Bentham Science Free Trial in Beijing Zhongke Import & Export Ltd | Free Trial ends on Sept 3rd, 2020

It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Beijing Zhongke Import & Export Ltd. The trial subscription covers access to Bentham Science journals and Books content.

Bentham Science uses the platforms Eurekaselect (our proprietary platform) & Ingenta Connect (a well-known content gateway) for offering journal and Books trials. The trial has been activated on both platforms, Eureka & Ingenta. (Note: Book trials are only available on Eurekaselect)

Members of your library can view all Bentham Science journal issues (2000-2020) in full text and eBook content which will allow your library users to access our catalog of over 800 eBooks for the same duration via the following URLs:

1.  https://eurekaselect.net

2. http://www.ingentaconnect.com/content/ben

Trial Duration:  1 Month
End Date: Sept 3rd, 2020

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Ingenta Connect: http://www.ingentaconnect.com/content/ben

Eureka Select:
For Journals: https://eurekaselect.net/bypublication
For eBooks:  https://eurekaselect.net/bybook

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

New Book Announcement –Perspectives in Lung Cancer

Perspectives in Lung Cancer compiles basic and advanced topics on lung cancer pathology and treatment in a single volume. Chapters introduce the reader to chest and lung anatomy followed by the biology of lung cancer. Subsequent chapters delve into diagnostic methods for lung cancer while progressing into treatment options. The book culminates into an explanation of the concept of the Lung Cancer Centre, which is a representation of the editors’ vision for organizing a lung cancer treatment unit.

Key features:

  1. -Organizes key topics covering both standard and avante-garde topics related to lung cancer
  2. -All contributions are presented by experts in lung cancer treatment
  3. -Addresses basic biology of lung cancer
  4. -Provides information about 3D surgical planning, a relatively new concept in the field of thoracic surgery
  5. -Addresses the standard method of resection, VATS and Mini VATS
  6. -Covers the role of radiation and systemic anti-cancer therapies in lung cancer treatment
  7. -Provides a glimpse of modern methods such as image guided surgery and therapy, laser therapy, and photo-dynamic therapy
  8. -Covers the role of palliative care for lung cancer
  9. -Presents information about a visionary organization of a lung cancer unit and treatment centre

The combination of carefully organised chapters covering a wide array of topics make this reference an essential reference for healthcare professionals interested in acquiring a broad perspective on lung cancer treatment with the goal of improving patient outcomes.

Read out the full version here

Podcast – Primary Hypertriglyceridemia: A Look Back on the Clinical Classification and Genetics of the Disease

Journal Name: Current Diabetes Reviews

Podcast by: Mohthash Musambil

Author(s): Mohthash Musambil, Khalid Al-Rubeaan*, Sara Al-Qasim, Dhekra Al Naqeb, Abdulrahman Al-Soghayer.

Abstract

Introduction: Hypertriglyceridemia (HTG) is one of the most common metabolic disorders leading to pancreatitis and cardiovascular disease. HTG develops mostly due to impaired metabolism of triglyceride-rich lipoproteins. Although monogenic types of HTG exist, most reported cases are polygenic in nature.

Aim: This review article is focused on the classification of Primary HTG and the genetic factors behind its development with the aim of providing clinicians a useful tool for early detection of the disease in order to administer proper and effective treatment.

Discussion: HTG is often characterized by a complex phenotype resulting from interactions between genetic and environmental factors. In many instances, the complexity, perplexing causes, and classification of HTG make it difficult for clinicians to properly diagnose and manage the disorder. Better availability of information on its pathophysiology, genetic factors involved, environmental causes, and their interactions could help in understanding such complex disorders and could support its effective diagnosis and treatment.

Conclusion: The current review has summarized the case definition, epidemiology, pathophysiology, clinical presentation, classification, associated genetic factors, and scope of genetic screening in the diagnosis of primary HTG.

Subscribe to our YouTube channel for more: https://bit.ly/2Uq4Cm9

Podcast – Editorial: Image Perception

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Podcast by Author(s): Euishin Edmund Kim.

Volume 15 , Issue 9 , 2019

Web: https://www.eurekaselect.com/174515/a…

Subscribe to our YouTube channel for more: https://bit.ly/2Uq4Cm9

New Book Announcement – Changing Landscapes in Urban British Churchyards

Changing Landscapes in Urban British Churchyards

Authors: “Sylvia E. Thornbush”“Mary J. Thornbush”

This interdisciplinary reference work presents a linked consideration, to the reader, of physical-cultural (physicocultural) representations of headstones located in urban churchyards in England and Scotland. The geomorphology of landscapes relevant to these locations is explained with the help of detailed case studies from Oxford and Edinburgh. The integrated physicocultural approach addresses the conservation of the archaeological record and presents a cross-temporal perspective of landscape change – of the headstones as landforms in their landscape (as part of deathscapes). The physical record (of headstones) is examined in the context of both cultural representation and change. In this way, an integrated approach is employed that connects the physical (natural) and cultural (social) records kept by historians and archeologists over the years.

Changing Landscapes in Urban British Churchyards is of interest to geomorphologists, historians and scholars interested in understanding landscaping studies and cultural nuance of specific historical urban sites in England and Scotland. Read out the full version HERE

PREFACE:

The proposed book is a collaborative work between an archaeologist with research expertise in historical archaeology and a geomorphologist with research interests in applied (environmental) geomorphology and landscape change. As an interdisciplinary work, the book provides a linked consideration of physical-cultural (physicocultural) representations of headstones located in urban churchyards in England and Scotland, with detailed case studies from 13 urban churchyards located in six urban centres, including two coastal sites. The integrated physicocultural approach that becomes apparent by the end of the book addresses the conservation of the archaeological record and presents a cross-temporal perspective of headstones as part of deathscapes. The physical record (of headstones) is examined in the context of cultural representation and change. In this way, an integrated approach is employed that connects physical and cultural aspects of the material culture.

CONFLICT OF INTEREST

The authors confirm that the content of this book has no conflict of interest.

S. E. Thornbush

School of History, Classics and Archaeology
University of Edinburgh
Scotland
UK

&


Mary J. Thornbush

Oriel College
University of Oxford
England
UK

New Issue – Current Pharmaceutical Analysis; Volume 16 Issue 1

AIMS & SCOPE

Current Pharmaceutical Analysis publishes full-length/mini reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.

Articles from the Journal 

For more details on the articles, please visit here

Register today for Subscription Discounts!

Register Now!

Register for FREE today and receive an exclusive 10% discount on current and upcoming journal subscriptions.

Editors Choice Article – Exploration of Ion Channels in Mycobacterium tuberculosis: Implication on Drug Discovery and Potent Drug Targets Against Tuberculosis

Author(s): Manish Dwivedi*.

Journal Name: Current Chemical Biology

Abstract:

Scientific interest in mycobacteria has been sparked by the medical importance of Mycobacterium tuberculosis (Mtb) that is known to cause severe diseases in mammals, i.e. tuberculosis and by properties that distinguish them from other microorganisms which are notoriously difficult to treat. The treatment of their infections is difficult because mycobacteria fortify themselves with a thick impermeable cell envelope. Channel and transporter proteins are among the crucial adaptations of Mycobacterium that facilitate their strength to combat against host immune system and anti-tuberculosis drugs. In previous studies, it was investigated that some of the channel proteins contribute to the overall antibiotic resistance in Mtb. Moreover, in some of the cases, membrane proteins were found responsible for virulence of these pathogens. Given the ability of M. tuberculosis to survive as an intracellular pathogen and its inclination to develop resistance to the prevailing anti-tuberculosis drugs, its treatment requires new approaches and optimization of anti-TB drugs and investigation of new targets are needed for their potential in clinical usage. Therefore, it is imperative to investigate the survival of Mtb. in stressed conditions with different behavior of particular channel/ transporter proteins. Comprehensive understanding of channel proteins and their mechanism will provide us direction to find out preventive measures against the emergence of resistance and reduce the duration of the treatment, eventually leading to plausible eradication of tuberculosis. To read out more, please visit: http://www.eurekaselect.com/180061/article

Press Release – Large-scale analysis of protein arginine methylation by mass spectrometry

The article by Dr. Tiziana Bonaldi et al. is published in Current Protein & Peptide Science, 2020

Methylation (namely addition of a methyl group) of arginine amino acid residues of proteins is a post-translational modification (PTM) catalyzed by a family of nine enzymes called Protein Arginine Methyl-Transferases (PRMTs).

PRMTs have been gaining increasing attention in the scientific landscape due their role in several essential physiological processes and implication in various diseases, including cancer and neurological disorders; loss of PRMT1 is lethal at the early developmental stages, while overexpression is frequently observed in different tumor types and correlates with poor patient prognosis, suggesting that inhibition of PRMTs may represent an effective therapeutic approach in oncology. Moreover, PTM levels are deregulated in different tumor types, and both local and global changes in PTM of the DNA-associated proteins – the histones – are linked to Amyotrophic Lateral Sclerosis. Due to the large body of scientific evidence indicating their role in cell pathophysiology, several PRMT inhibitors have been designed and developed as a potential new class of drugs. For instance, a potent, reversible type I PRMT inhibitor has been shown to have anti-tumor effects in human cancer models and some of the molecular candidates have entered clinical trials for solid tumors and lymphomas.

“Although it was first described in 1968,” says Dr Tiziana Bonaldi, Group Leader at the European Institute of Oncology, “for almost 30 years, very little was known about the extent of protein arginine methylation, its effect on protein activity, and its biological role. The first PRMT, capable of catalyzing arginine methylation, was discovered in 1996 and, since then, nine proteins exerting the same functions have been discovered. However, inefficient analytical approaches have largely limited a comprehensive understanding of their biological function. Quantitative Mass spectrometry has emerged as the ideal analytical strategy to study the extent of protein arginine-methylation in model systems and identify PRMT targets, thus contributing substantial knowledge in this field.”

In their article published in Current Protein & Peptide Science, Dr. Bonaldi and co-workers offer an overview on state-of-the-art arginine methyl-proteomics, describing the innovations that led – from the description by Mathias Mann’s group of the first high-quality methyl-proteome in 2004 – to the latest studies that profile protein-methylation events occurring on hundreds of cellular proteins. Throughout this review, the authors describe the implementations both in the biochemical methods and in the computational methods for Mass spectrometry data analysis or the identification of sites of arginine methylation, discussing the pros and cons of the most common strategies employed.

Furthermore, relevant issues related to protein-arginine methylation analysis that are still under development are also discussed, such as the discrimination of symmetric and asymmetric arginine-di-methylation from Mass spectrometry fragmentation spectra. “These two modifications have identical mass, yet they are catalyzed by different PRMTs and have substantially different biological outcomes,” explains Bonaldi; “Indeed, even though, for instance, both have a role in regulation of transcription, while asymmetric di-methylation is activating, symmetric di-methylation is repressive. Therefore, being able to distinguish between the two processes is crucial.”

Finally, major emphasis is devoted to the heavy methyl SILAC strategy, a variation of the more conventional SILAC (Stable Isotope Labelling with Amino acids in Cell culture). “The heavy methyl SILAC strategy was designed to increase the confidence of in vivo arginine methyl-peptides identification by Mass spectrometry,” – continues Bonaldi – “and the use will be facilitated by the recent development of ad hoc algorithms tailored for processing of heavy methyl SILAC datasets, such as MethylQuant and hmSEEKER.”

Importantly, the authors conclude that optimization of the currently available analytical approaches and their systematic application will play a key role in the future research on the involvement of protein methylation in biological processes, providing critical insights in the related cellular biology processes and likely offering potential novel targets to be exploited in a clinical context. Read the full Press Release to find out more: https://www.eurekalert.org/pub_releases/2020-05/bsp-lao052220.php

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To get the full-text article, please visit the following link: http://www.eurekaselect.com/181344/article

Become a Bentham Ambassador for the Journal “Coronaviruses”

BECOME A BENTHAM AMBASSADOR FOR THE  JOURNAL,

“Coronaviruses”   

NEW IN 2020

Bentham Science is interested in appointing active Bentham Ambassadors for a newly launched journal; Coronaviruses. If you are working in a related field of the journal and interested in becoming an Ambassador, please send us your CV and a list of publications. You can also recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. 

Mention in the subject line, the field of interest and send your CV at: hermain@benthamscience.net and CC: faizan@benthamscience.net

BENEFITS AVAILABLE TO BENTHAM SCIENCE AMBASSADORS:

Bentham Science has developed a comprehensive system of rewards and benefits for Bentham Science Ambassadors, some of which are mentioned below:

  1. Your name, photograph and brief biography will be published on a dedicated Bentham Science Ambassadors web-page, which will help you in your various promotional activities since your position will be visible to a large number of visitors on the website.
  2. As a Bentham Science Ambassador, you would have the possibility of having your first article published, in any Bentham Science journal of your choice, as Open Access, at a 50% discount on our standard publishing rates. For the list of journals, please refer to our website http://benthamscience.com/
  3. You will get an online Certificate of acknowledgement for your services as a Bentham Science Ambassador.
  4. The most active Ambassadors can avail discounts on any conferences that are supported by Bentham Science, in respect of registration fee.
  5. Other benefits can be viewed on the Bentham Science Ambassadors web-page http://www.benthamambassadors.com/

The responsibilities of Bentham Science Ambassadors are to:

  1. Introduce and promote Bentham Science journals among librarians, colleagues and researchers in your region.
  2. Encourage submission of articles to relevant Bentham Science journals, in your field, from eminent scientists.
  3. You may, if you wish, also appoint some young researchers as “Associate Bentham Science Ambassadors” to magnify this effort.

To know more about the journal, please visit: https://benthamscience.com/journals/Coronaviruses/

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