New Issue ::: Current Drug Delivery Volume 15, Issue 5

Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves.

The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.

cdd

Articles from the journal Current Drug Delivery Volume 15, Issue 5:

For details on the articles, please visit this link :: https://bit.ly/2IpgeSv

 

New Issue :: Current Drug Delivery 15, Issue 3

Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves.

The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.

cdd

Articles from the journal Current Drug Delivery 15, Issue 3:

                       For details on the articles, please visit this link :: https://bit.ly/2jQGMxl

 

 

MOST ACCESSED ARTICLE – Advances in the Delivery of Cancer Therapeutics – Current Drug Delivery

Journal: Current Drug Delivery

Author(s): Gunjan Jeswani*, Swarnali Das Paul, Arvind Kumar Jha

Graphical Abstract:

 

Abstract:

Background: The effects of various chemotherapeutic agents have been assessed for their capacity to inhibit the cell replication in variety of cancer cases. At present there are more than hundred chemotherapeutic agents capturing worth 42 billion dollar of drug market. The major obstacle in the successful treatment of cancer is the obnoxious side effects of chemotherapeutics and multi drug resistance, which deteriorates the quality of life of cancer patient.

Objective: This article attempts to summarize different novel chemotherapeutic delivery systems which aim to circumvent these unwanted effects.

Areas Covered: Outcomes of different tumor directed carrier systems have been discussed with special emphasis on nanocarriers systems, drug polymer conjugation, directly implantable matrices and others. In addition, combination therapy and immunotherapy are also discussed as a revolutionary alternative.

Conclusion: Even though significant contributions have been made in the development of carrier systems for the chemotherapeutic agents, merits and demerits of all the avenues should be critically examined. Potential of all novel strategies should be exploited by critically evaluating their strength, weakness, opportunities and threats. Further, clinical trials based on revised and critically scrutinized frameworks and protocols are needed so that the efficiency and safe action of these new systems can be guaranteed in cancer patients.

Read more here: http://www.eurekaselect.com/154483/article

 

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Current Pharmaceutical Biotechnology Volume 18, Issue 11
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Endocrine, Metabolic & Immune Disorders – Drug Targets Volume 18, Issue 2
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Mini-Reviews in Medicinal Chemistry Volume 18, Issue 5
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recent-issues

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

CNS & Neurological Disorders – Drug Targets 16-7

http://bit.ly/2i2fEOA

Current Physical Chemistry 7-3

http://bit.ly/2AKGPoB

Adolescent Psychiatry  7-1

http://bit.ly/2jBiqah

Current Molecular Medicine  17-3

http://bit.ly/2ka4SpY

Current Topics in Medicinal Chemistry  17-26

http://bit.ly/2zRRhKV

Current Diabetes Reviews   13-6

http://bit.ly/2ALkFCQ

Current Drug Metabolism  18-8

http://bit.ly/2kdV4eK

Current Respiratory Medicine Reviews  13-1

http://bit.ly/2BrLwjp

Current Alternative Energy  1-1

http://bit.ly/2iui8VY

Medicinal Chemistry  13-7

http://bit.ly/2AhCnwO

Current Drug Delivery 14 -7

http://bit.ly/2zFFlrD

Current Drug Targets 18 -15

http://bit.ly/2ALanm6

Current Nanoscience 13-6

http://bit.ly/2i7JE84

Combinatorial Chemistry & High Throughput Screening 20-6

http://bit.ly/2ivNMm6

recent-issues

 

 

 

 

 

Testimonial by Aline Gravinez Perissinato!

Aline Gravinez Perissinato

Contributed Article: “Simple Strategy To Protect Lactase Activity in Solid Formulation

Testimonial by Ahmed M. Agiba!

Ahmed M. Agiba

Contributed Article: Geriatric-Oriented High Dose Nutraceutical ODTs: Formulation and Physicomechanical Characterization 

Highlighted Article – Geriatric-Oriented High Dose Nutraceutical ODTs – Current Drug Delivery

cdd-Articles-14 -8-2017-Ahmed M. Agiba

http://www.eurekaselect.com/151011/article

Editor’s Choice – Chitosan Functionalized CuS Nanoparticles Boots Gene Transfection via Photothermal Effect – Current Drug Delivery

Journal: Current Drug Delivery

Author(s): Li Lin, Xiaoda Li, Yongbo Yang, Lijia Jing, Xiuli Yue, Xuzhu Chen, Zhifei Dai

 

Graphical Abstract:

Abstract:

Background: The lack of smart and controllable gene vectors with high safety and efficiency is still a main obstruction for clinical applications of gene therapy. Recently, the external physical stimuli, such as near infrared light induced temperature elevation, have been applied to enhance the gene transfection efficiency and specificity. The aim of this paper is to fabricate chitosan functionalized CuS nanoparticles (CuS@CS NPs) with small size and higher biocompatibility for enhanced gene delivery by photothermal effect.

Methods: CuS@CS NPs were successfully prepared by simple hydrothermal method. The biocompatibility was detected by MTT method and hymolytic analysis. pEGFP-C1was used as gene model, and its expression efficiency was detected by fluorescence microscopy and flow cytometry to investigate the effect of photothermal effect on the transfection efficiency.

Results: The CuS@CS NPs around 15 nm were successfully engineered. The modification of CuS nanoparticles with chitosan conduced to higher physiological stability and biocompatibility. The utilization of CuS@CS NPs in combination with external near infrared (NIR) laser irradiation could enhance gene transfection efficiency due to photothermal effect. The gene transfection efficiency of CuS@CS NPs found to increase from 5.05±0.54% (0 min) to 23.47±1.27% (10 min), significantly higher than the free polyethylenimine (18.15±1.03%).

Conclusion: CuS@CS NPs showed great capability to control gene delivery by an external NIR laser irradiation and enhance the gene transfection efficiency and specificity because of convenient preparation, stabilized optical properties, excellent photothermal effect and good biocompatibility. It encourages further exploration of the CuS@CS NPs as a photocontrollable nanovector for combined photothermal and gene therapy, as well as image guided therapy.

Read more here: http://www.eurekaselect.com/138394

Wishing A Very Happy Birthday Prof. Istvan Toth!

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Prof. Istvan Toth

Editor-in-Chief: Current Drug Delivery

School of Pharmacy, University of Queensland
Brisbane, 4072
Australia