RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Anti-Infective Agents Volume 15, Issue 2
http://bit.ly/2BsxK3F

Current Alzheimer Research Volume 15, Issue 3
http://bit.ly/2o3muSJ

Recent Advances in Electrical & Electronic Engineering Volume 11, Issue 1
http://bit.ly/2EFDyIX

Current Women`s Health Reviews Volume 14, Issue 1
http://bit.ly/2EFDyIX

Current Neuropharmacology Volume 16, Issue 2
http://bit.ly/2EAKJSG

Letters in Drug Design & Discovery Volume 15, Issue 2
http://bit.ly/2svXMQA

Letters in Drug Design & Discovery Volume 15, Issue 3
http://bit.ly/2G5Mi8f

recent-issues

EDITOR’S CHOICE – Ongoing Electroencephalographic Activity Associated with Cortical Arousal in Transgenic PDAPP Mice (hAPP V717F) – Current Alzheimer Research

Journal: Current Alzheimer Research

Author(s): Claudio Del Percio, Wilhelmus Drinkenburg, Susanna Lopez, Cristina Limatola, Jesper F. Bastlund,Ditte Z. Christensen, Jan T. Pedersen, Gianluigi Forloni, Angelisa Frasca, Francesco M. Noe, Marina Bentivoglio, Paolo F. Fabene, Giuseppe Bertini, Valeria Colavito, Sophie Dix, Raffaele Ferri, Regis Bordet, Jill C. Richardson, Claudio Babiloni

Abstract:

Background: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type (WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive condition; IMI PharmaCog project, http://www.pharmacog.eu).

Objective: The objective was to test if these EEG rhythms might be abnormal in old PDAPP mice modeling Alzheimer’s disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural transmission, cognitive deficits, and brain accumulation of Aβ1-42).

Methods: Ongoing EEG rhythms were recorded by a frontoparietal bipolar channel in 15 PDAPP and 23 WT C57 male mice (mean age of 22.8 months ±0.4 and 0.3 standard error, respectively). EEG absolute power (density) was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during passive and active states in the wakefulness.

Results: Compared with the WT group, the PDAPP group showed higher frequency of the IDF during the passive condition and lower frequency of the ITF during the active state. Furthermore, the WT but not PDAPP group showed significant changes in the frontoparietal EEG power (IDF, ITF) during active over passive state.

Conclusion: PDAPP mice were characterized by less changes in the brain arousal during an active state as revealed by frontoparietal EEG rhythms. Future studies will have to cross-validate the present results on large animal groups, clarify the neurophysiological underpinning of the effect, and test if the disease modifying drugs against AD amyloidosis normalize those candiate EEG biomarkers in PDAPP mice

Read more here: http://www.eurekaselect.com/153722

 

HIGHLIGHTED ARTICLE – Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity – CURRENT ALZHEIMER RESEARCH

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To access the article, please visit: http://www.eurekaselect.com/151645/article

NEW ISSUE :: Current Alzheimer Research 15, ISSUE 1

Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer’s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ‘bird’s-eye view’ of the current state of Alzheimer’s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

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Articles from the journal Current Alzheimer Research 15-1:

For details on the articles, please visit this link: http://bit.ly/2C6iyL4

Highlighted Article – Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment – Current Alzheimer Research

CAR-Articles_14-Zhanjun Zhang

To access this article, please visit: http://www.eurekaselect.com/151651

Highlighted Article – A Peptide Based Pro-Drug Ameliorates Amyloid-β Induced Neuronal Apoptosis in In Vitro SH-SY5Y Cells – Current Alzheimer Research

car-14-Sourav Kumar

To access this article, please visit: http://www.eurekaselect.com/154200

 

Testimonial by Rosanna Squitt!

Rosanna Squitt

Contributed Article: “Patients with Increased Non-Ceruloplasmin Copper Appear a Distinct Sub-Group of Alzheimer’s Disease: A Neuroimaging Study

 

 

World Mental Health Day 2017!

world-mental-health-day-bentham-science

World Mental Health Day is observed on 10 October every year, with the overall objective of raising awareness of mental health issues around the world and mobilizing efforts in support of mental health.

Bentham Science Publishers has various research journals dedicated to the mental health research. The most significant ones are:

CURRENT NEUROPHARMACOLOGY

CURRENT ALZHEIMER RESEARCH

World Alzheimer’s Day 2017!

Alzheimer's-Day-bentham-science-

World Alzheimer’s Day is observed annually on 21 September each year to raise awareness and challenge the stigma that surrounds dementia. Alzheimer’s disease is the most common form of dementia, a group of disorders that impairs mental functioning.

Bentham Science Publishers is in the forefront in creating awareness about this through the research in the journal:

Current Alzheimer Research

Open Access Article – iTRAQ-based Proteomic Analysis of APPSw,Ind Mice Provides Insights into the Early Changes in Alzheimer’s Disease – Current Alzheimer Research

Journal: Current Alzheimer Research

Author(s): Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-hong Luo, Junyu Xu.

Abstract:

Background: Several proteins have been identified as potential diagnostic biomarkers in imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse models. However, biomarkers for presymptom diagnosis of AD are still under investigation, as are the presymptom molecular changes in AD pathogenesis.

Objective: In this study, we aim to analyzed the early proteomic changes in APPSw,Ind mice and to conduct further functional studies on interesting proteins.

Methods: We used the isobaric tags for relative and absolute quantitation (iTRAQ) approach combined with mass spectrometry to examine the early proteomic changes in hippocampi of APPSw,Ind mice. Quantitative reverse transcription polymerase chain reaction (RT-PCR) and immuno-blotting were performed for further validation. Finally, the functions of interesting proteins β-spectrin and Rab3a in APP trafficking and processing were tested by shRNA knockdown, in N2A cells stably expressing β-amyloid precursor protein (APP).
Results: The iTRAQ and RT-PCR results revealed the detailed molecular changes in oxidative stress, myelination, astrocyte activation, mTOR signaling and Rab3-dependent APP trafficking in the early stage of AD progression. Knock down of β -spectrin and Rab3a finally led to increased APP fragment production, indicating key roles of β-spectrin and Rab3a in regulating APP processing.
Conclusion: Our study provides the first insights into the proteomic changes that occur in the hippocampus in the early stages of the AD mouse model. In addition to improving the understanding of molecular alterations and functional cascades involved in early AD pathogenesis, our findings raise the possibility of developing potential biomarkers and therapeutic targets for early AD.