MOST ACCESSED ARTICLE – Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

Journal Name: Recent Patents on Anti-Cancer Drug Discovery

Author(s): Marco L. Lolli, Stefano Sainas, Agnese C. Pippione, Marta Giorgis, Donatella Boschi, Franco Dosio*.





Background: Human dihydroorotate dehydrogenase (hDHODH, EC, a flavindependent mitochondrial enzyme involved in de novo pyrimidine biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. However, human DHODH inhibitors have also been investigated as treatment for cancer, parasite infections (i.e. malaria) and viruses as well as in the agrochemicals industry.

Objective: An overview of current knowledge of hDHODH inhibitors and their potential uses in diseases where hDHODH is involved.

Method: This review focuses on recent advances in the development and application of hDHODH inhibitors, specifically covering the patent field, starting from a brief description of enzyme topography and of the strategies usually followed in designing its selective inhibitors.

Results: The most important and well-described novelty is the fact that the discovery, in the autumn of 2016, that hDHODH inhibitors are able to induce in vivo myeloid differentiation has led to the possibility of developing novel hDHODH based treatments for Acute Myelogenous Leukemia (AML).

Conclusion: The review will describe a variety of specific inhibitor classes and conclude on recent and future therapeutic perspectives for this target.



Health Benefits of Deep Breathing

When we are stressed, angry or anxious, we might experience rapid, shallow breathing, tightened muscles, and other negative symptoms. Not only do these unpleasant symptoms feel bad, they may also lead to heart problems, sleeplessness, increased blood pressure, infections and autoimmune diseases in the long run, if experienced repeatedly.

Breathe Deeply

Luckily, deep breathing can help you avoid these unpleasant symptoms and diseases. But what exactly does deep breathing do for you? Here’s a list:

  1. It relaxes your muscles

It is hard to maintain physical tension when breathing deeply.

  1. It improves oxygen delivery

When you are relaxed and breathing deeply, fresh oxygen is supplied to every cell in your body. This leads to better functionality of body organs, as well as enhanced mental focus and physical strength.

  1. It lowers blood pressure

As your muscles release tension as a result of deep breathing, your blood vessels expand and your blood pressure is normalized.

  1. It causes endorphins’ release

Deep breathing causes the release of endorphins, thus increasing the sensations of comfort and relieving pain.

  1. It detoxifies

Taking long and deep breaths helps improve lymphatic system function which boosts dangerous toxin release, thus cleansing the body and allowing it to focus its energy to more fruitful tasks.

So, breathe deeply and live more joyfully!

Highlighted Article – Il-27: Friend or Foe in the Autoimmune Diseases – Current Immunology Reviews

CIR- Ali Ganji

Testimonial by Ali Ganji!

Ali Ganji

Contributed Article: “IL-27: Friend Or Foe in the Autoimmune Diseases

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