Bentham Science Central Nervous System Collection



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and many more Books…

✔ 130 Journals

✔ 7 Book Series

✔ 45 Books in Total 



♦ Access to over 11,000 scholarly articles covering several aspects of Central Nervous System

♦ Contents come from more than 100 Bentham Science Journals (40 journals indexed in JCR 2017 with impact factor rankings)

♦ Includes both; Original Research and Review Articles

♦ Research from leading institutions in USA, EUROPE, AUSTRALIA, JAPAN, CHINA and other regions

♦ Suitable for researchers in industry and academia wishing to keep updated with latest developments

♦ Easy access to institutions and individuals through IP-based authentication

♦ Access new Neuroscience Research included in this collection as soon as it is published



 Over 950 articles from 2018
 Over 2,764 articles from the last 3 years 
 More than 9,000 articles from the last 10 years


Annual addition of over 1,000 new Central Nervous System related articles each year

Tailor-made packages available for pharmaceuticals companies, research institutes, universities, hospitals, clinical/academic societies, and corporations.


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To learn more about our Central Nervous System Collection, please visit  our website:

Editors Choice Article | Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies for Treatment of the Central Nervous System Diseases

Journal Name: Current Drug Delivery

Author(s): Nur Izzati Mansor, Norshariza Nordin*, Farahidah Mohamed, King Hwa Ling, Rozita Rosli, Zurina Hassan.




Graphical Abstract:



Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug delivery systems across the blood-brain barrier are dependent on substrate-specific (i.e. protein transport and transcytosis) and non-specific (i.e. transcellular and paracellular) transport pathways, which are crucial factors in attempts to design efficient drug delivery strategies. This review describes how the blood-brain barrier presents the main challenge in delivering drugs to treat brain diseases and discusses the advantages and disadvantages of ongoing neurotherapeutic delivery strategies in overcoming this limitation. In addition, we discuss the application of colloidal carrier systems, particularly nanoparticles, as potential tools for therapy for the CNS diseases. To read out more, please visit:

EDITOR’S CHOICE – Calcium-engaged Mechanisms of Nongenomic Action of Neurosteroids – Current Neuropharmacology

Journal: Current Neuropharmacology

Author(s): Elzbieta Rebas, Tomasz Radzik, Tomasz Boczek, Ludmila Zylinska

Graphical Abstract:



Background: Neurosteroids form the unique group because of their dual mechanism of action. Classically, they bind to specific intracellular and/or nuclear receptors, and next modify genes transcription. Another mode of action is linked with the rapid effects induced at the plasma membrane level within seconds or milliseconds. The key molecules in neurotransmission are calcium ions, thereby we focus on the recent advances in understanding of complex signaling crosstalk between action of neurosteroids and calcium-engaged events.

Methods: Short-time effects of neurosteroids action have been reviewed for GABAA receptor complex, glycine receptor, NMDA receptor, AMPA receptor, G protein-coupled receptors and sigma-1 receptor, as well as for several membrane ion channels and plasma membrane enzymes, based on available published research.

Results: The physiological relevance of neurosteroids results from the fact that they can be synthesized and accumulated in the central nervous system, independently from peripheral sources. Fast action of neurosteroids is a prerequisite for genomic effects and these early events can significantly modify intracellular downstream signaling pathways. Since they may exert either positive or negative effects on calcium homeostasis, their role in monitoring of spatio-temporal Ca2+ dynamics, and subsequently, Ca2+-dependent physiological processes or initiation of pathological events, is evident.

Conclusion: Neurosteroids and calcium appear to be the integrated elements of signaling systems in neuronal cells under physiological and pathological conditions. A better understanding of cellular and molecular mechanisms of nongenomic, calcium-engaged neurosteroids action could open new ways for therapeutic interventions aimed to restore neuronal function in many neurological and psychiatric diseases.

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Article by disease – “The Yin and Yang of Antiviral Innate Immunity in Central Nervous System”

Article by disease on “Polio”

Abstract: The innate immune system provides protection against invading neurotropic viruses. It acts as the first line of defense against invading viruses and plays an elementary role in their pathogenesis. The list of viruses capable of infecting human central nervous system (CNS) is quite long, most important of them are Japanese Encephalitis virus (JEV), rabies virus, West Nile virus (WNV), herpes simplex virus (HSV), St. Louis encephalitis virus (SLEV), La Crosse virus, tick borne encephalitis virus (TEBE) and polio virus. Germ line pattern recognition receptors (PRRs) such as Toll like receptors (TLRs), nucleotide binding oligomerization domain (NOD) – like receptors (NLRs), retinoic acid-inducible gene I (RIG-I) -like helicases or RIG-I-like receptors (RLRs) and cytosolic DNA sensors recognize the pathogen associated molecular patterns (PAMPs) and initiate an immune response against invading pathogen. Although PRRs were originally characterized in peripheral immune cells but accumulating evidence also suggest their crucial roles in CNS to combat against neurotropic viruses. In this review, we will highlight the recent developments in our understating of the mechanisms by which PRRs in resident brain cells provide protection against invading neurotropic viruses.

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