MOST ACCESSED ARTICLE – Advances in the Delivery of Cancer Therapeutics – Current Drug Delivery

Journal: Current Drug Delivery

Author(s): Gunjan Jeswani*, Swarnali Das Paul, Arvind Kumar Jha

Graphical Abstract:

 

Abstract:

Background: The effects of various chemotherapeutic agents have been assessed for their capacity to inhibit the cell replication in variety of cancer cases. At present there are more than hundred chemotherapeutic agents capturing worth 42 billion dollar of drug market. The major obstacle in the successful treatment of cancer is the obnoxious side effects of chemotherapeutics and multi drug resistance, which deteriorates the quality of life of cancer patient.

Objective: This article attempts to summarize different novel chemotherapeutic delivery systems which aim to circumvent these unwanted effects.

Areas Covered: Outcomes of different tumor directed carrier systems have been discussed with special emphasis on nanocarriers systems, drug polymer conjugation, directly implantable matrices and others. In addition, combination therapy and immunotherapy are also discussed as a revolutionary alternative.

Conclusion: Even though significant contributions have been made in the development of carrier systems for the chemotherapeutic agents, merits and demerits of all the avenues should be critically examined. Potential of all novel strategies should be exploited by critically evaluating their strength, weakness, opportunities and threats. Further, clinical trials based on revised and critically scrutinized frameworks and protocols are needed so that the efficiency and safe action of these new systems can be guaranteed in cancer patients.

Read more here: http://www.eurekaselect.com/154483/article

 

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Protein & Peptide Science Volume 19, Issue 4
http://bit.ly/2oANZTZ

Combinatorial Chemistry & High Throughput Screening Volume 20, Issue 10
http://bit.ly/2CKt8CO

Current Pharmaceutical Biotechnology Volume 18, Issue 11
http://bit.ly/2F8GJZG

Endocrine, Metabolic & Immune Disorders – Drug Targets Volume 18, Issue 2
http://bit.ly/2HPH2Y6

Mini-Reviews in Medicinal Chemistry Volume 18, Issue 5
http://bit.ly/2BSPLIw

Current Drug Delivery Volume 15, Issue 2
http://bit.ly/2ozzaB9

recent-issues

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

CNS & Neurological Disorders – Drug Targets 16-7

http://bit.ly/2i2fEOA

Current Physical Chemistry 7-3

http://bit.ly/2AKGPoB

Adolescent Psychiatry  7-1

http://bit.ly/2jBiqah

Current Molecular Medicine  17-3

http://bit.ly/2ka4SpY

Current Topics in Medicinal Chemistry  17-26

http://bit.ly/2zRRhKV

Current Diabetes Reviews   13-6

http://bit.ly/2ALkFCQ

Current Drug Metabolism  18-8

http://bit.ly/2kdV4eK

Current Respiratory Medicine Reviews  13-1

http://bit.ly/2BrLwjp

Current Alternative Energy  1-1

http://bit.ly/2iui8VY

Medicinal Chemistry  13-7

http://bit.ly/2AhCnwO

Current Drug Delivery 14 -7

http://bit.ly/2zFFlrD

Current Drug Targets 18 -15

http://bit.ly/2ALanm6

Current Nanoscience 13-6

http://bit.ly/2i7JE84

Combinatorial Chemistry & High Throughput Screening 20-6

http://bit.ly/2ivNMm6

recent-issues

 

 

 

 

 

Testimonial by Aline Gravinez Perissinato!

Aline Gravinez Perissinato

Contributed Article: “Simple Strategy To Protect Lactase Activity in Solid Formulation

Testimonial by Ahmed M. Agiba!

Ahmed M. Agiba

Contributed Article: Geriatric-Oriented High Dose Nutraceutical ODTs: Formulation and Physicomechanical Characterization 

Highlighted Article – Geriatric-Oriented High Dose Nutraceutical ODTs – Current Drug Delivery

cdd-Articles-14 -8-2017-Ahmed M. Agiba

http://www.eurekaselect.com/151011/article

Editor’s Choice – Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect – Current Drug Delivery

Journal: Current Drug Delivery

Author(s): Li Lin, Xiaoda Li, Yongbo Yang, Lijia Jing, Xiuli Yue, Xuzhu Chen, Zhifei Dai

 

Graphical Abstract:

Abstract:

Background: The lack of smart and controllable gene vectors with high safety and efficiency is still a main obstruction for clinical applications of gene therapy. Recently, the external physical stimuli, such as near infrared light induced temperature elevation, have been applied to enhance the gene transfection efficiency and specificity. The aim of this paper is to fabricate chitosan functionalized CuS nanoparticles (CuS@CS NPs) with small size and higher biocompatibility for enhanced gene delivery by photothermal effect.

Methods: CuS@CS NPs were successfully prepared by simple hydrothermal method. The biocompatibility was detected by MTT method and hymolytic analysis. pEGFP-C1was used as gene model, and its expression efficiency was detected by fluorescence microscopy and flow cytometry to investigate the effect of photothermal effect on the transfection efficiency.

Results: The CuS@CS NPs around 15 nm were successfully engineered. The modification of CuS nanoparticles with chitosan conduced to higher physiological stability and biocompatibility. The utilization of CuS@CS NPs in combination with external near infrared (NIR) laser irradiation could enhance gene transfection efficiency due to photothermal effect. The gene transfection efficiency of CuS@CS NPs found to increase from 5.05±0.54% (0 min) to 23.47±1.27% (10 min), significantly higher than the free polyethylenimine (18.15±1.03%).

Conclusion: CuS@CS NPs showed great capability to control gene delivery by an external NIR laser irradiation and enhance the gene transfection efficiency and specificity because of convenient preparation, stabilized optical properties, excellent photothermal effect and good biocompatibility. It encourages further exploration of the CuS@CS NPs as a photocontrollable nanovector for combined photothermal and gene therapy, as well as image guided therapy.

Read more here: http://www.eurekaselect.com/138394

Wishing A Very Happy Birthday Prof. Istvan Toth!

ultah background1

Prof. Istvan Toth

Editor-in-Chief: Current Drug Delivery

School of Pharmacy, University of Queensland
Brisbane, 4072
Australia

Article by Disease – “Preparation and Optimization of Moxifloxacin Microspheres for Colon Targeted Delivery Using Quality by Design Approach: In Vitro and In Vivo Study”

ARTICLE BY DISEASE ON “GASTROENTEROLOGY

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Abstract:

Background: Gut microbiota has a significant role in the pathogenesis of diabetes. Colonic microflora modulation using an antibiotic might have an emerging role to treat the metabolic disorders. The present study was aimed to optimize the Moxifloxacin loaded chitosan microspheres (MCMs) by emulsion cross linking method for colon targeted delivery to alter the microflora.

Methods: Preliminary optimization of MCMs was carried out using Placket-Burman design (PBD) following by final optimization with Box-Behnken design (BBD). Optimized MCMs were evaluated for yield, particle size, entrapment efficiency and in vitro/ in vivo antimicrobial activities.

Results: FTIR spectroscopy of MCMs confirms the absence of chemical interactions during the formulation. MCMs were found to be smooth, spherical with particle size around 20μm. An enteric coating of MCMs prevented the drug release in the acidic environment of the stomach and ileum with complete release at the colon. MCMs had followed the korsmeyer – peppas model of drug release, indicating the drug release by non-fickian diffusion pattern. MCMs showed significant in vitro antimicrobial activity against Lactobacillus casei and Escherichia coli. In vivo results of MCMs exhibited prolonged antimicrobial effect of drug in the cecal content of rats. Significant protective activity observed in the ileum and colon histology in rats treated with MCMs compared to the pure drug.

Conclusion: MCMs were formulated by emulsion cross linking method using QBD approach. An enteric coating around the microspheres prevented the premature drug release at upper gastrointestinal tract, while chitosan cross linking has provided the sustain release of the drug in the colonic region over the time.

Read more: http://www.eurekaselect.com/node/142092/article 

New Issue :: Current Drug Delivery 14, Issue 2

Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves.

The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.

cdd

Articles from the journal Current Drug Delivery 14, Issue 2:

                          For details on the articles, please visit this link :: http://bit.ly/2n91Wq5