Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets

Author(s): Talambedu Usha, Sushil K. Middha, Anusha A. Kukanur, Rachamadugu V. Shravani, Mahantesh N. Anupama, Nagasamudram Harshitha, Ameena Rahamath, Sumedha S. Kulkarni, Arvind K. Goyal

Journal Name: Current Protein & Peptide Science

Why is it important?

Drug Repurposing (DR) is an alternative to the traditional drug discovery process. It is cost and time effective with high returns and low-risk process that can tackle the increasing need for interventions for varied diseases and new outbreaks. Repurposing of old drugs for other diseases has gained wider attention, as there have been several old drugs approved by the FDA for new diseases. In the global emergency of COVID-19 pandemic, this is one of the strategies implemented in the repurposing of old anti-infective, anti-rheumatic and anti-thrombotic drugs. The goal of the current review is to elaborate the process of DR, its advantages, repurposed drugs for a plethora of disorders, and the evolution of related academic publications. Further, detailed are the computational approaches: literature mining and semantic inference, network-based drug repositioning, signature matching, retrospective clinical analysis, molecular docking and experimental phenotypic screening. We discuss the legal and economic potential barriers in DR, existent collaborative models and recommendations for overcoming these hurdles and leveraging the complete potential of DR in finding new indications. Read more about the article here: https://bit.ly/3yMobGT

Lead finding from selected flavonoids with antiviral (SARS-CoV-2) potentials against COVID-19

What is it about?

In silico molecular docking studies can be useful to predict the binding affinity between the selected flavonoids and the target protein and play a vital role in finding an inhibitor through structure-based drug design.

Why is it important?

COVID-19 is a pandemic respiratory contagious viral (SARS-CoV-2) disease associated with high morbidity and mortality worldwide. Currently, there are no effective preventive or treatment strategies for COVID-19 and it has been declared as a global health emergency by WHO. Read more about the article here: https://bit.ly/3ys8vsq

Press Release | Children & coronavirus infection (COVID-19): How to avoid post-traumatic stress disorder

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This editorial by Prof. Michele Roccella is published in The Open Pediatric Medicine Journal, Volume 10, 2020

 

COVID-19 is a pandemic that has forced many states to declare restrictive measures in order to prevent their wider spread. These measures are necessary to protect the health of adults, children and people with disabilities. Long quarantine periods could cause an increase in anxiety crisis, fear of contagion and post-traumatic stress disorder (frustration, boredom, isolation, fear, insomnia, difficulty concentrating).

Post-traumatic stress disorder (PTSD) develops as a consequence of one or more physical or psychological traumatic events, such as exposure to natural disasters such as earthquakes, fires, floods, hurricanes, tsunamis; wars, torture, death threats; road accidents, robbery, air accidents; diseases with unfavorable prognosis; complicated or traumatic mourning; physical and sexual abuse and abuse during childhood; victimization and discrimination based on gender, sexual orientation, gender identity. It can also develop following changes in lifestyle habits caused by the COCOVID-19 epidemic. The arrival of the pandemic caused by the Coronavirus (Covid-19) in the world is bringing families, teachers, educators and all the people who care for children every day. Long quarantine periods could cause an increase in anxiety crisis, fear of contagion and post-traumatic stress disorder (frustration, boredom, isolation, fear, insomnia, difficulty concentrating). It is important to speak calmly and directly to children.

The child may also be told that isolation is needed to avoid contact with the virus until we have effective drugs or a vaccine. For children, staying at home is not a problem, they are used to holidays; they spend their time playing, watching television, talking with family members, in some cases where the restrictive measures are not too strict, I can play outdoors. In these cases it is essential to reassure the children, to structure their day, to divide the times and spaces according to patterns and rhythms. We can say that based on previous quarantine experiences that long periods of isolation can lead to psychological symptoms such as emotional disturbances, depression, stress, mood disturbances, irritability, insomnia and signs of traumatic post-stress disorders. Therefore it is important to be able to explain to children what is happening and how to manage this traumatic event following the COVID-19 pandemic. Read full Press Release to find out more: https://www.eurekalert.org/pub_releases/2020-05/bsp-cc050620.php

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This editorial can be obtained from the following link: https://benthamopen.com/ABSTRACT/TOPEDJ-10-1

Bentham Books | Making Chemistry Education More Engaging with Computers

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The recent COVID-19 outbreak has been the main reason behind several temporary school closures around the world. This has made the idea of continuing to pursue educational activities during this time a challenging proposition. The current lockdowns implemented in different countries has forced schoolteachers who wish to complete their current teaching periods to transition immediately to the online classroom. Many schools have already started online classes in the wake of the crisis caused by the global COVID-19 crises. Accessing and managing online teaching resources can be a bit difficult for educators or pupils accustomed to a conventional classroom.

A couple of our authors reached out to us and asked if Bentham Science had a solution for their book, Computer Based Projects for a Chemistry Curriculum – which is a great resource for school and college students and teachers interesting in using computers to illustrate fundamental concepts in chemistry. And we have responded. Starting today up to June 30, Bentham Science Publishers is making the eBook free to download. This means high school teachers and students anywhere in the world can access the content benefit from the projects presented in the book.

Computer Based Projects for a Chemistry Curriculum, authored by Thomas Manning and Aurora Grumatges, presents 24 chapters each giving information about activities employing applications such as MS excel (spreadsheets) and Spartan (computational modeling). Each project is explained in a simple, easy-to-understand manner. The content within this book is suitable as a guide for both teachers and students and each chapter is supplemented with practice guidelines and exercises. The book contents can be accessed here.

We hope that students around the world can benefit from the interesting and informative variety of projects presented in the book, while also allowing educators working in schools to continue their teaching activities throughout the academic year amidst the current pandemic crisis. Stay safe, and happy chemistry learning. Please visit the book page here: http://bit.ly/39uzhTW

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