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Reviews on Recent Clinical Trials Volume 13, Issue 1
Central Nervous System Agents in Medicinal Chemistry Volume 18, Issue 1
Drug Delivery Letters Volume 8, Issue 1
Current Nanoscience Volume 14, Issue 2
Current Nanomedicine Volume 8, Issue 1
Current Gene Therapy Volume 17, Issue 5
Nanoscience & Nanotechnology-Asia Volume 8, Issue 1
Adolescent Psychiatry Volume 7, Issue 2
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents.
Containing a series of timely in-depth reviews, original research articles, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
Articles from the journal Central Nervous System Agents in Medicinal Chemistry 17, Issue 1:
For details on the articles, please visit this link :: http://bit.ly/2nNp6U4
A series of Schiff bases of benzothiazol-2-ylamine/thiazolo [5, 4-b] pyridin-2-ylamine was synthesized. Aniline/4-aminopyridine was converted to the corresponding thiourea derivative, which was then cyclized to obtain benzothiazol-2-ylamine/thiazolo [5, 4-b] pyridin-2-ylamine. Finally, these were condensed with various aromatic and heteroaromatic aldehydes to obtain twelve novel Schiff bases of benzothiazol-2-ylamine and thiazolo [5, 4-b] pyridin-2-ylamine.
The synthesized compounds were characterized by spectral analysis and screened for their anticonvulsant activity using the maximal electroshock (MES) test and isoniazid (INH) induced convulsions test, with phenytoin and diazepam respectively, as the standard drugs. The majority of the compounds were more potent against MES induced convulsions than INH induced convulsions. The relationship between the synthesized compounds and the log P values was also studied, which revealed that the higher the value the better the activity. Schiff bases of benzothiazol-2-ylamine were more effective than thiazolo [5, 4-b] pyridin-2-ylamine against MES induced convulsions. The compound benzothiazol-2-yl-(1H-indol-2-ylmethylene)-amine was the most potent member of the series against both types of convulsions. All the synthesized compounds were predicted to be non-toxic by in-silico toxicity profiling through the Lazar and Osiris properties explorer. Thus, it may be concluded that the Schiff bases of benzothiazol-2-ylamine exhibit the potential to be promising and non-toxic anticonvulsant agents.
Reference: Shukla, R.; et al (2016). Schiff Bases of Benzothiazol-2-ylamine and Thiazolo[5,4-b] pyridin-2-ylamine as Anticonvulsants: Synthesis, Characterization and Toxicity Profiling. Central Nervous System Agents in Medicinal Chemistry., DOI: 10.2174/1871524916666160428110728
For more information about the article, please visit: http://benthamscience.com/journals/central-nervous-system-agents-in-medicinal-chemistry/volume/16/issue/3/page/240/
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