Press Release | Phytochemistry, traditional uses and pharmacological profile of rose hip

 

The genus Rosa from family Rosaceae is one of the most widespread species from the family. One species, rose hip (rose haw), is known as a good source of different types of micronutrients and phytochemicals such as phenolic acids, tannins, and flavonoids. It is known as a traditional treatment in folk medicine. It has been used for the treatment of several illness including ear, nose, and throat problems since old times.

This article by Dr. Amirhossein Sahebkar et al. is published in Current Pharmaceutical Design, 2018. To obtain the article, please visit: http://www.eurekaselect.com/166136

 

Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2018-12/bsp-ptu122718.php

MOST ACCESSED ARTICLE – Recent Progress in Biological Activities of Indole and Indole Alkaloids

Journal Name: Mini-Reviews in Medicinal Chemistry

Author(s): Thokchom Prasanta Singh, Okram Mukherjee Singh*.

 

 

 

 

Graphical Abstract:

 

Abstract:

The indole scaffold is found in a wide range of bioactive heterocycles and natural products. Moreover, the indole moiety is considered as the active principle in several alkaloids such as mitomycin C and reserpine. Thus, over the past decade, chemists are increasingly attracted towards the studies on the pharmacological and therapeutic activities of indole containing compounds. Furthermore, the molecular structures of well-known drugs such as sumatriptan, tadalafil, fluvastatin and rizatriptan are based on indole frameworks.

This mini-review covers some of the significant and recent achievements of indole derivatives with respect to their biological activities up to 2015.

 

READ MORE HERE: http://www.eurekaselect.com/154723

EDITOR’S CHOICE – Novel Findings of Anti-cancer Property of Propofol – Anti-Cancer Agents in Medicinal Chemistry

Journal: Anti-Cancer Agents in Medicinal Chemistry

Author(s): Jiaqiang Wang, Chien-shan Cheng, Yan Lu, Xiaowei Ding, Minmin Zhu, Changhong Miao*, Jiawei Chen*

Graphical Abstract:

Abstract:

Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia.

Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear.

Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol’s malignance-modulating properties and the potential molecular mechanisms.

Read more here: http://www.eurekaselect.com/155527/article

 

UPCOMING THEMATIC ISSUE – RECENT DEVELOPMENTS IN ANTI-CANCER DRUG RESEARCH – CURRENT MEDICINAL CHEMISTRY

https://benthamscience.com/journal/special-issues.php?journalID=cmc

Highlighted Article – Exploration of Angiotensin II Type 1 Receptor Modulators by Molecular Fingerprints and Docking Simulations – Letters in Drug Design & Discovery

To access this article, please visit: http://www.eurekaselect.com/152926

Highlighted Article – Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones – Anti-Cancer Agents in Medicinal Chemistry

To access this article, please visit: http://www.eurekaselect.com/152771

Editor’s Choice – “Novel Fluorescent Benzimidazoles: Synthesis, Characterization, Crystal Structure and Evaluation of Their Anticancer Properties”

Journal: Letters in Organic Chemistry

Author(s):  Yeong Keng Yoon, Tze Shyang Chia, Ching Kheng Quah, Wan Leng Lim, Chuan Wei Oo, Amir Nasrolahi Shirazi, Keykavous Parang,Tan Soo Choon

Abstract:

Background: The benzimidazole core structure is an interesting platform for drug discovery since it possess a wide spectrum of pharmacological activities such as antiviral, anti-inflammatory and anticancer. Previously the antiproliferative effect of novel substituted benzimidazole derivative was demonstrated based on the ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate scaffold through the inhibition of sirtuin activity. This work aimed to further explore the previous work for identifying novel fluorescent benzimidazoles which possess anti proliferative activities based on the reported scaffold.

Methods: Compounds were synthesized based on a multistep but facile protocol. Structure of the compounds was elucidated using NMR, FT-IR, LC-MS, elemental analysis and unambiguously confirmed through crystal X-ray diffraction. Molar extinction coefficient of the autofluorescence compounds were determined using UV spectroscopy while cancer cell growth inhibitory activity was carried out using MTS assay.

Results: Four novel benzimidazole derivatives were successfully synthesized in this study. All four compounds were found to emit blue fluorescence when light-irradiated with molar extinction coefficient ranging from 21000 to 29000 (mol L-1)-1cm-1. Two of the synthesized compounds showed good anti proliferative activity against four cancer cell lines tested in this study.

Conclusion: Four novel benzimidazole derivatives presented in this study were synthesized using multistep protocol starting from 4-fluoro-3-nitrobenzoic acid. Their structures have been elucidated using multiple techniques such as NMR, FT-IR, LC-MS, elemental analysis and X-ray crystallography where possible. They were found to have high autofluorescence and two of them were able to inhibit the growth of cancer cells tested in this study.

Read more here: http://www.eurekaselect.com/147990

Open Access Article: Novel Antibody Therapeutics Targeting Mesothelin in Solid Tumors

Journal: Clinical Cancer Drugs

Author(s): Xiao-Yan Zhao, Babu Subramanyam, Nenad Sarapa, Sven Golfier and Harald Dinter

Affiliation: Ph.D. 455 Mission Bay Blvd. (South), San Francisco, USA

Abstract: Monoclonal antibodies have become attractive clinical anti-cancer drugs in the last 3 decades due to their targeting specificity and suitable pharmacokinetic properties. Their treatment modalities include unconjugated antibodies, radioimmunotherapy, immunotoxins and antibody-drug conjugates. Mesothelin is a tumor-associated antigen, a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein, which is frequently over-expressed on the cell membrane of a number of epithelial malignancies and shows limited expression in non-malignant tissues. Mesothelin has been validated as a suitable target for cancer therapy. A number of unconjugated antibodies, immunotoxins and antibody-drug conjugates targeting mesothelin have been developed in recent years to treat solid tumors, some of them yielding promising results in early clinical evaluation. This review will focus on the recent development of novel antibody therapeutics targeting mesothelin in diseases of mesothelioma, pancreatic, ovarian, lung, triple negative breast and gastric cancers. Their mechanisms of action and preclinical/clinical data will also be discussed.

To read the complete research article, visit: http://benthamscience.com/journals/clinical-cancer-drugs/article/139615/

Let’s Fight Cancer – The Killer of the Stars and All Alike

We all are deeply saddened by the loss of certain well-known and beloved stars in the recent days. The news of the departing of David Bowie was enough to bring tears to his fans’ eyes, and then we heard how our favorite, Celine Dion, lost her husband and brother in very quick succession. The culprit was the same, gravely dreaded cancer.

Such heart-wrenching news turned our attention towards the fact that how deadly cancer has proven in 2015 and the start of 2016, be it in any form and part of the body. We gathered a list of media stars who lost their lives to this ‘You Know Who’.

Let’s take some time out and warm our hearts with their memories!!

Donna Douglas, ‘The Beverly Hillbillies’ actress died of pancreatic cancer on January 1, 2015

ESPN sportscaster Stuart Scott, 49, died on Jan. 3, following a long battle with cancer

‘Simpsons’ Co-Creator and philanthropist Sam Simon died on March 8 with cancer

Former pro wrestler Dusty Rhodes, died on June 11, 2015 at age 69 fighting stomach cancer

Roger Rees, ‘Cheers’ & ‘West Wing’ actor, passed away having brain cancer on July 10

‘Godfather’ actor Alex Rocco passed away on July 18

Yvonne Craig, the original Batgirl in TV series, Batman, lost to breast cancer

Wes Craven, the prolific horror film writer-director, lost on August 30 to brain cancer

Author Jackie Collins lost her battle with cancer on September 19

Former Sen. & ‘Law & Order’ Actor Fred Thompson passed away after a recurrence of lymphoma

Gunnar Hansen, the actor who played ‘Texas Chain Saw Massacre’ killer Leatherface, died on Nov. 7, 2015 of pancreatic cancer

Alan Rickman, who we know well as Prof. Severus Snape, passed away on 15^th Jan. 2016 succumbing to pancreatic cancer

 

Feeling aggrieved, we at Bentham Science ensure our utmost strife to eradicate this fatal disease from the face of the earth. Researchers, through our following journals, use their findings to give the best fight to cancer:

Recent Patents on Anti-Cancer Drug Discovery

Current Cancer Drug Targets

Anti-Cancer Agents in Medicinal Chemistry

… and many more. Have a look and support us in this battle!!

Most Cited Article:::Ganoderma lucidum: A Potential for Biotechnological Production of Anti-Cancer and Immunomodulatory Drugs

Author(s): Bojana Boh

Abstract: Based on the analysis of more than 270 patents and scientific articles, this state-of-the-art review presents Ganoderma lucidum, a medicinal basidiomycete mushroom with immunomodulatory and anti-cancer effects. Cultivation methods for the commercial production of G. lucidum fruit bodies and mycelia are summarized, with main active compounds of triterpenoids, polysaccharides, and proteins, often found in forms of proteoglycans or glycopeptides. Pharmacological effects with emphasis on anti-cancer and immunomodulatory functions are presented, separately for spores and dry mycelia, and for the groups of triterpenoids, polysaccharides, proteins and glycoproteins. Patents disclosing preparation methods of extracts and purified pharmaceutical isolates are reviewed, and examples of anti-cancer formulations, used as pharmaceuticals or nutraceuticals, are given. The review suggests that according to the present understanding, the anti-cancer activity of G. lucidum may be attributed to at least five groups of mechanisms: (1) activation/modulation of the immune response of the host, (2) direct cytotoxicity to cancer cells, (3) inhibition of tumor-induced angiogenesis, (4) inhibition of cancer cells proliferation and invasive metastasis behaviour, and (5) carcinogens deactivation with protection of cells. Although, the data from recent in vitro and in vivo studies demonstrate promising anti-cancer effects, a need is identified for further (1) isolation and purification of compounds, with deeper understanding of their individual and synergistic pharmacological effects, (2) molecular level studies of the antitumor and immuno-supportive mechanisms, (3) well designed in vivo tests and controlled clinical studies, and (4) standardisation and quality control for G. lucidum strains, cultivation processes, extracts and commercial formulations.

– See more at: http://eurekaselect.com/111726/article#sthash.BIKfJPN8.dpuf

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This article is from the journal Recent Patents on Anti-Cancer Drug Discovery