Press Release for EurekAlert! Neuroinflammation in Alzheimer’s and Parkinson’s diseases

This article by Dr. Jordan A. McKenzie et al. is published in Current Aging Science, Volume 10, Issue 3, 2017

In the journal Current Aging Science, a research team has reviewed modifiable risk factors for Alzheimer’s and Parkinson’s diseases. The reviewers focus on the possible role of neuroinflammation (inflammation of the nervous tissue) in neurodegenerative disease mechanisms. Alzheimer’s disease and Parkinson’s disease are among the most common causes of dementia, and increasingly contribute to morbidity and mortality worldwide. A common hallmark of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological molecular structures associated with these disorders. Chronic neuroinflammation is sustained by persistent activation of the non-neuronal glial cells in the brain, which results in damage or death of neighboring cells, including neurons and glial cells themselves. Persistent neuroinflammation of the brain is hypothesized to contribute to the neurodegeneration observed in Alzheimer’s and Parkinson’s diseases.

The reviewers note four modifiable risk factors for Alzheimer’s and Parkinson’s diseases: physical inactivity, vascular disease-related conditions, obesity and type two diabetes mellitus. These modifiable risk factors contribute to neuroinflammation through specific mechanisms that are directly linked to the pathologies of Alzheimer’s and Parkinson’s diseases. These risk factors are deemed modifiable as their occurrence in the general population can be reduced, or avoided by individuals, through various lifestyle changes, such as improved diet, regular exercise and effective treatment of vascular disease-related conditions such as high blood pressure. This review highlights that the control of the modifiable risk factors is a valid approach for managing the increased incidence of both Alzheimer’s and Parkinson’s diseases. In addition, the neuroinflammatory mechanisms common to Alzheimer’s and Parkinson’s diseases are described, which may link the above four common modifiable risk factors with both of these neurodegenerative diseases. A better understanding of the molecular mechanism of neuroinflammation could help identify new therapeutic targets for combating neurodegenerative diseases.

View the article here: http://www.eurekaselect.com/150884

Wishing A Very Happy Birthday to Prof. Debomoy K. Lahiri!

Prof. Debomoy k. Lahiri.jpg

Prof. Debomoy K. Lahiri

EDITOR-IN-CHIEF: Current Alzheimer Research & Current Aging Science

Department of Psychiatry Indiana University School of Medicine
Indianapolis, IN
USA

Highlighted Article – Neuron vs. Germline: A war of Hormetic Tradeoffs – Current Aging Science

cas-Articles-10 -4-2017-Marios Kyriazis

http://www.eurekaselect.com/151589/article

Highlighted Article Flyer for the journal “Current Aging Science”

cas-Articles-10 -4-2017-Luis Miguel Rondón García

http://www.eurekaselect.com/151590/article

New Issue :: Current Aging Science 10, Issue 2

Current Aging Science publishes frontier review and experimental articles in all areas of aging and age-related research that may influence longevity. This multidisciplinary journal will help in understanding the biology and mechanism of aging, genetics, pathogenesis, intervention of normal aging process and preventive strategies of age-related disorders. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, clinical, molecular, and animal models, including lower organism models (e.g., yeast, Caenorhabditis elegans and Drosophila). In addition to the affect of aging on integrated systems, the journal also covers original articles on recent research in fast emerging areas of adults stem cells, brain imaging, calorie restriction, immunosenescence, molecular diagnostics, pharmacology and clinical aspects of aging. Manuscripts are encouraged that relate to developmental programming of aging and the synergistic mechanism of aging with cardiovascular diseases, obesity and neurodegenerative disorders.

cas

Articles from the journal Current Aging Science 10, Issue 2:

                      For details on the articles, please visit this link :: http://bit.ly/2oHCHi6

 

Highlighted Article Flyer for the journal “Current Aging Science”

v-s-baranov-final

http://benthamscience.com/journals/current-aging-science/

New Issue :: Current Aging Science 10, Issue 1

Current Aging Science publishes frontier review and experimental articles in all areas of aging and age-related research that may influence longevity. This multidisciplinary journal will help in understanding the biology and mechanism of aging, genetics, pathogenesis, intervention of normal aging process and preventive strategies of age-related disorders. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, clinical, molecular, and animal models, including lower organism models (e.g., yeast, Caenorhabditis elegans and Drosophila). In addition to the affect of aging on integrated systems, the journal also covers original articles on recent research in fast emerging areas of adults stem cells, brain imaging, calorie restriction, immunosenescence, molecular diagnostics, pharmacology and clinical aspects of aging. Manuscripts are encouraged that relate to developmental programming of aging and the synergistic mechanism of aging with cardiovascular diseases, obesity and neurodegenerative disorders.

Book reviews, meeting reports and letters-to-the-editor and drug clinical trial studies are also published. The journal is essential reading for researchers, educators and physicians with interest in aging, age-related dementia and Alzheimer’s disease and longevity. Current Aging Science provides a comprehensive coverage of the current state of aging research for gerontologists, neuroscientists, clinicians, health science planners, granting agencies and pharmaceutical scientists.

cas

Articles from the journal Current Aging Science 10, Issue 1:

For details on the articles, please visit this link :: http://bit.ly/2kyZ6fN

 

International Day for the Elderly 2016!

international-day-for-the-elderly-1st-oct

International Day for the Elderly is celebrated every year on the 1st of October. The journals of Bentham Science Publishers related to this day are;

Current Alzheimer Research

Current Aging Science

A very Happy Birthday to Prof. Debomoy K. Lahiri!

Prof. Debomoy K. Lahiri

Editor-in-Chief: Current Alzheimer Research & Current Aging Science

Prof.Debomoy K. Lahiri

Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202
USA

What Motivates the Elderly to Learn?

Learning is a process that never ends. It can speed up and slow down depending on one’s ability, age, health and motivation level, but the day it ends is when one’s dead. Learning helps you grow mentally as well as physically as you keep getting more and more experiences and knowledge. When you are young it’s almost involuntary and thus you don’t tend to put too much effort to learn something unless you are not interested; though it’s not the same as you grow old. You have to prepare yourself, keep your mind sharp and healthy, and find potential motivating factors to keep your learning curve steep for long.

588-93

The question is what are the motivating factors? Researchers from the University of Hong Kong, Yuanyuan Fu, Xinyi Zhao and Ernest WT Chui, conducted research on the elderly Chinese in Hong Kong who were involved in studies or learning anyway. The research helped them realize that four factors play a major role in pushing people to learn. One of them is the aged Chinese’s need to stay with the world today and contribute to the society. Then it is their urge of personal fulfillment. Also, for them, learning is a means of engaging with the society and appearing as a regular part of it. The strongest reason for relatively less old people is that learning would help them get a job again.

All the factors vary according to ages of the older adults, their beliefs and certain more things that influence their life. To learn more about this research please read the article, Motivations of older Chinese adult learners in Hong Kong, published in the journal, Current Aging Science.