Testimonial By Arshad H. Rahmani

Read what our Authors have to say about publishing in our Journal

arshad h rahmani

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

 

Contributed Article: Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways

Testimonial | Read what our Authors have to say about publishing in our Journal – By Dr. Sherien M. El-Daly

 

Sherien M. El-Daly

 

Journal Name: Anti-Cancer Agents In Medicinal Chemistry

 

Contributed Article: Synergistic Effect of Α-Solanine and Cisplatin Induces Apoptosis and Enhances Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells

Testimonial by Dr. Wael M. El-Sayed!

READ WHAT OUR AUTHORS HAVE TO SAY ABOUT PUBLISHING IN OUR JOURNAL

Contributed Article: Substitution at Phenyl Rings of Chalcone and Schiff Base Moieties Accounts for their Antiproliferative Activity

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

 

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Editors Choice Article | EH-42: A Novel Small Molecule Induces Apoptosis and Inhibits Migration and Invasion of Human Hepatoma Cells through Suppressing STAT3 Signaling Pathway

Journal Name: Current Cancer Drug Targets

Author(s): Qi-Zhe Gong, Di Xiao, Gui-Yi Gong, Jian Xu, Xiao-Dong Wen*, Feng Feng*, Wei Qu*.

 

 

Background: Since signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in hepatocellular carcinoma (HCC) and plays a key role in this tumor progression. Inhibition of the STAT3 signaling pathway has been considered as an effective therapeutic strategy for suppressing HCC development.

Objective: In this study, we investigated the anti-cancer effects of EH-42 on HCC cells and tried to explain the underlying mechanism.

Methods: MTT assay, colon formation assay and AnnexinV-FITC/PI double-staining assay were performed to assess the effects of EH-42 on cell growth and survival. Wound healing assay and transwell invasion assay were performed to assess the effects of EH-42 on cell migration and invasion. Western blotting assay was performed to analyze the effects of EH-42 on relative proteins.

Results: According to the MTT assay, colon formation assay and AnnexinV-FITC/PI doublestaining assay, EH-42 could suppress the growth and induce apoptosis of HCC cells in a dosedependent manner. Further western blotting assay showed that the inhibitory effects of EH-42 on cell growth and survival were caused by activating caspase 3/9, suppressing the phospho-STAT3 (Tyr 705) and downregulating anti-apoptotic proteins like Bcl-2/Bcl-xL. Moreover, migration and invasion abilities of HCC cells were also inhibited by EH-42 in the wound healing assay and transwell invasion assay. The potential mechanism was that EH-42 could inhibit HCC metastasis via reversing epithelial-mesenchymal transition and downregulating the secretion of MMPs.

Conclusion: Taken together, these findings suggested that EH-42 could be a potential therapeutic agent for HCC treatment. To read out more, please visit: http://www.eurekaselect.com/168569/article

Press Release | Frontiers in clinical drug research — Anti-cancer agents, now in its 5th edition

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This eBook is authored by Dr. Ata-ur-Rahman, published on June 12, 2019.

For Further Details, Please visit https://ebooks.benthamscience.com/book/9789811405150/

 

Frontiers in Clinical Drug Research – Anti-Cancer Agents brings updated and critical information about developing clinical trials and research in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology researchers.

The fifth volume of the series features reviews on biochemical inhibitors (second-generation protein kinase Inhibitors, histone deacetylase inhibitors, immune checkpoint inhibitors, EGFR Tyrosine Kinase inhibitors, non-coding RNAs), apoptosis, and physical exercise therapy for cancer patients undergoing chemotherapy. The treatment strategies in this volume cover neoplasms such as acute myeloid leukemia, gastrointestinal cancer, breast cancer and lung cancer. Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2019-06/bsp-fic062019.php

eBook | Sex Steroids and Apoptosis In Skeletal Muscle: Molecular Mechanisms

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BY

ANDREA VASCONSUELO

 

Aging has serious consequences on skeletal muscle. ‘Sarcopenia’, the progressive loss of muscle mass and associated muscle weakness during elderly, affects radically the functional capacity and general health in adult people and renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. There is a vital need to recognise the molecular mechanisms and regulatory factors, underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or finally reverse sarcopenia. In this context, sexual hormones play a key role.

The book, SEX STEROIDS AND APOPTOSIS IN SKELETAL MUSCLE: MOLECULAR MECHANISMS, written by Dr. Andrea Vasconsuelo aims to provide a new way to perceive the role of sex hormones in skeletal muscle. The book present in integrated form the latest information on sarcopenia and its relation with apoptosis, from leading researchers studying the cellular and molecular mechanisms underlying age-linked changes in skeletal muscle emphasising on the role of satellite cells. The authors succeed to explain, how hormones are involved in muscle homeostasis and in the regulation of apoptosis process and how these two functions connect to maintain a healthy muscle or to trigger pathologies. Therefore, the goal of this work is the combination of that information focusing on the molecular level and resulting in the clarification of molecular mechanisms implicated in skeletal muscle aging; when apoptosis is more intense and sex hormones levels decline. Very interesting, the book contains a chapter describing molecular structure of phytoestrogens and their action on sex steroids receptors. In addition, it is possible to emphasize the drafting writing promoting easy and pleasant reading, numerous and careful documentation, high quality images of the authors’ experiments and comprehensive and updated bibliography. This ebook is of interest to graduates and postgraduates in the fields of medicine and biochemistry, researchers of different aspects of ageing biology and people of the pharmaceutical, and health-care industry. Read out the full version here.

 

eBooks Press Release — NEWS | The Seventh Volume of Topics in Anti-Cancer Research Is Now Available

 

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Topics in Anti-Cancer Research (Volume 7) covers important advances on both experimental (preclinical) and clinical cancer research in drug development.

 

The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.

The topics covered in the seventh volume of this series include:

– The role of inflammation in chemotherapy-induced neuromuscular effects

– Advances in nutrigenomics and relevant anti-cancer patents

– Stimuli-responsive nanocarriers for on-demand anti-cancer drug release

– Harnessing biochemical mechanisms that control autophagy for treating esophageal cancer

 

To read out more, please visit: https://ebooks.benthamscience.com/press-releases/19012401/

Podcast | Hypertension, Diabetes and Neurodegenerative Diseases: Is there a Clinical Link through the Ca2+/cAMP Signalling Interaction?

Author(s): Leandro Bueno Bergantin*.

Journal Name: Current Hypertension Reviews

 

 

For article details, please visit: http://www.eurekaselect.com/164730/article

To subscribe our YouTube Channel, please click here: https://bit.ly/1lr0czy

Press Release | Cell death mechanisms in stroke and novel molecular and cellular treatment options

This article by Dr. Emine Sekerdag et al. is published in Current Neuropharmacology, Volume 16, Issue 9, 2018

 

The blood circulation to neurons is affected due to Ischemic, hemorrhagic stroke and subarachnoid hemorrhage stimulation the activation of pathophysiological responses i.e. mitochondrial death pathways, protein misfolding, apoptosis, pyroptosis, necrosis, autophagy, mitophagy, ferritinophagy, excitotoxicity, free radicals release, and inflammation. The review focuses on the recent updates in our knowledge about cellular death mechanisms caused by the loss of neuronal cells and astrocytes, damage to white matter.

Novel treatment preferences in stroke involves restoration of blood flow control and the applicability of treatments is restricted due to a limited bioactive time window of thrombolytic agents. Ischemic, hemorrhagic stroke and subarachnoid hemorrhage are discussed in this review in relation to novel molecular, cellular treatment alternatives and cellular death mechanisms.

Browse the article details at: http://www.eurekaselect.com/160188

OPEN ACCESS ARTICLE – Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment

Journal Name: Mini-Reviews in Medicinal Chemistry

Author(s): Voon Yee-Lin*, Wong Pooi-Fong , Alan Khoo Soo-Beng

 

 

 

 

Graphical Abstract:

 

Abstract:

Nasopharyngeal carcinoma (NPC) is a form of head and neck cancer of multifactorial etiologies that is highly prevalent among men in the population of Southern China and Southeast Asia. NPC has claimed many thousands of lives worldwide; but the low awareness of NPC remains a hindrance in early diagnosis and prevention of the disease. NPC is highly responsive to radiotherapy and chemotherapy, but radiocurable NPC is still dependent on concurrent treatment of megavoltage radiotherapy with chemotherapy. Despite a significant reduction in loco-regional and distant metastases, radiotherapy alone has failed to provide a significant improvement in the overall survival rate of NPC, compared to chemotherapy. In addition, chemo-resistance persists as the major challenge in the management of metastatic NPC although the survival rate of advanced metastatic NPC has significantly improved with the administration of chemotherapy adjunctive to radiotherapy. In this regard, targeted molecular therapy could be explored for the discovery of alternative NPC therapies. Nutlin-3, a small molecule inhibitor that specifically targets p53-Mdm2 interaction offers new therapeutic opportunities by enhancing cancer cell growth arrest and apoptosis through the restoration of the p53-mediated tumor suppression pathway while producing minimal cytotoxicity and side effects. This review discusses the potential use of Nutlin-3 as a p53-activating drug and the future directions of its clinical research for NPC treatment.

 

READ MORE HERE: http://www.eurekaselect.com/154246 

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