EDITOR’S CHOICE ARTICLE | Heat Shock Factor (HSF): The Promoter of Chaperone Genes. A Mini Review

Journal Name: Current Proteomics

Author(s): Natália Galdi Quel,Carlos H.I. Ramos*.

 

 

Graphical Abstract:

 

Abstract:

Protein homeostasis, or proteostasis, is required for proper cell function and thus must be under tight maintenance in all circumstances. In crowded cell conditions, protein folding is sometimes unfavorable, and this condition is worsened during stress situations. Cells cope with such stress through the use of a Protein Quality Control system, which uses molecular chaperones and heat shock proteins as its major players. This system aids with folding, avoiding misfolding and/or reversing aggregation. A pivotal regulator of the response to heat stress is Heat Shock Factor, which is recruited to the promoters of the chaperone genes, inducting their expression. This mini review aims to cover our general knowledge on the structure and function of this factor.

 

To read out more, please visit: http://www.eurekaselect.com/163741/article

MOST ACCESSED ARTICLE – Synthesis of bis(indolyl)methanes Using Naturally Occurring, Biodegradable Itaconic Acid as a Green and Reusable Catalyst – Current Organic Synthesis

Journal: Current Organic Synthesis

Author(s): Sandeep B. Kasar, Shankar R. Thopate*

Graphical Abstract:

Abstract:

Aim and Objective: To explore the use of naturally occurring biodegradable organic acids as a catalyst in organic synthesis. The development of a simple, inexpensive, highly efficient yet ecofriendly catalyst for the synthesis of bis(indolyl)methanes is explored.

Materials and Method: A mixture of indole 1a (1.0 g, 8.53 mmol), benzaldehyde 2a (0.45 g. 4.26 mmol), and itaconic acid (0.12 g, 0.92 mmol, 20 mol%), in H2O (5.0 mL) was refluxed at 100°C for indicated time. After the completion of the reaction (TLC check), the reaction mixture was cooled to room temperature and extracted with ethyl acetate (3 × 5.0 mL), organic layer was dried over Na2SO4 and concentrated under vacuum. The crude residue was purified by column chromatography on silica gel using ethyl acetate:hexane as an eluent.

Results: Initially optimal reaction conditions were developed for the synthesis of bis(indolyl)methanes by selecting model reaction between indole and benzaldehyde. It was found that optimal conditions for the synthesis of bis(indolyl)methanes are use of indole (1.0 mmol), aldehyde (0.5 mmol) and catalyst 20 mol% in water as a solvent, under air atmosphere and at 100°C. Moreover, it was found that aqueous solution of the catalyst can be reused with the same catalytic efficiency for ten times without any pre-treatment. This is an important achievement with regard to the efficiency and reusability of the catalyst in synthesis.

Conclusion: We have shown that itaconic acid in water can be used as an excellent green catalyst with high reusability. It efficiently catalyzes electrophillic substitution reaction of indoles (ESRI) with various aldehydes to give the corresponding BIMs in an efficient manner. Therefore, itaconic acid in water as a catalyst can be a good alternative for the use of hazardous mineral acid and Lewis acid catalyst.

Read more here: http://www.eurekaselect.com/153471/article

 

Highlighted Article – Ag (I) Catalyzed Oxidation of SO2 in Aqueous Solution Differing Effect of Benzoate Ions in Acidic Medium – Current Physical Chemistry

CPC-Articles_7-4-Rashmi Sharma

To access this article, please visit: http://www.eurekaselect.com/152978

Press Release for EurekAlert! Synthesis of internal gem-diborylalkanes by copper-catalyzed double hydroboration

This research article by Dr. Yuma Netsu et al has been published in Letters in Organic Chemistry, Volume 14, Issue 4, 2017

Graphical Abstract:

 

Geminal organometallic reagents have attracted considerable attention due to their unique activity. Among them, gem-diboryl compounds are particularly valuable due to their stability, no-toxicity, and usability for a variety of transformations.

Despite the usefulness of the gem-diborylalkanes as synthetic reagents, effective methods for the synthesis of the gem-diborylalknaes have been still limited. Double hydroboration is a convenient and useful method because the reaction does not need unstable reagents such as diazo compounds or unusual directing groups, which are necessary for other synthetic methods. However, the double hydroboration has been applied mainly to terminal alkynes. In the reaction of internal alkynes, it is difficult to control the regioselectivity. Furthermore, 1,2-diboryl compounds can be obtained as side products if the regioselectivities of the first and the second hydroboration are opposite.

In this paper, the authors report the synthesis of internal geminal diboryl compounds by copper-catalyzed double hydroboration of internal alkynes bearing carbonyl groups. The regioselectivities of two hydroboration reactions can be perfectly restricted by the carbonyl groups. Although the second hydroboration is much slower by steric repulsion, the issue can be solved by an appropriate choice of ligands.

For more information about the article, please visit http://www.eurekaselect.com/151056

Press Release for EurekAlert! Synthesis of internal gem-diborylalkanes by copper-catalyzed double hydroboration

This research article by Dr. Yuma Netsu et al has been published in Letters in Organic Chemistry, Volume 14, Issue 4, 2017

 

Geminal organometallic reagents have attracted considerable attention due to their unique activity. Among them, gem-diboryl compounds are particularly valuable due to their stability, no-toxicity, and usability for a variety of transformations.

Despite the usefulness of the gem-diborylalkanes as synthetic reagents, effective methods for the synthesis of the gem-diborylalknaes have been still limited. Double hydroboration is a convenient and useful method because the reaction does not need unstable reagents such as diazo compounds or unusual directing groups, which are necessary for other synthetic methods. However, the double hydroboration has been applied mainly to terminal alkynes. In the reaction of internal alkynes, it is difficult to control the regioselectivity. Furthermore, 1,2-diboryl compounds can be obtained as side products if the regioselectivities of the first and the second hydroboration are opposite.

In this paper, the authors report the synthesis of internal geminal diboryl compounds by copper-catalyzed double hydroboration of internal alkynes bearing carbonyl groups. The regioselectivities of t+wo hydroboration reactions can be perfectly restricted by the carbonyl groups. Although the second hydroboration is much slower by steric repulsion, the issue can be solved by an appropriate choice of ligands.

For more information about the article, please visit http://www.eurekaselect.com/151056

 

 

 

BSP Patent Journals: ‘Recent Patents on Biotechnology’ and ‘Recent Patents on Catalysis’

Editor-in-Chief:

ImageRongling Wu

Departments of Public Health Sciences and Statistics
Pennsylvania State College of Medicine
Hershey, PA
USA

Aims & Scope

Recent Patents on Biotechnology publishes review and research articles, and guest edited thematic issues on recent patents in the field of biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.

Editor-in-Chief:

ImageShaobin Wang

Department of Chemical Engineering
Curtin University of Technology
Perth, WA 6845
Japan

Aims & Scope

Recent Patents on Catalysis publishes review, research articles and guest edited thematic issues on recent patents in the field of catalysis. The journal aims to provide recent patent information in all areas of catalysis science, including heterogeneous, homogeneous catalysis, synthesis and properties of new catalysts including synthesis and catalytic function of novel inorganic solids and complexes, studies that relate catalytic function to fundamental chemical processes in metal complexes and at surfaces, novel concepts in surface chemistry. A selection of important and recent patents on catalysis is also included in the journal. The journal is essential reading for all academic and industrial researchers, including IP authorities who wish to be kept informed about important patent breakthroughs in catalysis science and technology.

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