MOST ACCESSED ARTICLE – Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling

Journal Name: Current Molecular Medicine

Author(s): X. Xie, T. Zhou, Y. Wang, H. Chen, D. Lei, L. Huang, Y. Wang, X. Jin, T. Sun, J. Tan, T. Yin, J. Huang, H. Gregersen, G. Wang*.

 

 

Abstract:

Background: Vascular network formation induced by angiogenesis plays an important role in many physiological and pathological processes. However, the role of blood flow and underlying mechanisms in vascular network formation, for example for the development of the caudal vein plexus (CVP), is poorly understood.

Objective: The aim of this study was to explore the role of ERK5-klf2a-nos2b signaling in the CVP angiogenesis.

Method and Results: In this study on tnnt2a-MO injection and chemical blood flow modulator treatment in zebrafish embryos, we demonstrated that decreased blood flow disrupted CVP formation. The hemodynamic force was quantitatively analyzed. Furthermore, CVP angiogenesis in zebrafish embryos was inhibited by disruption of the blood flow downstream effectors ERK5, klf2a, and nos2b in response to treatment with the ERK5 specific inhibitor and to injection of klf2a-MO, nos2b-MO. Overexpression of klf2a mRNA or nos2b mRNA restored vascular defects in tnnt2a or klf2a morphants. The data suggest that flow-induced ERK5-klf2a-nos2b signaling is involved in CVP angiogenesis in zebrafish embryos.

Conclusion: We have demonstrated that blood flow is essential for vascular network formation, specifically for CVP angiogenesis in zebrafish. A novel genetic and mechanical mechanism was discovered in which ERK5 facilitates the integration of blood flow with the downstream klf2a-nos2b signaling for CVP angiogenesis.

 

READ MORE HERE: http://www.eurekaselect.com/160682

EVA – Ageing Of The Blood Vessels Before Time

Celebrating the World Heart Day on September 29th, we bring our focus to some serious problems related to the heart and vascular system that can lead a human being towards death. One such problem is the ageing of the blood vessels before their actual time. This phenomenon is called Early Vascular Ageing or EVA. Early vascular ageing is a significant marker for cardiovascular diseases and is generally identified by stiffening of the arteries.

artery_hardening

EVA is caused when the blood vessels show signs of ageing before they reach their chronological age. This renders the blood vessels to be less flexible and disturbs the control of blood flow from and to the heart. It may occur due to various reasons including genetic factors, environmental effects on vascular system or any damages caused to the blood vessels over time etc. As the researchers, Dr. Stephane Laurent et al. notify in their article published in the journal, Current Hypertension Reviews, EVA is a problem that needs a lot of attention and finding its prevention can ensure many cardiovascular diseases can be combatted.

The article, Early Vascular Ageing (EVA): Definitions and Clinical Applicability, explains the phenomenon, its consequences and opportunities for finding preventive measures.

Find more studies on Early Vascular Ageing here: http://benthamscience.com/journals/current-hypertension-reviews/

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