New eBook Announcement | Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications

 

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BY
ANUPAM JYOTI, NEETU MISHRA

Biomedical research is gaining prime attention as it is directly affecting human health. Biophysical, biochemical and cellular techniques are the backbone of biomedical sciences; a pre-requisite towards the understanding and treatment of human diseases. In the recent years, biomedical research has provided solutions for several problems faced by human beings. It is an integrated approach that includes various disciplines viz. biochemistry, microbiology, genetics and biochemical engineering. After some time, it has been integrated rapidly with new branches of science like molecular and cellular biology, genomics, proteomics, bioinformatics and nanotechnology. Biomedical research involves fundamental scientific principles applied to preclinical understanding of problems to clinical solutions. This book titled ‘Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications’, presents a broad overview regarding the basic applications of sophisticated and analytical techniques used in biophysics, biochemistry and cell biology. This book has covers the following areas: in vitro cell culture assay, real-time PCR, flow cytometry, and X-ray crystallography, discussed by authors who have quality publications in their proposed chapter area. Additionally each chapter includes application of techniques in specific areas like cells sorting by FACS, disease diagnosis by Real-time PCR, disease modeling under in vitro culture and many more. This will help students understand the importance of techniques in biophysics, biochemistry and cell biology research which will set a benchmark for further research.

As a biotechnology scientist, I am happy to recommend this book to the students of universities, both as a text and reference book. The section on technique will be used as textbook and the application section as reference. This book has been written in a way so that it is student-friendly with clean diagrams and protocols of specific techniques. I sincerely believe that the book has been prepared with the scientific skills and will serve as a useful document for the graduate and undergraduate students. Read out the full version here

 

Rajiv Kumar
ICAR-Central Sheep and Wool Research Institute
Avikanagar, Tonk, Rajasthan
India

EurekAlert! : Role of life’s timekeeper — a novel theory of animal evolution

This novel research disputes modern interpretations of Darwin’s theory, though probably remains compatible with Darwin’s original hypothesis.

This article presents a new theory of animal (metazoan) evolution, suggesting that it was partly mediated through a biochemical oscillator (cycler), named Life’s Timekeeper, present in all animal cells. The cycler controls cell maintenance and repair, thereby determining how long cells survive (longevity). It originated in the single-celled ancestor of all animals, which had very short cell longevity. Animal evolution progressed by extending cell longevity, and this was mediated by extended cycle time of the oscillator. Multi-celled animals and cell-cell communication systems evolved later. The cycler controls the overall rate of development and aging, these time periods being proportionate to maximum cell longevity. Simple animals have cell rejuvenating abilities hence are potentially long lived, whereas complex animals lost such ability and have limited lifespan determined by the maximum potential longevity of their cells.


Dr. David Neill

University of Newcastle,

Wear Base Unit, Monkwearmouth Hospital,

Newcastle Road, Sunderland, UK

Read more here: http://www.eurekalert.org/pub_releases/2016-04/bsp-rol042516.php

EurekAlert! – Drug-loaded nanocarriers in tumor targeted drug delivery

Nanoparticulate delivery systems in cancer therapies provide better penetration of therapeutic and diagnostic substances with the cancerous tissue in comparison to conventional cancer therapies.

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It is a leading cause of death and the burden is expected to grow worldwide due to the growth and aging of the population, mainly in less developed countries, in which about 82% of the world’s population resides. By 2030, the global burden is expected to grow to 21.7 million new cancer cases and 13 million cancer deaths simply due to the growth and aging of the population. Current cancer therapy approaches are based in surgery, radiotherapy and chemotherapy, being the chemotherapy the one that shows the greater efficiency for cancer treatment, mainly in more advanced stages. A major problem with this conventional chemotherapy is its toxicity and it also destroys healthy tissues resulting in systemic toxicity besides beneficial characteristics of killing cancer cells. Anticancer drugs also destroy healthy tissues resulting in systemic toxicity.


Meerza Abdul Razak, Shankarappa Devi Prasad Boggupalli and Buddolla Viswanath

Department of Virology, Sri Venkateswara University, Tirupati-517502, A.P, India

Read more here: http://www.eurekalert.org/pub_releases/2016-03/bsp-dni030716.php

Current Drug Targets

Dr. Faratian and Harrison present a series of articles on the use of Molecular Pathology in personalising therapy for patients with neoplastic and non-neoplastic disease in the upcoming issue. The articles cover genomic, post-genomic, and systems-based approaches to personalised medicine, with a focus on application in the clinic for real cancer patients.

The use of Molecular Pathology in personalising therapy
The use of Molecular Pathology in personalising therapy

 

Dr. Masatoshi Kitagawa edited a special issue on ‘Cell Cycle Control and Cell Fate’ for coming issue of the journal. Here is the brief introduction.

Cell cycle control is important for not only growth and arrest, but also cell fate determination including differentiation, stemness, malignant transformation, senescence and apoptosis. The special issues picks up several processes or pathways regulating “Cell cycle control and cell fate” such as ubiquitin system, signal transduction, chromatin regulation, non-coding RNA, licensing, EMT, senescence, RB- and p53-pathway. I believe that they are attractive as drug targets for not only cancer but also various human diseases.

Cell Cycle Control and Cell Fate
Cell Cycle Control and Cell Fate

 

http://benthamscience.com/cdt/

 

 

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