Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets

Author(s): Talambedu Usha, Sushil K. Middha, Anusha A. Kukanur, Rachamadugu V. Shravani, Mahantesh N. Anupama, Nagasamudram Harshitha, Ameena Rahamath, Sumedha S. Kulkarni, Arvind K. Goyal

Journal Name: Current Protein & Peptide Science

Why is it important?

Drug Repurposing (DR) is an alternative to the traditional drug discovery process. It is cost and time effective with high returns and low-risk process that can tackle the increasing need for interventions for varied diseases and new outbreaks. Repurposing of old drugs for other diseases has gained wider attention, as there have been several old drugs approved by the FDA for new diseases. In the global emergency of COVID-19 pandemic, this is one of the strategies implemented in the repurposing of old anti-infective, anti-rheumatic and anti-thrombotic drugs. The goal of the current review is to elaborate the process of DR, its advantages, repurposed drugs for a plethora of disorders, and the evolution of related academic publications. Further, detailed are the computational approaches: literature mining and semantic inference, network-based drug repositioning, signature matching, retrospective clinical analysis, molecular docking and experimental phenotypic screening. We discuss the legal and economic potential barriers in DR, existent collaborative models and recommendations for overcoming these hurdles and leveraging the complete potential of DR in finding new indications. Read more about the article here: https://bit.ly/3yMobGT

Podcast – The Role of Vitamin D and Sunlight Incidence in Cancer.

Podcast by Dr. Alice Câmara – May 19, 2020

A study aimed to review the relationship between VD deficiency and cancer: http://www.eurekaselect.com/170650/article

Subscribe to our YouTube channel for more: https://bit.ly/1lr0czy

Editors Choice Article | Mitotherapy as a Novel Therapeutic Strategy for Mitochondrial Diseases

 

Author(s): Ailing Fu*

Graphical Abstract:

 

Abstract:

Background: The mitochondrion is a multi-functional organelle that is mainly responsible for energy supply in the mammalian cells. Over 100 human diseases are attributed to mitochondrial dysfunction. Mitochondrial therapy (mitotherapy) aims to transfer functional exogenous mitochondria into mitochondria-defective cells for recovery of the cell viability and consequently, prevention of the disease progress.

 

Objective: The review summarizes the evidence on exogenous mitochondria that can directly enter mammalian cells for disease therapy following local and intravenous administration, and suggests that when healthy cells donate their mitochondria to damaged cells, the mitochondrial transfer between cells serve as a new mode of cell rescue. Then the transferred mitochondria play their roles in recipient cells, including energy production and maintenance of cell function.
Conclusion: Mitotherapy makes the of modulation of cell survival possible, and it would be a potential therapeutic strategy for mitochondrial diseases.

 

 

 

To read out more, please visit: http://www.eurekaselect.com/175033/article

Most Accessed Articles | Development of an HPLC-UV Method for Quantification of Stattic

Journal Name: Current Pharmaceutical Analysis

Author(s): Soheil Sedaghat, Ommoleila Molavi, Akram Faridi, Ali Shayanfar*, Mohammad Reza Rashidi.

Graphical Abstract:

 

 

Abstract:

Background: Signal transducer and activator of transcription 3 (STAT3), an oncogenic protein found constitutively active in many types of human malignancies, is considered to be a promising target for cancer therapy.

Objective: In this study for the first time, a simple and accurate method has been developed for the determination of a STAT3 dimerization inhibitor called stattic in aqueous and plasma samples.

Methods: A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18 column as stationary phase, and the mixture of acetonitrile (60%) and water (40%) as mobile phase with a UV detection at 215 nm were applied for quantification of stattic. The developed method was validated by Food and Drug Administration (FDA) guideline.

Results: The method provided a linear range between 1-40 and 2.5-40 µg mL-1 for aqueous and plasma samples, respectively, with a correlation coefficient of 0.999. The accuracy (as recovery) of the developed method was found to be between 95-105% for aqueous medium and 85-115% for plasma samples. The precision (as relative standard deviation) for aqueous and plasma samples was less than 6% and 15%, respectively. The sensitivity of the developed method based on FDA guideline was 1 µg mL-1 for aqueous and 2.5 µg mL-1 for plasma samples.

Conclusion: These results show that the established method is a fast and accurate quantification for stattic in aqueous and plasma samples. To read out more, please visit: http://www.eurekaselect.com/162366/article

eBook Highlights | A Guide to Evaluate Environmental Contaminants and Natural Products

 

This eBook is edited by Ashita Sharma, Manish Kumar, Satwinderjeet Kaur and Avinash Kaur Nagpal published on June 10, 2019. Book URL: https://ebooks.benthamscience.com/book/9789811410963/

 

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Rapid urbanization has pressed the need to assess the environment for the presence of toxic pollutants. Evaluation of Environmental Contaminants and Natural Products: A Human Health Perspective presents a guide to tackle this challenge in two parts which represent two different approaches. The book has two themed parts. The first part of the book summarizes the alarming effects of environmental contaminants. Studies depicting the direct relationship of environmental contaminants with cancer incidence have been referenced. Scientific studies have established an inverse relation between cancer and ingestion of dietary phytoconstituents (phytochemicals) in the form of fruits, vegetables and botanical herbs. Plant products as dietary supplements can suppress contaminant toxicity by regulating the resulting reactive species and also by assisting their bodily excretion through Phase 1 and Phase 2 enzyme metabolism. The second part of the book, shifts focus to phytoconstituents which, if included in diet, can prevent the harmful effects of pollutants. Notes on the anti-mutagenic, anti-genotoxic and anti-carcinogenic potential of many plant products are referenced. The combination of information about contemporary issues of carcinogenic contaminants in the environment coupled with the references to relevant studies in this handbook will enlighten readers studying courses in environmental chemistry, toxicology, botany, and ecology about environmental toxins and help them understand specific dietary measures known to reduce the toxic impact. Researchers in the field of nutrition can also benefit from the information provided. To read out more, please visit: https://ebooks.benthamscience.com/book-highlights/190725001/

Press Release | Bentham science’s latest book ‘Frontiers in Anti-Cancer Drug Discovery Volume 10’

 

This eBook is authored by Dr. Atta-ur-Rahman, published on June; this book is authored by Atta-ur-Rahman and M. Iqbal Choudhary; published on May 31, 2019. For Further Details, Please Visit : https://ebooks.benthamscience.com/book/9789811400711/

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Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The tenth volume of the series features chapters covering the following topics:

  • Challenges in the Management of Hepatoblastoma
  • The Emerging Role of Monocarboxylate Transporter-1 in Cancer
  • In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery
  • Recent Advances in the Development of Mesoporous Anti-Cancer Drug Nanocarriers
  • Polyphenols and Cancer
  • Glioblastoma Multiforme
  • Cutting Edge Targeting Strategies Utilizing Nanotechnology in Breast Cancer Therapy
Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2019-06/bsp-bsl062019.php

eBooks Press Release — NEWS | The Seventh Volume of Topics in Anti-Cancer Research Is Now Available

 

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Topics in Anti-Cancer Research (Volume 7) covers important advances on both experimental (preclinical) and clinical cancer research in drug development.

 

The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.

The topics covered in the seventh volume of this series include:

– The role of inflammation in chemotherapy-induced neuromuscular effects

– Advances in nutrigenomics and relevant anti-cancer patents

– Stimuli-responsive nanocarriers for on-demand anti-cancer drug release

– Harnessing biochemical mechanisms that control autophagy for treating esophageal cancer

 

To read out more, please visit: https://ebooks.benthamscience.com/press-releases/19012401/

eBook Highlights| Topics in Anti-Cancer Research -Volume 7

The seventh volume of the series covers topics such as drug delivery, new avenues for treatment of esophageal cancer and the role of nutrigenomics in finding new therapies.

Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.

The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy.

The latest volume of the series starts with a review on non-coding RNAs and associated patents. These patents help researchers to identify various cancer biomarkers and oncogenic regulatory mechanisms. 3 chapters cover nanocarrier patents for enhanced drug delivery of chemotherapeutic agents. Nanocarriers allow drug manufacturers to encapsulate chemotherapeutic agents within thin membranes which allows the molecules to reach the targeted cellular location in the body. The specific topics refer to Nanotaxol which is a nanotechnology enhanced version of Taxol® – a chemotherapeutic agent derived from chemicals in the bark of Taxus brevifolia, stimuli responsive nanocarriers which change behavior according to temperature and pH and smart nanoformulations which rely on different chemical formulations to reach molecular targets. Other topics covered in this volume include the role of autophagy in esophageal cancer, and nutrigenomics (the science of how biological nutrients affect gene expression) in cancer research. In terms of patents, the reader will find a list of compounds which modulate autophagy, and nutrigenomic methods that allow researchers to understand nutritional biomarkers of disease and customize nutraceutical formulations based on genetic and metabolic factors, respectively. To read out more, please visit: https://ebooks.benthamscience.com/book-highlights/190102001/

 

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CALL FOR PAPERS | Thematic Issue for Current Pharmaceutical Design

Journal: Current Pharmaceutical Design

Guest Editor(s): Ling-Qing Yuan
Tentative Publication Date: August, 2019

 

“Novel Strategies for Gene Therapy – Recent Advances in the use of Exosomes for Disease Treatment“

The aim of the present special issue is to invite researchers to contribute review or original research articles reporting the most recent and future therapeutic applications using exosomes in various diseases. Moreover, articles on the synthesis and isolation of exosomes, involvement of exosomes in the pathogenesis of different disease, and the use of exosomes in therapeutic strategies for different diseases are welcome. The objective and critical vision of this advance will be beneficial for us to understand and become familiar with the application of exosomes in treating different diseases. For more details please visit: https://bit.ly/2Je21qG

 

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

 

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CALL FOR PAPERS | Thematic Issue for Current Pharmaceutical Design

Journal: Current Pharmaceutical Design

 

Novel Strategies for Gene Therapy – Recent Advances in the use of Exosomes for Disease Treatment

 

The aim of the present special issue is to invite researchers to contribute review or original research articles reporting the most recent and future therapeutic applications using exosomes in various diseases. Moreover, articles on the synthesis and isolation of exosomes, involvement of exosomes in the pathogenesis of different disease, and the use of exosomes in therapeutic strategies for different diseases are welcome. The objective and critical vision of this advance will be beneficial for us to understand and become familiar with the application of exosomes in treating different diseases. For more details please visit: https://bit.ly/2Je21qG

 

Guest Editor(s): Ling-Qing Yuan
Tentative Publication Date: August, 2019

Email here to submit your paper:  faizan@benthamscience.net

                     CC: hermain@benthamscience.net 

 

cpd thematic flyers

 

 

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