New Issue | Current Drug Targets; Volume 21 Issue 5

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Current Drug Targets

Volume 21, Issue 5

AIMS & SCOPE

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

 

 

Articles from the Journal 

For more details on the articles, please visit HERE 

Editors Choice Article | Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer

 

Journal Name: Current Drug Targets

Author(s): Ashish Ranjan Dwivedi, Amandeep Thakur, Vijay Kumar, Ira Skvortsova, Vinod Kumar*

 

 

 

Graphical Abstract:

 

Abstract:

Resistance to chemotherapy and relapse are major hurdles for the effective treatment of cancer. Major reason for this is a small sub population of cancer stem cells (CSCs) and its microenvironment. CSCs are critical driving force for several types of cancer, such as gastric, colon, breast and many more. Hence, for the complete eradication of cancer, it is necessary to develop therapeutic approaches that can specifically target CSCs. Chemical agents that target different proteins involved in CSC signaling pathways, either as single agent or simultaneously targeting two or more proteins have generated promising pre-clinical and clinical results. In the current review article, we have discussed various targets and cellular pathways that can be explored for the effective and complete eradication of CSCs. Some latest developments in the field of design, synthesis and screening of ligands to target cancer stem cells have been summarized in the current review article. To read out more, please visit: http://www.eurekaselect.com/174388/article

Editors Choice Article | Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle

Journal Name: Current Drug Targets

Author(s): Jobin Jose, Aaron Mathew Thomas, Darewin Mendonsa, Mohammad M. Al-Sanea, Md. Sahab Uddin, Della Grace Thomas Parambi, R Narayana Charyulu, Bijo Mathew*

 

Graphical Abstract:

 

Abstract:

Implementation of novel and biocompatible polymers in drug design is an emerging and rapidly growing area of research. Even though we have a large number of polymer materials for various applications, the biocompatibility of these materials remains as a herculean task for researchers. Aptamers provide a vital and efficient solution to this problem. They are usually small (ranging from 20 to 60 nucleotides, single-stranded DNA or RNA oligonucleotides which are capable of binding to molecules possessing high affinity and other properties like specificity. This review focuses on different aspects of Aptamers in drug discovery, starting from its preparation methods and covering the recent scenario reported in the literature regarding their use in drug discovery. We address the limitations of Aptamers and provide valuable insights into their future potential in the areas regarding drug discovery research. Finally, we explained the major role of Aptamers like medical imaging techniques, application as synthetic antibodies, and the most recent application, which is in combination with nanomedicines.

 

To read out more, please visit: http://www.eurekaselect.com/173917/article

New Issue | Current Drug Targets; Volume 20 Issue 16

 

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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Articles from the journal: Current Drug Targets; Volume 20 Issue 16

For details on the articles, please visit this link: http://www.eurekaselect.com/node/590/current-drug-targets/issue/20/2521/16/9394

Read what our Authors have to say about publishing in our Journals | Dr. Rina Das

 

Rina Das.jpg

By Dr. Rina Das

Journal Name: Current Drug Targets

Contributed Article: Considering Circadian Pattern of Blood Pressure in the Treatment of Hypertension via Chronotherapy: A Conducive or Maladroit Approach

Press Release | Bentham Science journals improve impact factor ratings in 2019

 

The latest edition of Journal Citation Reports® 2019 has been published recently, and according to the report, Bentham Science Publishers (BSP) journals have significantly improved their Impact Factors. Current Neuropharmacology is leading the list again with the highest impact factor (IF: 4.568) among all the journals. In total, 40 BSP journals have received Impact Factor ratings this year. The latest results in the JCR 2019 reflect the high quality of research published by Bentham Science.

Journal Citation Reports (JCR) is an annual publication by Clarivate Analytics. JCR has been integrated with the Web of Science and is accessible from the Web of Science-Core Collections. Its purpose is to offer a systematic means to critically evaluate the world’s leading journals, with quantifiable, statistical information based on citation data.

Bentham Science publishes over 100 print & online scholarly subscription journals and books. Learn more about Bentham Science here: http://www.benthamscience.com

 

Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2019-06/bsp-bsl062019.php

Wishing you a very Happy Birthday | Dr. Francis J. Castellino

 

Dr  Francis J Castellino

 

Francis J. Castellino

Editor in Chief: Current Drug Targets

 

Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

New Issues of various Bentham Science Journals

 

1. Mini-Reviews in Medicinal Chemistry, Vol: 18, Issue: 16

https://bit.ly/2qCXROI

2. Mini-Reviews in Medicinal Chemistry, Vol: 18, Issue: 17

https://bit.ly/2qBcaDd

3. Current Drug Targets, Vol: 19, Issue: 13

https://bit.ly/2QttYLL

4. Current Drug Metabolism, Vol: 19, Issue: 10

https://bit.ly/2qAdypw

5. Current Cancer Drug Targets, Vol: 18, Issue: 8

https://bit.ly/2z3e6sN

6. Current Pharmaceutical Analysis, Vol: 14, Issue: 6

https://bit.ly/2PNXYVE

7. The Natural Products Journal, Vol: 8, Issue: 3

https://bit.ly/2yYGJY6

8. Current Organocatalysis, Vol: 5, Issue: 2

https://bit.ly/2RKY65t

9. Current Drug Safety, Vol: 13, Issue: 3

https://bit.ly/2OvKMjC

10. Current Topics in Medicinal Chemistry, Vol: 18, Issue: 12

https://bit.ly/2D9ecSA

 

Issues

EDITOR’S CHOICE ARTICLE – Microbial Biofilm and Quorum Sensing Inhibition: Endowment of Medicinal Plants to Combat Multidrug-Resistant Bacteria

Journal Name: Current Drug Targets

Author(s): Rina Das, Dinesh Kumar Mehta*.

 

 

 

Graphical Abstract:

 

Abstract:

 

Continued emergence and spread of multidrug-resistant bacteria behooved the development of alternative treatment strategies, including antimicrobial drugs. A hopeful approach is to target cellto- cell communications, commonly known as quorum-sensing (QS) and microbial biofilm formation. Quorum Sensing is a method used on bacteria to determine their physiological behavior and coordinate gene expression based on the cell to cell signaling. Many physiological functions of bacteria are controlled by quorum sensings such as virulence, motility, sporulation, luminescence, and biofilm formation. Microbial biofilms are organized aggregations of cells attached to a substratum and surrounded by a self-produced extrapolymeric substance (EPS) matrix. Currently, biofilm formation and quorum sensing are considered as a prospective novel target for antimicrobial therapy to control multidrug- resistant infections. Plant-based natural products have been comprehensively studied in this context. In this review, a comprehensive overview of various research papers published in the last decade on plant-derived molecules that are capable of inhibiting quorum sensing or microbial biofilm formation is reviewed, mentioning the biosynthetic classes of active compounds and their biological activity in the performed assays.

 

For more details, please visit: http://www.eurekaselect.com/161075/article

CALL FOR PAPERS – Special Thematic Issues

Forthcoming Special Issues of the journal Current Drug Targets”

“The Computational Methods in Drug Targets Discovery “

CDT -THEMATIC Prof. Hao Lin

Guest Editor: Hao Lin

Tentative Publication Date: March, 2019

Read the abstract here: https://bit.ly/2xjlr6y 

Email here to submit your paper:  hlin@uestc.edu.cn

CC at faizan@benthamscience.net

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