Editors Choice Article | Mitotherapy as a Novel Therapeutic Strategy for Mitochondrial Diseases

 

Author(s): Ailing Fu*

Graphical Abstract:

 

Abstract:

Background: The mitochondrion is a multi-functional organelle that is mainly responsible for energy supply in the mammalian cells. Over 100 human diseases are attributed to mitochondrial dysfunction. Mitochondrial therapy (mitotherapy) aims to transfer functional exogenous mitochondria into mitochondria-defective cells for recovery of the cell viability and consequently, prevention of the disease progress.

 

Objective: The review summarizes the evidence on exogenous mitochondria that can directly enter mammalian cells for disease therapy following local and intravenous administration, and suggests that when healthy cells donate their mitochondria to damaged cells, the mitochondrial transfer between cells serve as a new mode of cell rescue. Then the transferred mitochondria play their roles in recipient cells, including energy production and maintenance of cell function.
Conclusion: Mitotherapy makes the of modulation of cell survival possible, and it would be a potential therapeutic strategy for mitochondrial diseases.

 

 

 

To read out more, please visit: http://www.eurekaselect.com/175033/article

Testimonial | Read what our Authors have to say about publishing in our Journal – By Aditya Bhattacharyya

 

Aditya Bhattacharyya

 

Journal Name: Current Organic Chemistry

Contributed Article: Synthetic Routes to 1,4,5,6-Tetrahydropyrimidines: An Overview and Recent Advances

Testimonial | Read what our Authors have to say about publishing in our Journal –  By Dr. Sanjay Singh

Sanjay singh-01-01.jpg

 

Journal Name: Current Drug Metabolism

Contributed Article: Emerging Trends in Nanotechnology: Nanozymes, Imaging Probes and Biosensors and Nanocarriers

EDITOR’S CHOICE ARTICLE – Patents for the Morphophysiological Quality of Seedlings and Grafted Peach Trees: Effects of Nutrient Solution and Substrates

Journal Name: Recent Patents on Food, Nutrition & Agriculture

Author(s): Aline G. Souza*, Oscar J. Smiderle, Ricardo E. Muraro, Valmor J. Bianchi.

 

 

 

Graphical Abstract:

 

 

Abstract:

Background: This study aimed to verify the influence of different substrates with and without addition of nutrient solution on the roostocks production of Capdeboscq cultivar and grafted peach plants of ‘Chimarrita’ scion.

Methods: In the first experiment, the height and stem diameter of the rootstocks were evaluated every two weeks, up to 90 days after transplanting (DAT). At 90 DAT, dry weight of shoots and roots, total dry mass and Dickson Quality Index were evaluated. In the second experiment, seedlings of ‘Capdeboscq’ were grafted with ‘Chimarrita’ scion. The growth of the scions and the percentage of living grafts were evaluated. At 146 DAT, the stem diameter of the scions, the SPAD index, the chlorophyll and nitrogen balance index were evaluated.

Discussion: The greatest mean values for the stem diameter of seedlings of the cv. Capdeboscq were obtained with the substrates T4 (5.53 mm); T2 (5.47 mm) and T1 (5.23 mm) with addition of nutrient solution, with seedlings reaching the plant standards according to the ordinance number 173 of May 27th of 1984, which recommends that rootstocks have to have a minimum stem diameter of 5.0 mm. Thus, the substrates which received the addition of nutrient solution, except the soil substrate, were adequate considering the rules that governing the peach tree production in Brazilian Nurserioes.

Conclusion: The nutrient solution already avaliblabe for Recent patents is highly indicated to obtain seedlings of ‘Capbdboscq’ rootstocks with high mophophysiological quality in less time during nursery cycle of plant production. The largest stem diameter for ‘Capdeboscq’ was obtained with substrate 35% sand + 15% soil + 50% bovine manure (5.53 mm); 75% sand + 25% soil (5.47 mm) and 100% sand (5.23 mm) with addition of nutrient solution. The best morphophysiological characteristics of ‘Chimarrita’ plants grafted on ‘Capdeboscq’ seedlings was obtained with the use of substrates 75% sand + 25% soil and 35% sand + 15% soil + 50% bovine manure, whose plants reached a morphological standard for sale, in just four and a half months DAT, that is 56 days after grafting.

 

For more details, please visit: http://www.eurekaselect.com/161916/article

Most Accessed Articles – Nanomedicine for Intranasal Delivery to Improve Brain Uptake

Journal Name: Current Drug Delivery

Author(s): Amit A. Patel*, Ravish J. Patel*, Shachi R. Patel.

Graphical Abstract:

 

Abstract:

Intranasal drug delivery system provides distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for the treatment of central nervous system diseases is, low concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantages like improved bioavailability, law dose and quick onset of action and high patient compliance, and the major disadvantage is residence time of drug and irreversible entrapment of drug. This article provides anatomical and physiological information about nasal route and various factors. Article discusses various types of nanoparticles used intranasally and moreover article also emphasizes patents, formulation under development and some.

 

For more details, please visit: http://www.eurekaselect.com/156384

Open Access Articles – Ethosomes and Transfersomes: Principles, Perspectives and Practices

Journal Name: Current Drug Delivery

Author(s): Varun Garg, Harmanpreet Singh, Sneha Bimbrawh, Sachin Kumar Singh*,Monica Gulati, Yogyata Vaidya, Prabhjot Kaur.

 

 

Graphical Abstract:

 

 

Abstract:

Background: The success story of liposomes in the treatment of systemic infectious diseases and various carcinomas lead the scientists to the innovation of elastic vesicles to achieve similar success through transdermal route. In this direction, ethosomes and transfersomes were developed with the objective to design the vesicles that could pass through the skin. However, there is a lack of systematic review outlining the principles, method of preparation, latest advancement and applications of ethosomes and transfersomes. This review covers various aspects that would be helpful to scientists in understanding advantages of these vesicular systems and designing a unique nano vesicular delivery system.

Methods: Structured search of bibliographic databases for previously published peer-reviewed research papers was explored and data was culminated in terms of principle of these vesicular delivery systems, composition, mechanism of actions, preparation techniques, methods for their characterization and their application.

Results: A total of 182 papers including both, research and review articles, were included in this review in order to make the article comprehensive and readily understandable. The mechanism of action and composition of ethosomes and transfersomes was extensively discussed. Various methods of preparation such as, rotary film evaporation method, reverse phase evaporation method, vortex/ sonication method, ethanol injection method, freeze thaw methods, along with their advantages has been discussed. It was also discussed that both these elastic nanocarriers offer unique advantages of ferrying the drug across membranes, sustaining drug release as well as protecting the encapsulated bio actives from external environment. The enhanced bioavailability and skin penetration of ethosomes as compared to conventional vesicular delivery systems is attributed to the presence of ethanol in the bilayers while that for transfersomes accrues due to their elasticity along with their ability to retain their shape because of the presence of edge activators. Successful delivery of synthetic drugs as well as phytomedicines has been extensively reported through these vesicles.
Conclusion: Though these vesicular systems offer a good potential for rational drug delivery, a thoughtfully designed process is required to optimize the process variables involved. Industrial scale production of efficacious, safe, cost effective and stable formulations of both these delivery systems appears to be a pre-requisite to ensure their utility as the trans-dermal vehicles.

For more details, please visit: http://www.eurekaselect.com/142368

Testimonial by Dr. Jessy Shaji!

Dr  Jessy Shaji

Dr. Jessy Shaji

Contributed Article: “Characterization and in vitro Cytotoxicity Evaluation of Meloxicam Loaded PEGylated Mixed Micelles Fabricated Using Quality by Design Approach”

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Author: Dr. Fei Qiao

“We are very glad to work with Bentham Science. It is a valued experience to us. Thanks again.”

Contributed  Article: A Survey on Low-Complexity Video Coding Methods and Architectures

 

Journal: “Current Hypertension Reviews”

Author: Dr. Enrique Morales-Villegas

“It has been an excellent experience to collaborate with Bentham Science Publishers like always. And I hope such an alliance continues, between your company and Latin-American writers like me”

Contributed  Article: Coronary Atherosclerosis The Implications of Being a Woman

 

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Author: Dr. Estibaliz Sansinenea

“It has been a pleasure to work with Bentham Science Publishers. Your services were effective and efficient in managing manuscripts.

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Contributed  Article:Antitubercular Natural Terpenoids: Recent Developments and Syntheses

 

  • Journal “Letters in Drug Design & Discovery”.

Author Dr. Agnieszka Gunia-Krzyzak

“I have always had a pleasant experience with Bentham Science Publishers. I appreciate the opportunity of publishing my articles in Bentham journals and I hope for further collaboration.”

Contributed  Article: Synthesis and Anticonvulsant Activity of N-(trans)- 3-phenylprop-2-en-1-yl (Cinnamyl) Derivatives of Aminoalkanols

Author’s Testimonial

Author's Testimonial

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  • ImageCurrent HIV Research

I found Bentham Science Publishers very prompt and systematic in review, acceptance and production of galley proofs and all the other processes included in publishing a scholarly paper.

The procedure and method is excellent.

 

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Department of Biochemistry,

University of Allahabad-Allahabad, UP 211002, India

 

Article Contribution: Oxidative Stress in HIV Patients receiving Antiretroviral Therapy

 

  • Current HIV Research

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Dr. Marilena Chinali Komesu

Department of Morphology,

Stomatology and Physiology, School of Dentistry of Ribeirão Preto,

University of São Paulo, Via do Café s/n, 14040-904 Ribeirão Preto, SP,

Brazil

 

Article Contribution: Influence of Antiretroviral Therapy and Periodontal Disease on Human Salivary Beta-Defensin 2 in Patients Infected with HIV

 

  • Current HIV Research

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Dept. of Science, University

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Article Contribution: Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

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