Wishing you a very Happy Birthday | Prof. Xing-Jie Liang

 

Prof Xing Jie Liang

 

Prof. Xing-Jie Liang serves as the Editor-in-Chief of the Journal: Current Drug Delivery

 

Xing-Jie Liang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety
National Center for Nanoscience and Technology of China
Beijing
P.R.China

Editors Choice Article | Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies for Treatment of the Central Nervous System Diseases

Journal Name: Current Drug Delivery

Author(s): Nur Izzati Mansor, Norshariza Nordin*, Farahidah Mohamed, King Hwa Ling, Rozita Rosli, Zurina Hassan.

 

 

 

Graphical Abstract:

 

Abstract:

Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug delivery systems across the blood-brain barrier are dependent on substrate-specific (i.e. protein transport and transcytosis) and non-specific (i.e. transcellular and paracellular) transport pathways, which are crucial factors in attempts to design efficient drug delivery strategies. This review describes how the blood-brain barrier presents the main challenge in delivering drugs to treat brain diseases and discusses the advantages and disadvantages of ongoing neurotherapeutic delivery strategies in overcoming this limitation. In addition, we discuss the application of colloidal carrier systems, particularly nanoparticles, as potential tools for therapy for the CNS diseases. To read out more, please visit: http://www.eurekaselect.com/174513/article

New Issue | Current Drug Delivery; Volume 16 Issue 6

 

Current Drug Delivery aims to publish peer-reviewed articles, research articles, in-depth reviews/mini-reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves.

The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.

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Articles from the journal: Current Drug Delivery; Volume 16  Issue 6:

 

For details on the articles, please visit this link:  http://www.eurekaselect.com/node/595/current-drug-delivery/issue/16/2518/6/9222

Editors Choice Article | Bioactive Medications for the Delivery of Platelet Derivatives to Skin Wounds

Journal Name: Current Drug Delivery

Author(s): Maria Cristina Bonferoni*, Silvia Rossi, Giuseppina Sandri, Carla Caramella, Claudia Del Fante, Cesare Perotti, Dalila Miele, Barbara Vigani, Franca Ferrari.

 

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Chronic wounds are the result of alterations in the complex series of events of physiological wound healing. In particular, the prolonged inflammation results in increased protease activity, in the degradation of extracellular matrix (ECM) and of growth factors (GFs). The relevance of platelet GFs in maintaining and restoring the complex equilibrium of different moments in wound healing is well recognized. Moreover, the observed decrease of their levels in chronic wounds suggested a possible therapeutic role of the external application to the wounds. It has been also pointed out that tissue regeneration can be more efficiently obtained by the synergic use of different GFs. Platelet derivatives such as platelet- rich plasma (PRP) and platelet lysate (PL) are able to release GFs in a balanced pool. Their therapeutic use in regenerative medicine and wound healing has been therefore more and more frequently proposed in clinical trials and in the literature. The development of a suitable formulation able to control the GFs release rate, to protect the GFs, and to assure their prolonged contact with the wound site, is of paramount importance for the therapeutic success. The present review considers some formulation approaches for PRP and PL application to wounds. Read out full article at: http://www.eurekaselect.com/170878/article

 

 

Editor’s Choice Article | Stimulus Sensitive Smart Nanoplatforms: An Emerging Paradigm for the Treatment of Skin Diseases

Author(s): Divya, Gurpreet Kaur*.

Journal Name: Current Drug Delivery

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Over the past century, the prevalence of skin diseases has substantially increased. These diseases present a significant physical, emotional and socio-economic burden to the society. Such conditions are also associated with a multitude of psychological traumas to the suffering patients.

The effective treatment strategy implicates targeting of drugs to the skin. The field of drug targeting has been revolutionized with the advent of nanotechnology. The emergence of stimulus-responsive nanoplatforms has provided remarkable control over fundamental polymer properties for external triggers. This enhanced control has empowered pioneering approaches in the treatment of chronic inflammatory skin diseases. Read out more at: http://www.eurekaselect.com/169276/article

New Issues of various Bentham Science Journals

1. Current Medicinal Chemistry, Vol: 25, Issue: 30

https://bit.ly/2DxQIaA

2. Current Nanomaterials, Vol: 3, Issue: 1

https://bit.ly/2PLeKVA

3. Adolescent Psychiatry, Vol: 8, Issue: 2

https://bit.ly/2Oxq1UN

4. Current Proteomics, Vol: 15, Issue: 4

https://bit.ly/2QvB8PE

5. Current Signal Transduction Therapy, Vol: 13, Issue: 2

https://bit.ly/2OxFrs0

6. Current Pharmaceutical Design, Vol: 24, Issue: 19

https://bit.ly/2AVflvj

7. Current Organic Chemistry, Vol: 22, Issue: 16

https://bit.ly/2JQIP0k

8. Current Drug Delivery, Vol: 15, Issue: 9

https://bit.ly/2JOUug4

9. Letters in Drug Design & Discovery, Vol: 15, Issue: 11

https://bit.ly/2SX2Few

10. Current Medicinal Chemistry, Vol: 25, Issue: 29

https://bit.ly/2SYb2qb

 

Issues

AIMS & SCOPE – Current Drug Delivery

Aims & Scope:

 

Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves.

The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.

 

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For more details, please visit: https://benthamscience.com/journals/current-drug-delivery/aims-scope/#top

Most Accessed Articles – Nanomedicine for Intranasal Delivery to Improve Brain Uptake

Journal Name: Current Drug Delivery

Author(s): Amit A. Patel*, Ravish J. Patel*, Shachi R. Patel.

Graphical Abstract:

 

Abstract:

Intranasal drug delivery system provides distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for the treatment of central nervous system diseases is, low concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantages like improved bioavailability, law dose and quick onset of action and high patient compliance, and the major disadvantage is residence time of drug and irreversible entrapment of drug. This article provides anatomical and physiological information about nasal route and various factors. Article discusses various types of nanoparticles used intranasally and moreover article also emphasizes patents, formulation under development and some.

 

For more details, please visit: http://www.eurekaselect.com/156384

Open Access Articles – Ethosomes and Transfersomes: Principles, Perspectives and Practices

Journal Name: Current Drug Delivery

Author(s): Varun Garg, Harmanpreet Singh, Sneha Bimbrawh, Sachin Kumar Singh*,Monica Gulati, Yogyata Vaidya, Prabhjot Kaur.

 

 

Graphical Abstract:

 

 

Abstract:

Background: The success story of liposomes in the treatment of systemic infectious diseases and various carcinomas lead the scientists to the innovation of elastic vesicles to achieve similar success through transdermal route. In this direction, ethosomes and transfersomes were developed with the objective to design the vesicles that could pass through the skin. However, there is a lack of systematic review outlining the principles, method of preparation, latest advancement and applications of ethosomes and transfersomes. This review covers various aspects that would be helpful to scientists in understanding advantages of these vesicular systems and designing a unique nano vesicular delivery system.

Methods: Structured search of bibliographic databases for previously published peer-reviewed research papers was explored and data was culminated in terms of principle of these vesicular delivery systems, composition, mechanism of actions, preparation techniques, methods for their characterization and their application.

Results: A total of 182 papers including both, research and review articles, were included in this review in order to make the article comprehensive and readily understandable. The mechanism of action and composition of ethosomes and transfersomes was extensively discussed. Various methods of preparation such as, rotary film evaporation method, reverse phase evaporation method, vortex/ sonication method, ethanol injection method, freeze thaw methods, along with their advantages has been discussed. It was also discussed that both these elastic nanocarriers offer unique advantages of ferrying the drug across membranes, sustaining drug release as well as protecting the encapsulated bio actives from external environment. The enhanced bioavailability and skin penetration of ethosomes as compared to conventional vesicular delivery systems is attributed to the presence of ethanol in the bilayers while that for transfersomes accrues due to their elasticity along with their ability to retain their shape because of the presence of edge activators. Successful delivery of synthetic drugs as well as phytomedicines has been extensively reported through these vesicles.
Conclusion: Though these vesicular systems offer a good potential for rational drug delivery, a thoughtfully designed process is required to optimize the process variables involved. Industrial scale production of efficacious, safe, cost effective and stable formulations of both these delivery systems appears to be a pre-requisite to ensure their utility as the trans-dermal vehicles.

For more details, please visit: http://www.eurekaselect.com/142368

New Issue :: Current Drug Delivery (Volume: 15, Issue: 7)

 

Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves.

 

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Articles from the journal Current Drug Delivery Volume 15, Issue 7:

 

 

For details on the articles, please visit this link ::  https://bit.ly/2OpCzP4

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