Editors Choice Article | Trends in the Analysis of Biopharmaceuticals by HPLC

 

Journal Name: Current Analytical Chemistry

Author(s): Angela Tartaglia, Marcello Locatelli, Victoria Samanidou*.

 

 

Graphical Abstract:

 

Abstract:

Background: Biopharmaceuticals are biological drugs consisting of a complex compound that can be produced by a living organism or derive from it. Biopharmaceuticals are very complicated compounds from structural point of view and for this reason, they cannot be fully characterized in terms of their structure with current analytical methods as it happens instead of low molecular weight chemicals drugs.

Introduction: The regulatory guidelines require the characterization of the primary or higher sequence of these molecules and the characterization of any post-translational modifications. The use of biopharmaceuticals has really grown in the last few years: in 2016, the number of biopharmaceuticals approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for use in humans’ diseases was 1357. From 2013 to 2016, 73 of these compounds were approved for the treatment of cancer, inflammation, immune disorders, infections, anemia and cardiovascular diseases.

Aim/Conclusion: The aim of the present review is to provide an overview of recent approaches for the characterization of biopharmaceutical products in HPLC that have been presented in the literature in the last years. To read out more, please visit: http://www.eurekaselect.com/168075/article

ARTICLE TO READ ON NATIONAL NUTRITION WEEK!

“Motives Underlying Healthy and Unhealthy Eating Among University Students in Mauritius”

 

Journal Name: Current Nutrition & Food Science

Author(s): Ruvina Seebun, Fawzi M. Mahomoodally, Anwar H. Subratty, Deerajen Ramasawmy.

 

 

 

Abstract:

Panoply of influences operates to shape particular food choices. Thus, probing into the drivers of people’s healthy food choices is primordial to addressing the public health issue of obesity. The aim of the current study was to investigate the factors that influence University students’ choice for healthy and unhealthy foods. For the cross-sectional study, data using a structured questionnaire were collected from a stratified sample of 370 students at the University of Mauritius. Both descriptive and inferential statistical tools namely factor analysis, Pearson correlations and independent sample t-tests were used for data analysis. Choice decisions were affected by various factors. Students who attached significantly more importance to health, weight control and natural content ate more healthily as opposed to those who were influenced by the social & physical factor. Decisions to choose foods varied significantly with respect to gender. Girls considered factors such as health, weight control, convenience and attitude to be more important and ate more healthily as opposed to boys (p < 0.05). Health benefits derived from foods were perceived as the predominant food motive for students believed that their current diets were nutritionally adequate. These results are salient for health professionals and suggest that interventions should be geared to increase awareness about the nutritional inadequacy of diets consumed by University students and should specifically target boys. To the best of one’s knowledge, this is the only explicit research on food motives of University of Mauritius students.

 

For more details, please visit: http://www.eurekaselect.com/104377 

Testimonial by Roberto Mandrioli!

Contributed Article: “New-Generation, Non-SSRI Antidepressants: Therapeutic Drug Monitoring and Pharmacological Interactions”