New Issue | Current Bioactive Compounds; Volume 15 Issue 5

cbc-flyer

 

AIMS & SCOPE

The journal aims to provide full-length/mini review articles as well as research papers on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.

 

Articles from the Journal: Current Bioactive Compounds; Volume 15 Issue 5

For details on the Articles, Please visit this Link: http://www.eurekaselect.com/node/583/current-bioactive-compounds/issue/15/2545/5/9467

Editors Choice Article | Genus Moquiniastrum (Asteraceae): Overview of Chemical and Bioactivity Studies

 

Journal Name: Current Bioactive Compounds

Author(s): Victoria de Moraes Goncalves, Angelita Da Silveira Moreira*, Patricia Diaz de Oliveira.

 

Abstract:

The genus Moquiniastrum belongs to the Asteraceae family and is widely and exclusively dispersed throughout South America. Its species adapt easily to different cultivation conditions, and present a varied chemical composition with a great performance in pharmacological and pharmacognosy studies, mainly for sesquiterpene lactones. Moquiniastrum polymorphum is a species distinguished in the genus, presenting socioeconomic potential in several sectors, besides great application in folk medicine to treat respiratory diseases. The bioactive properties highlighted in the research are antioxidant, allelopathic, anti-inflammatory, insecticidal, antiviral and antimicrobial activity, and toxicity against different cancer lines, among others. To date, from 21 species belonging to the genus Moquiniastrum 11 species have been studied for their chemical composition, and only five species have been studied for their biological or toxicological activity. Different parts of the plants have been analysed, such as flowers, leaves and bark of the trunk and roots, and extracts obtained by different extraction methods and solvents. The genus has in its chemical composition classes of molecules such as sesquiterpene lactones, sesquiterpenes, diterpenes, triterpenes, flavonoids, coumarins, caffeic acid derivatives, acetylene and non-protein amino acids. Isolation studies of the chemical constituents of the species are promising considering that they are safe to use since they do not cause changes in DNA and can be used even during the gestational period. To read out more, please visit: http://www.eurekaselect.com/162417/article

New Issue | Current Bioactive Compounds (Volume: 15, Issue: 3)

 

The journal aims to provide full-length/mini review articles as well as research papers on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.

 

cbc-flyer.jpg

Articles from the journal: Current Bioactive Compounds; Volume: 15, Issue: 3

For details on the articles, please visit this link: http://www.eurekaselect.com/node/583/current-bioactive-compounds/issue/15/2545/3/9038

EDITOR’S CHOICE ARTICLE –Preparation, Characterization and In vitro Biological Activity of Soyasapogenol B Loaded onto Functionalized Multi-walled Carbon Nanotubes

Journal Name: Current Bioactive Compounds

Author(s): Ahmed A. Haroun*, Hala A. Amin, Sameh H. Abd El-Alim.

 

 

 

Graphical Abstract:

 

 

Abstract:

Background: Using Multi-Walled Carbon Nanotubes (MWCNTs) as a drug delivery system, can avoid the need for solvents and preventing drug precipitation in aqueous solution. Soyasapogenol B (SSB) acts as an important therapeutic agent owing to its numerous reported biological activities. Hence, this work deals with preparation and characterization of SBB loaded onto functionalized MWCNTs with tetraethyl orthosilicate (TEOS) and/or chitosan.

Method: SSB was immobilized onto functionalized MWCNTs using miniemulsion technique. Moreover, niosomes were utilized to encapsulate the prepared systems. The formulations were analyzed by Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscope (TEM) and particle size distribution analysis. In vitro release profiles of loaded SSB particles were carried out and kinetics of release were also studied. In vitro cytotoxicity of the prepared materials was examined and evaluated by SRB assay using different human cell lines such as normal melanocytes (HFB4), and carcinoma breast and liver (MCF7 and HepG2, respectively) in comparison with the standard doxorubicin.

Results: SSB loaded materials exhibited successful encapsulation in niosomes, resulting in sustainable in drug release. Study of kinetics of release revealed presence of several complex factors affecting SSB release. Mathematical processing of the in vitro release data showed that the release of SSB from niosomal formulations obeyed more than one model. The second order and Higuchi’s models were the most fitting models in case of presence of chitosan or TEOS, respectively. While, all formulations exhibited low cytotoxic properties on all tested cell lines.

Conclusion: FTIR, particle size and TEM analysis confirmed that SSB was successfully loaded onto functionalized MWCNTs. Moreover, the different niosome formulations based on functionalized MWCNTs were prepared with sustainable SSB release in. The cytotoxicity could be minimized in case of chitosan and TEOS functionalization.

 

For more details, please visit: http://www.eurekaselect.com/151456/article

THEMATIC ISSUE – SYNTHESIS, ANTI-HIV AND ANTI-INFECTIVE POTENTIAL OF MEDICINAL IMPORTANT HETEROCYCLIC COMPOUNDS

 

THEMATIC ISSUE OF THE JOURNAL: CURRENT BIOACTIVE COMPOUNDS

 

“SYNTHESIS, ANTI-HIV AND ANTI-INFECTIVE POTENTIAL OF MEDICINAL IMPORTANT HETEROCYCLIC COMPOUNDS”

 

cbc- Dr  Aakash Deep.jpg

New Issue :: Current Bioactive Compounds (Volume: 14, Issue: 3)

 

The journal aims to provide comprehensive review articles as well as research papers on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

cbc.jpg

 

Articles from the journal Current Bioactive Compounds Volume 14 Issue 3:

 

For details on the articles, please visit this link ::  https://bit.ly/2L6nwvA

EDITOR’S CHOICE – Synthesis, Characterization and Evaluation of 1,3-Bisindolyl-2-Propen-1- One Derivatives as Potent Anti-Breast Cancer Agents

JOURNAL NAME: Current Bio-active Compounds.

AUTHOR(S):  Pravin S. Bhale, Hemant V. Chavan*, Sakharam B. Dongare, Sadanand N. Shringare, Yoginath B. Mule, Praffula B. Choudhari, Babasaheb P. Bandgar*.

 

Graphical Abstract:

 

Abstract:

Background: Breast cancer is the most common invasive cancer in female worldwide. Indole scaffold represents an important class of therapeutic agents in medicinal chemistry. Many indole derivatives are reported as potent anticancer agents. This study aims to design, and synthesize anti-breast cancer potential of new bisindole derivatives.

Method: The target molecules were prepared by reacting cyano acetyl indoles with substituted indole-3- carboxyaldehydes in the presence of piperidine. All the newly synthesized compounds were in vitro screened for their anticancer activities against breast carcinoma (MCF-7) by employing the sulforhodamine B (SRB) assay method.

Results: Preliminary in vitro evaluation indicated that most of the compounds possess distinct cytotoxicity profile against MCF-7 cell line compared to standard drug adriamycin. Among them, compounds 5g, 5b, and 5q demonstrated excellent activities against breast carcinoma (GI50 < 0.1µM) as good as adriamycin (GI50 < 0.1µM). Active compounds were further subjected for molecular docking and bioavailability studies. These studies supported activities of the present series compounds.

Conclusion: New anti-breast cancer agents are the need of time, we believe that the new α-cyano substituted 1,3-bisindolyl-2-propen-1-one derivative 5g reported in this work may provide an interesting insight for further optimization.

 

Read more here: http://www.eurekaselect.com/151992/article 

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Bioactive Compounds 14-2

https://bit.ly/2sRuB8d

Current Topics in Medicinal Chemistry 18-5

https://bit.ly/2JvIWSg

Mini-Reviews in Medicinal Chemistry 18-11

https://bit.ly/2l7XtoF

Current Hypertension Reviews 14-1

https://bit.ly/2MgTgv0

Recent Innovations in Chemical Engineering 11-1

https://bit.ly/2HHqAI5

Current Cancer Drug Targets 18-6

https://bit.ly/2JO5e0P

RIA

UPCOMING THEMATIC ISSUE – RECENT TRENDS ON CANNABIS SATIVA L. AND CANNABINOIDS – CURRENT BIOACTIVE COMPOUNDS

CBC-THEMATIC FLYER - Marco Biagi Ph.D.

https://benthamscience.com/journals/current-bioactive-compounds/#top

OPEN ACCESS ARTICLE – Antiplasmodial Compounds from Leaves of Dodonaea angustifolia – Current Bioactive Compounds

Journal: Current Bioactive Compounds

Author(s): Yadessa Melaku, Tefera Worku, Yemane Tadesse, Yalemtsehay Mekonnen, Juergen Schmidt,Norbert Arnold, Ermias Dagne

Graphical Abstract:

 

Abstract:

Background: Dodonaea angustifolia is used in Ethiopian traditional medicine to treat malaria. The objective of this work was to conduct bioassay guided fractionation of the leaves of D. angustifolia using Plasmodium berghei infected mice.

Method: The antiplasmodial activity of the extracts and pure compounds was evaluated using the standard Peter’s four-day suppressive method. The structures of isolated compounds were elucidated using chemical and spectroscopic methods.

Results: In this study, the ethyl acetate soluble portion of the 80% aqueous MeOH extract of the leaves significantly suppressed parasitaemia in Plasmodium berghei infected mice (80.28% at 150 mg/kg). Three active compounds which exhibited significant percent suppression of parasitaemia by 81% at 40 mg/kg, 80% at 50 mg/kg and 70% at 40 mg/kg, respectively were identified. These are the flavanone pinocembrin (1), the flavanol santin (2) and the clerodane diterpene 2-hydroxy-15,16-epoxyceloda- 3,13(16),14-trien-18-oic acid (3). Under similar conditions, chloroquine suppressed parasitaemia by 100% at 25 mg/kg. Chemical study of the ethanol extract of the leaves yielded 5,7,4′-trihydroxy-3,6- dimethoxyflavone (4), ent-16-hydroxy-labdan-3,8-dihydroxy,13(14)-en-15,16-olide (5) and 5,6,7- trihydroxy-3,4′-dimethoxyflavone (6). Compound 6 has not been reported before as a natural product.
Conclusion: From the leaves of D. angustifolia, three compounds with significant antiplasmodial activities were isolated and characterized, with pinocembrin as the most active compound.

 

%d bloggers like this: