are featured in indexing lists, such as Journal Citation Reports/Science Edition, MEDLINE/Index Medicus, PubMed, Scopus, Chemical Abstracts, and EMBASE.

Bentham Science has recently launched its Ambassador Program with the aim of creating a more effective liaison between article contributors and researchers in the broad scientific community. The Ambassadors program serves as a very useful platform for Bentham Science authors and editorial board members to promote Bentham Science Amcontent and connect with other researchers, enabling them to access our peer review services and publish their research in Bentham Science journals. The program encourages our existing collaborators to mobilize their activities for bringing new and established researchers to share their work in Bentham Science’s publications. Ambassadors participating in the program can receive points -based rewards from Bentham Science Publishers upon reaching specific milestones. The Ambassadors program is conveniently managed though an online portal which facilitates the ambassadors in managing and tracking their performance.

Activities performed by Bentham Ambassadors are as follows:

• Distribution of promotional materials at local and international events (flyers, catalogs, copies)
• Invitations to fellow researchers and peers for contributing articles in Bentham Science journals and books
• Recommendations for Free Online Trial Subscriptions and Annual Subscription Packages to libraries, universities and industrial organizations

Bentham Science Publishers will award Ambassadors who consistently reach milestones (promotion goals, successful contributions by invited authors, subscriber acquisitions) with several offers on and discounts on Bentham Science products and services. The most effective Ambassadors will also receive a certificate of appreciation.

New Issue | Letters in Drug Design & Discovery (Volume: 16, Issue: 6)

 

 

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

 

Articles from the journal: Letters in Drug Design & Discovery; Volume: 16, Issue: 6

• Virtual Screening, Docking, Synthesis and Bioactivity Evaluation of Thiazolidinediones as Potential PPARγ Partial Agonists for Preparation of Antidiabetic Agents

• Design, Synthesis and Evaluation of Thiourea Derivatives as Antimicrobial and Antiviral Agents

• Virtual Screening of Henna Compounds Library for Discovery of New Leads against Human Thymidine Phosphorylase, an Overexpressed Factor of Hand-Foot Syndrome

• In Silico Prediction and Validation of Oxygen-Regulated Protein N-myc Downstream Regulated Gene 3 and Virtual Screening of Competitive Inhibitors of L-Lactate as Therapeutics

• New Procaspase Activating Compound (PAC-1) Like Molecules as Potent Antitumoral Agents Against Lung Cancer

• Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities

• Synthesis and Anti-Tumor Activity Evaluation of Novel 7-Fluoro-4-(1- Piperazinyl) Quinolines

• Exploring Energy Profiles of Protein-Protein Interactions (PPIs) Using DFT Method

• Design and Synthesis of the Diazirine-based Clickable Photo-affinity Probe Targeting Sphingomyelin Synthase 2

• Synthesis, Formulation and Analytical Method Validation of Rutin Derivative

• Action of Thioglycosides of 1,2,4-Triazoles and Imidazoles on the Oxidative Stress and Glycosidases in Mice with Molecular Docking

 

For details on the articles, please visit this link: http://www.eurekaselect.com/node/634/letters-in-drug-design-discovery/issue/16/2491/6/9079

Science Alert | Scientists Have Found a Way to Preserve Vaccines Without Refrigeration For Months

 

 

Vaccines are only as good as the people they treat and absolutely no good if they are spoiled by heat along the way.

It’s a challenge so great that in some remote parts of the world, this precious medicine has to be transported by camels carrying solar-powered mini refrigerators on their backs. Other populations never get them at all.

The need or an uninterrupted, refrigerated trail of vaccines is known as the “cold chain“, and in most cases requires consistent storage between 2–8 °C, all the way from production to dispersal; otherwise, it could lay waste to the entire process.

“You can spend all kinds of money developing a vaccine, but if it is deactivated by high temperature an hour before you can give it to someone, it doesn’t matter,” says Ali Ashkar, a pathologist who specialises in immunology at McMaster University in Canada.

There are few technical immunisation issues more important, and Ashkar and his colleagues now think they have invented a potential solution, one that could allow vaccines to go unrefrigerated for weeks at a time in warm and remote areas.

While other tactics have focused on reengineering the vaccines or modifying their vectors, this new method is based on the simple addition of sugar.

In this case, however, the viruses are mixed and then dried into a sugary film, created from a combination of two FDA-approved food preservatives, called pullulan and trehalose.

 

Suspended in this solution, the vaccines can be transported without the need for constant cooling. To reactive them, local clinicians need only add water before administering them to patients, as fresh as if they came from a fridge. To read out more, please visit: https://bit.ly/2WlhtsQ

eBooks Press Release — NEWS | The Seventh Volume of Topics in Anti-Cancer Research Is Now Available

 

 

Topics in Anti-Cancer Research (Volume 7) covers important advances on both experimental (preclinical) and clinical cancer research in drug development.

 

The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.

The topics covered in the seventh volume of this series include:

– The role of inflammation in chemotherapy-induced neuromuscular effects

– Advances in nutrigenomics and relevant anti-cancer patents

– Stimuli-responsive nanocarriers for on-demand anti-cancer drug release

– Harnessing biochemical mechanisms that control autophagy for treating esophageal cancer

 

To read out more, please visit: https://ebooks.benthamscience.com/press-releases/19012401/