Tag: Cancer

eBook Highlights | A Guide to Evaluate Environmental Contaminants and Natural Products

 

This eBook is edited by Ashita Sharma, Manish Kumar, Satwinderjeet Kaur and Avinash Kaur Nagpal published on June 10, 2019. Book URL: https://ebooks.benthamscience.com/book/9789811410963/

 

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Rapid urbanization has pressed the need to assess the environment for the presence of toxic pollutants. Evaluation of Environmental Contaminants and Natural Products: A Human Health Perspective presents a guide to tackle this challenge in two parts which represent two different approaches. The book has two themed parts. The first part of the book summarizes the alarming effects of environmental contaminants. Studies depicting the direct relationship of environmental contaminants with cancer incidence have been referenced. Scientific studies have established an inverse relation between cancer and ingestion of dietary phytoconstituents (phytochemicals) in the form of fruits, vegetables and botanical herbs. Plant products as dietary supplements can suppress contaminant toxicity by regulating the resulting reactive species and also by assisting their bodily excretion through Phase 1 and Phase 2 enzyme metabolism. The second part of the book, shifts focus to phytoconstituents which, if included in diet, can prevent the harmful effects of pollutants. Notes on the anti-mutagenic, anti-genotoxic and anti-carcinogenic potential of many plant products are referenced. The combination of information about contemporary issues of carcinogenic contaminants in the environment coupled with the references to relevant studies in this handbook will enlighten readers studying courses in environmental chemistry, toxicology, botany, and ecology about environmental toxins and help them understand specific dietary measures known to reduce the toxic impact. Researchers in the field of nutrition can also benefit from the information provided. To read out more, please visit: https://ebooks.benthamscience.com/book-highlights/190725001/

Press Release | Bentham science’s latest book ‘Frontiers in Anti-Cancer Drug Discovery Volume 10’

 

This eBook is authored by Dr. Atta-ur-Rahman, published on June; this book is authored by Atta-ur-Rahman and M. Iqbal Choudhary; published on May 31, 2019. For Further Details, Please Visit : https://ebooks.benthamscience.com/book/9789811400711/

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Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The tenth volume of the series features chapters covering the following topics:

  • Challenges in the Management of Hepatoblastoma
  • The Emerging Role of Monocarboxylate Transporter-1 in Cancer
  • In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery
  • Recent Advances in the Development of Mesoporous Anti-Cancer Drug Nanocarriers
  • Polyphenols and Cancer
  • Glioblastoma Multiforme
  • Cutting Edge Targeting Strategies Utilizing Nanotechnology in Breast Cancer Therapy
Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2019-06/bsp-bsl062019.php

eBooks Press Release — NEWS | The Seventh Volume of Topics in Anti-Cancer Research Is Now Available

 

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Topics in Anti-Cancer Research (Volume 7) covers important advances on both experimental (preclinical) and clinical cancer research in drug development.

 

The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.

The topics covered in the seventh volume of this series include:

– The role of inflammation in chemotherapy-induced neuromuscular effects

– Advances in nutrigenomics and relevant anti-cancer patents

– Stimuli-responsive nanocarriers for on-demand anti-cancer drug release

– Harnessing biochemical mechanisms that control autophagy for treating esophageal cancer

 

To read out more, please visit: https://ebooks.benthamscience.com/press-releases/19012401/

eBook Highlights| Topics in Anti-Cancer Research -Volume 7

The seventh volume of the series covers topics such as drug delivery, new avenues for treatment of esophageal cancer and the role of nutrigenomics in finding new therapies.

Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.

The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy.

The latest volume of the series starts with a review on non-coding RNAs and associated patents. These patents help researchers to identify various cancer biomarkers and oncogenic regulatory mechanisms. 3 chapters cover nanocarrier patents for enhanced drug delivery of chemotherapeutic agents. Nanocarriers allow drug manufacturers to encapsulate chemotherapeutic agents within thin membranes which allows the molecules to reach the targeted cellular location in the body. The specific topics refer to Nanotaxol which is a nanotechnology enhanced version of Taxol® – a chemotherapeutic agent derived from chemicals in the bark of Taxus brevifolia, stimuli responsive nanocarriers which change behavior according to temperature and pH and smart nanoformulations which rely on different chemical formulations to reach molecular targets. Other topics covered in this volume include the role of autophagy in esophageal cancer, and nutrigenomics (the science of how biological nutrients affect gene expression) in cancer research. In terms of patents, the reader will find a list of compounds which modulate autophagy, and nutrigenomic methods that allow researchers to understand nutritional biomarkers of disease and customize nutraceutical formulations based on genetic and metabolic factors, respectively. To read out more, please visit: https://ebooks.benthamscience.com/book-highlights/190102001/

 

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CALL FOR PAPERS | Thematic Issue for Current Pharmaceutical Design

Journal: Current Pharmaceutical Design

Guest Editor(s): Ling-Qing Yuan
Tentative Publication Date: August, 2019

 

“Novel Strategies for Gene Therapy – Recent Advances in the use of Exosomes for Disease Treatment“

The aim of the present special issue is to invite researchers to contribute review or original research articles reporting the most recent and future therapeutic applications using exosomes in various diseases. Moreover, articles on the synthesis and isolation of exosomes, involvement of exosomes in the pathogenesis of different disease, and the use of exosomes in therapeutic strategies for different diseases are welcome. The objective and critical vision of this advance will be beneficial for us to understand and become familiar with the application of exosomes in treating different diseases. For more details please visit: https://bit.ly/2Je21qG

 

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

 

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CALL FOR PAPERS | Thematic Issue for Current Pharmaceutical Design

Journal: Current Pharmaceutical Design

 

Novel Strategies for Gene Therapy – Recent Advances in the use of Exosomes for Disease Treatment

 

The aim of the present special issue is to invite researchers to contribute review or original research articles reporting the most recent and future therapeutic applications using exosomes in various diseases. Moreover, articles on the synthesis and isolation of exosomes, involvement of exosomes in the pathogenesis of different disease, and the use of exosomes in therapeutic strategies for different diseases are welcome. The objective and critical vision of this advance will be beneficial for us to understand and become familiar with the application of exosomes in treating different diseases. For more details please visit: https://bit.ly/2Je21qG

 

Guest Editor(s): Ling-Qing Yuan
Tentative Publication Date: August, 2019

Email here to submit your paper:  faizan@benthamscience.net

                     CC: hermain@benthamscience.net 

 

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Press Release | The landscape of protein tyrosine phosphatase (Shp2) and cancer

 

As the proteomics technology develops and human genomic analysis becomes easier to execute, molecules involved in the regulation of biochemical signaling pathways have become interesting subjects for researchers. Earlier research was based on assumptions that metabolic cascades such as phosphorylation was linear. However, current studies indicate a multi-network signaling cascade. The interlinked signals performing in synchrony can be observed being responsive to a stimulus during physiological regulation. Although phosphatase is not considered as an inert house-keeping enzyme in the process of phosphorylation and regulation, its catalytic and regulatory actions show an involvement in signal transduction pathways. The key role of phosphatases is now defined to maintain and regulate the degree of signal’s intervals. According to recent studies, Shp2, a phosphatase protein has shown to have a remarkable role in governing the signaling response amplitude.

 

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Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2018-12/bsp-tlo122718.php

ARTICLE BY DISEASE – Docking and Molecular Dynamics Study on the Inhibitory Activity of Novel Inhibitors on Epidermal Growth Factor Receptor (EGFR)

ARTICLE BY DISEASE ON ” ANAL CANCER “

 

 

Abstract:

EGFR is the cell-surface receptor. Its overexpression or overactivity has been associated with a number of cancers, including breast, lung, ovarian, and anal cancers. Many therapeutic approaches are aimed at the EGFR. A series of 2, 7-diamino-thiazolo [4,5-d] pyrimidine analogues are among the most highly potent and selective inhibitors of EGFR described to date. For in-depth investigation into the structural and chemical features responsible for the binding recognition mechanism concerned, as well as for exploring the binding pocket of these compounds, we performed a series of automated molecular docking operations. It was revealed that the binding site consisted of three main areas (P1, P2 and P3) composed of most of the hydrophobic amino acids able to accommodate the lipophilic arms of the compounds investigated. However, the solvent interface did not make much contribution to the binding of the inhibitors. The presence of residues Met793 and Asp855 may also be responsible for the binding recognition through H-bond interactions, with Phe856 through a T-shape π-π stacking interaction. The interaction model and pharmacophore of EGFR inhibitors were derived that can be successfully used to explain the different biologic activities of these inhibitors. Moreover, the docking results were quite robust as further validated by molecular dynamics. It is anticipated that the findings reported here may provide very useful information or clue for designing effective drugs for the therapeutic treatment of EGFR-related cancer.

 

For more details, please visit: http://www.eurekaselect.com/node/87265/article

Most Accessed Articles – CAR T-cell Therapy: A New Era in Cancer Immunotherapy

Journal Name: Current Pharmaceutical Biotechnology

Author(s): Miliotou N. Androulla, Papadopoulou C. Lefkothea*.

 

 

 

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Abstract:

Background: Cancer is one of the leading causes of death worldwide. Over the years, a number of conventional cytotoxic approaches for neoplastic diseases has been developed. However, due to their limited effectiveness in accordance with the heterogeneity of cancer cells, there is a constant search for therapeutic approaches with improved outcome, such as immunotherapy that utilizes and enhances the normal capacity of the patient’s immune system.

Methods: Chimeric Antigen Receptor (CAR) T-cell therapy involves genetic modification of patient’s autologous T-cells to express a CAR specific for a tumor antigen, following by ex vivo cell expansion and re-infusion back to the patient. CARs are fusion proteins of a selected single-chain fragment variable from a specific monoclonal antibody and one or more T-cell receptor intracellular signaling domains. This T-cell genetic modification may occur either via viral-based gene transfer methods or nonviral methods, such as DNA-based transposons, CRISPR/Cas9 technology or direct transfer of in vitro transcribed-mRNA by electroporation.

Results: Clinical trials have shown very promising results in end-stage patients with a full recovery of up to 92% in Acute Lymphocytic Leukemia. Despite such results in hematological cancers, the effective translation of CAR T-cell therapy to solid tumors and the corresponding clinical experience is limited due to therapeutic barriers, like CAR T-cell expansion, persistence, trafficking, and fate within tumors.

Conclusion: In this review, the basic design of CARs, the main genetic modification strategies, the safety matters as well as the initial clinical experience with CAR T-cells are described.

 

For more details, please visit: http://www.eurekaselect.com/161365

World Heart Day, 2018!

 

 

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World Heart Day is part of an international campaign to spread awareness about heart disease and stroke prevention. This is the perfect day to quit smoking, get exercising and start eating healthy – all in the name of keeping your ticker in good working order, and improving the health and well being of people the world over.

The World Heart Federation have found that heart disease and strokes are the world’s leading cause of death, killing 17.1 million people every year – that’s more than victims of cancer, HIV and AIDS and malaria.

 

Bentham Science publishes articles related to World Heart Day in its Subscription based journals including:

To Avail 20% Discount on related eBooks, kindly visit: https://ebooks.benthamscience.com/

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