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Current Chinese Medical Science
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Current Chinese Engineering Science publishes original research articles, letters, case reports, reviews/mini-reviews and guest edited thematic issues dealing with various topics related to engineering in China, while contributions from abroad are also welcome.
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Author(s): Soheil Sedaghat, Ommoleila Molavi, Akram Faridi, Ali Shayanfar*, Mohammad Reza Rashidi.
Background: Signal transducer and activator of transcription 3 (STAT3), an oncogenic protein found constitutively active in many types of human malignancies, is considered to be a promising target for cancer therapy.
Objective: In this study for the first time, a simple and accurate method has been developed for the determination of a STAT3 dimerization inhibitor called stattic in aqueous and plasma samples.
Methods: A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18 column as stationary phase, and the mixture of acetonitrile (60%) and water (40%) as mobile phase with a UV detection at 215 nm were applied for quantification of stattic. The developed method was validated by Food and Drug Administration (FDA) guideline.
Results: The method provided a linear range between 1-40 and 2.5-40 µg mL-1 for aqueous and plasma samples, respectively, with a correlation coefficient of 0.999. The accuracy (as recovery) of the developed method was found to be between 95-105% for aqueous medium and 85-115% for plasma samples. The precision (as relative standard deviation) for aqueous and plasma samples was less than 6% and 15%, respectively. The sensitivity of the developed method based on FDA guideline was 1 µg mL-1 for aqueous and 2.5 µg mL-1 for plasma samples.
Conclusion: These results show that the established method is a fast and accurate quantification for stattic in aqueous and plasma samples. To read out more, please visit: http://www.eurekaselect.com/162366/article
Author(s): Anindita Mukherjee, Nirnita C. Ghosal, Grigory V. Zyryanov, Adinath Majee*, Sougata Santra*
Aziridines are highly versatile intermediates in organic synthesis due to their easy access and their susceptibility to ring-opening by facile C-N bond cleavage. They are synthetically very important as they are valuable precursors of amino sugars, β-lactam antibiotics and alkaloids or present in various natural products that exhibit potent biological activities. The synthesis of this moiety from the easily available chemicals is desirable due to its tremendous use in the various branches of chemistry. Here, a short review has been reported on the synthesis of this scaffold employing different strategies under different greener conditions. Various methods have been developed in the presence of green catalysts and solvents.
To read out more, please visit: http://www.eurekaselect.com/176129/article
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Publish your Medical Research for FREE in our journal: Current Chinese Computer Science
Bentham Science is interested in appointing active Executive Guest Editors for the journal; Current Chinese Computer Science. If you are working in the related field as of the mentioned journals and are interested in becoming an Executive Guest Editor, please send us your CV and a list of publications. You can also recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications.
Mention in the subject line, the field of interest and send your CV at: hermain@benthamscience.net and CC: faizan@benthamscience.net
Current Chinese Computer Science publishes original research articles, letters, reviews/mini-reviews and guest edited thematic issues dealing with various topics related to computer science in China, while contributions from abroad are also welcome.
Current Chinese Computer Science is not limited to a specific aspect of the field but is instead devoted to a wide range of sub fields in the field. Articles of interdisciplinary nature are particularly welcome. Submission in the following areas are of special interest to the readers of this journal:
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