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Journal Name: Current Enzyme Inhibition
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NEW ISSUE ::: Current Enzyme Inhibition 14, ISSUE 1
Current Enzyme Inhibition aims to publish original research, review and letter articles in all the latest and outstanding developments on enzyme inhibition studies. The coverage includes the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Current Enzyme Inhibition is an essential journal for every pharmaceutical researcher and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.
Articles from the journal Recent Patents on Current Enzyme Inhibition Volume 14, Issue 1:
- Recent Developments on Tyrosinase Inhibitors based on the Chalcone and Aurone Scaffolds
- In vitro Evaluation of Biological Effects of Metallic Compounds with Quinolines
- Pyrazolyl Benzamides: Synthesis, Characterization and Potent Biological Activity, Part-2
- 17β-N-arylcarbamoylandrost-4-en-3-one Derivatives as Inhibitors of the Enzymes 3α-Hydroxysteroid Dehydrogenase and 5α-Reductase
- Predicted Mechanism of Antiasthmatic Drugs in Depression Based on Their Interaction with SERT and 5-HT1A Receptors
- Molecular Modeling Interaction Between Enzyme Diabetes Type 2 Dipeptidyl- Peptidase (DPP-4) and Main Compound of Cinnamon
- Angiotensin I Converting Enzyme-inhibiting Peptides Purified from Elastase-degraded Elastin Prepared from Pig Aorta
- Vigna unguiculata Trypsin Inhibitor: A Protein with Versatile Biological Applications
For details on the articles, please visit this link: https://bit.ly/2GvzmfU
EDITOR’S CHOICE – Vigna unguiculata Trypsin Inhibitor – Current Enzyme Inhibition
Journal: Current Enzyme Inhibition
Author(s): Romana Parveen, Tooba Naz Shamsi, Sumbul Afreen, Mudsser Azam, Tasneem Fatma, Qazi Mohd. Rizwanul Haque, Sadaf Fatima*
Graphical Abstract:
Abstract:
Background: Trypsin Inhibitors are one of the most promising and investigated subject for their role in pharmacognostical and pharmacological studies.
Aim: The paper describes purification and characterization of trypsin inhibitor obtained from blackeyed cowpea (Vigna unguiculata).
Methods: The purification procedure of Vigna unguiculata trypsin inhibitor (VUTI) includes homogenization followed by ammonium sulphate precipitation. The protein thus precipitated was further dialysed and purified by ion exchange chromatography and gel permeation chromatography. The molecular weight was determined by SDS-PAGE. The protein thus purified was characterized biochemically to demonstrate curative potential as strong antioxidant, anti-inflammatory and antimicrobial agent.
Results: The 15 kDa VUTI obtained showed IC50 values 490 µg/ml compared to standard which was 254µg/ml in 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay. Also, the highest ferric reducing antioxidant power (FRAP) results confirmed the highest FRAP value of 0.405 mM at 1000 µg/ml and the lowest value of 0.113 mM at 100 μg/ml which were quite comparable to ascorbic acid (standard). Anti-inflammatory activity of VUTI was depicted by the method of inhibition of albumin denaturation where, VUTI showed high IC50 value of 696.46 µg/ml. Also, VUTI showed good antibacterial potential by inhibiting all tested bacterial strains with maximum inhibition against Bacillus subtilis (99.62%) and minimum against Staphylococcus aureus (34.62%). The results were quite comparable with standard drug ampicillin (5 mg/ml). Unfortunately, VUTI failed to show any activity against fungi.
Conclusion: Thus, the results obtained depict that VUTI additionally be a wonderful candidate for development of novel antibacterial drugs, and it can also be used to reduce the deletorious effects of free radicals.
Read more here: http://www.eurekaselect.com/153396/article
Wishing A Very Happy Birthday Prof. Claudia T. Supuran!
EDITOR-IN-CHIEF: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry & Current Enzyme Inhibition
University of Florence, Neurofarba Department
Sesto Fiorentino (Firenze)
Italy
New Issue :: Current Enzyme Inhibition 13, Issue 1
Current Enzyme Inhibition aims to publish original research, review and letter articles in all the latest and outstanding developments on enzyme inhibition studies. The coverage includes the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Current Enzyme Inhibition is an essential journal for every pharmaceutical researcher and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.
Articles from the journal Current Enzyme Inhibition 13, Issue 1:
- In vitro and In silico: Selectivities of Seychellene Compound as Candidate Cyclooxygenase Isoenzyme Inhibitor on Pre-Osteoblast Cells
- An in silico Approach Towards Crop Improvement by ACC Synthase Inhibition Declining Ethylene Production
- Targeting HIV-1 Envelope Proteins Using a Fragment Discovery All-Atom Computational Algorithm
- Acethylcholinesterase Inhibition, Antibacterial and Antioxidant Properties of Diaryl Oxalates
- Inhibitory Effects of Some Bryophytes on Glutathione-S -Transferase
- Screening of Potential Plant Compounds as Survivin Inhibitors and its Anti-Cancer Efficacy by Molecular Docking
- Phytochemical and Biological Activities of five Turanecio Hamzaoglu (Asteraceae) Species from Turkey
- Biochemical Characterization and Kinetics of Carboxylesterase Isolated from Rabbit Liver and Lung in order to Application in the Detoxification of Environmental Pollutants
- α-Glucosidase Inhibitory Effect and Antioxidant Activity of the Extracts of Eighteen Plant Traditionally Used in Algeria for Diabetes
For details on the articles, please visit this link :: http://bit.ly/2nrdtEV
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