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Current Aging Science publishes frontier review and experimental articles in all areas of aging and age-related research that may influence longevity. This multidisciplinary journal will help in understanding the biology and mechanism of aging, genetics, pathogenesis, intervention of normal aging process and preventive strategies of age-related disorders. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, clinical, molecular, and animal models, including lower organism models (e.g., yeast, Caenorhabditis elegans and Drosophila). In addition to the affect of aging on integrated systems, the journal also covers original articles on recent research in fast emerging areas of adults stem cells, brain imaging, calorie restriction, immunosenescence, molecular diagnostics, pharmacology and clinical aspects of aging. Manuscripts are encouraged that relate to developmental programming of aging and the synergistic mechanism of aging with cardiovascular diseases, obesity and neurodegenerative disorders.
Book reviews, meeting reports and letters-to-the-editor and drug clinical trial studies are also published. The journal is essential reading for researchers, educators and physicians with interest in aging, age-related dementia and Alzheimer’s disease and longevity. Current Aging Science provides a comprehensive coverage of the current state of aging research for gerontologists, neuroscientists, clinicians, health science planners, granting agencies and pharmaceutical scientists.
Author(s): Alon Seifan, Christine A. Ganzer*, Krista Ryon, Michael Lin, Rahman Mahmudur, Henriquez Adolfo, Cindy Shih, Alan R. Jacobs, Molly Greenwald, Richard S. Isaacson.
Background: Prodromal Neurodegenerative Disease (ND) due to tauopathies such as Alzheimer’s Disease (AD) and Synucleinopathies (SN) such as Parkinson’s Disease (PD) and Dementia with Lewy Bodies (DLB) present subtly. Although ND are considered cognitive disorders, in fact ND present with behavioral and even medical symptomatology years to decades prior to the onset of cognitive changes. Recognizing prodromal ND syndromes is a public health priority because ND is common, disabling and expensive. Diagnosing prodromal ND in real world clinical settings is challenging because ND of the same pathology can present with different symptoms in different people. Individual variability in nature and variability in nurture across the life course influence how ND pathology manifests clinically. The objective of this study was to describe how non-cognitive symptoms from behavioral, medical, neurological and psychiatric domains cluster in prodromal and early stages of ND.
Methods: This was an observational study of patients receiving routine clinical care for memory disorders. All patients receiving a standardized evaluation including complete neurological history and examination and standardized brief neuropsychological testing. A Principal Component Analysis (PCA) considering emotion, motor, sensory and sleep factors was performed on the entire sample of patients in order to identify co-occurring symptom clusters. All patients received a consensus diagnosis adjudicated by at least two dementia experts. Patients were grouped into Cognitively Normal, Detectable Cognitive Impairment, and Mild Cognitive Impairment categories due to AD and/or PD/LBD or NOS pathology. Symptom cluster scores were compared between clinical diagnostic groups. Read out full article at: http://www.eurekaselect.com/169580/article
Current Aging Science publishes frontier review and experimental articles in all areas of aging and age-related research that may influence longevity. This multidisciplinary journal will help in understanding the biology and mechanism of aging, genetics, pathogenesis, intervention of normal aging process and preventive strategies of age-related disorders. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, clinical, molecular, and animal models, including lower organism models (e.g., yeast, Caenorhabditis elegans and Drosophila). In addition to the affect of aging on integrated systems, the journal also covers original articles on recent research in fast emerging areas of adults stem cells, brain imaging, calorie restriction, immunosenescence, molecular diagnostics, pharmacology and clinical aspects of aging. Manuscripts are encouraged that relate to developmental programming of aging and the synergistic mechanism of aging with cardiovascular diseases, obesity and neurodegenerative disorders.
Book reviews, meeting reports and letters-to-the-editor and drug clinical trial studies are also published. The journal is essential reading for researchers, educators and physicians with interest in aging, age-related dementia and Alzheimer’s disease and longevity. Current Aging Science provides a comprehensive coverage of the current state of aging research for gerontologists, neuroscientists, clinicians, health science planners, granting agencies and pharmaceutical scientists.
Background: Physical activity is known for its many health benefits; among them being the positive effect on bone health during the life cycle. During childhood, physical stress stimulates bone remodeling and increases density. However, due to hormonal changes during adulthood, and mainly during postmenopause the rate of bone remodeling is slowed down and is less efficient. As a result, argument has arisen in the literature regarding the benefit or harm of physical activity on bone health among postmenopausal women.
Objective: The study aims to examine the efficacy of physical activity for improving Bone Mineral Density (BMD) in postmenopausal women based on a review of the literature.
Methods: The articles included in the review were chosen from three databases (PubMed, SPORT Discus with full text and Science Direct). Only publications with intervention studies which provided BMD measures clearly affected by physical activity in postmenopausal women were included. Twelve articles met the criteria for inclusion.
Results: In general, physical activity had a positive effect on BMD. Exercise prevented bone loss and in some cases, it contributed to the increase in BMD.
Conclusion: Physical activity may improve BMD in postmenopausal women. However, the exact type of activity, its intensity, its duration and its frequency, are still unclear. Further studies are needed to determine the precise training protocol for postmenopausal women.
To access the article, please visit: http://www.eurekaselect.com/152354
‘Man is a social animal’ – this statement has become a cliché over time but still holds its significance. The reason is that it is as true in practice as it is in theory. We see in our surroundings that the people who have families around them who care for them are visibly more satisfied than the ones who are alone. Apart from family if they are getting support from their friends, neighbors and society, then they find it much easier to maintain their health and wellbeing.
This topic has gained much attention from the social scientists as well as medical and life scientists, as they are curious to find the social factors and their correlations that are vital for human ageing, morbidity and mortality. The findings have been clear that the people who were old and had little access to others and social support were found more susceptible to ailments and were leading rapidly towards death. Whereas those older ones who had people near them to talk to them, hear and address their problems, provide emotional as well as social support, were more satisfied and more capable of keeping healthy for long.
One of the important researches finding this correlation is published in the journal, Current Aging Science journal and can be read here:
Journal: Current Aging Science
Author(s): Christian William Callaghan
Background: Advances in big data analytics can enable more effective and efficient research processes, with important implications for aging research. Translating these new potentialities to research outcomes, however, remains a challenge, as exponentially increasing big data availability is yet to translate into a commensurate era of ‘big knowledge,’ or exponential increases in biomedical breakthroughs. Some argue that big data analytics heralds a new era associated with the ‘end of theory.’ According to this perspective, correlation supersedes causation, and science will ultimately advance without theory and hypotheses testing. On the other hand, others argue that theory cannot be subordinate to data, no matter how comprehensive data coverage may ultimately become.
Objective: Given these two tensions, namely (i) between exponential increases in data that have not translated into exponential increases in biomedical research outputs; and (ii) between the promise of comprehensive data coverage and inductive data-driven modes of enquiry versus theory-driven deductive modes, this critical review seeks to offer useful perspectives of big data analytics and to derive certain theoretical implications for aging research.
Method: This work offers a critical review of theory and literature relating big data to aging research.
Results: The rise of big data provides important insights into the theory development process itself, highlighting potential for holistic theoretical assemblage to ultimately enable near real time research capability.
Conclusion: Big data may represent a new paradigm of aging research that can dramatically increase the rate of scientific breakthroughs, but innovative theory development remains key to this potential.
Read more here: http://www.eurekaselect.com/154309
This article by Dr. Jordan A. McKenzie et al. is published in Current Aging Science, Volume 10, Issue 3, 2017
In the journal Current Aging Science, a research team has reviewed modifiable risk factors for Alzheimer’s and Parkinson’s diseases. The reviewers focus on the possible role of neuroinflammation (inflammation of the nervous tissue) in neurodegenerative disease mechanisms. Alzheimer’s disease and Parkinson’s disease are among the most common causes of dementia, and increasingly contribute to morbidity and mortality worldwide. A common hallmark of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological molecular structures associated with these disorders. Chronic neuroinflammation is sustained by persistent activation of the non-neuronal glial cells in the brain, which results in damage or death of neighboring cells, including neurons and glial cells themselves. Persistent neuroinflammation of the brain is hypothesized to contribute to the neurodegeneration observed in Alzheimer’s and Parkinson’s diseases.
The reviewers note four modifiable risk factors for Alzheimer’s and Parkinson’s diseases: physical inactivity, vascular disease-related conditions, obesity and type two diabetes mellitus. These modifiable risk factors contribute to neuroinflammation through specific mechanisms that are directly linked to the pathologies of Alzheimer’s and Parkinson’s diseases. These risk factors are deemed modifiable as their occurrence in the general population can be reduced, or avoided by individuals, through various lifestyle changes, such as improved diet, regular exercise and effective treatment of vascular disease-related conditions such as high blood pressure. This review highlights that the control of the modifiable risk factors is a valid approach for managing the increased incidence of both Alzheimer’s and Parkinson’s diseases. In addition, the neuroinflammatory mechanisms common to Alzheimer’s and Parkinson’s diseases are described, which may link the above four common modifiable risk factors with both of these neurodegenerative diseases. A better understanding of the molecular mechanism of neuroinflammation could help identify new therapeutic targets for combating neurodegenerative diseases.
View the article here: http://www.eurekaselect.com/150884
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